• Journal of Ginseng Research
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• v.7 no.2
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• pp.125-132
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• 1983

It was attempted in the present study to determind the effect of Korean ginseng on acute viral(B type) hepatitis by double blind test clinically and the results were as follows. 1. The double blind test of 4 week period showed no statistical significance of the effect of ginseng on the disease. 2. The double blind test of 2 week period, however, showed a significant effect in such clinical symptoms as appetite, stomach ache, headache, chillness dizziness, nausea and vomitting, stool habit change and jaundice. Improvement of the blood serum level of transaminases, bilirubin. alkaline phosphatase and cholesterol Chillness feeding period was observed.

• The Korean Journal of Pharmacology
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• v.6 no.1
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• pp.23-26
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• 1970

1) Efficacy of Moltase, a digestive enzyme preparation, was evaluated by double-blind test. 2) The clinical symptoms assessed in this study were anorexia, vomiting, nausea, eructation, hunger pain, epigastralgia, fullness in epjgastrium, abdominal fullness, constipation, and diarrhea. Effect of Moltase on gastric acidity was also examined by double-blind test. 3) People subjected to this study were 42 students and 22 patients who had signs of chronic dyspepsia. 4) In general, the clinical symptoms were more effectively improved by Moltase than placebos. The marked differences in efficacy between both medication were observed in epigastralgia, fullness in epigastrium, abdominal fullness, and anorexia. 5) Six out of 9 patients with no free gastric acid became to have free gastric acid after Moltase medication.

• Journal of the Korean Solar Energy Society
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• v.33 no.1
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• pp.89-95
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• 2013

A DBLP(Double blind light pipe) daylight system can be installed at a building exterior wall or roof to replace artificial light during the day time. This system was consisted of a double blind light collector, a mirror duct type light transformer and a prism light pipe distributor. The double blinds were used to track the sun's altitude and azimuth movements to collect the sunlight throughout the day. The sunlight collected by the light collector was reflected on the first mirror and the second mirror and sent to the light pipe through the light transformer. The transformer was designed to deliver the sunlight into the light pipe efficiently. The light distributor plays a role in diffusing the sunlight coming in through the light collector to be used for indoor lighting. In this paper, a DBLP system has been designed, installed and tested at a KIER daylighting twin test cell. The DBLP daylighting system was applied to the experimental test cell which has an indoor area of 2.0 m wide ${\times}$ 2.4 m height ${\times}$ 3.8 m length. The experiment was conducted from January 30 to February 27, 2012, under clear skies and partially cloudy skies. Data was collected from 10:00 am to 16:00 pm every 2 minute and the average was calculated for every 30 minute of the data collection to obtain the system efficiency. The results indicated that the DBLP system efficiency was evaluated as 11.67%. The DBLP system indoor illumination energy reduction was predicted as 0.822 kWh/day. This could replace 4 sets of a 32W fluorescent lamp operating 6.4 hours per a day.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.42
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• pp.40.1-40.5
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• 2020

Background: Hyaluronic acid (HA) is well known to exert an anti-inflammatory effect during oral wound healing and is commonly applied after tooth extraction. However, no double-blind randomized controlled study comparing two hyaluronate mouthwash products has been conducted so far. The aim of this study was to comparatively analyze the efficacy of Mucobarrier^® and Aloclair^® in terms of clinical symptoms. Results: A total of 112 patients were randomly assigned to assess the degree of discomfort, pain reduction, redness, burning sensation, and swelling between two groups on the day of surgery and 7 days later in a double blind test, with a total 56 Aloclair patients and 56 Mucobarrier patients. There was no statistically significant difference in the overall discomfort, degree of pain reduction, redness, burning sensation, and swelling between the Mucobarrier and Aloclair groups. Conclusion: The local application of hyaluronic acid mouth wash after wisdom tooth extraction is beneficial in reducing overall discomfort and pain reduction, and the clinical utility of Mucobarrier^® is no different from Aloclair^®. Trial registration: Institutional Review Board of Yonsei University College of Dentistry, 2-2018-0036. Registered 10 September 2018-prospectively registered, https://eirb.yuhs.ac/

