• Biomolecules & Therapeutics
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• v.22 no.3
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• pp.184-192
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• 2014

${\beta}$-lapachone is a naturally occurring quinone that selectively induces apoptotic cell death in a variety of human cancer cells in vitro and in vivo; however, its mechanism of action needs to be further elaborated. In this study, we investigated the effects of ${\beta}$-lapachone on the induction of apoptosis in human gastric carcinoma AGS cells. ${\beta}$-lapachone significantly inhibited cellular proliferation, and some typical apoptotic characteristics such as chromatin condensation and an increase in the population of sub-G1 hypodiploid cells were observed in ${\beta}$-lapachone-treated AGS cells. Treatment with ${\beta}$-lapachone caused mitochondrial transmembrane potential dissipation, stimulated the mitochondria-mediated intrinsic apoptotic pathway, as indicated by caspase-9 activation, cytochrome c release, Bcl-2 downregulation and Bax upregulation, as well as death receptor-mediated extrinsic apoptotic pathway, as indicated by activation of caspase-8 and truncation of Bid. This process was accompanied by activation of caspase-3 and concomitant with cleavage of poly(ADP-ribose) polymerase. The general caspase inhibitor, z-VAD-fmk, significantly abolished ${\beta}$-lapachone-induced cell death and inhibited growth. Further analysis demonstrated that the induction of apoptosis by ${\beta}$-lapachone was accompanied by inactivation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. The PI3K inhibitor LY29004 significantly increased ${\beta}$-lapachone-induced apoptosis and growth inhibition. Taken together, these findings indicate that the apoptotic activity of ${\beta}$-lapachone is probably regulated by a caspase-dependent cascade through activation of both intrinsic and extrinsic signaling pathways, and that inhibition of the PI3K/Akt signaling may contribute to ${\beta}$-lapachone-mediated AGS cell growth inhibition and apoptosis induction.

• Journal of Sensor Science and Technology
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• v.4 no.1
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• pp.51-63
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• 1995

Polycrystalline $CdS_{1-x}Se_{x}$ thin films were grown on ceramic substrate using a chemical bath deposition method. They were annealed at various temperature and X-ray diffraction patterns were measured by X-ray diffractometer in order to study $CdS_{1-x}Se_{x}$ polycrystal structure using extrapolation method of X-ray diffraction patterns for the CdS, CdSe samples annealed in $N_{2}$ gas at $550^{\circ}C$ it was found hexagonal structure which had the lattice constant $a_{0}=4.1364{\AA}$, $c_{0}=6.7129{\AA}$ in CdS and $a_{0}=4.3021{\AA}$, $c_{0}=7.0142{\AA}$ in CdSe, respectively. Hall effect on these samples was measured by Van der Pauw method and then studied on carrier density and mobility depending on temperature. We measured also spectral response, sensitivity(${\gamma}$), maximum allowable power dissipation and response time on these samples.

• Journal of Internet Computing and Services
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• v.10 no.5
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• pp.41-47
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• 2009

Routing through a backbone, which is responsible for performing and managing multipoint communication, reduces the communication overhead and overall energy consumption in wireless sensor networks. However, the backbone nodes will need extra functionality and therefore consume more energy compared to the other nodes. The power consumption imbalance among sensor nodes may cause a network partition and failures where the transmission from some sensors to the sink node could be blocked. Hence optimal construction of the backbone is one of the pivotal problems in sensor network applications and can drastically affect the network's communication energy dissipation. In this paper a distributed algorithm is proposed to generate backbone trees through robust multi-hop clusters in wireless sensor networks. The main objective is to form a properly designed backbone through multi-hop clusters by considering energy level and degree of each node. Our improved cluster head selection method ensures that energy is consumed evenly among the nodes in the network, thereby increasing the network lifetime. Comprehensive computer simulations have indicated that the newly proposed scheme gives approximately 10.36% and 24.05% improvements in the performances related to the residual energy level and the degree of the cluster heads respectively and also prolongs the network lifetime.

