• 한국자기공명학회논문지
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• 제22권1호
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• pp.18-25
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• 2018

Replication protein A (RPA) is an essential single-stranded DNA binding protein in DNA processing. It is known that N terminal domain of RPA70 (RPA70N) recruits various protein partners including damage-response proteins such as p53, ATRIP, Rad9, and MRE11. Although the common binding residues of RPA70N were revealed, dynamic properties of the protein are not studied yet. In this study, we measured $^{15}N$ relaxation parameters ($T_1,\;T_2$ and heteronuclear NOE) of human RPA70N and analyzed them using model-free analysis. Our data showed that the two loops near the binding site experience fast time scale motion while the binding site does not. It suggests that the protein binding surface of RPA70N is mostly rigid for minimizing entropy cost of binding and the loops can experience conformational changes.

• 음성과학
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• 제14권4호
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• pp.7-24
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• 2007

This paper discusses some current issues regarding how prosodic structure is manifested in fine-grained phonetic details, how prosodically-conditioned articulatory variation is explained in terms of speech dynamics, and how such phonetic manifestation of prosodic structure may be exploited in spoken word recognition. Prosodic structure is phonetically manifested in prosodically important landmark locations such as prosodic domain-final position, domain-initial position and stressed/accented syllables. It will be discussed how each of the prosodic landmarks engenders particular phonetic patterns, ow articulatory variation in such locations are dynamically accounted for, and how prosodically-driven fine-grained phonetic detail is exploited by listeners in speech comprehension.

• 한국자동차공학회논문집
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• 제5권1호
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• pp.136-145
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• 1997

To analyzed ride quality and to predict durability in vehicle dynamics, it is essential to describe a road surface profile precisely. This paper presents a technique to generate road surface profiles in a spatial domain by using a power spectral density function. A single track power spectral density function is proposed to describe a road surface profile, which is also applicable for multi-track vehicle response analysis, The derived road surfaces are compared to ISO(International Organization for Standardization) standards and classifications, proposed by the MIRA(Motor Industry Research Association). The methodology in this paper is also proposed to generate road roughness description with a limited external data. A small amount of external curve data is combined with an internal PSD function to generate road surface roughness in a spatial domain.

• Ocean Systems Engineering
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• 제2권4호
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• pp.239-255
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• 2012

Analysis of ship parametric roll has generally been restricted to simple analytical models and sophisticated time domain simulations. Simple analytical models do not capture all the critical dynamics while time-domain simulations are often time consuming to implement. The model presented in this paper captures the essential dynamics of the system without over simplification. This work incorporates various important aspects of the system and assesses the significance of including or ignoring these aspects. Special consideration is given to the fact that a hull form asymmetric about the design waterline would not lead to a perfectly harmonic variation in metacentric height. Many of the previous works on parametric roll make the assumption of linearized and harmonic behaviour of the time-varying restoring arm or metacentric height. This assumption enables modelling the roll motion as a Mathieu equation. This paper provides a critical assessment of this assumption and suggests modelling the roll motion as a Hills equation. Also the effects of non-linear damping are included to evaluate its effect on the bounded parametric roll amplitude in a simplified manner.

• Structural Engineering and Mechanics
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• 제85권2호
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• pp.207-216
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• 2023

Three time-discontinuous Galerkin quadrature element methods (TDGQEMs) are developed for structural dynamic problems. The weak-form time-discontinuous Galerkin (TDG) statements, which are capable of capturing possible displacement and/or velocity discontinuities, are employed to formulate the three types of quadrature elements, i.e., single-field, single-field/least-squares and two-field. Gauss-Lobatto quadrature rule and the differential quadrature analog are used to turn the weak-form TDG statements into a system of algebraic equations. The stability, accuracy and numerical dissipation and dispersion properties of the formulated elements are examined. It is found that all the elements are unconditionally stable, the order of accuracy is equal to two times the element order minus one or two times the element order, and the high-order elements possess desired high numerical dissipation in the high-frequency domain and low numerical dissipation and dispersion in the low-frequency domain. Three fundamental numerical examples are investigated to demonstrate the effectiveness and high accuracy of the elements, as compared with the commonly used time integration schemes.

• Bulletin of the Korean Chemical Society
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• 제29권2호
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• pp.347-351
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• 2008

Acetyl-CoA carboxylase (ACC) is an excellent candidate for antibiotics drug target, which mediates malonyl-CoA synthesis from acetyl-CoA through acetylation process. It is also involved in the committed step of fatty acid synthesis which is essential for living organisms. We have determined the three dimensional structure of C terminal domain of HP0371, biotin-carboxyl carrier protein of H. pyroli, in solution state using heteronuclear multi-dimensional NMR spectroscopy. The structure of HP0371 shows a flatten b-sheet fold which is similar with that of E. coli. However, the sequence and structure of protruding thumb are different with that of E. coli and the thumb shows different basis of structural rigidity based on backbone dynamics data.

