• 대한간호학회지
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• 제49권3호
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• pp.329-339
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• 2019

Purpose: The purpose of this study was to investigate the frequency, patterns, and factors of reversals in decisions about life-sustaining treatment (LST) among older patients with terminal-stage chronic cardiopulmonary disease. Methods: This was a retrospective correlational descriptive study based on medical chart review. De-identified patient electronic medical record data were collected from 124 deceased older patients with terminal-stage cardiopulmonary disease who had made reversals of LST decisions in an academic tertiary hospital in 2015. Data were extracted about the reversed LST decisions, LST treatments applied before death, and patients' demographic and clinical factors. Multivariate logistic regression analysis was used to identify the factors associated with the reversal to higher intensity of LST treatment. Results: The use of inotropic agents was the most frequently reversed LST treatment, followed by cardiopulmonary resuscitation, intubation, ventilator therapy, and hemodialysis. Inconsistency between the last LST decisions and actual treatments occurred most often in hemodialysis. One-third of the reversals in LST decisions were made toward higher intensity of LST treatment. Patients who had lung diseases (vs. heart diseases); were single, divorced, or bereaved (vs. married); and had an acquaintance as a primary decision maker (vs. the patients themselves) were significantly more likely to reverse the LST decisions to higher intensity of LST treatment. Conclusion: This study demonstrated the complex and turmoil situation of the LST decision-making process among older patients with terminal-stage cardiopulmonary disease and suggests the importance of support for patients and families in their LST decision-making process.

• 한국산학기술학회논문지
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• 제17권6호
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• pp.181-191
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• 2016

이 연구의 목적은 8주간 동일한 운동량(일일 400kcal)으로 강도별 유산소성운동과 복합운동이 인슐린저항성과 심혈관질환 위험요인, 시간적 효율성에 어떠한 영향을 미치는 지를 구명하고자 한다. 2014년6월부터 2014년8월까지 40세 이상의 체지방률 30%이상인 여성 32명을 대상으로 하였으며, 유산소운동집단은 VO2max 50%(MAE, n=8)과 VO2max 80%(VAE, n=8)으로, 복합운동집단은 VO2max 50%+저항성운동(MARE, n=8)과 VO2max 80%+저항성운동(VARE, n=8)으로 각각 무선배정 하였다. 이 연구의 결과에서, 체지방률은 운동 후 모든 집단에서 유의한 감소를 보였으며, 인슐린저항성은 복합운동 두 집단에서 운동 후 유의하게 감소하였다(p<.05 & p<.01). CRP는 운동 후 낮아지는 경향을 보였지만 통계적으로 유의한 차이는 나타나지 않았으며 IL-6 또한 모든 집단에서 낮아지는 경향을 보였으나 VAE집단에서만 유의하게 낮아진 것으로 나타났다(p<.05). TNF-${\alpha}$의 농도의 변화에서는 MAE집단에서는 8주 후, 유의하게 감소되었지만(p<.05), VARE집단에서는 오히려 유의하게 증가되었다(p<.05). 운동시간의 변화에서는 모든 시기에서 낮은 강도의 운동집단보다는 높은 강도의 운동집단에서 유의하게 운동시간이 짧은 것으로 나타났다(p<.001). 이러한 결과는 체지방률은 운동의 강도와 형태에 관계없이 영향을 받는 것으로 나타났으며 CRP는 운동의 강도와 형태에 별다른 영향을 받지 않는 것으로 나타났다. 인슐린저항성과 TNF-${\alpha}$의 농도는 운동의 형태에 따라 어느 정도 영향을 받는 것으로 생각되며 IL-6와 TNF-${\alpha}$, 운동시간은 운동 강도에 영향을 받는 것으로 나타났고 특히 운동시간의 변화에서는 보다 큰 영향을 미치는 것으로 사료된다.

• 융합신호처리학회논문지
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• 제21권1호
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• pp.49-54
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• 2020

심혈관질환은 전 세계 주요 사망 원인으로 다양한 원인에 의해 발생한다. 심혈관질환의 가장 높은 위험인자는 고혈압으로 뚜렷한 증상이 없지만 방치할 경우 여러 합병증을 유발한다. 고혈압을 치료하기 위하여 약물치료와 규칙적 운동을 진행해야한다. 고혈압 환자의 경우 과도한 신체 활동 시 심장에 큰 무리가 발생해 심혈관질환으로 이어질 수 있다. 따라서 적정 강도로 운동을 진행할 수 있는 PTT 계측을 통한 운동 강도 모니터링 시스템이 요구된다. 본 연구에서는 심전도와 맥파 계측을 통해 PTT를 산출하여 운동 강도에 따른 PTT 변화 모니터링 시스템을 구현하였다. 구현된 시스템은 심전도의 R-peak와 맥파의 P-peak를 미분하여 peak간의 시간차를 이용하여 PTT를 산출한다. 운동 강도에 따른 PTT 변화 모니터링을 위하여 달리기 실험을 진행하였다. 실험결과 저강도는 0.313s, 중강도는 0.220s, 고강도는 0.188s의 PTT가 측정되었으며, 운동 강도가 증가함에 따라 PTT는 감소하는 것을 확인하였다.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2020년도 추계국제학술대회
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• pp.61-61
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• 2020