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.42 no.2
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• pp.84-89
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• 2016

Objectives: To compare the efficacy of intravenous ondansetron (4 mg, 2 mL) and granisetron (2 mg, 2 mL) for preventing postoperative nausea and vomiting (PONV) in patients during oral and maxillofacial surgical procedures under general anesthesia. Materials and Methods: A prospective, randomized, and double blind clinical study was carried out with 60 patients undergoing oral and maxillofacial surgical procedures under general anesthesia. Patients were divided into two groups of 30 individuals each. Approximately two minutes before induction of general anesthesia, each patient received either 4 mg (2 mL) ondansetron or 2 mg (2 mL) granisetron intravenously in a double blind manner. Balanced anesthetic technique was used for all patients. Patients were assessed for episodes of nausea, retching, vomiting, and the need for rescue antiemetic at intervals of 0-2, 3, 6, 12, and 24 hours after surgery. Incidence of complete response and adverse effects were assessed at 24 hours postoperatively. Data was tabulated and subjected to statistical analysis using the chi-square test, unpaired t-test, or the Mann-Whitney U-test as appropriate. A P-value less than 0.05 was considered statistically significant. Results: There was no statistically significant difference between the two groups for incidence of PONV or the need for rescue antiemetic. Both study drugs were well tolerated with minimum adverse effects; the most common adverse effect was headache. The overall incidence of complete response in the granisetron group (86.7%) was significantly higher than the ondansetron group (60.0%). Conclusion: Granisetron at an intravenous dose of 2 mg was found to be safe, well tolerated, and more effective by increasing the incidence of complete response compared to 4 mg intravenous ondansetron when used for antiemetic prophylaxis in maxillofacial surgery patients receiving general anesthesia. Benefits of granisetron include high receptor specificity and high potency, which make it a valuable alternative to ondansetron.

• Proceedings of the Ginseng society Conference
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• 1978.09a
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• pp.85-92
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• 1978

The aim of the double blind test was to assess the prophylactic and therapeutic efficacy of the preparation GINSANA, containing the standardized ginseng extract PHARMATON G115,. The determination was carried out with special emphasis on the following features : general physical condition, physical performance, mental performance, enjoyment of life/mood, concentration and memory, as well as sleeping habits. Sixty test persons took part in the study, men and women between the ages of 22 and 80. The 90-day test was carried out in the form of a double blind experiment. Experimental measurements were made and the persons were also questioned. The reaction time, the optical merging threshold, the coordination of both hands and the recovery quotients, as well as the recovery rates were analyzed. The results for the serum group were clearly better than those for the placebo group, particularly for the characteristics: general physical condition, physical performance and sleeping habits. The results of the test methods used, especially with regard to the reaction time, the coordination of both hands, the recovery quotient and the recovery period, permit the following conclusion to be drawn: when administered for several weeks, GINSANA has a positive action, in the sense of an activation of the entire personality by the ginseng glycosides contained in the standardized Extracts G115.

• Journal of Ginseng Research
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• v.43 no.3
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• pp.402-407
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• 2019

Background: To investigate the neurobiological evidence supporting the adaptogenic effects of Korean Red Ginseng in reducing the harmful consequences of stress using a double-blind, placebo-controlled trial. Method: Sixty-three subjects with high stress levels were randomized to receive an orally administered, double-blind, 6-week treatment with Korean Red Ginseng (n = 32) or placebo (n = 31). All participants underwent a comprehensive psychological evaluation using Beck Depression Inventory and Stress Response Inventory, cognitive evaluation using the continuous performance test, biological evaluation by measuring blood levels of lipids, catecholamines, inflammation markers, and heart rate variability at baseline and after 6 weeks. Results: At baseline, both groups showed no significant differences in age, sex, years of education, Beck Depression Inventory, and Stress Response Inventory. After 6 weeks, triglyceride levels were significantly increased within the normal limit in the Korean Red Ginseng group (F = 4.11, p = 0.048), and the epinephrine level was decreased in this group (F = 4,35, p = 0.043). The triglyceride increase was significantly associated with epinephrine decrease (B = 0.087, p = 0.041), suggesting that Korean Red Ginseng may stabilize the sympathetic nervous system. In addition, we detected a significant group by time effect in the visually controlled continuous performance test, suggesting positive effects of Korean Red Ginseng on cognition. Conclusion: Korean Red Ginseng might help to stabilize the sympathetic nervous system and improve cognition in individuals with high stress.

