• 대한의생명과학회지
• /
• 제12권4호
• /
• pp.311-318
• /
• 2006

The GJB2 mutation is mostly recessive in non-syndromic hearing loss, but specific mutations display a dominant type and syndromic hearing impairment. Both U54K and R75Q mutations present a dominant type in pedigrees with associated skin disorders. The purpose of this study was to investigate whether two GJB2 mutations can exhibit a dominant-negative effect on the growth abrogation and the gap junctional intercellular communication capacity exerted by wild-type connexin 26. A specific mutant region of GJB2 showed a loss of gap junction activity and a dominant negative effect on wild-type GJB2. The two mutants exerted a dominant-negative effect on the GJIC capacity and have independently effected GJB2 regulated growth of Hela cells; however, they have no dominant-negative growth effect on wild-type GJB2. It is proposed that the different mechanisms of the dominant-negative effect on wild-type GJB2 involve cell growth and GJIC function. This study describes mutations found in Korean deaf patients and that are typical of other east Asian regions.

• 대한물리치료과학회지
• /
• 제16권4호
• /
• pp.59-65
• /
• 2009

Background: Human body is formed of symmetric bilateral structures that are comprised of eye, upper arm, lower arm and etc. but, we are used only dominant components. The purpose of this study was to analysis length cognition ability in dominant eye & hand. Method: Total 180 persons (male 32, female 138) were participated in this study. They were tested with 'hole in the card' test for identification of dominant eye's side and the question for identification of dominant hand's side, then the length cognition ability was measured in right & left axillary level by describing 10cm line. Results: The results by independent t-test were as follows. In difference of length cognition ability in right axillary level between right dominant eyed group & left dominant eyed group, right dominant eyed group was superior to left dominant eyed group, but significant difference was not existed statistically(p>.05). In left axillary level, right dominant eyed group was superior to left dominant eyed group, but significant difference was not existed statistically(p>.05). In axillary level of dominant eye's side, non-crossed group was superior to crossed group, but significant difference was not existed statistically(p>.05). In axillary level of non-dominant eye's side, non-crossed group was superior to crossed group, but significant difference was not existed statistically(p>.05). Conclusion: These result can be applied to the learning of palpation & observation skill in physical therapy.

• 대한인간공학회지
• /
• 제32권6호
• /
• pp.503-509
• /
• 2013

Objective: The purpose of this study is to analyze the individual finger force between dominant hand and non-dominant hand and to investigate an effect of the individual finger on the total grip strength depending on dominant hand and non-dominant hand. Background: Many studies on the ratio of the grip force between dominant hand and non-dominant hand has been researched. While a 10% rule which is a ratio of the grip force between dominant hand and non-dominant hand has been applied in most studies, studies on the rate of the individual finger force between dominant hand and non-dominant hand have been insufficiently researched. Method: The experiment was preceded with 17 subjects (male, mean 25.8 ages). The individual finger force and total grip strength were measured using pliers being able to change the grip span from 45 to 80mm. Results: The difference of total grip strength between dominant hand and non-dominant hand is following 10% rule. However, the difference of individual finger force between dominant hand and non-dominant hand are not same as the difference of total grip strength. Especially in the case of grip span with 50mm, the differences between total grip strength, index finger, middle finger, ring finger, and little finger were $9.87{\pm}14.80%$, $8.95{\pm}37.17%$, $13.71{\pm}28.27%$, $6.77{\pm}24.35%$, $39.29{\pm}42.46%$, respectively, with p=0.018 of statistical significance. Additionally, the results of regression analysis in 50 and 60mm of grip span showed that the difference in ring finger affected the most to the total grip strength; and the effects followed in order of index finger, middle finger, and little finger. Conclusion: Our study suggests that an effect of individual finger and grip span of pliers have to be considered when explaining the difference of the total grip strength between dominant hand and non-dominant hand. Application: This result is expected to be used for designing ergonomic hand tool.

