• Title/Summary/Keyword: distribution of exposure factors

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The Immunotyping Distribution of Serum Monoclonal Paraprotein and Environmental Impact on Multiple Myeloma (MM) and Monoclonal Gammopathy of Uncertain Significance (MGUS) in Taiwan: A Medical Center-Based Experience

  • Chang, Chih-Chun;Su, Ming-Jang;Lee, Shu-Jene;Tsai, Yu-Hui;Kuo, Lin-Yin;Lin, I-Hsin;Huang, Hui-Ling;Yen, Tzung-Hai;Chu, Fang-Yeh
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.1
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    • pp.395-399
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    • 2016
  • Background: Whether ambient exposure to environmental pollutants leads to hematopoietic malignancies such as multiple myeloma (MM) remains to be ascertained. Therefore, we aimed to investigate the immunotyping distribution of serum monoclonal paraprotein and the environmental influence on MM and monoclonal gammopathy of uncertain significance (MGUS) in the Taiwanese population. Materials and Methods: Serum protein electrophoresis with immunosubtraction by the capillary zone electrophoresis method was performed as primary screening for MM and MGUS. Clinical, pathological, and residence data of patients were also obtained. Results: From August, 2013 to June, 2015, a total of 327 patients underwent serum protein electrophoresis with immunosubtraction. Among these, 281 demonstrated no remarkable findings or non-malignant oligoclonal gammopathy, 23 were detected to have MGUS, 18 were identified as MM, and a further 5 were found as other malignancies. The most frequent immunotyping distribution of serum monoclonal paraprotein was IgG kappa (54.3%, n=25), followed by IgA lambda (15.2%, n=7) and IgG lambda (10.9%, n=5) in subjects with gammopathy. Additionally, it was shown that the elderly (OR: 4.61, 95% CI: 1.88-11.30, P<0.01) and males (OR: 2.04, 95% CI: 1.04-4.02, P=0.04) had significantly higher risk of developing MM and MGUS. There was no obvious impact of environmental factors on the health risk of MM and MGUS evolution (OR: 0.77, 95% CI: 0.40-1.50, P=0.49). Conclusions: The most frequent immunotyping distribution of serum monoclonal paraprotein included IgG kappa, IgA lambda and IgG lambda in MM and MGUS in the Taiwanese population. The elderly and male subjects are at significantly higher risk of MM and MGUS development, but there was no obvious impact of environmental factors on risk.

Characteristics of Particulate Matter Generated during the Operation of a Small Directly Fired Coffee Roaster (소형 직화식 커피 로스터 이용 시 발생하는 미세먼지 특성 연구)

  • Yu, Da Eun;Kim, Seung Won
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.30 no.2
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    • pp.236-248
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    • 2020
  • Objectives: The purpose of this study was to evaluate the concentrations of particulate matter generated during coffee roasting and to study various factors affecting the concentrations. Methods: Differences in concentration levels were investigated based on various factors to understand the emission rates of particulate matter over time and to compare the mass and number concentrations according to their size. Sampling was performed in closed laboratories without the operation of air conditioning or ventilation. Optical Particle Sizer(OPS) was used as a measuring device. An OPS measures using a light-scattering method. Sampling was performed for sixty minutes at one-minute intervals. The background concentration was measured for about 30 minutes before starting of coffee roasting. The concentrations of particulate matter generated during coffee roasting were monitored until roasted coffee beans were removed from the roaster and cooled down. Several factors affecting the concentrations of particulate matter were investigated, which includes the origins of green beans, the roasting level, and the input amount of green beans. Results: The results of this study may be summarized as follows: 1) There was no difference in particulate matter concentration levels by the origin of the green beans, but a statistically significant difference in concentration levels by roasting level and the input amount of green beans; The higher the roasting level, the higher was the particulate matter concentration. The more green beans we put in the roaster, the higher were the concentrations; 2) The PM10 mass concentrations increased over time. The average concentration after roasting was higher than the average concentration during roasting; 3) In the distribution of mass and number concentration by particle diameter, the majority of particles was below 2.5 ㎛. Conclusions: Persons who work in roastery cafes can be exposed to high concentrations of particulate matter. Therefore, personal exposure and risk assessment should be conducted for roastery cafe workers.

