Browse > Article

FDG PET Imaging For Dementia  

Ahn, Byeong-Cheol (Department of Nuclear Medicine, Kyungpook National University Medical School and Kyungpook National University Hospital)
Publication Information
Nuclear Medicine and Molecular Imaging / v.41, no.2, 2007 , pp. 102-111 More about this Journal
Abstract
Dementia is a major burden for many countries including South Korea, where life expectancy is continuously growing and the proportion of aged people is rapidly growing. Neurodegenerative disorders, such as, Alzheimer disease, dementia with Lewy bodies, frontotemporal dementia, Parkinson disease, progressive supranuclear palsy, corticobasal degeneration, Huntington disease, can cause dementia, and cerebrovascular disease also can cause dementia. Depression or hypothyroidism also can cause cognitive deficits, but they are reversible by management of underlying cause unlike the forementioned dementias. Therefore these are called pseudodementia. We are entering an era of dementia care that will be based upon the identification of potentially modifiable risk factors and early disease markers, and the application of new drugs postpone progression of dementias or target specific proteins that cause dementia. Efficient pharmacologic treatment of dementia needs not only to distinguish underlying causes of dementia but also to be installed as soon as possible. Therefore, differential diagnosis and early diagnosis of dementia are utmost importance. F-18 FDG PET is useful for clarifying dementing diseases and is also useful for early detection of the diseases. Purpose of this article is to review the current value of FDG PET for dementing diseases including differential diagnosis of dementia and prediction of evolving dementia.
Keywords
FDG; PET; diagnosis; dementia; pseudodementia; alzheimer disease; frontotemporal dementia; vascular dementia; dementia with lewy bodies;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Tedeschi E, Hasselbalch SG, Waldemar G, Juhler M, Hogh P, Holm S, Garde L, et al. Heterogeneous cerebral glucose metabolism in normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry 1995;59:608-15   DOI
2 Friedland RP, Fritsch T, Smyth KA, Koss E, Lerner AJ, Chen CH, Petot GJ, et al. Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members. Proc Natl Acad Sci U S A 2001;98:3440-5   DOI   ScienceOn
3 Herholz K, Nordberg A, Salmon E, Perani D, Kessler J, Mielke R, Halber M, et al. Impairment of neocortical metabolism predicts progression in Alzheimer's disease. Dement Geriatr Cogn Disord 1999;10:494-504   DOI   ScienceOn
4 Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. Alpha-synuclein in Lewy bodies. Nature 1997;388: 839-40   DOI   ScienceOn
5 Albin RL, Minoshima S, D'Amato CJ, Frey KA, Kuhl DA, Sima AAF. Fluoro-deoxyglucose positron emission tomography in diffuse Lewy body disease. Neurology 1996;47:462-6   DOI   ScienceOn
6 Lebert F, Stekke W, Hasenbroekx C, Pasquier F. Frontotemporal dementia: a randomized, controlled trial with trazodone. Dement Geriatr Cogn Disord 2004;17:355-9   DOI   ScienceOn
7 Josephs KA, Knopman DS, Whitwell JL, Boeve BF, Parisi JE, Petersen RC, Dickson DW. Survival in two variants of tau-negative frontotemporal lobar degeneration: FTLD-U vs. FTLD-MND. Neurology 2005;65:645-7   DOI   ScienceOn
8 Galvin JE. Cognitive change in Parkinson disease. Alzheimer Dis Assoc Disord 2006;20:302-10   DOI   ScienceOn
9 Foster NL, Gilman S, Berent S, Morin EM, Brown MB, Koeppe RA. Cerebral hypometabolism in progressive supranuclear palsy studied with positron emission tomography. Ann Neurol 1988;24: 399-406   DOI   ScienceOn
10 Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, Orgogozo JM, Brun A, Hofman A, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 1993;43:250-60   DOI