• 디지털융복합연구
• /
• 제12권1호
• /
• pp.127-139
• /
• 2014

본 연구의 목적은 스마트폰 운영체제의 지배적 디자인을 결정하는 주요 요인이 무엇인지 제시하고 제시된 요인들과 사용만족 간의 논리적 인과관계를 검증하는데 있다. 이를 위해 지배적 디자인을 결정하는 스마트폰 운영체제의 주요 결정요인을 OS호환성, OS향상성, 사용자기반, 그리고 네트워크 효과 등으로 제시했다. 그리고 사용만족과의 논리적 인과관계를 실증분석했다. 연구결과, 스마트폰 운영체제의 OS호환성과 OS향상성은 사용기반 확대에 긍정적인 영향을 미치는 것으로 나타났다. 특히 OS향상성은 사용기반을 확대 시킬 뿐만 아니라 네트워크 효과를 강화시키는 원인으로 나타났다. 그리고 직접적으로 사용만족에도 긍정적인 영향을 미치는 것으로 나타났다. 연구결과는 그동안 실증연구가 이루어지지 않았던 운영체제의 지배적 디자인 결정과정에 대해 논리적 인과관계를 제시하여 학문적으로 뿐만 아니라 실무적으로도 크게 기여했다고 판단된다.

• 한국토양비료학회지
• /
• 제49권6호
• /
• pp.807-812
• /
• 2016

Soil amendment, especially addition of clay minerals, has been widely conducted to improve the physical and chemical properties of cultivated soils. However, there are no systematic studies on the effects of the structural type of clay minerals added. This study was conducted to investigate the effects of structural type of clay minerals on physical properties of soils. Two experimental soils, layer-dominant and granule-dominant ones, were mixed with either a layer-type smectite or a granule-type zeolite at a level of 2.0 wt%. It was observed that water permeability of soils was decreased by smectite whereas not significantly changed by zeolite. This effect was much greater in layered clay-dominant soil than in granular clay-dominant soil. Our results clearly indicated that the relationship of structural type between a soil and an amendment plays a decisive role in the soil properties. Therefore, it is highly recommended that the structural types of both soil and amendment be taken into consideration for soil amendment by clay minerals.

• 국제물리치료학회지
• /
• 제2권1호
• /
• pp.229-236
• /
• 2011

The purpose of this study was to comparatively analyze the active stability of shoulder joints according to the frequency of overhead motions, such as serving and spiking, engaged in by female professional volleyball athletes who play different positions, and to provide the results as the basic data for developing exercise programs to prevent shoulder joint injuries. The subjects of this study were 50 Korean female professional volleyball players and positions were as follows: left and right attackers, centers, setters, and liberos. The external rotation and internal rotation muscle strength and muscle strength ratios of the dominant and non-dominant arms of all subjects were measured using Biodex. The results of this study are as follows: Frist, no significant differences were found in the internal and external rotation muscle strength of the dominant and non-dominant arms between positions. Second, for the shoulder joint muscle strength ratio of the dominant arm, by position, the setter showed significantly greater stability compared to the other positions. Third, for the shoulder joint muscle strength ratio of the non-dominant arm, by position, no significant difference in stability between positions was found. Fourth, it was found that the dominant arm had significantly greater instability of the shoulder joint than the non-dominant arm for attackers and centers, but no significant difference was found for setters and liberos. This study comparatively analyzed the muscle strength ratios of the external/internal rotations and dominant/non-dominant arms, which can determine the stability of the shoulder joints between female professional volleyball playing positions that engage in jumps and spikes using only the dominant hand and positions that do not.