• Journal of the Korea institute for structural maintenance and inspection
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• v.15 no.3
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• pp.186-194
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• 2011

The reinforced concrete beam-column connections are in lack of constructability and are likely to show anchorage failure because of the complex details of joint regions. Under seismic loads, a destruction of the column or the beam-column joint leads to collapse of the whole structures. For this reason, the safety of structures has to be guaranteed by following procedures which are based on the strong column-weak beam design concept: 1) failure of beam by generating plastic hinge in the beam maintained a certain distance from the surface of column, 2) failure of column or beam-column joint. In this study, headed bars were used as longitudinal reinforcements of beam and joint reinforcements in order to improve the strength and constructability of joint and to relocate plastic hinge. The finite element analyses (FEAs) were performed to the reinforced concrete beam-column joints utilizing headed bar reinforcements. To verify the availability of the analysis models, the FEAs for experimental tests performed by previous researchers were conducted and compared with the experimental results. Additional variables are also considered to confirm the excellence of headed bars. Analysis results indicate that the constructability of beam-column connections can be improved by using headed bars for the full anchorage of longitudinal reinforcements of beam under similar structural performance. In addition, the plastic hinge was relocated to the intended place by using headed bars as joint reinforcements. Under cyclic displacement loading, the energy dissipation capacity and ultimate stress were increased and the decrease in stiffness was minimized.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.22 no.1
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• pp.25-33
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• 2010

The matching condition at a perforated wall with vertical slits involves the permeability parameter, which can be calculated by two different methods. One expresses the permeability parameter in terms of energy dissipation coefficient and jet length at the perforated wall, being advantageous in that all the related variables are known, but it gives wrong result in the limit of long waves. The other expresses the permeability parameter in terms of friction coefficient and inertia coefficient, giving correct result from short to long waves, but the friction coefficient should be determined on the basis of a best fit between measured and predicted values of such hydrodynamic coefficients as reflection and transmission coefficients. In the present study, an empirical formula for the friction coefficient is proposed in terms of known variables, i.e., the porosity and thickness of the perforated wall and the water depth. This enables direct estimation of the friction coefficient without invoking a best fit procedure. To obtain the empirical formula, hydraulic experiments are carried out, the results of which are used along with other researchers' results. The proposed formula is used to predict the reflection and transmission coefficients of a curtain-wall-pile breakwater, the upper part of which is a curtain wall and the lower part consisting of a perforated wall with vertical slits. The concurrence between the experimental data and calculated results is good, verifying the appropriateness of the proposed formula.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.5
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• pp.340-350
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• 2020

A rapid refresh wave forecasting system has been developed using the sea wind on the Korea Local Analysis and Prediction System. We carried out a numerical experiment for wind-wave interaction as an important parameter in determining the forecasting performance. The simulation results based on the seasons of with typhoon and without typhoon has been compared with the observation of the ocean data buoy to verify the forecasting performance. In case of without typhoon, there was an underestimate of overall forecasting tendency, and it confirmed that an increase in the wind-wave interaction parameter leads to a decrease in the underestimate tendency and root mean square error (RMSE). As a result of typhoon season by applying the experiment condition with minimum RMSE on without typhoon, the forecasting error has increased in comparison with the result without typhoon season. It means that the wave model has considered the influence of the wind forcing on a relatively weak period on without typhoon, therefore, it might be that the wave model has not sufficiently reflected the nonlinear effect and the wave energy dissipation due to the strong wind forcing.

