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http://dx.doi.org/10.5762/KAIS.2016.17.6.181

Effect of Exercise Type and Intensity on Insulin Resistance and Cardiovascular Disease Risk Factors in Obese Middle Aged Women  

Lee, Dae-Hee (Dept. of Kinesiology & Medical Science, Graduate School, Dankook University)
Oh, Du-Hwan (Dept. of Kinesiology & Medical Science, Graduate School, Dankook University)
Zhang, Seok-Am (Dept. of Kinesiology & Medical Science, Graduate School, Dankook University)
Lee, Jang-Kyu (Dept. of Kinesiology & Medical Science, Graduate School, Dankook University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.17, no.6, 2016 , pp. 181-191 More about this Journal
Abstract
This study examined the effects of exercise intensity and type on insulin resistance, cardiovascular disease risk factors, and exercise time. Obese thirty-two subjects (>body fat 30%) were randomly assigned one of four experimental groups: VO2 max 50% aerobic exercise group (MAE, n=8), VO2 max 80% aerobic exercise group (VAE, n=8), VO2 max 50% + resistance exercise group (MARE, n=8), and VO2 max 80% + resistance exercise group (VARE, n=8). Body fat significantly decreased in all groups and insulin resistance decreased significantly in MARE and VARE (p<.05 & p<.01) after exercise. CRP and IL-6 were slightly reduced after exercise, although these did not reach statistical significance, whereas the IL-6 level of the VAE group decreased significantly (p<.05). TNF-${\alpha}$ significantly decreased in the MAE group (p<.05) but significantly increased in the VARE group after exercise (p<.05). For exercise time, higher intensity exercise groups were significantly less than the lower intensity exercise groups (p<.001). These results suggest that body fat is affected by all kinds of exercise intensity and type while CRP is not. Insulin resistance and TNF-${\alpha}$ were affected by exercise type, whereas IL-6, TNF-${\alpha}$, and exercise time were affected by exercise intensity.
Keywords
Cardiovascular disease risk factor; Exercise intensity; Exercise type; Insulin resistance;
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1 Statistics Korea, 2014 Social Survey in Busan, 2015.
2 Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, & Friedman, J. M, "Positional cloning of the mouse obese gene and its human homologue. Nature", Erratum in: Nature, 1, 372(6505), pp. 425-32, 1994.   DOI
3 Rokling-Andersen M. H, Reseland J. E, Veierod M. B, Anderssen S. A, Jacobs D. R, Jr, Urdal. P, Jansson J. O, & Drevon C. A, "Effects of long-term exercise and diet intervention on plasma adipokine concentrations," American Joural of Clinical Nutrition, 86(5), pp. 1293-301, 2007.   DOI
4 Fain JN. Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review. Mediators Inflamm. 2010; 2010:513948. Epub 2010 May 23. Review. DOI: http://dx.doi.org/10.1155/2010/513948   DOI
5 Caprio S1. Definitions and pathophysiology of the metabolic syndrome in obese children and adolescents. Int J Obes (Lond). Suppl 2, pp. 24-5, 2005.
