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DIVERGENT ROLES OF A NOVEL PHOSPHOLIPASE $A_2$ IN CELL DEATH

  • Schnellmann, Rick G.
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.11b
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    • pp.68-88
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    • 2002
  • Phospholipase A$_2$ (s) are esterases that hydrolyze the sn-2 ester bond in phospholipids, releasing a fatty acid and a lysophospholipid. We previously showed that most PLA$_2$ activity in rabbit renal proximal tubule cells (RPTC) was Ca$\^$2+/-independent, localized to the endoplasmic reticulum (ER-iPLA$_2$), and inhibited by the specific Ca$\^$2+/-independent PLA$_2$ inhibitor bromoenol lactone (BEL).(omitted)

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Elementary Gifted Students' Creative Problem Solving Through Fermi Estimate (초등 영재의 페르미 추정을 통한 창의적 문제해결력 분석)

  • Heo, Jung-In;Noh, Jihwa
    • East Asian mathematical journal
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    • v.40 no.2
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    • pp.167-181
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    • 2024
  • This study explored the characteristics of elementary gifted students' creative problem-solving skills combining creativity and problem-solving ability based on their work on Fermi estimation problems. The analysis revealed that gifted students exhibited strong logical validity and breadth but showed some weaknesses in divergent thinking abilities (fluency, flexibility, originality).

What are the Differences Between Scientifically Gifted and Normal Students in the Aspects of Creativity? (과학 영재 학생과 일반 학생은 창의성에서 어떻게 다른가? - 서울대학교 과학영재교육센터 학생들을 중심으로 -)

  • Shin, Ji-Eun;Han, Ki-Soon;Jung, Hyun-Chul;Park, Byung-Gun;Choe, Seung-Urn
    • Journal of The Korean Association For Science Education
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    • v.22 no.1
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    • pp.158-175
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    • 2002
  • In the present study we have compared and analyzed three different measures of creativity in 135 gifted and 161 normal students to understand the nature of creativity and to propose the guideline for measuring creativity. The instruments used to measure creativity in this study are the Torrance Test of Creativity Thinking (TTCT), the Test of Creative Problem solving and Finding in Science (CPFS), and the Creative Behavior Checklist in Science (CBCS). The TTCT is the most widely used divergent thinking test and measures creativity in the aspect of domain-generality. The CPFS and the CBCS were developed for the purpose of this study and measure domain-specific creativity in the area of Science. The findings of this study revealed that gifted students are significantly more creative compared to normal students in all measures of creativity used in the study. The biggest difference between the gifted and normal students was found in the aspect of CPFS. This study implies that creativity, which is considered less useful to identify gifted students compared to achievement or IQ scores, is the important factor to consider for judging giftedness. The low correlations revealed among the TTCT, CPFS, and CBCS imply that the three measures of creativity address relatively different aspects of creativity. The results also suggest that it is essential to consider multiple criteria of creativity not to overlook potential creative students in the area of science. Implications of the study in connection with the identification and educational practices for gifted education program is discussed.

Review on Instrumental Task and Program Characteristics for Measuring and Developing Mathematical Creativity (수학적 창의성 계발을 위한 과제와 수업 방향 탐색)

  • Sung, Chang-Geun;Park, Sung-Sun
    • Journal of Elementary Mathematics Education in Korea
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    • v.16 no.2
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    • pp.253-267
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    • 2012
  • In this paper, we primarily focus on the perspectives about creative process, which is how mathematical creativity emerged, as one aspect of mathematical creativity and then present a desirable task characteristic to measure and program characteristics to develop mathematical creativity. At first, we describe domain-generality perspective and domain-specificity perspective on creativity. The former regard divergent thinking skill as a key cognitive process embedded in creativity of various discipline domain involving language, science, mathematics, art and so on. In contrast the researchers supporting later perspective insist that the mechanism of creativity is different in each discipline. We understand that the issue on this two perspective effect on task and program to foster and measure creativity in mathematics education beyond theoretical discussion. And then, based on previous theoretical review, we draw a desirable characteristic on instruction program and task to facilitate and test mathematical creativity, and present an applicable task and instruction cases based on Geneplor model at the mathematics class in elementary school. In conclusion, divergent thinking is necessary but sufficient to develop mathematical creativity and need to consider various mathematical reasoning such as generalization, ion and mathematical knowledge.