• 한국전문물리치료학회지
• /
• 제25권3호
• /
• pp.51-59
• /
• 2018

Background: Despite muscle latency times and patterns were used as broad examination tools to diagnose disease and recovery, previous studies have not compared the dominant arm to the non-dominant arm in muscle latency time and muscle recruitment patterns during reaching and reach-to-grasp movements. Objects: The present study aimed to investigate dominant and non-dominant hand differences in muscle latency time and recruitment pattern during reaching and reach-to-grasp movements. In addition, by manipulating the speed of movement, we examined the effect of movement speed on neuromuscular control of both right and left hands. Methods: A total of 28 right-handed (measured by Edinburgh Handedness Inventory) healthy subjects were recruited. We recorded surface electromyography muscle latency time and muscle recruitment patterns of four upper extremity muscles (i.e., anterior deltoid, triceps brachii, flexor digitorum superficialis, and extensor digitorum) from each left and right arm. Mixed-effect linear regression was used to detect differences between hands, reaching and reach-to-grasp, and the fast and preferred speed conditions. Results: There were no significant differences in muscle latency time between dominant and non-dominant hands or reaching and reach-to-grasp tasks (p>.05). However, there was a significantly longer muscle latency time in the preferred speed condition than the fast speed condition on both reaching and reach-to-grasp tasks (p<.05). Conclusion: These findings showed similar muscle latency time and muscle activation patterns with respect to movement speeds and tasks. Our findings hope to provide normative muscle physiology data for both right and left hands, thus aiding the understanding of the abnormal movements from patients and to develop appropriate rehabilitation strategies specific to dominant and non-dominant hands.

• JSTS:Journal of Semiconductor Technology and Science
• /
• 제11권4호
• /
• pp.287-294
• /
• 2011

In this paper, two competing mechanisms determining drain current of tunneling field-effect transistors (TFETs) have been investigated such as band-to-band tunneling and drift. Based on the results, the characteristics of TFETs have been discussed in the tunneling-dominant and drift-dominant region.

• 한국세라믹학회지
• /
• 제35권7호
• /
• pp.671-678
• /
• 1998

Hertzian indentation tests with sphere indenters were used to study the mechanical properties of glass-in-filtrated alumina and spinel composites and evaluated the effect of preform microstructure and evaluated the effect of preform microstructure and glass con-tents on contanct damage and strength. The spinel composite showed more brittle behavior than the alumina composite which is verified from indentation stress-strain curve cone cracks and quasi-plastic deformation developed at subsurface. Failure originated from either cone cracks(brittle mode) or deformation zone(quasi-plastic mode) above critical load for cracking(Pc) and yield ({{{{ {P }_{Y } }}) with the brittle mode more dominant in the spinels and the quasi-plastic mode more dominant in the aluminas. Even though brittle mode was dominant in the spinel composites the strength degradation from accumulation of damage above these critical loads was conspicuously small suggesting that the glass-infiltrated composites should be highly damage tolerant to the blunt contacts.

• 한국전문물리치료학회지
• /
• 제12권4호
• /
• pp.7-11
• /
• 2005

The purposes of this study were to investigate the effects of variability of training on the acquisition of motor skill of closed loop type tracking task using Rotary Pursuit, and to determine if there was a bilateral transfer effect to the non-dominant hand following practice with the dominant hand. Twelve healthy volunteer students (5 males and 7 females, aged 25 to 37) were randomly divided into a constant practice group and a variable practice group. A photoelectric rotary pursuit apparatus with stop clock and repeat cycle timer by Lafayette Instrumentation Co. was used for this study. Rotary pursuit is a closed loop task in which a subject attempts to keep a photoelectric stylus on a lighted target in motion. Subjects performed the clockwise circular pursuit task while standing. Experimental procedure was divided into three sessions, namely, pre-test, training, and post-test. The constant group practiced all 60 trials at 30 rpm. Variable practice group did a varied practice session with 15 trials at speeds of 20 rpm, 26 rpm, 34 rpm, and 46 rpm. No one in either group practiced with their non-dominant arm. A Mann-Whitney test and a Wilcoxon Signed Ranks test were used for statistical analyses. The results of this study showed no different training effect between groups on the post-test with the dominant hand. However, bilateral transfer effect of rotary pursuit task between hands was demonstrated. Possible mechanisms are discussed.