• Journal of Pharmaceutical Investigation
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• v.22 no.1
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• pp.33-40
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• 1992

This study was aimed to control the release characteristics of ketoprofen by microencapsulating $ketoprofen-{\beta}-cyclodextrin\;(KF-{\beta}-CyD)$ solid dispersion with Eudragit RS by the phase separation method using a nonaqueous vehicle. KF alone was also microencapsulated with Eudragit RS by the evaporation process in water phase. The results obtained showed that it was not possible to microencapsulate KF alone by phase separation in a chloroform-cyclohexane system while it was easy to microencapsulate $(KF-{\beta}-CyD)$ solid dispersion system. For the microcapsules, the release test was performed in the first fluid (pH 1.2) and the second fluid (pH 6.8) of K.P.V disintegration medium at $37^{\circ}C$. The release of KF from $(KF-{\beta}-CyD)$ solid dispersion microcapsules (1:1 core wall ratio) was more sustained than that from KF microcapsules, and followed zero-order kinetics. Especially, solid dispersion microcapsules showed pH-independent release patterns with higher wall to core ratio (1:1 w/w).

• Journal of the Korean Society of Safety
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• v.18 no.1
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• pp.64-70
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• 2003

For the unconfined vapor cloud explosion(UVCE) accident by the continuous release of gas-liquid flow of various saturated liquids in a vessel at ground level, overpressures were estimated by TNT equivalency model with two estimation methods, such as UVCE I model based on a constant release time and UVCEII model based on a real travel time of vapor by dispersion and analyzed with various release conditions. As a simulation result the simple, easy, and correct method of evaluation of consequences of the UVCE accident was proposed by using consequences of UVCE I model and correlation equations for differences of overpressures between UVCE models, so that this evaluation method could be used easily in the small and medium size enterprises without using the dispersion model.

• Transactions of the Korean Society of Mechanical Engineers
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• v.18 no.7
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• pp.1697-1704
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• 1994

Elastic wave propagation in discrete random medium studies to predict dynamic effective properties of composite materials containing spherical inclusions. A self-consistent method is proposed which is analogous to the well-known coherent potential approximation. Three conditions that must be satisfied by two effective elastic moduli and effective density are derived for the time without limit of frequency. The derived self-consistency conditions have the physical meaning that the scattering of coherent wave by the constituents in effective medium is vanished on the average. The frequency-dependent complex effective wave speed and coherent attenuation can be obtained by solving the derived self-consistency conditions numerically. The wave speed and attenuation obtained from present theory are shown to be in the better agreements with previous experimental observations than the previous theory.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2001.05a
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• pp.420-425
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• 2001

Theoretical analysis of noise reduction by a membrane-duct system is presented. When acorn waves propagate in the membrane-duct, the membrane is also excited and its motion is coup with interior medium. It has been shown that propagating waves with supersonic wave speed exist beyond a certain critical frequency that is determined from the mass ratio of the me and the fluid. Also found are subsonic waves which couple strongly wi th the membrane a provide a powerful mechanism of energy dissipation. Existence of an exterior medium alter dispersion characteristics. It provides additional mass loading and reduces the subsort speed further. The effect of mean flow speed on dispersion characteristics is also consider results show that the membrane-duct system can be applied to diminish and absorb 1 frequency noise in duct instead of passive muffler, such as a simple expansion chamber absorption material.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.33 no.2
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• pp.105-110
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• 2007

The stability of titanium dioxide dispersion was evaluated by zeta ($\zeta$) potential and we intended to apply it for improvement of dispersion stability. Both theories related to $\zeta$ potential (electric double layer, electrophoresis, isoelectric point and electroosmosis) and a method to measure $\zeta$ potential were explained in this study. The change in $\zeta$ potential of $TiO_2$ dispersion was measured by means of Henry's function of Helmholtz-Smoluchowski's equation (H-S equation). The $\zeta$ potentials of $TiO_2$ dispersion were negative in all measured pH values ($3.0{\sim}9.0$), and absolute values of $\zeta$ potentials of $TiO_2$ increased as pH values increased. $TiO_2$ dispersion was maintained in pH 8.0 and 9.0 respectively. From these results, we suggest that $\zeta$ potentials have an effect on $TiO_2$ dispersion and absolute value of $\zeta$ potentials played an important role in the stability of $TiO_2$ dispersion in aqeous medium.

