• Parasites, Hosts and Diseases
• /
• 제60권6호
• /
• pp.429-432
• /
• 2022

Inflammatory eyelid symptoms are common in primary care and there have been several reports on Demodex blepharitis. In the present study, we evaluate the 9 patients with Demodex blepharitis, who showed inflammation of the eyelids, dry eye, and cylindrical dandruff at the base of the eyelashes. The causative species from all patients was Demodex folliculorum of either the adult or nymph stage. Two patients had recurrent chalazion and 3 patients had keratitis. Weekly lid scrubs with 50% tee tree oil were performed for 6 weeks. After treatment, the symptoms of blepharitis and keratitis had improved in all patients. This case report provides clinical reference source for the proper treatment of ocular demodicosis.

• Biomolecules & Therapeutics
• /
• 제21권2호
• /
• pp.170-172
• /
• 2013

The pyrimidine nucleoside uridine has recently been reported to have a protective effect on cultured human corneal epithelial cells, in an animal model of dry eye and in patients. In this study, we investigate the pharmacokinetic profile of uridine in rabbits, following topical ocular (8 mg/eye), oral (450 mg/kg) and intravenous (100 mg/kg) administration. Blood and urine samples were serially taken, and uridine was measured by high-performance liquid chromatography-tandem mass spectrometry. No symptoms were noted in the animals after uridine treatment. Uridine was not detected in either plasma or urine after topical ocular administration, indicating no systemic exposure to uridine with this treatment route. Following a single intravenous dose, the plasma concentration of uridine showed a bi-exponential decay, with a rapid decline over 10 min, followed by a slow decay with a terminal half-life of $0.36{\pm}0.05$ h. Clearance and volume of distribution were $1.8{\pm}0.6$ L/h/kg and $0.58{\pm}0.32$ L/kg, respectively. The area under the plasma concentration-time curves (AUC) was $59.7{\pm}18.2{\mu}g{\cdot}hr/ml$, and urinary excretion up to 12 hr was ~7.7% of the dose. Plasma uridine reached a peak of $25.8{\pm}4.1{\mu}g/ml$ at $2.3{\pm}0.8$ hr after oral administration. The AUC was $79.0{\pm}13.9{\mu}g{\cdot}hr/ml$, representing ~29.4% of absolute bioavailability. About 1% of the oral dose was excreted in the urine. These results should prove useful in the design of future clinical and nonclinical studies conducted with uridine.

• Asian-Australasian Journal of Animal Sciences
• /
• 제27권5호
• /
• pp.683-689
• /
• 2014

This study examined carcass and meat quality parameters in growing/finishing pigs fed unconventionally versus the concentrate-based system. Ninety-six, 12 wk old pigs ($34{\pm}SD0.3kg$) were randomly divided into three groups, assigned to one of the three dietary treatments: standard complete concentrate mixture, conventional (C diet); unconventional, steamed potato-green forage-concentrate based diet (U diet), and unconventional basal diet+herbage mix (UH diet). Pigs fed U diet showed lower dressing percentage, meatiness, loin eye area, and weight of pork neck ($p{\leq}0.05$), but their carcasses were significantly ($p{\leq}0.05$) longer and had increased backfat depth ($p{\leq}0.05$). There was no impact of the diet on the meat content of dry matter, crude ash, acidity, and colour parameters of m. longissimus. Unconventional feeding significantly ($p{\leq}0.05$) elevated water the holding capacity of m. longissimus and slightly improved the sensory attributes analysis of meat. The addition of herbs resulted in increased loin eye area ($p{\leq}0.05$), decreased fat content ($p{\leq}0.05$) in m. longissimus, and tended to improve some sensory attributes of meat. There were significant gender differences in response to all diets. There were significant diet${\times}$sex interactions for some measured variables, but there were no clearly identifiable trends with regard to any specific carcass or meat parameters. Feeding unconventional diet to pigs may offer better culinary attributes of the meat, and improve some technologically important characteristics of pig carcass, but may negatively affect some carcass or meat parameters.