• 한국해양공학회지
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• 제29권3호
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• pp.255-262
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• 2015

The present study developed a numerical simulation tool for the coupled dynamic analysis of multiple turbines on a single floater (or Multiple Unit Floating Offshore Wind Turbine (MUFOWT)) in the time domain, considering the multiple-turbine aero-blade-tower dynamics and control, mooring dynamics, and platform motions. The numerical tool developed in this study was designed based on and extended from the single-turbine analysis tool FAST to make it suitable for multiple turbines. For the hydrodynamic loadings of floating platform and mooring-line dynamics, the CHARM3D program developed by the authors was incorporated. Thus, the coupled dynamic behavior of a floating base with multiple turbines and mooring lines can be simulated in the time domain. To investigate the effect of asymmetric aerodynamic loading on the global performance and mooring line tensions of the MUFOWT, one turbine failure case with a fully feathered blade pitch angle was simulated and checked. The aerodynamic interference between adjacent turbines, including the wake effect, was not considered in this study to more clearly demonstrate the influence of the asymmetric aerodynamic loading on the MUFOWT. The analysis shows that the unbalanced aerodynamic loading from one turbine in MUFOWT may induce appreciable changes in the performance of the floating platform and mooring system.

• Current Applied Physics
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• 제18권11호
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• pp.1327-1337
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• 2018

This paper investigates the vibration behavior of pristine and defected triangular graphene sheets; which has recently attracted the attention of researchers and compare these two types in natural frequencies and sensitivity. Here, the molecular dynamics method has been employed to establish a virtual laboratory for this purpose. After measuring the different parameters obtained by the molecular dynamics approach, these data have been analyzed by using the frequency domain decomposition (FDD) method, and the dominant frequencies and mode shapes of the system have been extracted. By analyzing the vibration behaviors of pristine triangular graphene sheets in four cases (right angle of 45-90-45 configuration, right angle of 60-90-30 configuration, equilateral triangle and isosceles triangle), it has been demonstrated that the natural frequencies of these sheets are higher than the natural frequency of a square sheet, with the same number of atoms, by a minimum of 7.6% and maximum of 26.6%. Therefore, for increasing the resonance range of sensors based on 2D materials, nonrectangular structures, and especially the triangular structure, can be considered as viable candidates. Although the pristine and defective equilateral triangular sheets have the highest values of resonance, the sensitivity of defective (45,90,45) triangular sheet is more than other configurations and then, defective (45,90,45) sheet is the worst choice for sensor applications.

• International Journal of Naval Architecture and Ocean Engineering
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• 제9권3호
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• pp.266-281
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• 2017

Hydroelastic interactions of a deformable floating body with random waves are investigated in time domain. Both hydroelastic motion and structural dynamics are solved by expansion of elastic modes and Fourier transform for the random waves. A direct and efficient structural analysis in time domain is developed. In particular, an efficient way of obtaining distributive loads for the hydrodynamic integral terms including convolution integral by using Fubini theory is explained. After confirming correctness of respective loading components, calculations of full distributions of loads in random waves are expedited by reformulating all the body loading terms into distributed forms. The method is validated by extensive convergence tests and comparisons against the counterparts of the frequency-domain analysis. Characteristics of motion/deformation responses and stress resultants are investigated through a parametric study with varying bending rigidity and types of random waves. Relative contributions of componential loads are identified. The consequence of elastic-mode resonance is underscored.

• Journal of Magnetics
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• 제17권4호
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• pp.242-244
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• 2012

We report on the basis of experiments that magnetic domain structures exhibit a transition between single and dendrite domains with respect to the width of ferromagnetic nanowires. This transition is directly observed in CoFe/Pt multilayered nanowires having a width in the range of 580 nm to 4.2 ${\mu}m$ with a magnetic force microscope. Nanowires wider than 1.5 ${\mu}m$ show typical dendrite domain patterns, whereas the nanowires narrower than 690 nm exhibit single domain patterns. The transition occurs gradually between these widths, which are similar to the typical widths of the dendrite domains. Such a transition affects the strength of the domain wall propagation field; this finding was made by using a time-resolved magneto-optical Kerr effect microscope, and shows that the domain wall dynamics also exhibit a transition in accordance with the domain configuration.