• 대한의생명과학회지
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• 제27권4호
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• pp.208-215
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• 2021

The purpose of this study was to explain the pathology of Alzheimer's disease (AD) and to investigate the correlation between AD and microRNA. AD is the most common type of dementia, accounting for about 80% of all types of dementia, causing dysfunction in various daily activities such as memory loss, cognitive impairment, and behavioral impairment. The typical pathology of AD is explained by the accumulation of beta-amyloid peptide plaques and neurofibrillary tangles containing hyperphosphorylated tau protein. On the other hand, microRNA is small non-coding RNA 22~23 nucleotides in length that binds to the 3' untranslated region of messenger RNA to inhibit gene expression. Many reports explain that microRNAs found in circulating biofluids are abundant in the central nervous system, are involved in the pathogenic mechanism of AD, and act as important factors for early diagnosis and therapeutic agents of AD. Therefore, this paper aims to clarify the correlation between AD and microRNA. In this review, the basic mechanism of miRNAs is described, and the regulation of miRNAs in the pathological processes of AD are highlighted. Furthermore, we suggest that miRNA-based system in development of therapeutic and diagnostic agents of AD can be a promising tool.

• 한국임상수의학회지
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• 제19권2호
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• pp.219-224
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• 2002

Fifty six dogs diagnosed with intervertebral disk disease between January 1999 and August 2001 were reviewed to characterize signalments and prognosis. Seventy-five percent was chondrodystrophoid breeds (42 dogs). Mean age was 5.1$\pm$3.0 year-old and fifty-four percent had acute onset. Interspaces between eleventh thoracic vertebrae and fourth lumbar vertebrae were affected most commonly. Success rate of conservative treatment to dogs with paresis was 83% and that of operation to dogs with paralysis was 67%. Six dogs were recurred and 50% of them had recovered again. There was significant correlation between success rate of treatment and the degree of clinical signs but there was no significant correlation between success rate of treatment and rate of onset, status of clinical signs, duration of clinical signs.

• 한국임상수의학회지
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• 제38권1호
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• pp.16-20
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• 2021

Recently, a new method of evaluating left atrial size called vertebral left atrial size (VLAS) was introduced in dogs. Total 155 dogs were examined at the Veterinary Medical Teaching Hospital of Chungnam National University. In this study, myxomatous mitral valve disease (MMVD) stage and VLAS showed a significant correlation in those dogs. Also, the relationship between C-reactive protein (CRP) and VLAS has yet to be examined. We found a strong positive correlation between VLAS and CRP-a significant increase in CRP was observed with increasing VLAS values. Thus, it would be beneficial to measure VLAS besides employing the current radiological and echocardiographic methods when evaluating heart size. Measuring VLAS could be an additional diagnostic tool for diagnosing MMVD in dogs.

• 한국치위생학회지
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• 제17권3호
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• pp.431-440
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• 2017

Objectives: The study was conducted to evaluate the effects of the students majoring in dental hygiene on their oral health beliefs and oral health behavior. Methods: The survey was conducted using selfadministered questionnaires targeting 619 female students majoring in dental hygiene at three Universities in k and J province. The stronger health oral belief means higher score in susceptibility, severity, benefit and salience, but the higher score in barrier means stronger recognition in obstacle. Results: There was significant correlation between susceptibility and experience of not-treated oral disease (OR [odds ratio] 2.40; 95% CI [confidence interval] 1.73-3.34)' and 'dental caries (OR 2.36; 95% CI 1.25-4.45)'. Benefit had significant correlation with 'visiting dental clinic (OR 1.58; 95% CI 1.14-2.19)'. Salience had significant correlation with 'experience of not-treated oral disease (OR 0.70; 95% CI 0.52-0.94)'. Barrier had significant correlation with 'visiting dental clinic (OR 0.73; 95% CI 0.56-0.95)' and 'removing oral plaque (OR 0.71; 95% CI 0.52-0.95)'. There was no significant correlation between oral health belief and 'using of oral hygiene device' or 'regular tooth brushing'. Conclusions: Diverse oral health behaviors were affected by susceptibility, benefit, salience and barrier in oral health belief. The programs for oral health education and preventing oral disease should be prepared to change oral health belief to promote the oral health systematically based on the results of this study.

