• KSBB Journal
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• v.29 no.1
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• pp.58-66
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• 2014

Demand for in vitro pharmacological evaluation and toxicity test using human hepatocytes has been increasing. In USA and Europe, human hepatocytes obtained from donated whole liver unsuitable for transplantation were distributed to researchers and deposited in cell bank facility as cryopreserved vial. In Korea, however, incidence of transplantation- inappropriate whole liver has been quite low and the whole livers almost have so severe liver disease such as fatty or fibrotic liver that cannot meet the demand. In this study we aimed to isolate human hepatocytes from liver resection surgery-originated partial liver, and assure the isolated human hepatocytes and its cryopreserved hepatocytes to be qualified for the in vitro pharmacological evaluation and drug toxicity tests. We compared those with commercially available human hepatocyte, BD $GenTest^{TM}$ by cell morphology, hepatic gene expression, urea synthesis, albumin secretion, ammonia removal, and cytochrome P450 induction activities. Changes in hepatotoxic gene expression after cryopreservation are evaluated with a typical hepatotoxic drug, acetaminophen. Consequently, the fresh hepatocytes from the partial liver and its cryopreserved hepatocytes expressed their intrinsic hepatic functions well and showed equal hepatotoxicity gene expression trend regardless to cryopreservation. Therefore, liver resection surgery-originated partial liver can be used as a useful source of human hepatocytes for various pharmacological and hepatotoxicity test.

• Journal of the Mineralogical Society of Korea
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• v.18 no.3 s.45
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• pp.165-181
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• 2005

The granitic rocks distributed in the southern part of the Yangsan Fault are classified into five distinct rock facies based on the field relation, petrography and geochemical characteristics. These five different rock facies can be grouped into two considering their origins. Group I, which reveals various evidences of magma mixing, includes three rock facies of granodiorite, enclave-rich porphyritic granite, and enclave-poor porphyritic granite. Group H intruding Croup I includes equigranular granite and micrographic granite with no evidence of magma mixing. It is suggested that the distinctively different trace element and isotopic chemistries between group I and II, support evolution from the different parental magma. It is suggested that the three rock facies in group I were generated by different degrees of magma mixing in addition to fractionation of plagioclase. MMEs experienced fractionation of biotite. The two facies in group H seem to have been generated from different parent magma from group I and evolved by fractionation of K-feldspar. The Rb-Sr whole-rock ages of the group I rocks yield $59.2\~58.9Ma$, and those of the group II rocks give 53. $3\~51.7Ma$, regardless of their distribution whether they occur in the eastern or western parts of the Yangsan Fault. Based on Sm-Nd isotope compositions, depleted mantle model ages $(T_2DM)$ of the group I range $0.8\~0.9Ga$, while those of the group II$0.6\~0.7Ga$.

• Fisheries and Aquatic Sciences
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• v.8 no.3
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• pp.138-141
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• 2005

This study was conducted to investigate the effect of partially substituting meat meal for fish meal on the growth and body composition of juvenile olive flounder Paralichthys olivaceus during the winter season. Twenty-five fish (initial body weight, 23 g) were distributed into twelve 250 L flow-through tanks. Four experimental diets were prepared in triplicate: the control, MM20, MM40, and MM60 diets. Sixty percent mackerel meal was used as the primary protein source in the control diet. Meat meal was substituted for 20, 40, and 60$\%$ of the mackerel meal in the MM20, MM40, and MM60 diets, respectively. Survival was not significantly affected by the experimental diets. However, the weight gain and specific growth rate of fish fed the control, MM20, and MM40 diets were significantly higher than those of fish fed the MM60 diet (P<0.05). The feed efficiency ratio of fish fed the control, MM20, and MM40 diets was significantly higher than that of fish fed the MM60 diet (P<0.05). The protein efficiency ratio for fish fed the control diet was significantly higher than that for fish fed the MM40 and MM60 diets (P$\%$ substitution of meat meal for fish meal in the diet could be implemented without a reduction in growth or deterioration of the feed efficiency of juvenile olive flounder during the winter season.

