• 대한후두음성언어의학회지
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• 제12권1호
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• pp.46-54
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• 2001

Background and Objectives : Nitric oxide(NO) is a short-lived molecule with messenger and cytotoxic functions in nervous, cardiovascular, and immune systems. Among the three distinct NOS isoforms, the neuronal isoform is expressed in small, discrete neuronal populations of CNS and PNS. Axonal injury in adult animals results in a dramatic NOS up-regulation in many types of central and peripheral neurons which normally lack the enzyme or express it only at very low levels. In previous study, we confirmed the efficacy of PEMS on the early functional recovery in rats with surgically transected and reanastomosed recurrent laryngeal nerve. Therefore, after we obtained functionally recovered rats using PEMS in this study, we studied to evaluate the expression of nNOS through the analysis of the difference between functional recovery group and non-recovery group in the recurrent laryngeal nerve. Materials and Method : Using 84 healthy male Sprague-Dawley rats, transections and primary anastomosis were performed on their left recurrent laryngeal nerves. Rats were then randomly assigned to 2 groups. The rats in group A(n=42) received PEMS by placing them in custom cages equipped with Helm-holz coils(3 hr/day, 5 days/wk, for 12 wk). The rats in group B(n=42) were handled the same way as the group A, except that they did not receive PEMS. Laryngovideoendoscopy was performed before and after surgery and followed up weekly. Laryngeal EMG was obtained in both PCA and TA muscles. Immunohistochemisty staining using monoclonal anti-neuronal nitric oxide synthase(nNOS) antibody was performed to detect nNOS in recurrent laryngeal nerve and nodose ganglion. Results : 20 rats(63%) in group A and 5 rats(17%) in the group B showed recovery of vocal fo1d motion. The number of NOS-positive cells was increased in functionally-recovered rats. NOS-staining intensity was reduced 12 weeks after nerve injury. The difference between PEMS group and non-stimulated group was not found. Conclusion : This study shows that nNOS may exert a beneficial effect on nerve regeneration and functional repair.

• Earthquakes and Structures
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• 제16권5호
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• pp.563-573
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• 2019

When generating spectrum-compatible artificial ground motion in engineering practices, the effect of the variation in fitting parameters on the distribution of the peak ground displacement (PGD) has not yet drawn enough attention. In this study, a method for simulating ground motion matching for multiple targets is developed. In this method, a frequency-dependent amplitude envelope function with statistical parameters is introduced to simulate the nonstationarity of the frequency in earthquake ground motion. Then, several groups of time-history acceleration with different temporal and spectral nonstationarities were generated to analyze the effect of nonstationary parameter variations on the distribution of PGD. The following conclusions are drawn from the results: (1) In the simulation of spectrum-compatible artificial ground motion, if the acceleration time-history is generated with random initial phases, the corresponding PGD distribution is quite discrete and an uncertain number of PGD values lower than the limit value are observed. Nevertheless, the mean values of PGD always meet the requirement in every group. (2) If the nonstationary frequencies of the ground motion are taken into account when fitting the target spectrum, the corresponding PGD values will increase. A correlation analysis shows that the change in the mean and the dispersion values, from before the frequencies are controlled to after, correlates with the modal parameters of the predominant frequencies. (3) Extending the maximum period of the target spectrum will increase the corresponding PGD value and, simultaneously, decrease the PGD dispersion. Finally, in order to control the PGD effectively, the ground motion simulation method suggested in this study was revised to target a specified PGD. This novel method can generate ground motion that satisfies not only the required precision of the target spectrum, peak ground acceleration (PGA), and nonstationarity characteristics of the ground motion but also meets the required limit of the PGD, improving engineering practices.

• 한국강구조학회 논문집
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• 제17권1호통권74호
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• pp.103-113
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• 2005

본 연구에서는 선행 연구에서 개발된 강구조물에 대한 직접비탄성설계 방법을 설계실무의 활용성을 확대할 수 있도록 개선하였다. 그룹부재에 대한 설계, 불연속적인 단면 성능, 축력에 따른 휨재하능력의 변화, 접합방식에 따른 거동특성, 다중하중조건 및 성능기준 등 강구조물 설계실무의 제한조건을 고려하여 비탄성설계를 수행할 수 있는 방법을 개발하였다. 본 연구에서는 제안된 방법의 해석 및 설계절차를 정립하였고, 이를 적용한 컴퓨터 해석/설계 프로그램을 개발하였다. 전통적인 탄성설계와 제안된 직접비탄성설계법을 사용한 설계결과를 비교하였으며, 기존의 비선형해석프로그램을 이용하여 설계결과를 검증하였다. 비탄성 변형을 고려할 수 있는 제안된 설계법은 전통적인 탄성해석을 사용한 한계상태설계에 비하여 강재량을 절감하고, 구조물의 변형능력을 향상하였다. 제안된 설계방법은 비탄성 거동을 구조물의 설계에 직접 반영할 수 있으므로 설계에 편리하고 각 소성힌지의 변형을 제어함으로써 구조안전성을 확보하고 동시에 변형능력을 최대로 활용하는 설계를 수행할 수 있다.

