• 대한전기학회:학술대회논문집
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• 대한전기학회 1992년도 하계학술대회 논문집 B
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• pp.567-569
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• 1992

Design sensitivity analysis is proposed for the optimal shape design of three dimensional magnetostatic problems. The direct differentiation method is introduced for design sensitivity analysis and the boundary element method with reduced magnetic scalar potential as the state variable is used to analyze the magnetic characteristics. In the direct differentiation method, the design sensitivity, defined as the total derivative of the objective function with respect to the design variables, is calculated based on the variation of the state variable with respect to the design variable. And the variation of He state variable is calculated by differentiating the both sides of the system matrix equation obtained by applying boundary element method. Through the numerical example with simple electromagnet, the usefullness is proved.

• 대한기계학회논문집A
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• 제29권11호
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• pp.1455-1462
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• 2005

In this paper, we intend to introduce a nonlinear finite element method based on the fully nonlinear potential flow theory in order to simulate the large amplitude sloshing flow in two-dimensional baffled tank subject to horizontally forced excitation. The free surface is tracked by a direct time differentiation scheme with the four-step predictor-corrector time integration method. The flow velocity is accurately recovered from the velocity potential by second-order least square method. In order to maintain the finite element mesh regularity and total mass, the semi-Lagrangian surface tracking method with area conservation is applied. According to the numerical formulae, we perform the parametric experiments by varying the installation height and the opening width of baffles, in order to examine the effects of baffle on the nonlinear liquid sloshing. From the numerical results, the hydrodynamic characteristics of the large amplitude sloshing are investigated.

• Journal of Mechanical Science and Technology
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• 제19권spc1호
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• pp.350-356
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• 2005

A method of dynamic analysis of mechanical systems considering probabilistic properties is proposed in this paper. Probabilistic properties that result from manufacturing tolerances can be represented by means and standard deviations (or variances). The probabilistic characteristics of dynamic responses of constrained multi-body systems are obtained by two ways : the proposed analytical approach and the Monte Carlo simulation. The formerpaper, necessitates sensitivity information to calculate the standard deviations. In this a direct differentiation method is employed to find the sensitivities of constrained multi-body systems. To verify the accuracy of the proposed method, numerical examples are solved and the results obtained by using the proposed method are compared to those obtained by Monte Carlo simulation.

• Journal of Welding and Joining
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• 제19권2호
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• pp.228-234
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• 2001

A methodology is developed and used to evaluate the response sensitivity of the thermal systems to variations in their design parameters. Technique for computing the sensitivity of temperature distributions to changes in processing parameters needed to decide the more effective laser input parameters for laser surface hardening treatment is considered. In this study, a state equation governing the heat flow in laser surface treatment is analyzed using a three-dimensional finite element method and sensitivity data of the processing parameter obtained using a direct differentiation method is applied to the sensitivity analysis. The interesting processing parameters are taken as the laser scan velocity and laser beam radius ( $r_{ b}$), and the sensitivities of the temperature T versus v and $r_{b}$ are analyzed. These sensitivity results are obtained with another parameters fixed. To verify the numerical analysis results, hardened layer dimensions (width and depth) of the numerical analysis are compared with the experimental ones.nes.

• 한국자동차공학회논문집
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• 제5권1호
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• pp.38-48
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• 1997

A method for performing kinematic design sensitivity analysis of vehicle suspension systems is presented. For modeling of vehicle suspensions, the multibody dynamic formulation is adopted, where suspensions are assumed as combination of rigid bodies and ideal frictionless joints. In a relative joint coordinate setting, kinematic constraint equations are obtained by imposing cut-joints that transform closed-loop shape suspension systems into open-loop systems. By directly differentiating the constraint equations with respect to kinematic design variables, such as length of bodies, notion axis, etc., sensitivity equations are derived. By solving the sensitivity equations, sensitivity of static design factors that can be used for design improvement, can be obtained. The validity and usefulness of the method are demonstrated through an example where kinematic sensitivity analysis of a MacPherson strut suspension of performed.