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Insights into evolution and speciation in the red alga Bostrychia: 15 years of research

  • Zuccarello, Giuseppe C.;West, John A.
    • ALGAE
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    • v.26 no.1
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    • pp.21-32
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    • 2011
  • Studies of the red algal genus Bostrychia over the last 15 years have made it a model system for many evolutionary processes within red algal species. The combination of newly developed, or first employed methods, in red algal species studies has made Bostrychia a pioneer genus in intraspecific studies. Bostrychia was the first genus in which a mitochondrial marker was used for intraspecific red algal phylogeny, and the first for which a 3-genome phylogeny was undertaken. The genus was the first red alga used to genetically show maternal plastid and mitochondria inheritance, and also to show correlation between cryptic species (genetically divergent intraspecific lineages) and reproductive incompatibility. The chemotaxonomic use, and physiological function of osmolytes, has also been extensively studied in Bostrychia. Our continuous studies of Bostrychia also highlight important aspects in algal species studies. Our worldwide sampling, and resampling in certain areas, show that intensive sampling is needed to accurately assess the genetic diversity and therefore phylogeographic history of algal species, with increased sampling altering evolutionary hypotheses. Our studies have also shown that long-term morphological character stability (stasis) and character convergence can only be correctly assessed with wide geographic sampling of morphological species. While reproductive incompatibility of divergent lineages supports the biological species nature of these lineages, reproductive incompatibility is also seen between isolates with little genetic divergence. It seems that reproductive incompatibility may evolve quickly in red algae and the unique early stages of fertilization (e.g., gametes covered by walls, active movement of spermatium nuclei to the distant egg nucleus), also well investigated in Bostrychia,. may be key to our understanding of this process.

Searching of Information on Reverse left/right Space in Sports-Shop and Features of Its Visual Appreciation - Through Comparison of Original and Reverse left/right Image Space - (스포츠 매장의 전회에 따른 정보 탐색과 시각적 이해 특성 - 원-공간과 전회-공간의 이미지 비교를 통해 -)

  • Kim, Jong-Ha
    • Korean Institute of Interior Design Journal
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    • v.25 no.5
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    • pp.71-81
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    • 2016
  • This research has been carried out with the objects of sporting goods shops to find out what structure of those shops raises more interest from customers. The tracking eyes on the objects which are the same but seen to have different structures has revealed the followings. Customers' visual appreciation of Reverse left/right Images (11.1) was found to be higher than that of Original Images (10.6). Furthermore, the reverse left/right image of the space also was found to attract more interest from customers, which led them to have longer observation. The below is about the interpretation of the spatial exploration by observation time and the appreciation of its visual content in line with the experiment objects of selling spaces. The longer the space was observed, (1)the higher the expansive searching of space was, (2)the more spots were observed as if they did not know what to see after they first observed at early hours, (3)later (in the time range of 64~73 seconds) they came to look at the spots in which they got interested, (4)and then again they suddenly got lost what to see. When the change of observation characteristics by time range is reviewed, it can be seen that the searching of original images is changed from Divergent Feature to Convergent Feature when the observation time increases from the early stage of observation to the later. On the contrary, the reverse left/right images were found to have the opposite searching features, that is, from convergent exploration to divergent exploration. These findings show that the reverse left/right images of the sporting goods shops, which were the experiment objects, have more factors attracting customers' attention and interest and that it is the very shop-structure which makes customers have better visual appreciation of those shops.

Investigation of Combustion Characteristics of Hybrid Rocket with Tapered Grain Port (경사진 그레인 포트를 가진 하이브리드 로켓의 연소 특성)

  • Kim, Jae-Woo;Kim, Soo-Jong;Oh, Jung-Soo;Do, Gyu-Sung;So, Jung-Soo;Moon, Hee-Jang
    • Journal of the Korean Society of Propulsion Engineers
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    • v.15 no.2
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    • pp.8-14
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    • 2011
  • In this paper, the combustion characteristics of hybrid rocket fuel with tapered grain port were investigated experimentally. The charging efficiency of convergent and divergent port shape fuel with $1^{\circ}$ taper angle was 6.8% higher than that of cylindrical port shape fuel. The regression rate was increased about 17.5% by using the convergent port shape fuel. On the other hand, in case of divergent port shape fuel, no notable difference of regression rate was observed when compared to that of the cylindrical port shape fuel. In the case of convergent port shape fuel, characteristic velocity and its efficiency were notably increased with respect to cylindrical port fuel. It was found that convergent port shape of hybrid rocket fuel can lead to a better option compared to the conventional cylindrical port in terms of combustion efficiency and performance improvement.