• 지질공학
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• 제12권3호
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• pp.345-360
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• 2002

이 연구는 활동 가능성이 높은 퇴적암 사면에 대한 안정성을 분석하기 위해 수치해석을 수행하고, 안정성을 확보할 수 있는 보강공법을 제시하기 위한 목적으로 수행되었다. 연구지역은 백악기 하양층군의 학봉 현무암층에 해당하는 지역으로 대부분이 현무암질 응회암으로 구성되어 있으며, 지질 구조요소로는 크게 1차 구조 요소인 층리와 2차 구조요소인 절리 및 단층이 확인되었다 층리는 단사구조를 보이는데, 대부분의 경우 경사방향이 120~160/15~25(dip direction/dip)이고, 절리의 경우에는 크게 3개 조의 절리군이 확인되는데 세트 1은 310~330/65~85, 세트 2는 230~250/70~85이며, 세트 3은 뚜렷한 연장성을 보이지는 않지만 020의 경사방향에 85$^{\circ}$이상의 고각을 보이고 있다. 사면에 대한 안정성 해석은 운동학적 해석과 한계평형 해석을 수행한 후, 수치해석 방법으로 FLAC을 이용하였다. FLAC은 유한차분법을 이용하는 연속체 역학모델이지만, Interfaces Module을 이용하여 UDEC과 같은 불연속체 모델의 해석효과를 얻을 수 있었다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2004년도 학술대회지
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• pp.477-481
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• 2004

High Quality CD, OAT audio requires that large amount of data. Currently, multi channel preference has been rapidly propagated among latest users. The MPEG(Moving Picture Expert Group) is provides data compression technology of sound and image system. The MPEG standard provides multi channel and 5.1 sounds, using the same audio algorithm as MPEG-l. And MPEG-2 audio is forward and backward compatible. The MDCT (Modified Discrete Cosine Transform) is a linear orthogonal lapped transform based on the idea of TDAC(Time Domain Aliasing Cancellation). In this paper, we proposed the micro-program type vector processor architecture a benefit in MDCT/IMDCT of MPEG-II AAC. And it's reduced operating coefficient by overlapped area to bind. To compare original algorithm with optimized algorithm that cosine coefficient reduced $0.5\%$multiply operating $0.098\%$ and add operating 80.58\%$. Algorithm test is used C-language then we designed hardware architecture of micro-programmed method that applied to optimized algorithm. This processor is 20MHz operation 5V.

• Advances in Computational Design
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• 제2권4호
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• pp.313-331
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• 2017

In this study, teaching-learning based optimization (TLBO) is improved by incorporating model of multiple teachers, adaptive teaching factor, self-motivated learning, and learning through tutorial. Modified TLBO (MTLBO) is applied for simultaneous topology, shape, and size optimization of space and planar trusses to study its effectiveness. All the benchmark problems are subjected to stress, displacement, and kinematic stability constraints while design variables are discrete and continuous. Analyses of unacceptable and singular topologies are prohibited by seeing element connectivity through Grubler's criterion and the positive definiteness. Performance of MTLBO is compared to TLBO and state-of-the-art algorithms available in literature, such as a genetic algorithm (GA), improved GA, force method and GA, ant colony optimization, adaptive multi-population differential evolution, a firefly algorithm, group search optimization (GSO), improved GSO, and intelligent garbage can decision-making model evolution algorithm. It is observed that MTLBO has performed better or found nearly the same optimum solutions.

• Computers and Concrete
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• 제8권1호
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• pp.71-96
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• 2011

Existing reinforced concrete (RC) beams can be strengthened with externally bolted steel plates to the sides of beams. The effectiveness of this type of bolted side-plate (BSP) beam can however be affected by partial interaction between the steel plates and RC beams due to the mechanical slip of bolts. To avoid over-estimation of the flexural strength and ensure accurate prediction of the load-deformation response of the beams, the effect of partial interaction has to be properly considered. In this paper, a special non-linear macro-finite-element model that takes into account the effects of partial interaction is proposed. The RC beam and the steel plates are modelled as two different elements, interacting through discrete groups of bolts. A layered method is adopted for the formulation of the RC beam and steel plate elements, while a special non-linear model based on a kinematic hardening assumption for the bolts is used to simulate the bolt group effect. The computer program SiBAN was developed based on the proposed approach. Comparison with the available experimental results shows that SiBAN can accurately predict the partial interaction behaviour of the BSP beams. Further numerical simulations show that the interaction between the RC beam and the steel plates is greatly reduced by the formation of plastic hinges and should be considered in analyses of the strengthened beams.