6 Frank LL, Sorensen BE, Yasui Y, Tworoger SS, Schwartz RS, Ulrich CM, Irwin ML, Rudolph RE, Rajan KB, Stanczyk F, Bowen D, Weigle DS, Potter JD, McTiernan A. "Effects of exercise on metabolic risk variables in overweight postmenopausal women". a randomized clinical trial. Obes Res, 13(3), pp. 615-25, 2005. DOI: http://dx.doi.org/10.1038/oby.2005.66   DOI
7 Pacifico L, Anania C, Martino F, Poggiogalle E, Chiarelli F, Arca M, Chiesa C. "Management of metabolic syndrome in children and adolescents". Nutr Metab Cardiovasc Dis, 21(6), pp. 455-66, 2011. DOI: http://dx.doi.org/10.1016/j.numecd.2011.01.011   DOI
8 Goedecke JH1, Micklesfield LK. "The effect of exercise on obesity, body fat distribution and risk for type 2 diabetes". Med Sport Sci. 60, pp. 82-93, 2014. DOI: http://dx.doi.org/10.1159/000357338   DOI
9 Hawley JA. "Adaptations of skeletal muscle to prolonged, intense endurance training". Clin Exp Pharmacol Physiol, 29(3), pp. 218-222, 2002. DOI: http://dx.doi.org/10.1046/j.1440-1681.2002.03623.x   DOI
10 Fitts RH, Booth FW, Winder WW, Hollosay JO. "Effect of exercise on response of liver lipogenic enzymes to a high fructose diet". Proc Soc Exp Biol Med 148(4), pp. 1150-1154, 1975. DOI: http://dx.doi.org/10.3181/00379727-148-38706   DOI
11 Hawley, JA. "Specificity of training adaptation: time for a rethink?". Journal of Physiology, pp. 586:1-2, 2008. DOI: http://dx.doi.org/10.1113/jphysiol.2007.147397   DOI
12 Trost SG, Owen N, Bauman AE, Sallis JF and Brown W, "Correlates of adults' participation in physical activity: review and update," Med Sci Sports Exerc, 34, pp. 1996-2001, 2002. DOI: http://dx.doi.org/10.1097/00005768-200212000-00020   DOI
13 Marcus BH, King TK, Clark MM, Pinto BM, Bock BC. "Theories and techniques for promoting physical activity behaviours". Sports Med 22(5), pp.321-331, 1996. DOI: http://dx.doi.org/10.2165/00007256-199622050-00005   DOI
14 ACSM, "Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults," Medicine & Science in Sports & Exercise, 41(2), pp. 459-471, 2009. DOI: http://dx.doi.org/10.1249/MSS.0b013e3181949333   DOI
15 Rintala P, Dunn J. M, & McCubbin J. A, "Validity of a cardiorespiratory fitness test for men with mental retardation," Medicine and Science in sports and Exercise, 24, pp. 941-945, 1992. DOI: http://dx.doi.org/10.1249/00005768-199208000-00017   DOI
16 Siri W. E, "Body composition from fluid spaces and densities : analysis of methods. In Brozek, J., Henschel, A.(eds): Techniques for Measuring Body. Composition," Washington DC, National Academy of Sciences, pp. 223-244, 1961.
17 Jackson A. S, Pollock M. L, & Waed A, "Generalized equations for predicting body density of women," Medicine and Science in Sports and Exercise, 12(3), pp. 175-181, 1980. DOI: http://dx.doi.org/10.1249/00005768-198023000-00009
18 Matthews D. R, Hosker J. P, Rudenski A. S, Naylor B. A, Treacher D. F, & Turner R. C,. "Homeostasis model assessment: nsulin resistance and beta-cell function from fastiog plasma glucose and insulin concentrations in man," Diabetologia, 28(7), pp. 412-419, 1985. DOI: http://dx.doi.org/10.1007/BF00280883   DOI
19 Venables M. C, & Jeukendrup A. E, "Physical inactivity and obesity: links with insulin resistance and type 2 diabetes mellitus. Diabetes," Metabolism Research and Reviews, 25(Suppl 1), pp. S18-S23, 2009. DOI: http://dx.doi.org/10.1002/dmrr.983   DOI
20 Chang-Soo Han, Gyu-Seung Lee, Moo-sik Lee, & Hye-Jeong Hwang "The Effect of Changing the Order of Exercise Types on Body Composition and Blood Lipid in Obese Women". Korea Academia- Industrial cooperation Society, 10(12), pp. 3888-3894, 2009.   DOI
21 Kondo T, Kobayashi I., & Murakami M, "Effect of exercise on circulating adipokine levels in obese young women," Endocr. J., 53(2), pp. 189-195, 2006. DOI: http://dx.doi.org/10.1507/endocrj.53.189   DOI