• Geophysics and Geophysical Exploration
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• v.12 no.3
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• pp.225-232
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• 2009

As part of seismic experiments investigating crustal velocity structures of the Korean peninsula, permanent (fixed) seismographs of the Korea Meteorological Administration (KMA) network recorded seismic signals from four and eight large explosions in Korean Crustal Research Team (KCRT) profiles shot in 2004 and 2008, respectively. Among the seismograms recorded by 43 velocity sensors and 103 accelerometers at KMA stations distributed throughout the southern Korean Peninsula, 156 records with epicentral distances less than 120 km and high signal-to-noise ratios were analyzed to determine velocity anisotropy of the Pg phase. Relative elevation corrections of -101.6 to 105.3 ms were made using velocity information derived from the 2004 KCRT profile data and differences in elevation between the permanent KMA stations and the temporary stations in the KCRT profiles at the same source-receiver offsets. To remove site effects, receiver-station corrections of -89.6 to 192.2 ms were additionally made to the KMA station data by subtracting the average differences in traveltimes between KMA stations and portable stations at the same offsets for all available shots with different azimuths. With the exception of anomalously fast velocities along trends of the Chugaryeong fault zone and the Okchon fold belt and anomalously slow velocities in the regions of high terrestrial heat near Yeongduk and Ulsan, the analysis of crustal velocity anisotropy using the Pg phase indicates overall isotropy in the southern half of the Korean peninsula.

• Food Science and Preservation
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• v.23 no.7
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• pp.1004-1011
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• 2016

Flavonoids, non-nutrient secondary metabolites of plants, are widely distributed in commonly consumed agro-food resources. Flavonoids include aglycones, and their glycosides are reported to have potential health-promoting compounds. The aim of this study was to investigate flavonoid glycosides in the fruit and leaves of Zizyphus jujuba var. inermis (Bunge) Rehder (jujube). A total of six flavonoids (five flavonols and one chalcone) were identified in jujube fruit and leaves by using ultra-performance liquid chromatography-diode array detector-quadrupole time of flight mass spectrometry along with chemical library and an internal standard. In positive ion mode, six flavonoids were linked to the C- and O-glycosides which were conjugated with sugar moieties based on kaempferol, quercetin, and phloretin aglycones. Total flavonoid contents of leaves (8,356.5 mg/100 g dry weight (DW)) was approximately 900-fold higher than that of fruit (fresh fruit, 13.6 mg/100 g dry DW; sun-dried fruits, 9.2 mg/100 g dry DW). Quercetin 3-O-rutinoside (rutin) and quercetin 3-O-robinobioside were the predominant flavonols in fruit and leaves of jujube. In particular, rutin had the highest content (6,735.2 mg/100 g DW) in leaves, and rutin is a widely reported bioactive compound. Phloretin 3',5'-di-C-glucoside (chalcone type) was detected only in leaves. The leaves of jujube contain a high content of flavonoids and the results of this study indicate that jujube leaves may be a source of bioactive flavonoids.

• Journal of KIISE:Computer Systems and Theory
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• v.32 no.7
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• pp.349-358
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• 2005

False sharing is a result of co-location of unrelated data in the same unit of memory coherency, and is one source of unnecessary overhead being of no help to keep the memory coherency in multiprocessor systems. Moreover. the damage caused by false sharing becomes large in proportion to the granularity of memory coherency. To reduce false sharing in a page-based DSM system, it is necessary to allocate unrelated data objects that have different access patterns into the separate shared pages. In this paper we propose call-site tracing-based shared memory allocator. shortly CSTallocator. CSTallocator expects that the data objects requested from the different call-sites may have different access patterns in the future. So CSTailocator places each data object requested from the different call-sites into the separate shared pages, and consequently data objects that have the same call-site are likely to get together into the same shared pages. We use execution-driven simulation of real parallel applications to evaluate the effectiveness of our CSTallocator. Our observations show that by using CSTallocator a considerable amount of false sharing misses can be additionally reduced in comparison with the existing techniques.