• 환경위생공학
• /
• 제22권2호
• /
• pp.1-8
• /
• 2007

This research is based on self-filling survey which 656 dental hygienists who work in, seoul, the metropolitan area, jeon-buk area participated on July 2006 through August 2006. This survey was analyzed the relationship between the subjective symptoms(6 types) and outdoor air quality($O_3,\;NO_2,\;CO,\;SO_2,\;PM_{10}$) As follows analyzed results. The health condition of dental hygienists were "Feel Good" more than 50% in last month. The experience the symptoms level is higher then non-experience level in "Dry eye, itch, smarting", "Headaches", "Fatigue and sleepiness", "Red eye", "Hypersensitivity", "Dorsalgia, omarthralgia, cervicodynia". We anticipated that the more experience the subjective symptom the more likely it is that outdoor air quality will be high rate level. But we could not find the uniformity in metropolitan-area and seoul-area. In the case of jeonbuk area, the group's pollution density levels which experienced the subjective symptom were appeared high rate than inexperienced group except $SO_2$. It probably comes from sensibility for an air pollution in this area. Dental hygienists who work in jeonbuk area have an unusual sensibility for an air pollution because outdoor air quality of jeonbuk area was rule good rather than others area. especially $SO_2$ was revealed out even though low rate level in inexperienced group it is that the number of cars in jeonbuk area is increasing rapidly.

• 동의신경정신과학회지
• /
• 제20권1호
• /
• pp.119-146
• /
• 2009

Objectives : In this study, patients with tic disorders who visited an Oriental medicine clinic were examined for their demographic characteristics, characteristics of symptoms, relation to Attention-deficit Hyperactivity Disorder(ADHD) and peculiarity according to various variables such as motor and vocal tics. Methods : After surveying 292 patients who visited an Oriental medicine clinic with tic symptoms as main complaints for 17 months, SAS 9.1, a statistical program was used for statistical analysis. Results : 1. The BMI of male tic patients was significantly higher than female ones and it was similar to or higher than the normal group. 2. Patients who are eldest children were 1.7 times higher than those who are not eldest ones. 3. The most usual case of motor tics was the eye blink and the most one of vocal tics was a dry cough. 4. There was no significant difference between male and female patients for all symptoms of motor and vocal tics, but male patients had significantly more obsessions related to tics than female ones. 5. There was no significant difference in the age of initial occurrence of Transient tic disorder(TTD), Chronic tic disoder(CTD) and Tourette's disorder(TD). 6. For the general disorder of a tic and Conners' ADHD rating scale, there was no significance in TTD, CTD and TD. 7. 66% out of the total subjects of 197 cases were found to score more than 65 points in more than 1 items among 8 items such as the time, hearing, wrong alarm, mean response time and standard deviation in the response time, etc. of the ADHD diagnosis system(ADS). 8. The eye blink among motor tics was shown mainly by patients under 10 years old and the frown, movement of the head, shrug and movement of the arms were shown mainly by 11-19 years old patients. Conclusions : For the number, frequency, seriousness and inconvenience in life of tics, TD showed a significantly higher result than TTD and CTD.

• 대한본초학회지
• /
• 제31권4호
• /
• pp.79-85
• /
• 2016

Objectives : The aim of this study is to investigate anti-atopic dermatitis effect using ato-tang.Methods : Ato-tang was external treatment to NC/Nga mice for 4 weeks, where atopic dermatitis was induced by DNCB at 1% and 0.4% for 3 weeks. Atopic dermatitis index score was measured using eye observation and picture evaluation. The histopathological change of dorsal skin was observed by hematoxylin and eosin (H&E) staining. Cytokines including IL-4, IL-5 and IL-13 were measured by Luminex or reverse transcriptase polymerase chain reaction (RT-PCR) analysis and immunoglobulin E (IgE) was measured by ELISA reader.Results : The dorsal skin of Ato-tang group showed decrease in erythema, pruritus, dry skin, edema, excoriation, erosion and lichenification level through naked eye observations. Immunoglobulin cell infiltration and the thickness of epidermis were significantly decreased in the dorsal skin compared to control. Production of Th2 cytokines (IL-4, IL-5, IL-13) and IgE level in serum were all significantly decreased, in comparison with control. In addition, mRNA expression level of Th2 cytokines (IL-4, IL-5, IL-13) in spleen was decreased, in comparison with control.Conclusion : The results indicated that external treatment of ato was improved skin barrier function in the symptoms of atopic dermatitis disease. Also, atopic dermatitis factors where cytokine as well as immunoglobulin E in serum and mRNA expression were decreased, respectively, in comparison with control. Therefore, we suggest that ato could be effectively used as a external therapeutic drug based on atopic dermatitis factors.