• 대한간호학회지
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• 제34권5호
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• pp.702-711
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• 2004

Purpose: The purpose of this study was to identify the relationship among perceived stress, ways of coping, and health promoting behaviors in patients with chronic cardiovascular disease(CCVD). Method: Data was collected by questionnaires from 436 patients with CCVD in a General Hospital in Seoul. The data was analyzed using descriptive statistics, Pearson correlation coefficients, and stepwise multiple regression. Result: The health promoting behavior showed a significant positive correlation with self-efficacy and social support. Also, the health promoting behavior showed a significant negative correlation with perceived stress and symptoms of stress. The stepwise multiple regression analysis revealed that the most powerful predictor of health promoting behaviors was symptoms of stress. Conclusion: A combination of symptoms of stress, social support, self-efficacy, and perceived stress account for 41% of the variance in health promoting behaviors of patients with CCVD. Data from this study suggest that symptoms of stress, social support, ways of coping, and perceived stress are significant influencing factors on health promoting behaviors of patients with CCVD.

• 한국응급구조학회지
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• 제26권2호
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• pp.47-59
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• 2022

Purpose: This study aimed to survey coronavirus disease (COVID-19) related knowledge, preventive possibility, and preventive behaviors levels among college students and identify the correlation between these variables. Methods: An online survey was conducted among college students from October 25 to November 5, 2021. The data were analyzed by an independent t-test and Pearson's correlations. Results: A total of 344 college students participated. The correct answer rate for COVID-19 knowledge level was high, infection and preventive possibility levels were moderate, and the anxiety level was high. Infection possibility had a positive correlation with anxiety and preventive behaviors had a positive correlation with preventive possibility. Conclusion: The findings regarding COVID-19 perception can be used to develop appropriate health policies for infectious disease prevention behaviors in educational fields.

• 한국치위생학회지
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• 제16권6호
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• pp.1093-1104
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• 2016

Objectives: The purpose of this study was to examine the impact of chronic disease on oral health behavior. Methods: The subjects were 317 adults over 30-years old living in urban and rural areas. They were selected by convenience sampling method and filled out the self-reported questionnaire. The questionnaire consisted of general characteristics, dental treatment, chronic disease, and oral health behavior including oral health self-care behavior and professional oral health care. Results: The self-care oral health behavior and the professional oral health care had a negative correlation with the chronic diseases. Especially, the self-care oral health behavior and the professional oral health care had a statistically significant negative correlation with hypertension and osteoporosis. Multiple regression analysis was performed after including general characteristics, dental treatment, chronic disease. Meanwhile the presence of chronic disease had a significant influence on the self-care oral health behavior and the professional oral health care. Hypertension and Osteoporosis were the most influential factors of chronic diseases and had a significant influence on the oral health behavior. In conclusion, the chronic diseases aggravated the oral health behavior practice. Conclusions: presence of chronic disease affects oral health behavior. Therefore, the effective intervention and education programs related to oral health care are necessary to enhance adult's oral health behavior and total health. The continuous follow-up study will determine the causal relationship between oral health behavior and the presence of chronic disease.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제12권2호
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• pp.171-176
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• 2009