Spatial Heterogeneity and Long-term Changes in Bivalve Anadara broughtoni Population: Influence of River Run-off and Fishery

  • Silina, Alla V.
    • Ocean Science Journal
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    • v.41 no.4
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    • pp.211-219
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    • 2006
  • A comparison was made of population of the economically important cockle Anadara (=Scapharca) broughtoni (Bivalvia, Arcidae) inhabiting different areas of the Razdolnaya River estuary at the head of Amurskii Bay (Peter the Great Gulf, East Sea). Also, changes in cockle population density and structure, as well as in cockle growth rates during the last 20 years were studied. In all years of investigation, the morphometrical parameters and growth rates of cockles were smaller at the sites located close to the River mouth than farther down-estuary. The differences can be attributed to higher concentration of suspended particulate matter, decreased salinity and water temperature, as well as a longer exposure to these unfavorable environmental factors at sites located close to the River mouth, compared to farther sites. For two decades, cockle population density had decreased by almost 30 times at some sites in the River estuary. The main reason for this population decline is commercial over-fishing of the cockle. Besides, for the last 20 years, linear parameters of the cockles in the population decreased approximately by 30% and weight parameters, almost two times. Cockle growth rates also decreased for this period. Evidently, these facts are due to the damaging effect of dredging.

Psychosocial Working Environment and Mental Health of Financial Clerks (금융사무원의 심리사회적 작업환경과 정신건강)

  • Lee, Bokim;Lee, Joohyun
    • Korean Journal of Occupational Health Nursing
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    • v.30 no.4
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    • pp.224-231
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    • 2021
  • Purpose: The purpose of this study was to identify the psychosocial working environment and mental health of financial workers, and analyze the impact of the former on the latter. Methods: Data of 257 financial clerks were extracted from the 2017 5th Korean Working Conditions Survey. Psychosocial working environment was divided into five fields: demands at work, work organizations, interpersonal relations, workplace violence, and working hour quality. Mental health included sleeping problems, psychological well-being, and job stress. Results: A total of 6.1% subjects reported sleep problems, 28.2% experienced poor psychological well-being, and 39.6% had job stress. More than half the subjects were exposed to tight deadlines, complex tasks, hiding feelings at work, fair treatment, fair distribution of work, colleagues' support, and managers' support. Tight deadlines, workplace violence, long working hours, hiding feelings at work, and managers' support had a significant impact on the mental health of financial clerks. Conclusion: Based on the results of this study, we propose that employers, workers, and health managers in the financial industry should work together to establish a respectful organizational culture, prevent long working hours through recruitment, and conduct programs to protect emotional health.

Growing Environment Characteristics and Vegetation Structure of Daphne Pseudomezereum var. Koreana Native Habitats in Korea

  • Lee, Da-Hyun;Son, Ho-Jun;Park, Sung-Hyuk;Kim, Se-Chang;Park, Wan-Geun
    • Journal of Forest and Environmental Science
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    • v.35 no.1
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    • pp.31-40
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    • 2019
  • Daphne pseudomezereum var. koreana is an endangered deciduous shrub distributed in mountain areas that is vulnerable to climate change. The purpose of this study was to provide foundational data on the physical characteristics, soil environment, and vegetation structure of habitats of Daphne pseudomezereum var. koreana habitat in Korea in order to help with management decisions on ecosystem restoration. Rock exposure was 15 to 35%, with an average of 24%. The native habitat of D. pseudomezereum included 129 taxa consisting of 46 families and 95 genera. Two-way cluster analysis divided the habitat into three plant communities: Community I (dominaterd by Tilia amurensis and Quercus mongolica), Community II (dominaterd by Fraxinus rhynchophylla and Acer pseudosieboldianum), and Community III (dominaterd by Ulmus davidiana var. japonica). The diversity indices for Communities I, II, and III were 1.124, 1.047 and 0.932, respectively. The soils were loam or clay loam. Soil pH, organic matter content, and available phosphoric acid were 5.40, 14.38%, and 31.08 ppm, respectively. Ordination analysis resulted that most significant factors influencing D. pseudomezereum distribution were magnesium content of soil, shrub layer, and altitude.

