• Transactions on Electrical and Electronic Materials
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• 제8권6호
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• pp.289-292
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• 2007

Polymethly methacrylate(PMMA) and polydimethlysiloxane(PDMS) surfaces were treated to improve adhesiveness by irradiation of a Nd:YAG pulse laser beam($\lambda=266nm$). A pulse laser beam was directed on a polymer surface in air, and the number of pulses was controlled by mobile velocity of a motorized stage. The laser treated surfaces were investigated using an optical microscope and a contact angle measuring instrument. It was thereby revealed that the contact angles were decreased in the laser treated surface. This in turn led to an increase of oxygen content and improved adhesiveness on the modified surface. With improved surface adhesion, a fluid channel could be formed on the laser treated surface region.

• The Journal of Korean Physical Therapy
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• 제11권3호
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• pp.133-140
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• 1999

Why does the CNS not regenerate after injury? The failure of axonal regeneration in the CNS after injury is not due to an inherent inability of these neurons to regrowth axon. Recently, an inhibitory substrate effect of CNS has been discovered which could be directly invoked in the lack of regeneration. The failure of axon regrowth in the CNS is crucially influenced by the presence of neurtie growth inhibitor NI35/250 and possibly also by molecules such as myelin associated glycoprotein(MAG) and chondroitin sulphate proteoglycans(CSPGs). The application of the monoclonal antibody IN-1, which efficinetly neutralizes the N135/250 inhibitory molecules. This new finding has a strong impact on the development of, a new neuroscienctific research directed to stimulate axonal regeneration. In this review summarize the current knowledge on the factors and molecules involved in the regeneration failure.

• 한국컴퓨터교육학회 학술대회
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• 한국컴퓨터교육학회 2018년도 하계학술대회
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• pp.41-44
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• 2018

최근 가상현실의 시대가 다시 각광 받고 있는 시점에서 콘텐츠 확산을 위해 노력하는 것은 의미를 가진다. 본 연구에서는 중학교 과학에서 항상성과 몸의 조절 중 1차 면역 반응을 학습하는데 도움을 줄 수 있는 VR 학습 콘텐츠를 개발하였다. VR 게임으로 구현하여 학습자가 직접 몸속에 들어가 1차 면역 반응을 체험하도록 개발하였다. 학습자의 흥미를 높이기 위해 게임이라는 컨텐츠를 이용하여 학습자가 게임을 하며 학습할 수 있어 자기주도적 학습이 가능하다. 또한 최근 디지털 교과서에서 VR/AR 콘텐츠가 제공되기 시작하여 가상현실 기술의 교육적 활용 가능성을 높이고자 하였다.

• 대한안전경영과학회지
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• 제4권1호
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• pp.37-47
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• 2002

Risk analysis is a formal deductive procedure for determining combinations of component failures and human errors that could result in the occurrence of specified undesired events at the system level. This method can be used to analyze the vast majority of industrial system reliability problems. This study deals with the application of knowledge-engineering and a methodology for the assessment ＆ measurement of reliability, availability, maintainability, and safety of industrial systems using FTA(fault tree analysis), A fuzzy methodology for fault-tree evaluation seems to be an alternative solution to overcome the drawbacks of the conventional approach (insufficient Information concerning the relative frequencies of hazard events). To improve the quality of results, the membership functions must be approximated based on heuristic considerations, The purpose of this study is to describe the knowledge engineering approach, directed to integrate the various sources of knowledge involved in a FTA.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2004년도 봄 학술발표논문집 Vol.31 No.1 (B)
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• pp.7-9
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• 2004

With the development of e-commerce and information access, recommender systems have become a popular technique to prune large information spaces so that users are directed toward those items that best meet their needs and preferences. In this paper, clustering technique is applied in the collaborative recommender framework to consider semantic contents available from the user profiles. We also suggest methods to construct user profiles from rating information and attributes of items to accommodate user preferences. Further, we show that the correct application of the semantic content information obtained from user profiles does enhance the effectiveness of collaborative recommendation.