This experiment was carried out using artificial bed soil and LED in the plastic film house(irradiation time: 07:00-17:00/day). Seedlings(n=63 per 3.3 m²) of ginseng was planted on May 17, 2018. LED was combined with red and blue light in a 3:1 ratio and irradiated with different light intensity(40-160 µmol/m²/s). Average air temperature from April to September according to the light intensity test was 20.4℃-20.9℃. Average artificial bed soil temperature was 20.1℃-21.7℃. The test area where fluorescent lamp was irradiated tended to be somewhat lower than the LED irradiation area. The chemical properties of the test soil was as follows. pH levels was 6.6-6.7, EC levels 0.9-1.3 dS/m and OM levels 30.6-32.0%. The available P₂O₅ contents was 73.3-302.3 mg/kg. Exchangeable cations K and Ca contents were higher than the allowable ranges and mg content was high in the fluorescent lamp treatment. The photometric characteristics of LED light intensity are as follows. The greater the light intensity, the higher the PPFD(Photosynthetic Photon Flux Density) value, illuminance and solar irradiation. Fluorescent lamp treatment had high illuminance value, but PPFD and solar irradiation were lower than LED intensity 40 µmol/m²/s treatment. The photosynthetic rate increased(2.0-3.8 µmolCO²/m²/s) as the amount of light intensity increased, peaking at 120 µmol/m²/s, and then decreasing. The SPAD (chlorophyll content) value decreased as the amount of light intensity increased, and was the highest at 36.1 in fluorescent lamp treatment. Ginseng germination started on April 5 and took 14-17 days to germinate. The overall germination rate was 68.8-73.6%. The growth of aerial parts(plant height etc.) were generally excellent in the treatment of light intensity of 120-160 µmol/m²/s. The plant height was 41.9 cm, stem length was 24.1 cm, leaf length was 9.8 cm and stem diameter was 5.6 mm. The growth of underground part (root length etc.) was the best in the treatment with 120 µmol/m²/s of light intensity. Due to the root length was long(24.8 cm) and diameter of taproot was thick(18.7 mm), the fresh root weight was the heaviest at 24.8 g. There were no disease incidence such as Alternaria blight, Gray mold and Anthracnose. Disease of Damping-off caused by Rhizoctonia solani occurred 0.6-1.5% and incidence ratio of rusty root ginseng was 30.8-62.3%. It is believed that the reason for the high incidence of rusty root ginseng is that the amount of field moisture capacity of artificial bed soil is larger than the soil. Leaf discoloration rate was 13.7-32.3%.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1687-1692
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• 2015

Nasopharyngeal carcinoma is an endemic disease within specific regions in the world. Radiotherapy is the main treatment. In recent decades, intensity-modulated radiation therapy has undergone a rapid evolution. Compared with two-dimensional radiotherapy and/or three-dimensional conformal radiotherapy, evidence has shown it may improve quality of life and prognosis for patients with nasopharyngeal carcinoma. In addition, helical tomotherapy is an emerging technology of intensity-modulated radiation therapy. Its superiority in dosimetric and clinical outcomes has been demonstrated when compared to traditional intensity-modulated radiation therapy. However, many challenges need to be overcome for intensity-modulated radiation therapy of nasopharyngeal carcinoma in the future. Issues such as the status of concurrent chemotherapy, updating of target delineation, the role of replanning during IMRT, the causes of the main local failure pattern require settlement. The present study reviews traditional intensity-modulated radiation therapy, helical tomotherapy, and new challenges in the management of nasopharyngeal carcinoma.

• 대한방사선기술학회지:방사선기술과학
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• 제23권1호
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• pp.39-47
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• 2000

In this study, we showed a comparison and analysis making use of DWI(diffusion weighted image) using early diagnosis of cerebral Infarction and with the classified T2 weighted image, FLAIR images signal intensity for brain infarction period. period of cerebral infarction after the condition of a disease by ischemic stroke. To compare 3 types of image, we performed polynomial warping and affined transform for image matching. Using proposed algorithm, calculated signal intensity difference between T2WI, DWI, FLAIR and DWI. The quantification values between hand made and calculated data are almost the same. We quantified the each period and performed pseudo color mapping by comparing signal intensity each other according to previously obtained hand made data, and compared the result of this paper according to obtained quantified data to that of doctors decision. The examined mean and standard deviation for each brain infarction stage are as follows ; the means and standard deviations of signal intensity difference between DWI and T2WI for each period are $197.7{\pm}6.9$ in hyperacute, $110.2{\pm}5.4$ in acute, and $67.8{\pm}7.2$ in subacute. And the means and standard deviations of signal intensity difference between DWI and FLAIR for each period are $199.8{\pm}7.5$ in hyperacute, $115.3{\pm}8.0$ in acute, and $70.9{\pm}5.8$ in subacute. We can quantificate and decide cerebral infarction period objectively. According to this study, DWI is very exact for early diagnosis. We classified the period of infarction occurrence to analyze the region of disease and normal region in DW, T2WI, FLAIR images.