22 Snowling N. L, & Hopkins W. G, "Effects of different models of exercise training on gulcose control and risk factor for complications in type 2 diabetic patients: a meta analysis," Diabetes Care, 29, pp. 2518-2527, 2006. DOI: http://dx.doi.org/10.2337/dc06-1317   DOI
23 Dohm G. L, "Invited review: Regulation of skeletal muscle GLUT-4 expression by exercise," Journal of Applied physiology, 93(2), pp. 782-787, 2002. DOI: http://dx.doi.org/10.1152/japplphysiol.01266.2001   DOI
24 Friedenreich C, M, Neilson H. K, Woolcott C. G, McTieman A, Wang Q, Ballard-Barbash R, et al. "Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women," Endocr Relat Cancer., 18(3), pp. 357-369, 2011. DOI: http://dx.doi.org/10.1530/ERC-10-0303   DOI
25 Holten M. K, Zacho M, Gaster M, Juel C, Wojtaszewski J. F, & Dela F. "Strength training increased insulin mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes," Diabetes, 53, pp. 294-305, 2004. DOI: http://dx.doi.org/10.2337/diabetes.53.2.294   DOI
26 Davidson L. E, Hudson R, Kilpatrick K, Kuk J. L, McMillan K, Janiszewski P. M, Lee S, Lam M, & Ross R. "Effects of exercise modality on insulin resistance and functional limitation in older adults: a randomized controlled trial," Archives of Internal Medicine, 169(2), pp. 122-131, 2009. DOI: http://dx.doi.org/10.1001/archinternmed.2008.558   DOI
27 Kelly D. E, & Goodpaster B. H, "Effects of physical activity on insulin action and olucose tolerance in obesity," Medicine and Science in Sport and Exercise, 31, pp. 619-623, 1999. DOI: http://dx.doi.org/10.1097/00005768-199911001-00021   DOI
28 Wannamethee S. G, Lowe G. D, Whincup P. H, Rurnley A, Walker M, & Lennon L. "Physical actibity and hemostatic and inflammatory variables in elderly men," Circulation, 105(15), pp. 1785-1790, 2002. DOI: http://dx.doi.org/10.1161/hc1502.107117   DOI
29 Gonzalez, A. S, Guerrero D. B, Soto M. B., Diaz S. .P, Martinez-Olmos M, & Vidal O. "Metabolic syndrome, insulin resistance and the inflammation makers C-reactive protein and ferritin," European journal of Clinical Nutrition, 60(6), pp. 802-809, 2006. DOI: http://dx.doi.org/10.1038/sj.ejcn.1602384   DOI
30 Festa A, D'Agostino, R, Howard G, Mykkanen L, Tracy R. P, & Harrner S. M, "Chronic subclinical inflammation as part of the insulin resistance syndrome: The insulin resistance atherosclerosis study(IRAS)," Circulation, 102, pp. 42-47, 2000. DOI: http://dx.doi.org/10.1161/01.CIR.102.1.42   DOI
31 Albert M. A, Glynn R. J, & Ridker P. M, "Effect of physical activity on serum C-reactive protein," Am, J. Cardiol., 93, pp. 221-225, 2004. DOI: http://dx.doi.org/10.1016/j.amjcard.2003.09.046   DOI
32 Marfella R, Esposito K, Siniscalchi M, Cacciapuoti F, Giugliano F, Labriola D, Ciotola M, Di Palo C, Misso L, & Giugliano D. "Effect of weight loss on cardiac synchronization and proinflammatory cytokines in premenopausal obese women," Diabetes Care, 27(1), pp. 47-52, 2004. DOI: http://dx.doi.org/10.2337/diacare.27.1.47   DOI
33 Geffken D. F, Cushman M, Burke G. L, Polak J. F, Sakkinen P. A, & Tracy R. P, "Association between Physical Activity and Markers of Inflammation In a Healthy Elderly Population," American Journal of epidemiology, 153, pp. 242-250, 2001. DOI: http://dx.doi.org/10.1093/aje/153.3.242   DOI
34 Nieman D. C, "Current perspective on exercise immunology," Current Sports Medicine Reports, 2(5), pp. 239-242, 2003. DOI: http://dx.doi.org/10.1249/00149619-200310000-00001   DOI
35 Aidhahi W, & Hamdy O, "Adipokines, inflammation and the endothelium in diabetes," Current Diabetes Reports, 3(4), pp. 293-298, 2003. DOI: http://dx.doi.org/10.1007/s11892-003-0020-2   DOI
36 Tall A. R, "C-reactive protein reassessed," New. Engl. J. Med., 350(14), pp.1450-1452, 2004. DOI: http://dx.doi.org/10.1056/NEJMe048020   DOI