• 비교문화연구
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• 제31권
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• pp.263-286
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• 2013

The goal of this study is to explore the possibility of applying the podcasting in Korean education for foreign students. To achieve this goal, concepts and applicability of the podcasting is discussed. Previous studies on foreign language education are reviewed and the cases on Korean language education based on technology using mobile phones are investigated. Some of the outstanding merits of the podcasting are found to be its accessibility, mobility and variability along with its room for control by the learners. It also enables the learners to be motivated and to enhance their learning ability. In addition, the podcasting with the content-based instruction is applied for the foreign students majoring in business and its results and implications are discussed. Based on the above results of this study, more active discussions are expected on such issues as educational designs through the podcasting, related variables and the performance evaluation.

• Molecules and Cells
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• 제44권8호
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• pp.541-548
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• 2021

The discovery of human pluripotent stem cells (PSCs) at the turn of the century opened the door to a new generation of regenerative medicine research. Among PSCs, the donors available for induced pluripotent stem cells (iPSCs) are greatest, providing a potentially universal cell source for all types of cell therapies including cancer immunotherapies using natural killer (NK cells). Unlike primary NK cells, those prepared from iPSCs can be prepared with a homogeneous quality and are easily modified to exert a desired response to tumor cells. There already exist several protocols to genetically modify and differentiate iPSCs into NK cells, and each has its own advantages with regards to immunotherapies. In this short review, we detail the benefits of using iPSCs in NK cell immunotherapies and discuss the challenges that must be overcome before this approach becomes mainstream in the clinic.

• Mass Spectrometry Letters
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• 제11권4호
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• pp.103-107
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• 2020

We report the application of 2,4,6-trichlorobenzoyl chloride (often referred to as Yamaguchi esterification reagent) for the selective derivatization of the carboxylic group for GC-MS with the sample preparation method optimized for GC-MS analysis. The reagent was shown to be capable of selectively turning the carboxylic group into a reaction center, i.e., anhydride, of which the further reaction was directed to a near complete formation of required esters by unique steric and electronic effects of the reagent. Using the developed method, the chiral separation of hydroxycarboxylic acids by GC-MS using non-chiral columns was successfully demonstrated.

• 국제학술발표논문집
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• The 6th International Conference on Construction Engineering and Project Management
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• pp.700-701
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• 2015

Nuclear power plant construction project can be called essential to establish a systematic project management system compared to other construction projects, taking into account the size and complexity and safety. To develop into a project management system for the Korea situation with the ongoing construction of the nuclear power plant was directed to promote nuclear power project management. In this paper, we introduce a comprehensive project management system for nuclear power projects. Currently considering the nuclear life cycle design, construction, and was developed by considering the flow of information to operate, and test each step linkage. The systems in English were developed to meet owner's requirements for advancing into overseas projects. Another point is that the systems were developed by management module, so that functions of each area can be selectively applied. It is expected that the system will establish itself as one that can be used for the entire lifecycle of nuclear power plants through gradual and systematic establishment of necessary data.

• 한국미생물·생명공학회지
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• 제34권1호
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• pp.58-62
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• 2006

티로신 및 방향족 아미노산 유도체의 생물학적 합성에 이용되는 유용 효소인 tyrosine phenol-lyase(TPL) 활성을 평판배지에서 정량적으로 감지할 수 있는 기술을 개발하였다. 불투명 평판배지(turbid plate)의 제조과정은 먼저, 2 N염산과 DMSO로 조성된 공용매에 난용성 티로신을 400 mM 농도로 녹여서 배지에 가하고, 온도를 조절하여 니들형 티로신을 형성하도록 결정화를 유도하는 것이었다. 니들형 티로신은 일반적인 컬럼형에 비하여 약 $5{\sim}6$배 낮은 농도인 3.6g/L에서도 불투명 평판배지를 제조할 수 있었으며, 효소활성에 의하여 쉽게 분해되고, TPL활성의 고감도 고속탐색기술 개발에 적합하였다. 이 불투명 평판배지에 변이유발PCR법으로 제조한 TPL 라이브러리를 도말하고, 단일 콜로니 주변에서 형성되는 투명환의 크기와 실측한 TPL활성을 비교한 결과 직접적인 비례관계가 있음을 확인하였다. 따라서 난용성 물질의 미세입자를 평판배지에서 직접 발생시킨 후, 효소활성에 의한 투명환의 형성을 정량 관찰하는 본 연구의 방법은 신규 고활성 TPL의 분리 및 방향성 분자진화 등을 위한 고속탐색기술에 유용하게 사용될 수 있다.