• Korean Journal of Environmental Agriculture
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• v.31 no.1
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• pp.45-51
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• 2012

BACKGROUND: This study was carried out to establish pre-harvest residue limit of fungicides pyrimethanil and trifloxystrobin in persimmon, based on dissipation and biological half-lives of two fungicides residue. METHODS AND RESULTS: Both pyrimethanil and trifloxystrobin were extracted with acetonitrile, clean-up with $NH_2$ SPE cartridge and residue were analyzed by HPLC/DAD. Limit of Detection was 0.01 mg/kg. Average recovery were $81{\pm}1.62%$, $98{\pm}1.58%$ of pyrimethanil, and $91{\pm}2.94%$, $98{\pm}1.25%$ of trifloxystrobin at fortification levels at 0.1 and 0.5 mg/kg, respectively. CONCLUSION: The biological half-lives of pyrimethanil were 15.6 and 11.6 days at sprayed with recommended and double dosage, respectively. The biological half-lives of trifloxystrobin were 10.4 and 10.3 days at sprayed with recommended and double dosage, respectively. The pre-harvest residue limit of pyrimethanil and trifloxystrobin were recommended as 2.69 and 0.83 mg/kg for 10 days before harvest, respectively.

• Journal of Sensor Science and Technology
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• v.4 no.3
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• pp.60-70
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• 1995

Polycrystalline $Cd_{1-x}Zn_{x}S$ thin film were grown on slide glass(corning-2948) substrate using a chemical bath deposition (C.B.D) method. They were annealed at various temperature and X -ray diffraction patterns were measured by X-ray diffractometor in order to study $Cd_{1-x}Zn_{x}S$ polycrystal structure using extrapolation method of X-ray diffraction patterns for the CdS, ZnS sample annealed in $N_{2}$ gas at $550^{\circ}C$. It was found hexagonal structure which had the lattice constant $a_{0}\;=\;4.1364{\AA}$, $c_{0}\;=\;6.7129{\AA}$ in CdS and $a_{0}\;=\;3.8062{\AA}$, $c_{0}\;=\;6.2681{\AA}$ in ZnS, respectively. Hall effect on these sample was measured by Van der Pauw method and then studied on carrier density and mobility depending on temperature. We measured also spectral response, sensitivity maximum allowable power dissipation and response time on these sample.

• Applied Chemistry for Engineering
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• v.7 no.3
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• pp.464-472
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• 1996

The mechanism of thin-film formation by Ionized Cluster Beam Deposition(ICBD) was investigated. A simulation program based on the Monte-Carlo method was developed in order to investigate the effects of the acceleration voltage, substrate temperature, activation energy for the surface migration, and critical nuclei size on grain size and surface roughness. Studies of the effect of kinetic energy of clusters on the film formation processes revealed that high acceleration voltage enhanced the surface-migration of adatoms and made it easier for an epitaxial film to be formed. The relaxation time of kinetic energy of adatoms increased with the substrate temperature, which in turn increased the grain size of the crystalline film. This effect was more clearly distinguished when the critical nuclei size was large. The surface-migration activation energy was found to affect the interaction between the adatoms and the substrate and thus the relaxation time of kinetic energy. Investigations of the surface roughness revealed that the acceleration voltage, the substrate temperature, and the surface-migration activation energy exerted a collective effect on the morphology of the film surface.

• Journal of the Korean Geotechnical Society
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• v.30 no.7
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• pp.27-40
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• 2014

So far, studies on the settlement of breakwater have mainly been conducted through numerical model tests focusing on an analysis or through the laboratory wave tank tests using a scaled model. There has not been a study on the settlement that is measured in an actual breakwater structure. This study analyzed the data of settlement that has been measured in an actual caisson breakwater for a long time and the characteristics and causes of wave-induced settlement in the caisson (including beneath ground), based on qualitative aspect, were examined. The analysis revealed that wave clearly has an effect on the settlement in caisson, especially in the condition of high wave such as typhoon. Caisson settlement is caused by the liquefaction of ground, which is due to the increase of excess pore pressure, the combination of oscillatory excess pore pressure and residual excess pore water pressure, and the solidification process of ground due to dissipation of the accumulated excess pore pressure. The behavior of excess pore pressure in the ground beneath the caisson is entirely governed by the behavior of the caisson. Ground that has gone through solidification is not likely to go through liquefaction in a similar or a smaller wave condition and consequently, the possibility of settlement is reduced.