The Colorectal Cancer Mortality-to-Incidence Ratio as a Potential Cancer Surveillance Measure in Asia

  • Sunkara, Vasu;Hebert, James R
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.9
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    • pp.4323-4326
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    • 2016
  • Background: The cancer mortality-to-incidence ratio (MIR) has been established as an important measure of health disparities in local and global circumstances. Past work has corroborated a linkage between the colorectal cancer MIR and the World Health Organization (WHO) Health System ranking. The literature further documents many Asian countries having incomplete cancer registries and a lack of comprehensive colorectal cancer screening guidelines. Materials and Methods: The colorectal cancer MIR values for 23 Asian countries were calculated from data obtained from the 2012 GLOBOCAN database. The 2000 World Health Organization (WHO) Health System rankings were used as a proxy for health system infrastructure and responsiveness. A regression equation was calculated with the MIR as the dependent variable and the WHO Health System ranking as the independent variable. Predicted MIR values were next calculated based on the regression results. Actual MIR values that exceeded 0.20 from the predicted MIR were removed as 'divergent' points. The regression equation was then re-plotted. Goodness-of-fit for both regressions was assessed by the R-squared test. Results: Asian countries have a relatively wide colorectal cancer MIR range, from a minimum of 0.24 to a maximum of 0.86. For the full dataset, the adjusted R-squared value for this regression was 0.53. The equation was then used to calculate a predicted MIR, whereby two data points were identified as 'divergent' and removed. The adjusted R-squared for the edited dataset increased to 0.66. Conclusions: Asian countries have a marked range in their colorectal cancer MIR values and there is a strong correlationwith the WHO Health System ranking. These results corroborate the contribution of the MIR as a potentially robust tool in monitoring changes in colorectal cancer care for Asian nations.

Risk Governance Models Seen from the STS Perspectives: Risk Analysis Framework and the Precautionary Principles (STS 관점에서 본 위험 거버넌스 모델: 위험분석과 사전주의 원칙을 중심으로)

  • Hyun, Jaehwan;Hong, Sungook
    • Journal of Science and Technology Studies
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    • v.15 no.1
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    • pp.281-325
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    • 2015
  • In this paper, we continue our previous study on the differences, similarities and interfaces between the various models of scientific governance discussed in STS and those in risk governance developed by risk studies. In the previous paper we illuminated that theoretical differences among STS scholars on scientific governance and public participation goes back to the 1970s and 1980s, during which they first laid down the conceptual basis of STS. In this paper we investigate how these divergent positions among STS scholars influenced their evaluations of precautionary principle and the framework of risk analysis (especially the separation between risk assessment and risk management), which are the two main paradigms in the area of risk regulation. By doing that, this paper will show divergent positions of STS scholars on risk analysis and precautionary principle. Further, we will suggest some theoretical and practical interfaces between STS and risk governance models.

Genetic Parameters and Responses in Growth and Body Composition Traits of Pigs Measured under Group Housing and Ad libitum Feeding from Lines Selected for Growth Rate on a Fixed Ration

  • Nguyen, Nguyen Hong;McPhee, C.P.
    • Asian-Australasian Journal of Animal Sciences
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    • v.18 no.8
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    • pp.1075-1079
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    • 2005
  • The main objective of this study is to examine genetic changes in growth rate and carcass composition traits in group housed, ad libitum fed pigs, from lines of Large White divergently selected over four years for high and low post-weaning daily gain on a fixed but restricted ration. Genetic parameters for production and carcass traits were also estimated by using average information-restricted maximum likelihood applied to a multivariate individual animal model. All analyses were carried out on 1,728 records of group housed ad libitum fed pigs, and include a full pedigree of 5,324 animals. Estimates of heritability (standard errors in parentheses) were 0.11 (0.04) for lifetime daily liveweight gain (LDG), 0.13 (0.04) for daily carcass weight gain (CDG) and 0.28 (0.06) for carcass backfat (CFT). Genetic correlations between LDG and CDG were highly positive and between LDG and CFT negative, suggesting that selection for lifetime daily gain under commercial conditions of group housing with ad libitum feeding would result in favourable improvement in carcass traits. CFT showed negative genetic correlations with CDG. Correlated genetic responses evaluated as estimated breeding values (EBVs) were obtained from a multivariate animal model-best linear unbiased prediction analysis. After four years of divergent selection for 6 week post-weaning growth rate on restricted feeding, pigs performance tested on ad libitum feeding in groups exhibited changes in EBVs of 6.77 and -9.93 (g/d) for LDG, 4.25 and -7.08 (g/d) for CDG, and -1.42 and 1.55 (mm) for CFT, in the high and low lines, respectively. It is concluded that selection for growth rate on restricted feeding would significantly improve genetic performance and carcass composition of their descendants when group housed and ad libitum fed as is a common commercial practice.