• Journal of Genetic Medicine
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• 제14권2호
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• pp.49-55
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• 2017

Pre-eclampsia is known to cause considerable maternal morbidity and mortality. Thus, many studies have examined the etiopathogenesis of pre-eclampsia. While many pathophysiological factors related to pre-eclampsia have been identified, the precise etiopathogenesis of pre-eclampsia remains unclear. Numerous studies have identified factors for the early prediction for pre-eclampsia to lead to preparation and closer observation on pre-eclampsia when it occurs. This article reviews on current studies of biomarkers and genetic factors related to pre-eclampsia, which may be important for developing strategies for early prediction of pre-eclampsia.

• 대한안전경영과학회지
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• 제14권1호
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• pp.87-93
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• 2012

The purpose of this study suggests a personalized algorithm of physical activity energy expenditure prediction through comparison and analysis of individual physical activity. The research for a 3-axial accelerometer sensor has increased the role of physical activity in promoting health and preventing chronic disease has long been established. Estimating algorithm of physical activity energy expenditure was implemented by using a tri-axial accelerometer motion detector of the SVM(Signal Vector Magnitude) of 3-axis(x, y, z). A total of 10 participants(5 males and 5 females aged between 20 and 30 years). The activities protocol consisted of three types on treadmill; participants performed three treadmill activity at three speeds(3, 5, 8 km/h). These activities were repeated four weeks.

• 대한임베디드공학회논문지
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• 제18권2호
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• pp.59-65
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• 2023

Currently, polysomnography is essential to diagnose sleep-related breathing disorders. However, there are several disadvantages to polysomnography, such as the requirement for multiple sensors and a long reading time. In this paper, we propose a system for predicting the severity of sleep-related breathing disorders at home utilizing measurable elements in a wearable device. To predict severity, the variables were refined through a three-step variable selection process, and the refined variables were used as inputs into three machine-learning models. As a result of the study, random forest models showed excellent prediction performance throughout. The best performance of the model in terms of F1 scores for the three threshold criteria of 5, 15, and 30 classified as the AHI index was about 87.3%, 90.7%, and 90.8%, respectively, and the maximum performance of the model for the three threshold criteria classified as the RDI index was approx 79.8%, 90.2%, and 90.1%, respectively.

• Journal of information and communication convergence engineering
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• 제21권4호
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• pp.294-299
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• 2023

Micro ribonucleic acids (miRNAs) can regulate the protein expression levels of genes in the human body and have recently been reported to be closely related to the cause of disease. Determining the genes related to miRNAs will aid in understanding the mechanisms underlying complex miRNAs. However, the identification of miRNA-related genes through wet experiments (in vivo, traditional methods are time- and cost-consuming). To overcome these problems, recent studies have investigated the prediction of miRNA relevance using deep learning models. This study presents a method for predicting the relationships between miRNAs and genes. First, we reconstruct a negative dataset using the proposed method. We then extracted the feature using an autoencoder, after which the feature vector was concatenated with the original data. Thereafter, the concatenated data were used to train a long short-term memory model. Our model exhibited an area under the curve of 0.9609, outperforming previously reported models trained using the same dataset.

• 감성과학
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• 제10권2호
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• pp.147-154
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• 2007

심장의 활동을 기록한 심전도는 심장의 상태에 대한 가치 있는 임상 정보를 제공한다. 지금까지 심전도를 이용한 심장 질환 진단 알고리즘에 대한 많은 연구가 진행되어 왔으나, 심장 질환에 대한 국내 진단 결과의 부정확성 때문에 외국의 진단 알고리즘을 사용하고 있다. 이 논문에서는 원시 심전도 데이터로부터 심장 질환 진단의 파라미터인 ST-segment 추출 방법을 제안한다. ST-segment는 관상동맥 질환 예측에 활용되므로 데이터마이닝의 분류기법을 적용하여 질환을 예측한다. 또한 연관규칙 마이닝을 통해 환자들의 임상 데이터로부터 심장 질환자들의 임상적 특징을 예측한다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume II
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• pp.868-871
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• 2006

Mortality of domestic people from cardiovascular disease ranked second, which followed that of from cancer last year. Therefore, it is very important and urgent to enhance the reliability of medical examination and treatment for cardiovascular disease. Heart Rate Variability (HRV) is the most commonly used noninvasive methods to evaluate autonomic regulation of heart rate and conditions of a human heart. In this paper, our aim is to extract a quantitative measure for HRV to enhance the reliability of medical examination for cardiovascular disease, and then develop a prediction method for extracting multi-parametric features by analyzing HRV from ECG. In this study, we propose a hybrid Bayesian classifier called FP-based Bayesian. The proposed classifier use frequent patterns for building Bayesian model. Since the volume of patterns produced can be large, we offer a rule cohesion measure that allows a strong push of pruning patterns in the pattern-generating process. We conduct an experiment for the FP-based Bayesian classifier, which utilizes multiple rules and pruning, and biased confidence (or cohesion measure) and dataset consisting of 670 participants distributed into two groups, namely normal and patients with coronary artery disease.