• Journal of Pharmaceutical Investigation
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• v.41 no.4
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• pp.239-247
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• 2011

Simvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in the biosynthesis of cholesterol. Simvastatin has good permeability, but it also has low solubility (BCS class II), which reduces its bioavailability. To overcome this problem, a solid dispersion is formed using a spray-dryer with polymeric material carrier to potentially enhance the dissolution rate and extend drug absorption. As carriers for solid dispersion, Gelucire$^{(R)}$44/14 and Gelucire$^{(R)}$ 50/13 are semisolid excipients that greatly improve the bioavailability of poorly-soluble drugs. To avoid any toxic effects of an organic solvent, we used aqueous medium to melt Tween$^{(R)}$ 80 and distilled water. The structural behaviors of the raw materials and the solid dispersion were analyzed by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM). The DSC and PXRD data indicated that the crystalline structure of simvastatin was transformed to an amorphous structure through solid dispersion. Then, solid dispersion-based tablets containing 20 mg simvastatin were prepared with excipients. Dissolution tests were performed in distilled water and artificial intestinal fluid using the USP paddle II method. Compared with that of the commercial tablet (Zocor$^{(R)}$ 20 mg), the release of simvastatin from solid dispersion based-tablet was more efficient. Although the stability study is not complete, this solid dispersion system is expected to deliver poorly water-soluble drugs with enhanced bioavailability and less toxicity.

• Journal of Powder Materials
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• v.17 no.5
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• pp.390-398
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• 2010

Aqueous gold nanoparticle dispersion was synthesized by chemical reduction method using diethanolamine as reducing agent and polyethyleneimine as dispersion stabilizer. The synthesis conditions for the stable dispersion of the gold nanoparticle suspension were determined by changing the amount of the reducing agent and dispersant during the wet chemical synthesis procedures. The face centered cubic lattice structure of the gold nanoparticles was confirmed by using X-ray diffraction and the morphologies of the nanoparticles were observed by transmission electron microscope. The synthesized gold nanoparticle dispersion was concentrated by evaporating the dispersion medium at room temperature followed by the addition of ethyleneglycol as humectant for the increase of the elastic properties to obtain gold nanoparticle inks for direct ink writing process. The line patterns were obtained with the gold nanoparticle inks during the writing procedures and the morphologies of the fine patterns were observed by scanning electron microscope.

• Korean Journal of Food Science and Technology
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• v.28 no.5
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• pp.827-833
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• 1996

Along with the increased necessity for an efficient utilization of Korean wild edible plants growing in fields and mountains, attempts were made to investigate the patterns of flavor changes accompanied hy various conditions of dispersion medium. The effect of various pH values and concentration of sucrose or NaCl of dispersion medium on volatile flavor patterns was investigated to evaluate the applicability of flavor components extracted from Capsella bursa-pastoris for food industry. Essential oils from this wild plant were isolated by simultaneous steam distillation-extraction (SDE) method using diethyl ether as solvent. Concentrated samples were analyzed s chromatography (GC) and combined gas chromatography-mass spectrometry (GC-MS). Most volatile flavor components of Capsella bursa-pastoris showed good recovery when steam distilled at pH 7 by SDE method. Increasing concentration of sucrose and 15% by NaCl, resulted in greater numbers of identified flavor components from Capsella bursa-pastoris.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.3A
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• pp.168-177
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• 2005

In this paper, we numerically investigated the optimum pump light power resulting best compensation of pulse distortion due to both chromatic dispersion and self phase modulation (SPM) in long-haul 3×40 Gbps wavelength division multiplexing (WDM) systems. We used mid-span spectral inversion (MSSI) method with path-averaged intensity approximation (PAIA) as compensation approach, which have highly nonlinear dispersion shifted fiber (HNL-DSF) as nonlinear medium of optical phase conjugator (OPC) in the mid-way of total transmission line. We confirmed that HNL-DSF is an useful nonlinear medium in OPC for wideband WDM transmission, and in order to achieve the excellent compensation the pump light power is selected to equal the conjugated light power into the latter half fiber section with the input light power of WDM channel depending on total transmission length. Also we confirmed that compensation degree of WDM channel with small conversion efficiency is improved by using pump light power increasing power conversion ratio upper than 1.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.15 no.5
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• pp.517-524
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• 2004

In this paper, we investigated the compensation characteristics of distorted NRZ format and RZ format signal dependence on dispersion variation of each transmission section in 8-channel WDM system. The WDM system have two transmission sections of unequal length with respect to optical phase conjugator(OPC) position. We select highly-nonlinear dispersion shifted fiber(HNL-DSF) as a nonlinear medium of OPC in order to convert wideband signal waves to conjugated waves. First, we confirmed that RZ is better than NRZ as a modulation format for maintenance or stable performance, when total dispersion or both sections in WDM system is different each other. Also, we confirmed that total dispersion of the short length section must be smaller than that of the long length section in order to excellently compensate for NRZ format signal.