Inhibitory Effects of Ramulus Mori Extracts on Melanogenesis

  • Lee, Ghang-Tai;Shin, Bong-Soo;Kim, Beom-Jun;Kim, Jeong-Ha;Jo, Byoung-Kee
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.23 no.2
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    • pp.63-70
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    • 1997
  • It has been observed that local increase in melanin synthesis or uneven distribution can cause local hyperpigmintation or spot. Pigmentary disorders are caused by various factors, including inflammation, imbalance of hormones, and genetic disorder. Recently the harmfulness of Ultraviolet radiation is increasing due to destruction of ozone layer. Excessive exposure to UV radiation caused post-inflammatory pigmentation. Most women want to avoid uneven skin pigmentation. To satisfy this desire many cosmetic companies have been developing melanogenesis inhibitors and finding promising active agents for use in cosmetic preparations for skin whitening. In cosmetic preparations, many inhibitors such as kojic acid, arbutin, ascorbic acid, and licorice extracts6 have been used as whitening purpose. Plant extracts having an inhibitory effect on melanin formation may be a good choice for cosmetic purpose because of their relatively lower side effects. Therefore, we screened 285 plant extracts for their inhibitory activity in tyrosinase. Of the plant extracts, ramulus mori extracts showed potent tyrosinase inhibition activity. We also identified the active compound in the extract.

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Space-time-dissociated differential sedimentation and its relationship with the rate of relative sea-level change: the Lower Ordovician Mungok Formation, Korea

  • Choi Yong Seok;Lee Yong Il
    • 한국석유지질학회:학술대회논문집
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    • autumn
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    • pp.14-30
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    • 2000
  • Hierarchically controlled sequence stratigraphic analysis shows that the Lower Ordovician mixed carbonate-siliciclastic Mungok Formation, Korea consists of three depositional sequences: T1, T2, and T3. Sequence boundaries are generally marked by abrupt transition from coarse-grained shallow-water carbonates to fine-grained deeper-water carbonates mixed with fine-grained siliciclastics, and show indication of subaerial exposure such as karstification. Within this sequence stratigraphic framework, facies characteristics indicate that the Mungok sequences were mostly deposited in subtidal ramp environments. High-frequency cycles consist of upward-shallowing facies successions. Cycles of shallow-water and basinal deposits are not represented well, probably due to cycle amalgamation. Cycle stacking patterns do not show a consistent thickness change that reflects a large-scale sea-level change due to unfilled accommodation space. The Mungok sequences show that many factors including relative sea-level change and topography are involved in controlling sequence development on carbonate ramps. The depositional setting evolved from the high-energy ramps in the sequences T1 and T2 into the low-energy ramp in the sequence T3. Topography is interpreted to have been responsible for the different energy regimes of the carbonate ramps in the Mungok sequences. The high ramp gradient in the sequences T1 and T2 seems to be caused by space-time-dissociated differential sedimentation resulting in spatially narrow distribution of sediment filling, which in turn may be related to high rate of relative sea-level change. In contrast, low ramp gradient was maintained in the sequence T3 during slow changes of relative sea level resulting in broad distribution of sediment filling.

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The Effect of Prior Price Trends on Optimistic Forecasting (이전 가격 트렌드가 낙관적 예측에 미치는 영향)

  • Kim, Young-Doo
    • The Journal of Industrial Distribution & Business
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    • v.9 no.10
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    • pp.83-89
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    • 2018
  • Purpose - The purpose of this study examines when the optimism impact on financial asset price forecasting and the boundary condition of optimism in the financial asset price forecasting. People generally tend to optimistically forecast their future. Optimism is a nature of human beings and optimistic forecasting observed in daily life. But is it always observed in financial asset price forecasting? In this study, two factors were focused on considering whether the optimism that people have applied to predicting future performance of financial investment products (e.g., mutual fund). First, this study examined whether the degree of optimism varied depending on the direction of the prior price trend. Second, this study examined whether the degree of optimism varied according to the forecast period by dividing the future forecasted by people into three time horizon based on forecast period. Research design, data, and methodology - 2 (prior price trend: rising-up trend vs falling-down trend) × 3 (forecast time horizon: short term vs medium term vs long term) experimental design was used. Prior price trend was used between subject and forecast time horizon was used within subject design. 169 undergraduate students participated in the experiment. χ2 analysis was used. In this study, prior price trend divided into two types: rising-up trend versus falling-down trend. Forecast time horizon divided into three types: short term (after one month), medium term (after one year), and long term (after five years). Results - Optimistic price forecasting and boundary condition was found. Participants who were exposed to falling-down trend did not make optimistic predictions in the short term, but over time they tended to be more optimistic about the future in the medium term and long term. However, participants who were exposed to rising-up trend were over-optimistic in the short term, but over time, less optimistic in the medium and long term. Optimistic price forecasting was found when participants forecasted in the long term. Exposure to prior price trends (rising-up trend vs falling-down trend) was a boundary condition of optimistic price forecasting. Conclusions - The results indicated that individuals were more likely to be impacted by prior price tends in the short term time horizon, while being optimistic in the long term time horizon.