목 적: 최근 우리나라 소아에서 염증장병이 꾸준히 증가추세에 있으나 이들의 혈액학적 특징에 대해서는 알려진 바가 없다. 국내 염증장병 환아들의 장기간 관리에 도움이 되고자 혈액학적 소견을 분석하여 보았다. 방 법: 가천의대 길병원 소아청소년과에서 2002년 9월부터 2008년 9월 사이에 대장경과 생검으로 확진된 염증장병 환자 중 18세 이하인 25명의 염증장병 환아를 대상으로 하였다. 진단 당시의 혈색소, 적혈구용적률, 백혈구 수, 혈소판 수, 평균적혈구용적, 평균적혈구 혈색소량을 조사했다. 환아의 빈혈 빈도, 혈색소와 질병 이환기간과의 관계, 혈색소와 활동도지수와의 관계에 대하여 알아보았다. 결 과: 빈혈은 전체적으로 76% (19/25)에서 있었으며, 크론병 환아에서는 88% (14/16), 궤양결장염 환아에서는 56% (5/9)였다. 백혈구증가와 혈소판증가는 크론병 환아에서만 있었으며 빈도는 각각 56% (9/16), 25% (4/16)였다. 증상의 이환기간과 혈색소치는 크론병과 궤양결장염 모두에서 통계적인 유의성이 없었다. 활동도지수와 혈색소치도 크론병과 궤양결장염 모두에서 통계적인 유의성이 없었다. 결 론: 본 연구에서 염증장병 환아의 혈액학적 소견은 외국 문헌의 보고 내용과 큰 차이는 없었으나 빈혈의 빈도가 높았으며 질병의 이환기간 또는 활동도지수와 빈혈은 상관관계가 없었다. 이러한 사실은 염증장병환아를 장기간 관리하는 동안 빈혈에 대한 관리 역시 포함해야 하는 것을 시사하였다. 백혈구증가와 혈소판증가는 크론병에서만 관찰되어 궤양성장염과 감별진단하는데 도움이 될 수 있음을 제시하였다.

• 산업융합연구
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• 제16권4호
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• pp.1-8
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• 2018

본 연구는 일지역 중년기 성인의 심뇌혈관질환에 대한 지식, 예방에 대한 태도 및 자기효능감을 파악하고 그 관계를 확인하여 중년기 성인의 심뇌혈관질환 예방을 위한 건강증진 프로그램의 중재 전략에 필요한 기초 자료를 제공하기 위하여 시도되었다. 연구대상자는 S시에 거주하는 40대, 50대의 중년기 성인 198명을 대상으로 설문지를 이용해 조사하였다. 자료 분석은 기술통계와 t-test, ANOVA, Pearson's correlation coefficient로 분석하였다. 연구결과 대상자의 나이, 교육정도, 월수입에 따라 지식에 유의한 차이가 있었으며, 교육정도와 월수입에 따라 태도에 차이가 있는 것으로 나타났다. 또한 성별에 따라 자기효능감이 유의한 차이가 있는 것으로 나타났다. 상관관계 분석에서 심뇌혈관질환에 대한 지식과 예방에 대한 태도는 유의한 상관관계가 있는 것으로 나타났다(t=.45, p<.001). 즉 심뇌혈관질환에 대한 지식수준이 높을수록 질환의 예방에 대해 긍정적인 태도를 갖는다고 할 수 있다. 따라서 심뇌혈관질환의 예방에 대한 긍정적인 태도를 형성할 수 있는 교육 및 중재프로그램의 개발과, 중년기 남성의 자기효능감을 높일 수 있는 동기강화 프로그램이 개발이 필요하다.

• 대한의생명과학회지
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• 제15권2호
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• pp.135-139
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• 2009

The CA(carbohydrate antigen)19-9 is complex protein that can be used as an important marker which aids the clinical diagnosis and prognosis of various pancreaticobiliary tumors. However, it was also reported that there were some CA19-9 positive patients with benign disease as using RIA method. The purpose of this study is to evaluate the clinical usefulness of serum level of CA19-9 with RIA(radioimmuno assay), CIA(chemiluminescence immuno assay), and conventional liver function tests. The correlation between CIA and RIA in CA19-9 of pancreatobiliary disease was 0.9833(P<0.01). Also, the correlations between CIA and RIA in CA19-9 of benign and malignant pancreaticobiliary tumor patients was 0.8714(P<0.01) and 0.9727(P<0.01) respectively. The correlation between CA19-9 and ALP was 0.5140(P<0.01) and CEA was 0.3385(P<0.05) as using CIA. The measurement of serum CA19-9 levels by CIA method may be useful in differentiating patients with malignant disease from those with benign disease in pancreaticobiliary tumors.