• 한국재료학회지
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• 제16권8호
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• pp.473-478
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• 2006

The coherent interface energies and misfit strain energies of Fe/XN (X=Ti, Zr, Hf) systems were calculated by first principles method. The interface energies in Fe/TiN, Fe/ZrN and Fe/HfN systems were 0.343, 0.114, and 0.030 $J/m^2$, respectively. Influence of bond energy was estimated using the discrete lattice plane/nearest neighbor broken bond(DLP/NNBB) model. It was found that the dependence of interface energy on the type of nitride was closely related to changes of the bond energies between Fe, X and N atoms before and after formation of the Fe/XN interfaces. The misfit strain energies in Fe/TiN, Fe/ZrN, and Fe/HfN systems were 0.239, 1.229, and 0.955 eV per 16 atoms(Fe; 8 atoms and XN; 8 atoms). More misfit strain energy was generated as the difference of lattice parameters between the bulk Fe and the bulk XNs increased.

• 한국정보전자통신기술학회논문지
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• 제12권1호
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• pp.13-21
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• 2019

내용기반 영상검색은 영상 내의 정보인 색상, 질감, 형태 등의 특징 값을 추출하여 검색에 이용한다. 본 논문에서는 $8{\times}8$ 이산여현변환, 즉 $8{\times}8$ DCT(Discrete Cosine Transform) 후 얻어지는 DC, AC계수를 이용하여 필터뱅크(filter-bank)를 생성하고, 이를 영상의 내용기반 검색에 이용하는 검색방법을 제안한다. 제안된 방법은 생성된 DCT 필터뱅크에서 DC성분과 주요한 AC성분인 AC01, AC10, AC11 만을 이용하며, DC성분에 대한 양자화를 수행하여 계산량을 최소화한다. 그리고 양자화된 DC성분에 대한 히스토그램 정보를 기반으로 영상 검색에 필요한 특징 값을 산출한다. AC성분에 대해서는 Otsu 이진화를 통하여 개괄적인 형태정보를 취득한 다음 이에 대한 수평/수직 방향으로의 투영 히스토그램을 계산하여 특징 값을 취득한다. 추출된 AC성분의 특징 값은 DC성분의 특징 값과 함께, 특징벡터 빈(feature vector bins)을 구성하여 검색을 수행한다. 실험은 1000장의 데이터베이스를 이용하여 수행 되었으며, 기존의 색상정보를 이용한 검색방법보다 우수한 성능을 보임을 확인하였다.

• Journal of Forest and Environmental Science
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• 제25권2호
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• pp.93-100
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• 2009

In Malaysia, Labisia pumila Benth & Hook f, popularly known as 'Kacip Fatimah' has been used traditionally to treat various elements of the woman's health in Malay community. The objective of this study was to develop randomly amplified polymorphic DNA (RAPD) based DNA markers for the identification of L. pumila and to distinguish its three varieties from each other. Total DNA from nine accessions of L. pumila was extracted by CTAB method and polymerase chain reactions (PCR) were carried out to amplify the segments of DNA using different primers to develop DNA barcode using RAPD technique. To find out variety-specific DNA marker/s, twenty different 10-mer primer sequences with annealing temperature from 36-$40^{\circ}C$ were evaluated in triplicate. Out of 20 random primers, two primers (OPA-1 and OPA-2/A10) were selected which produced reliable RAPD band patterns. To have DNA based handle, two RAPD amplification products were cloned and sequenced to determine the identity of the DNA. RAPD analysis using two random primers generated 72 discrete bands ranging in size 200 bp-3,000 bp. Fifty nine of these were polymorphic loci (82%) and thirteen were non-polymorphic loci (18%). A total of 32 bands polymorphic loci (72%) were amplified with primer OPA-1 and analyzed by cluster analysis and UPGMA (Unweighted Pair Group Method with Arithmetic) to present a dendogram depicting the degree of genetic relationship among nine accessions of L. pumila. Our results shows the reasonable genetic diversity among the L. pumila varieties and within varieties; and two RAPD marker sequences obtained could be used to identify L. pumila at species level.