Distribution and Exposure Prevalence of Carbohydrate-based Food Intake among Obese Korean Adults Based on the Health Examinees (HEXA) Study (한국 성인 비만 집단의 탄수화물 급원 식품 섭취 분포 및 노출 위험도: 대규모 한국인유전체 역학 자료 활용)

  • Han, Yuri;Kwon, Sung-Ok;Lee, Sang-Ah
    • Korean Journal of Community Nutrition
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    • v.22 no.2
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    • pp.159-170
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    • 2017
  • Objectives: The purpose of this study was to estimate the distribution and exposure prevalence of total carbohydrate intake and the carbohydrate-based foods such as rice, noodles, sweet potatoes, sweet drinks, milk and fruits and to characterize intake patterns among obese Korean adults. Methods: Subjects included 137,363 adults aged 40 years or older who participated in a Health Examinees (HEXA) Study. Multiple regression analysis of data from Semi-Quantitative Food Frequency Questionnaire (SQFFQ) identified food sources of carbohydrates. Weight, height and waist circumstance (WC) were measured, and the body mass index (BMI) was calculated. Obesity was defined as $BMI{\geq}25kg/m^2$ and abdominal obesity as $WC{\geq}90cm$ and ${\geq}85cm$ for males and females, respectively. Results: Obese adults appeared to have a higher total carbohydrate intake in the univariate analysis but had eaten less after adjustment for general and lifestyle factors, compared to normal weight adults (OR 0.78, 95% CI 0.73-0.82 for general obesity; OR 0.79, 95% CI 0.74-0.85, for abdominal obesity; P trend < 0.0001, respectively). Based on advance analysis for the food sources of carbohydrates, obese subjects had lower intake of rice (OR 0.86, 95% CI 0.68 -1.09 for general obesity; OR 0.87, 95% CI 0.67-1.13, for abdominal obesity; P trend < 0.0001, respectively) and higher intake of noodles (OR 1.21, 95% CI 1.16-1.27 for general obesity; OR 1.25, 95% CI 1.19-1.32, for abdominal obesity; P trend < 0.0001 respectively). With regard to other food sources of carbohydrates such as milk and fruits, intake was lower among obese compared to normal weight subjects. Conclusions: In the Korean middle-aged and older obesity groups, the intake of carbohydrates and the related foods was lower than in normal weight subjects, except for noodles. We conclude that a higher intake of noodles may enhance weight-gain. Therefore, this study suggested that the guidelines should consider the types of carbohydrate sources and the amount consumed from foods in order to provide proper guidance with regard to control and prevent obesity among Korean adults.

Toxicological Assessment to Environmental Stressors Using Exoskeleton Surface Roughness in Macrophthalmus japonicus: New Approach for an Integrated End-point Development (칠게 외골격 표면 거칠기를 이용한 노출 독성 평가: 새로운 융합적 연구)

  • Park, Kiyun;Kwak, Ihn-Sil
    • Korean Journal of Ecology and Environment
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    • v.54 no.4
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    • pp.265-271
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    • 2021
  • Intertidal mud crab (Macrophthalmus japonicus) is an organism with a hard chitinous exoskeleton and has function for an osmotic control in response to the salinity gradient of seawater. Crustacean exoskeletons change in their natural state in response to environmental factors, such as changes in the pH and water temperature, and the presence of pollutant substances and pathogen infection. In this study, the ecotoxicological effects of irgarol exposure and heavy metal distribution were presented by analyzing the surface roughness of the crab exoskeleton. The exoskeleton surface roughness and variation reduced in M. japonicus exposed to irgarol. In addition, it was confirmed that the surface roughness and variation were changed in the field M. japonicus crab according to the distribution of toxic heavy metals(Cd, Pb, Hg) in marine sediments. This change in the surface roughness of the exoskeleton represents a new end-point of the biological response of the crab according to external environmental stressors. This suggests that it may affect the functional aspects of exoskeleton protection, support, and transport. This approach can be utilized as a useful method for monitoring the aquatic environment as an integrated technology of mechanical engineering and biology.