37 de Salles B. F, Simao R, Fleck S. J, Dias I, Kraemer-Aguiar L. G, & Bouskela E. "Effects of resistance training on cytokines," Int. J. Sports. Med. 31(7), pp. 441-450, 2010. DOI: http://dx.doi.org/10.1055/s-0030-1251994   DOI
38 Nicklas B. J, Ambrosius W, Messier S. P, Miller G. D, Penninx B. W, Loeser J. H, Palla R. F, Bleecker E, & Pahor M. "Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial," Am. J. Clin. Nut, 79, pp.544-551, 2004.   DOI
39 Ryan A. S, & Nicklas B. J, "Reductions in plasma cytokine lecels with weight loss improve insulin sensitivity in overweight and obese postmenopausal women," Diabetes Care, 27(7), pp. 1699-1705, 2004. DOI: http://dx.doi.org/10.2337/diacare.27.7.1699   DOI
40 Smith L. L, Mckune A. J, Semple S. J, Sibanda E, Steel H, & Anderson R. "Changes in serum cytokine safer repeated outs of down hill running," Appl. Physiol. Nutr. Metab, 32(2), pp.233-240, 2007. DOI: http://dx.doi.org/10.1139/h06-106   DOI
41 Ostrowski K, Rohde T, Asp S, Schjerling P, & Pedersin B. K, "Pro-and anti- inflammatory cytokine balance in strenuous exercise in humans," J. Physiol(Lond), 515, pp. 287-291, 1999. DOI: http://dx.doi.org/10.1111/j.1469-7793.1999.287ad.x   DOI
42 Trayhum P, & Wood I. S, "Signaling role of adipose tissue: adipokines and inflammation in obesity," Biochem. Soc. Trans, 33, pp. 1078-1081, 2005. DOI: http://dx.doi.org/10.1042/BST20051078   DOI
43 Kohut M. L, McCann D. A, Russell D. W, Konopka D. N, Ounnick J. E, Franke W. D, Castillo M, C, Reighaed A. E, & Vanderah E, "Aerobic exercise, but not flexibility/resistanceexercise, reduces serum IL-1, CRP and IL-6 independent of beta-blockers, BMI and psychological factors in older adults," Brain Below. Immun., 24, pp. 252-265, 2006.
44 Matsuzawa T, Funahashi T, & Nakamura T, "Molecular mechanism of metabolic syndrome X: contribution of adipocyrokines adipocytederived bioactive substances," Ann. NY. Acad. Sci, 892, pp. 146-154, 1999. DOI: http://dx.doi.org/10.1111/j.1749-6632.1999.tb07793.x   DOI
45 Roth S. M, Metter E. J, Ling S, & Ferrucci L. "Inflammatory factors in age-related muscle wasting. Eurr," Opin. Rheumatol., 18, pp.625-630, 2006. DOI: http://dx.doi.org/10.1097/01.bor.0000245722.10136.6d   DOI
46 Olsznaecka-Glinianowicz M, Zahorska-Markiewicz B, & Janowska J. "The effect of weight loss on serum concentrations of nitric oxide, TNF-${\alpha}$ and soluble TNF-${\alpha}$ receptors," Endokrynologia Polska, 57(5), pp. 487-493, 2006.
47 Laimer M, Ebenbichler C. F, Kaser S, Sandhofer A, Weiss H, Nehoda H, et al. "Markers of chronic inflammation and obesity:a prospective study on the reversibility of this association in middle-aged women undergoing weight loss by surgical intervention," Int J Obes Relat Metab Disord, 26(5) pp. 659-662, 2002. DOI: http://dx.doi.org/10.1038/sj.ijo.0801970   DOI
48 Ferguson M. A, White L. J, McCoy S, Kim H. W, Petty T, & Wilsey J. "Plasma adiponectin response to acute exercise in healthy subjects," Eur. J. Appl. Physiol, 91(2-3), pp. 324-329, 2004. DOI: http://dx.doi.org/10.1007/s00421-003-0985-1   DOI
49 Dvorakova-Lorenzova A, Suchanek P, Havel P. J, Stavek P, Karasova L, Valenta Z, Tintera J, & Poledne R, "The decrease in C-reactive protein concentration after diet and physical activity induced weight reduction is associated with changes in plasma lipids, but not interleukin-6 or adiponectin," Metabolism, 55(3), pp. 359-365, 2006. DOI: http://dx.doi.org/10.1016/j.metabol.2005.09.010   DOI
50 Straczkowski M, Kowalska I, Dzienis-Straczkowska S, Stepien A, Skibinska E, Szelachowska M, et al. "Changes in tumor necrosis factor-alpha system and insulin sensitivity during an exercise training program in obese women with normal and impaired glucose tolerance," Eur J Endocrinol, 145(3) pp. 273-280, 2001. DOI: http://dx.doi.org/10.1530/eje.0.1450273   DOI