• 한방안이비인후피부과학회지
• /
• 제20권3호
• /
• pp.169-180
• /
• 2007

Objective : This study was to explore the change of new outpatients in ophthalmology, otolaryngology, dermatology. Methods : We did stastical analysis about 4638 new outpatients who had visited the department of ophthalmology, otolaryngology, dermatology in Kyunghee oriental medicine center from January 1, 2004 to December 31, 2006 and had ophthalmologic, otologic, rhinologic, laryngologic and dermatologic diseases. Results : The results were as follows. 1. Distribution of ophthalmology, otology, rhinology, laryngology and dermatology classification in new outpatients was 44.74% in dermatology the most, 26.50% in rhinology, 14.45% in otology, 8.78% in ophthalmology, 5.54% in laryngology. In all classifications except ophthalmology, outpatients increased, but the proportion of outpatients increased the most in dermatology. 2. The proportion of the new outpatients in ophthalmology was 20.15% in 51-60 years old the most. And 36.61% in dry eye the most, next 27.03% in visual disorder, 10.07% in strabismus. The proportion of the new outpatients in ophthalmology in strabismus decreased by 43.93 percent point but in dry eye increased by 32.17 percent point. 3. The proportion of the new outpatients in otology was 24.94% in 61+ years old the most. And 64.03% in tinnitus, hearing loss the most, next 17.46% in vertigo, dizziness. By 17.36 percent point, it in tinnitus, hearing loss decreased. But in vertigo, dizziness increased by 14.91 percent point. 4. The proportion of the new outpatients in rhinology was 40.93% in 0-10 years old the most. And it increased by 20.08 percent point. 69.30% in rhinitis the most but it decreased by 17.70 percent point. But 32.59% in sinusitis, that means it increased by 14.41 percent point. 5. The proportion of the new outpatients in laryngology was 68.09% in female, 23.35% in 51-60 years old the most. And it was 29.96% in laryngopharyngitis, 19.07% in stomatitis, 14.40% in the diseases of tongue. 6. The proportion of the new outpatients in dermatology was 37.21% in 21-30 years old the most.And it was 22.93% in atopic dermatitis the most, next 14.77% in urticaria. That means it increased by 8.19 percent point. But the proportion of the new outpatients in dermatology decreaed in acne, pruritus. Conclusions : We could know that there had been many changes of new outpatients in ophthalmology, otolaryngology, dermatology

• Journal of Acupuncture Research
• /
• 제21권6호
• /
• pp.281-289
• /
• 2004

Objective : Blepharoptosis is drooping of eyelid which causes impairment of visual field by covering partially or completely, and it is classified into congenital ptosis and acquired one. In western medicine, idiopathic blepharoptosis is usually treated by tarsectomy. Contrary to that concept, we consider eyelid is assigned to Yookryoon(肉輪) among Ohryoon(五輪) which matches to spleen. In oriental medicine, it can be treated by promoting spleen and kidney. Here I report two cases of idiopathic blepharoptosis improved by conservative acupuncture therapy and herb medicine. Methods : The changes in clinical symptoms of general body weakness, anorexia, dizziness, dry eye, etc, in degree of eyelid drooping and in individual expression were described as they were treated with acupuncture therapy, herb medicine, Bojoong-ikgi-tang(補中益氣湯) and some physical therapy including Negative, I.C.T, S.S.P and Carbon. Results : Symptoms(ex) general body weakness, anorexia, dizziness, dry eye, etc) at admission improved and disappeared gradually with acupuncture therapy and herb medicine. The patients could discharge with favorable recovery. Conclusions : In oriental medicine, blepharoptosis is mainly treated by promoting Qihyul(氣血) and enhancing flow of that. If the patient has deficiency of Suhnchun-poomboo(先天稟褓賦) and Mungmoon-hwa(命門火), he is treated by promoting Shin-yang(腎陽). If he is weak in Bee-qi(脾氣), he needs to be treated by strengthening Bee-yang(脾陽) where patient with lack of Ganhyul(肝血) is supposed to be treated by promoting Hyul(血). These following two cases were managed by acupuncture, herb medicine and physical therapy on idiopathic blepharoptosis.