11 Haglund M, Sjobeck M, Englund E. Severe cerebral amyloid angiopathy characterizes an underestimated variant of vascular dementia. Dement Geriatr Cogn Disord 2004;18:132-7   DOI   ScienceOn
12 Jellinger KA, Attems J. Prevalence and impact of cerebrovascular pathology in Alzheimer's disease and parkinsonism. Acta Neurol Scand 2006;114:38-46   DOI   ScienceOn
13 Zanni GR, Wick JY. Differentiating dementias in long-term care patients. Consult Pharm 2007;22:14-6, 18, 21-8   DOI   ScienceOn
14 Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, et al. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am J Psychiatry 1999;156:675-82
15 Guze BH, Baxter LR, Schwartz JM, Szuba MP, Mazziotta JC, Phelps ME. Changes in glucose metabolism in dementia of the Alzheimer type compared with depression: a preliminary report. Psychiatry Res 1991;40:195-202   DOI
16 Whybrow PC 1996 Behavioral and psychiatric aspects of hypothyroidism. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's The thyroid, ed 7. Philadelphia: Lippincott-Raven; 866-9
17 Constant EL, de Volder AG, Ivanoiu A, Bol A, Labar D, Seghers A, Cosnard G, Melin J, Daumerie C. Cerebral blood flow and glucose metabolism in hypothyroidism: a positron emission tomography study. J Clin Endocrinol Metab 2001;86:3864-70   DOI
18 DH Kim, Epidemiology of dementia in Korea. J Korean Med Assoc 2002;45:356-60   DOI
19 Na DL. A clinical approach for patients with dementia. J Korean Med Assoc 2002;45:361-7   DOI
20 Saez-Fonseca JA, Lee L, Walker Z. Long-term outcome of depressive pseudodementia in the elderly. 2006 doi:10.1016/j.jad. 2006.11.004
21 MY Park. Differential diagnosis of vascular dementia and Alzheimer disease. J Korean Med Assoc 2002;45:392-400   DOI
22 Petersen RC, Stevens JC, Ganguli M, Tangalos EG, Cummings JL, DeKosky ST. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001;56:1133-42   DOI   ScienceOn
23 Imamura T, Ishii K, Sasaki M, Kitagaki H, Yamaji S, Hirono N, Shimomura T, Hashimoto M, Tanimukai S, Kazui H, Mori E. Regional cerebral glucose metabolism in dementia with Lewy bodies and Alzheimer's disease: a comparative study using positron emission tomography. Neurosci. Lett. 1997;235:49-52   DOI   ScienceOn
24 Walker Z, Costa DC, Walker RW, Shaw K, Gacinovic S, Stevens T, Livingston G, et al. Differentiation of dementia with Lewy bodies from Alzheimer's disease using a dopaminergic presynaptic ligand. 2002;73:134-40   DOI   ScienceOn
25 Gustafson L. Frontal lobe degeneration of non-Alzheimer type. II. Clinical picture and differential diagnosis. Arch Gerontol Geriatr 1987;6:209-23   DOI   ScienceOn
26 Kennedy AM, Frackowiak RS, Newman SK, Bloomfield PM, Seaward J, Roques P, Lewington G, et al. Deficits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease. Neurosci Lett 1995;186:17-20   DOI   ScienceOn
27 Metter EJ, Mazziotta JC, Itabashi HH, Mankovich NJ, Phelps ME, Kuhl DE. Comparison of glucose metabolism, x-ray CT, and postmortem data in a patient with multiple cerebral infarcts. Neurology 1985;35:1695-701   DOI
28 Mosconi L. Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. Eur J Nucl Med Mol Imaging 2005;32:486-510   DOI
29 Park J, Ko HJ, Park YN, Jung CH. Dementia among the elderly in a, rural Korean community. British J Psychiat 1994;167:796-801
30 Minoshima S, Giordani B, Berent S. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol 1997;42:85-94   DOI   ScienceOn
31 Greenberg SM, Gurol ME, Rosand J, Smith EE. Amyloid angiopathy-related vascular cognitive impairment. Stroke 2004; 35(11 Suppl 1):2616-9   DOI   ScienceOn