• Nuclear Medicine and Molecular Imaging
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• 제41권2호
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• pp.102-111
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• 2007

Dementia is a major burden for many countries including South Korea, where life expectancy is continuously growing and the proportion of aged people is rapidly growing. Neurodegenerative disorders, such as, Alzheimer disease, dementia with Lewy bodies, frontotemporal dementia, Parkinson disease, progressive supranuclear palsy, corticobasal degeneration, Huntington disease, can cause dementia, and cerebrovascular disease also can cause dementia. Depression or hypothyroidism also can cause cognitive deficits, but they are reversible by management of underlying cause unlike the forementioned dementias. Therefore these are called pseudodementia. We are entering an era of dementia care that will be based upon the identification of potentially modifiable risk factors and early disease markers, and the application of new drugs postpone progression of dementias or target specific proteins that cause dementia. Efficient pharmacologic treatment of dementia needs not only to distinguish underlying causes of dementia but also to be installed as soon as possible. Therefore, differential diagnosis and early diagnosis of dementia are utmost importance. F-18 FDG PET is useful for clarifying dementing diseases and is also useful for early detection of the diseases. Purpose of this article is to review the current value of FDG PET for dementing diseases including differential diagnosis of dementia and prediction of evolving dementia.

• 통합자연과학논문집
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• 제8권4호
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• pp.305-312
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• 2015

The present study showed WHtR to be significantly better than BMI and WC for prediction of metabolic-related diseases in the middle-aged and older people in Korea, based on Bayesian ordered probit model analysis. The variations of WC, BMI and WHtR were compared according to the number of metabolic-related diseases such as hypertension, dyslipidemia, stroke, myocardial infarction, angina pectoris and diabetes. It was found that the three measures showed the similar variation except a very few extreme cases for age less than 40. For subjects over the age of 40, WC was not significant and WHtR gave more influence in greater variability than BMI on the number of metabolic diseases. Also, the rate of change for WHtR was higher than for BMI as the number of metabolic-related diseases increased. Specifically, the difference of the marginal effect of WHtR between no disease and only one disease was 1.81 times higher than that of BMI. Moreover, it was pointed out that the threshold value of WHtR for obesity should be considered differently by age.

• International Journal of Computer Science & Network Security
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• 제21권3호
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• pp.177-184
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• 2021

All over the world, people are affected by many chronic diseases and medical practitioners are working hard to find out the symptoms and remedies for the diseases. Many researchers focus on the feature detection of the disease and trying to get a better health recommendation system. It is necessary to detect the features automatically to provide the most relevant solution for the disease. This research gives the framework of Health Recommendation System (HRS) for identification of relevant and non-redundant features in the dataset for prediction and recommendation of diseases. This system consists of three phases such as Pre-processing, Feature Selection and Performance evaluation. It supports for handling of missing and noisy data using the proposed Imputation of missing data and noise detection based Pre-processing algorithm (IMDNDP). The selection of features from the pre-processed dataset is performed by proposed ensemble-based feature selection using an expert's knowledge (EFS-EK). It is very difficult to detect and monitor the diseases manually and also needs the expertise in the field so that process becomes time consuming. Finally, the prediction and recommendation can be done using Support Vector Machine (SVM) and rule-based approaches.

• ETRI Journal
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• 제45권3호
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• pp.448-461
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• 2023

This article performs a detailed data scrutiny on a chronic kidney disease (CKD) dataset to select efficient instances and relevant features. Data relevancy is investigated using feature extraction, hybrid outlier detection, and handling of missing values. Data instances that do not influence the target are removed using data envelopment analysis to enable reduction of rows. Column reduction is achieved by ranking the attributes through feature selection methodologies, namely, extra-trees classifier, recursive feature elimination, chi-squared test, analysis of variance, and mutual information. These methodologies are ranked via Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) using weight optimization to identify the optimal features for model building from the CKD dataset to facilitate better prediction while diagnosing the severity of the disease. An efficient hybrid ensemble and novel similarity-based classifiers are built using the pruned dataset, and the results are thereafter compared with random forest, AdaBoost, naive Bayes, k-nearest neighbors, and support vector machines. The hybrid ensemble classifier yields a better prediction accuracy of 98.31% for the features selected by extra tree classifier (ETC), which is ranked as the best by TOPSIS.