• 한방안이비인후피부과학회지
• /
• 제30권4호
• /
• pp.1-24
• /
• 2017

Objectives : The purpose of this study is to research on the characteristics of outpatients and distributions of diseases in ophthalmology, otolaryngology of Korean medicine in 2012-2016 and compare the result with previous studies. Methods : This study is based on the analysis of medical records of total 2,319 outpatients in ophthalmology, otolaryngology of Korean medicine at Kyung Hee Korean medicine hospital from January 1, 2012 to December 31, 2016. We searched on the demographic characteristics of outpatients and the distributions of diseases in order of frequency by age and sex. Then, we compared these results to previous results of papers at same hospital in 2000 and 2007. Results : The common diseases in 2012-2016 were dry eye syndrome in ophthalmology(32.14%), tinnitus and hearing loss in otology(72.69%), rhinitis in rhinology(82.20%) and laryngopharyngitis in laryngology(67.77%). The most increasing diseases in the distribution between 2004-2006 and 2012-2016 were retinopathy in ophthalmology(+366.77%), etc including the eustachian tube disorder in otology(+151.55%), olfactory disorder in rhinology(+167.50%) and laryngopharyngitis in laryngology(+126.20%). Conclusions : If we accumulate these kinds of epidemiologic studies on ophthalmology, otolaryngology of Korean medicine, it will be great help to make Korean medical preparations for the increasing diseases on these fields.

• 한국안광학회지
• /
• 제17권1호
• /
• pp.47-52
• /
• 2012

목적: 본 연구는 장시간 3D TV 시청 경험과 단시간 TV 시청 경과에 따른 시청피로를 평가하기 위함이다. 방법: 98명의 성인(여자12 명과 남자86명)으로 실시하였으며, 이들의 나이는 $33.5{\pm}5.5$세(22세~51세)였다. 대상자는 52인치 2D와 3D LED TV(shutter glasses 방식)를 2.7 m 거리에서 대상자가 주로 착용하는 안경 또는 콘택트렌즈를 착용한 상태에서 65분간 2D TV와 3D TV를 각각 시청하게 하였다. 시청피로도 평가를 위해 3D와 2D를 시청하는 동안 11개 항목, 눈의 당김, 눈의 통증, 눈건조, 눈의 따끔거림, 눈물, 눈부심, 흐림, 복시, 눈피로, 두통, 어지럼 등을 0에서 3의 점수로 평가하였다. 결과: 시청피로의 평균점수는 3D 시청시작 후 5분, 25분, 45분, 65분에서 각각 $2.08{\pm}2.14$, $3.19{\pm}3.02$, $3.40{\pm}3.37$, $3.53{\pm}3.07 $으로 나타났고, 2D 시청 시작 후는 각각$0.40{\pm}1.03$, $0.22{\pm}0.70$, $0.22{\pm}0.58$, 그리고 $0.17{\pm}0.52$으로 나타났다. 3D TV 시청 시 시청피로가 2D TV 시청 시 피로 보다 전체 영역에서 유의적인 수준에서 높게 나타났다(paired t-test, p < 0.001). 3D TV 시청 피로는 65분간 유의적인 수준에서 증가하였으며(RM-ANOVA, p < 0.001), 25분까지는 유의적 수준에서 증가하였고(paired t-test, p < 0.001), 그 후부터 서서히 증가하였다. 시청경험과 시청피로에 있어서 눈부심, 복시, 흐림, 어지럼은 시청 경험의 증가할수록 감소하였으나 (ANOVA, all F(1, 96) = 4.500, all p <0.05) 다른 증상에 있어서는 유의한 차이가 없었다(F(1,96) = 0.033, all p >0.05) 결론: 3D TV 시청에 있어서 시청피로는 2D에서 보다 높았으며, 25분까지 증가하였다. 3D 시청 경험과 자각증상 정도와의 관계에 있어서는 자각증상에 따라 다르게 나타났다.