32 Gilman S, Low PA,Quinn N, Albanese A, Ben-Shlomo Y, Fowler CJ,Kaufmann H,Klockgether T, Lang AE, Lantos PL, Litvan I,Mathias CJ,Oliver E, Robertson D, Schatz I,Wenning GK. Consensus statement on the diagnosis of multiple system atrophy. J Auton Nerv Syst 1998;74:189-92
33 Rockwood K, Bowler J, Erkinjuntti T, Hachinski V, Wallin A. Subtypes of vascular dementia. Alzheimer Dis Assoc Disord 1999;13(Suppl 3):S59-65   DOI
34 Jellinger KA. Alzheimer disease and cerebrovascular pathology: an update. J Neural Transm 2002;109:813-36   DOI   ScienceOn
35 Mayberg HS. Positron emission tomography imaging in depression: a neural systems perspective. Neuroimaging Clin N Am 2003; 13:805-15   DOI   ScienceOn
36 Litvan I. Cognitive disturbances in progressive supranuclear palsy. J Neural Transm 1994;42:69-78
37 Minoshima S, Foster NL, Sima AA, Frey KA, Albin RL, Kuhl DE. Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Ann Neurol 2001;50:358-65   DOI   ScienceOn
38 Geser F, Wenning GK. The diagnosis of multiple system atrophy. J Neurol 2006;253(Suppl 3):iii2-iii15   DOI
39 Quinn NP. How to diagnose multiple system atrophy. Mov Disord 2005;20(Suppl 12):S5-S10   DOI   ScienceOn
40 Petrella JR, Coleman RE, Doraiswamy PM. Neuroimaging and early diagnosis of Alzheimer's disease: a look to the future. Radiology 2003;226:315-36   DOI   ScienceOn
41 Hodges JR, Warlow CP. The etiology of transient global amnesia: a case-control study of 114 cases with prospective follow-up. Brain 1990;113:639-58   DOI   ScienceOn
42 Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, et al. Current concepts in mild cognitive impairment. Arch Neurol 2001;58:1985-92   DOI   ScienceOn
43 Agdeppa ED, Kepe V, Liu J, Small GW, Huang SC, Petric A, Satyamurthy N, Barrio JR. 2-dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): novel diagnostic and therapeutic tools in Alzheimer's disease. Mol Imaging Biol 2003;5: 404-17   DOI   ScienceOn
44 Vander Borght T, Minoshima S, Giordani B, Foster NL, Frey KA, Berent S, Albin RL, Koeppe RA, Kuhl DE. Cerebral metabolic differences in Parkinson's and Alzheimer's diseases matched for severity. J Nucl Med 1997;38:797-802
45 Looi JC, Sachdev PS. Differentiation of vascular dementia from Alzheimer's disease on neuropsychological tests. Neurology 1999;53:670-8   DOI
46 A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell 1993;72:971-83   DOI   ScienceOn
47 Y Jeong, DL Na. PET studies in Alzheimer disease and other degenerative dementias. Korean J Nucl Med 2003;37:13-23   과학기술학회마을
48 Rapp MA, Schnaider-Beeri M, Grossman HT, Sano M, Perl DP, Purohit DP, Gorman JM, et al. Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression. Arch Gen Psychiatry 2006;63:161-7   DOI   ScienceOn
49 Gilman S, Koeppe RA, Little R, An H, Junck L, Giordani B, Persad C, et al. Differentiation of Alzheimer's disease from dementia with Lewy bodies utilizing positron emission tomography with [18F]fluorodeoxyglucose and neuropsychological testing. Exp Neurol 2005;191(Suppl 1):S95-S103   DOI   ScienceOn
50 American Psychiatric Association. Diagnostic and statistical manual of mental disorders, Forth edition(DSM-IV). Washington, DC : American Psychiatric Association. 1994
51 Fratiglioni L, Launer LJ, Andersen K, Breteler MM, Copeland JR, Dartigues JF, Lobo A, et al. Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 2000;54:S10-S15
52 Rinne JO, Lee MS, Thompson PD, Marsden CD. Corticobasal degeneration. A clinical study of 36 cases. Brain 1994;117:1183-96   DOI   ScienceOn
53 Jorm AF, Korten AE, Henderson AS. The prevalence of dementia: a quantitative integration of the literature. Acta Psychiatr Scand 1987;76:465-79   DOI   ScienceOn
54 Jack CR Jr, Shiung MM, Gunter JL, O'Brien PC, Weigand SD, Knopman DS, Boeve BF, et al. Comparison of different MRI brain atrophy measures with clinical disease progression in AD. Neurology 2004;62:591-600   DOI   ScienceOn