• Journal of KIISE:Information Networking
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• v.30 no.1
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• pp.134-142
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• 2003

We present an ATM switch architectures based on the multistage interconnection network(MIN) for the efficient multicast traffic control. Many of these applications require multicast connections as well as point-to-point connections. Muiticast connection in which the same message is delivered from a source to arbitrary number of destinations is fundamental in the areas such as teleconferencing, VOD(video on demand), distributed data processing, etc. In designing the multicast ATM switches to support those services, we should consider the fairness(impartiality) and priority control, in addition to the overflow problem, cell processing with large number of copies, and the blocking problem. In particular, the fairness problem which is to distribute the incoming cells to input ports smoothly is occurred when a cell with the large copy number enters upper input port. In this case, the upper input port sends before the lower input port because of the calculating method of running sum, and therefore cell arrived into lower input port Is delayed to next cycle to be sent and transmission delay time becomes longer. In this paper, we propose the cell splitting and group splitting algorithm, and also the fairness scheme on the basis of the nonblocking characteristics for issuing appropriate copy number depending on the number of Input cell in demand. We evaluate the performance of the proposed schemes in terms of the throughput, cell loss rate and cell delay.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.11
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• pp.7990-8000
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• 2015

Plant factories are plant cultivation systems which produce farm products uniformly under the controlled environmental condition regardless of seasons and places. Thermal flow in the plant factory is an important parameter in cultivating plants. In this research, we study thermal flow characteristics for a hybrid plant factory with multi-layer cultivation shelves using computer simulation techniques. In order to obtain numerical solutions for thermal flow characteristics, a finite volume method was applied. We consider a low-Reynolds-number ${\kappa}-{\epsilon}$ turbulence model, incompressible viscous flows, and pressure boundary conditions for numerical simulation. Commercial software Solid Works Flow Simulation is then used to investigate characteristics of thermal flows in the plant factory applying several different inflow air velocities and arrangements of cultivation shelves. From numerical analysis results, we found that temperatures in cultivation shelves were uniformly distributed for Case 3 when the inflow air velocity was 1.6 m/s by using a blower in the plant factory. However in Case 1 lower temperature distributions were observed in test beds, TB2 and TB3, which indicated that additional temperature control efforts would be required. Average shelf temperature increased by $3^{\circ}C$ using artificial light source (DYLED47) with 50% blue and 50% red LED ratios. Korea Academia-Industrial cooperation Society.

• The KIPS Transactions:PartA
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• v.19A no.1
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• pp.1-8
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• 2012

Network-based intelligent robot is connected with network system, provides interactions with humans, and carries out its own roles on ubiquitous computing environments. URC (Ubiquitous Robot Companion) robot has been proposed to develop network-based robot by applying distributed computing techniques. On URC robot, it is possible to save the computing power of robot client by environments, has been proposed to develop robot software using service-oriented architecture on server-client computing environments. The SOMAR client robot consists of two layers - device service layer and robot service layer. The device service controls physical devices, and the robot service abstracts robot's services, which are newly defined and generated by combining many device services. RSEL (Robot Service Executing Language) is defined in this paper to represent relations and connections between device services and robot services. A RESL document, including robot services by combining several device services, is translated to a programming language for robot client system using RSEL translator, then the translated source program is compiled and uploaded to robot client system with RPC (Remote Procedure Call) command. A SOMAR client system is easy to be applied to embedded systems of host/target architecture. Moreover it is possible to produce a light-weight URC client robot by reducing workload of RSEL processing engine.

• Journal of Conservation Science
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• v.31 no.1
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• pp.47-64
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• 2015

The excavated potteries and raw clays of the Bronze Age from the archaeological sites in the Cheonan-Asan area were studied on material scientific characteristics and homogeneity. Under the microscope, grainsize of the tempers in the potteries were distributed from less than 1mm to 10mm. Microtexture of the potteries showed various shapes and sizes of pores. In addition to the main minerals such as quartz, feldspar, mica, hornblende, chlorite and talc were found from the X-ray diffraction analysis of potteries, while talc was not found in the raw clay. Therefore, it was considered as an artificially added mineral. Firing temperature of the potteries, which did not contain chlorite, are assumed that they were baked below $850^{\circ}C$. On the other hand, the potteries which had mica and talc, are assumed that they were fired below $900^{\circ}C$. The geochemical characteristics of the potteries and raw clays showed very similar patterns, that means the potteries were produced by using the raw clay sources from each site.