• 대한임상검사과학회지
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• 제50권2호
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• pp.144-154
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• 2018

본 연구의 목적은 2014년 조사되어진 제 6기 2차 국민건강영양조사 자료를 바탕으로 연령별 신체활동에 따른 대사성질환과의 관계를 파악하여 연령별 신체활동에 따른 대사성질환과의 관련성을 규명하여 예방적 기초자료를 제공하기 위한 연구이다. 본 연구는 제 6기 2차(2014) 국민건강영양조사의 자료를 이용하여 수행되었다. 정상군의 382명과 대사질환군의 1,525명을 총 9,701명의 설문 응답자 중 관련 자료가 없는 2,506명을 제외하고 총 7,295명을 분석했다. 본 연구에서 신체활동은 국제신체활동 설문지 (IPAQ)를 기반으로 재분류 되었다. 대사증후군의 정의는 2004년 개정 된 NCEP-ATP III에 근거하여 다음과 같은 결론을 얻었다. 연령에 따른 대사성질환과 신체활동과의 관계에서 10~29세 정상군과 50~69세의 대사질환군에서 혈색소, 적혈구용적, 크리아티닌의 수치는 고강도 신체활동이 수행되었을 때 증가했고 저강도 신체활동을 수행되었을 때 감소했다. 30~49세의 정상군과 대사질환군에서 고밀도 지단백 콜레스테롤 수치는 고강도 신체활동이 수행되었을 때 증가했지만, 저강도 신체활동이 수행되었을 때 감소하였다. 따라서 연령과 운동강도가 고밀도 지단백 콜레스테롤 수치에 미치는 영향을 조사하였다. 결과는 정상군에서 연령과 운동강도에 따라 고밀도 지단백 콜레스테롤 수치에 차이는 없었지만 대사질환군에서는 연령에 따라 고밀도 지단백 콜레스테롤 수치가 감소하였고 운동강도에 따라 증가하였다. 종합하면, 본 연구의 결과는 대사질환군에서 고밀도 지단백 콜레스테롤 수치는 고강도 신체활동에서 긍정적인 효과를 나타내고 연령은 부정적인 효과를 나타냈다. 이러한 결과는 우리가 신체활동과 연령에 따라 대사성질환을 더 잘 이해하는데 도움이 될 수 있다.

• Fisheries and Aquatic Sciences
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• 제26권3호
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• pp.234-240
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• 2023

Enteromyxum leei has been identified as the causative agent of emaciation disease in a wide range of marine fish hosts. In this study, we aimed to determine the effect of the parasitic infection of Enteromyxum species on starry flounder that were cultured in aquaculture farms of Jeju island in Korea. As the mortality of cultured olive flounder Paralichthys olivaceus because of E. leei infection increased, some fish farms on Jeju island attempted to culture the starry flounder Platichthys stellatus, as an alternative. Myxosporeans with a developmental stage similar to E. leei were found in the intestines of cultured starry flounders. The partial 18S rDNA of myxosporeans showed 100% similarity with E. leei. To reveal the effect of E. leei infection on starry flounder, the intensity of E. leei infection measured using quantitative polymerase chain reaction, and the condition factor (CF) of fish were measured and analyzed statistically. The results showed that high-intensity E. leei infection significantly decreased the CF of the starry flounder. However, the pathogenicity of E. leei to starry flounder is low, considering its mortality and clinical signs.

• The Journal of Korean Physical Therapy
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• 제14권3호
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• pp.323-333
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• 2002

Number of elderly, above 65 years old are 3,384,576 in korea on AD2000. Half of them will be have an experiencing in fall and decreasing of balance performance from musculoskeletal problems. Muscle strengthening exercise, empty hand gymnastics, gait training, rhythmic gymnastics are improved increasing of balance performance and prevent fall. Regular exercise program will make improve the balance performance and prevent fall. The exercise program have to perform continually that intensity and frequency will be once in day or 3-4 times in a week. Intensity and frequency of the exercise program start with low intensity and low frequency and gradually increasing of the intensity and frequency.

• Journal of Korean Neurosurgical Society
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• 제57권6호
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• pp.432-435
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• 2015

Moyamoya disease is a unique cerebrovascular disorder characterized by idiopathic progressive stenosis at the terminal portion of the internal carotid artery (ICA) and fine vascular network. The aim of this review is to present the clinical application of quantitative digital subtraction angiography (QDSA) in pediatric moyamoya disease. Using conventional angiographic data and postprocessing software, QDSA provides time-contrast intensity curves and then displays the peak time ($T_{max}$) and area under the curve (AUC). These parameters of QDSA can be used as surrogate markers for the hemodynamic evaluation of disease severity and quantification of postoperative neovascularization in moyamoya disease.