55 Ferreri F, Agbokou C, Gauthier S. Recognition and management of neuropsychiatric complications in Parkinson's disease. CMAJ 2006;175:1545-52   DOI   ScienceOn
56 Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry 2006;63:530-8   DOI   ScienceOn
57 Grossman H, Bergmann C, Parker S. Dementia: a brief review. Mt Sinai J Med. 2006;73:985-92
58 McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44
59 Huang Y. Apolipoprotein E and Alzheimer disease. Neurology 2006;66(Suppl 1):S79-S85   DOI
60 Steele JC, Richardson JC, Olszewski J. Progressive supranuclear palsy. A heterogenous degeneration involving the brain stem, basal gangliaand cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia dementia. Arch Neurol 1964;10:333-59   DOI   ScienceOn
61 Erkinjuntti T, Inzitari D, Pantoni L, Wallin A, Scheltens P, Rockwood K, Roman GC, Chui H, Desmond DW. Research criteria for subcortical vascular dementia in clinical trials. J Neural Transm Suppl 2000;59:23-30
62 Tanzi R, Bertram L. New frontiers in Alzheimer's disease genetics. Neuron 2001;32:181-4   DOI   ScienceOn
63 Mayeux R, Sano M. Treatment of Alzheimer disease. New Engl J Med 2000;341:1670-9   DOI   ScienceOn
64 Coleman RE. Positron emission tomography diagnosis of Alzheimer's disease. Neuroimag Clin N Am 2005;15:837-46   DOI   ScienceOn
65 Katzman R. Education and the prevalence of dementia and Alzheimer's disease. Neurology 1993;43:13-20   DOI
66 Jellinger KA. The enigma of mixed dementia. Alzheimer's and dementia 2007;3:40-53   DOI   ScienceOn
67 Silverman DH. Brain 18F-FDG PET in the diagnosis of neurodegenerative dementias: comparison with perfusion SPECT and with clinical evaluations lacking nuclear imaging. J Nucl Med 2004;45:594-607
68 Herholz K, Salmon E, Perani D, Baron JC, Holthoff V, Frolich L, Schonknecht P , et al. Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage 2002;17:302-16   DOI   ScienceOn
69 Woo JI, Lee JH, Yoo KY, Kim CY, Kim YI, Shin YS. Prevalence estimation of dementia in a rural area of Korea. J Am Geriatr Soc 1998;46:983-7   DOI
70 St George-Hyslop P. Molecular genetics of Alzheimer's disease. Biol Psychiatry 2000;47:183-99   DOI   ScienceOn
71 Kalaria RN. The role of cerebral ischemia in Alzheimer's disease. Neurobiol Aging 2000;21:321-30   DOI   ScienceOn
72 Hirono N, Mori E, Ishii K, Ikejiri Y, Imamura T, Shimomura T, et al. Frontal lobe hypometabolism and depression in Alzheimer's disease. Neurology 1998;50:380-3   DOI   ScienceOn
73 Alzheimer A. Uber eine eigenartige Erkrangkung der Hirnrinde, Allg Zeitschr Psychiatr Psychiatr-Gerichtl Med 1907;146-8
74 Moretti R, Torre P, Antonello RM, Cazzato G, Bava A. Frontotemporal dementia: paroxetine as a possible treatment of behavior symptoms. A randomized, controlled, open 14-month study. Eur Neurol 2003;49:13-9   DOI   ScienceOn
75 Herholz K. PET studies in dementia. Ann Nucl Med 2003; 17:79-89   DOI
76 Knopman DS, DeKosky ST, Cummings JL, Chui H, Corey-Bloom J, Relkin N, Small GW, et al. Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001;56:1143-53   DOI   ScienceOn
77 Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 1997;277(10):813-7
78 Stern Y, Alexander GE, Prohovnik I, Stricks L, Link B, Lennon MC, Mayeux R. Relationship between lifetime occupation and parietal flow: implications for reserve against Alzheimer's disease pathology. Neurology 1995;45:55-60   DOI   ScienceOn
79 Grossman H. Does diabetes protect or provoke Alzheimer's disease? Insights into the pathobiology and future treatment of Alzheimer's disease. CNS Spectr 2003;8:815-23   DOI
80 Knibb JA, Kipps CM, Hodges JR. Frontotemporal dementia. Curr Opin Neurol 2006;19:565-71   DOI   ScienceOn