• Proceedings of the Ginseng society Conference
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• 1974.09a
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• pp.65-67
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• 1974

In a double-blind test performed for 33-days on healthy students 2 capsules daily of Geriatric Pharmaton (ginsengextractvitamins and diethylaminoethanol) and of Gerikomplex Vitamex (ginsengextract viatmins but no diethylaminoethanol) showed a significant positive effect on psychomotor activity and simultaneous capacity. With the two methods used no difference between the prerarations could be demonstrated.

• Journal of Periodontal and Implant Science
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• v.44 no.2
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• pp.71-78
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• 2014

Purpose: Host modulatory therapy has been proposed as a treatment for periodontal diseases. A class of herbal medicines, known to be immunomodulators, alters the activity of immune function through the regulation of informational molecules such as cytokines. In the current study, we tested the hypothesis that herbal immunomodulator drugs act as an adjuvant to scaling and root planing (SRP) in alleviating periodontal inflammation by improving clinical and biochemical parameters. Methods: Sixty healthy subjects (30 in each group) with moderate and severe chronic periodontitis were enrolled in a double-blind, placebo-controlled, double-masked randomised controlled trial. The control group was treated with SRP and a placebo, whereas the test group was treated with SRP followed by dietary supplementation of Septilin for 3 weeks. Periodontal clinical parameters and serum C-reactive protein (CRP) levels were evaluated for all patients at the baseline, 3 weeks, and 6 weeks. Results: Improved gingival index scores found in the test group as compared to the control group were found to be statistically significant only after 3 weeks (P<0.001). In contrast, the decrease in the sulcus bleeding index and pocket depth scores was statistically highly significant in the test group as compared to the control group after 3 weeks and 6 weeks (P<0.001). However, reduced clinical attachment level and CRP scores, as reflected in the test group as compared to the control group, were not found to be statistically significant after both 3 weeks (P>0.05) and 6 weeks (P>0.05). Conclusions: The results of this clinical-biochemical study suggest that dietary supplementation with herbal immunomodulatory agents may be a promising adjunct to SRP and may aid in improving periodontal treatment outcomes.

• Journal of the Korean Solar Energy Society
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• v.34 no.5
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• pp.89-99
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• 2014

The determination of the solar and thermal performance of fenestration is required for the evaluation of fenestration energy performance, estimating building load. Presently, there exist several methods for determining the thermal transmission(U-value) and solar heat gain coefficient (SHGC) of fenestration system. These method are commonly grouped under calculation or experimental methods. While U-value testing and calculation methods have been long established, SHGC has been evaluated only by the method of calculation under the lack of any established testing method. However, it is difficult to assess the exact SHGC for various types of fenestration with sun-shading or other solar control systems. The purpose of this study was to evaluate the effect of interior venetian blind and roll screen on the SHGC of glazing system. SHGC has been evaluated by the KS L 9107 test method and exiting calculation method for precise comparison of the energy performances of various shading devices. In this research, the test sample consists of three different types of double glazing unit with venetian blind and roll screen. Slat angles of venetian blind were changed to $-45^{\circ}$, $0^{\circ}$, and$-45^{\circ}$. For the roll screen, measurements were taken with the roll screen in the closed position. In result, the venetian blind reduced SHGC by 21.2~28.4% at $45^{\circ}$, when compared to the double glazing unit. The roll screen reduced SHGC by 34.4~41.7% at closed. The differences between the measured and calculated SHGC were found to range between 0.001(0.2%) and 0.047(11.1%) for all test cases. For the cases of venetian blind $-45^{\circ}$, $0^{\circ}$ and $45^{\circ}$, the deviation ratio were 3.6~9.8%, 1.1~2.6%, 4.2~11.1%, respectively. For the case of roll screen, the deviation ratio were 4.1~5.7%.