• 대한전기학회논문지
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• 제41권8호
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• pp.850-857
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• 1992

Design sensitivity analysis is proposed for the optimal shape design of three-dimensional magnetostatic problems. The direct differentiation method is introduced for design sensitivity analysis and the boundary element method with reduced magnetic scalar potential as the state variable is used to analyze the magnetic characteristics. In the direct differentiation method, the design sensitivity, defined as the total derivative of the objective function with respect to the design variables, is calculated based on the variation of the state variable with respect to the design variable. And the variation of the state variable is calculated by differetiating the both sides of the system matrix equation obtained by applying boundary element method. Through the numerical example with simple electromagnet, the usefulness is proved.

• Journal of Welding and Joining
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• 제16권3호
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• pp.141-147
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• 1998

Design sensitivity analysis of a vehicle system is an essential tool for design optimization and trade-off studies. Most optimization algorithms require the derivatives of cost and constraint function with respect to design in order to calculate the next improved design. This paper presents an efficient algorithm application for the design sensitivity analysis, using the direct differentiation method. A mounting area of suspension that welded on chassis frame is analyzed to show the validity and the efficiency of the proposed method. A mounting area of suspension that welded on chassis frame is analyzed to show the validity and the efficiency of the proposed method.

• Journal of Ship and Ocean Technology
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• 제8권3호
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• pp.50-60
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• 2004

In this paper, a continuum-based design sensitivity analysis (DSA) method is developed for the weakly coupled thermo-elasticity problems. The temperature and displacement fields are described in a common domain. Boundary value problems such as an equilibrium equation and a heat conduction equation in steady state are considered. The direct differentiation method of continuum-based DSA is employed to enhance the efficiency and accuracy of sensitivity computation. We derive design sensitivity expressions with respect to thermal conductivity in heat conduction problem and Young's modulus in equilibrium equation. The sensitivities are evaluated using the finite element method. The obtained analytical sensitivities are compared with the finite differencing to yield very accurate results. Extensive developments of this method are useful and applicable for the optimal design problems incorporating welding and thermal deformation problems.

• Nutritional Sciences
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• 제6권3호
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• pp.148-154
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• 2003

Although various raw plant materials have been demonstrated to exert anti-obesity effects to a greater or lesser extent in both humans and animals when they are used to supplement the diet, it has not been shown extensively that they influence adipocyte cell differentiation involving lipid metabolic gene expressions. Using a well-established 3T3-L1 preadipocyte differentiation system, we decided to look into molecular and cellular event occurring during adipocyte differentiation when raw plant materials aye included in the process, in an effort to demonstrate the potential use of a screening system to define the functions of traditionally well-known materials. To these ends, the effects of ethanol (EtOH) or EtOH/distilled water (DW) extracts of Wax Gourd were examined using cytochemical and molecular analyses to determine whether components of the extracts modulate adipocyte differentiation of 3T3-Ll preadipocytes in vitro. The cytochemical results demonstrated that EtOH or EtOH/DW extracts did not affect lipid accumulation and cell proliferation, although the degree of lipid accumulation was influenced slightly depending on the extract. EtOH extract was highly effective in apoptotic induction during differentiation of 3T3-Ll preadipocytes (p<0.05). Reverse transcription-polymerase chain reaction (RT-PCR) analysis of lipoprotein lipase (LPL), Uncoupling protein (Ucp) 2, 3 and 4 also showed that while LPL expression was not influenced, Ucp2, 3 and 4 were up regulated in the EtOH extract-treated group and down regulated in the EtOH/DW extract-treated group. These changes in gene expressions suggest that the components in different fractions of Wax Gourd extracts may modulate lipid metabolism by either direct or indirect action. Taking these results together, it was concluded that molecular and cellular analyses of adipocyte differentiation involving lipid metabolic genes should facilitate understanding of cellular events occurring during adipocyte differentiation. Furthermore, the experimental scheme and analytical methods used in this study should provide a screening system for the functional study of raw plant materials in obesity research.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2015년도 제49회 하계 정기학술대회 초록집
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• pp.158-158
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• 2015

Myoblast are myogenic precursors that proliferate, activate, and differentiate on muscle injury to sustain the regenerative capacity of skeletal muscle; The neuronal isoform of nitric oxide synthase (nNOS, termed also NOS-I) is expressed in normal adult skeletal muscle, suggesting important functions for Nitric oxide (NO) in muscle biology1,2,3. However, the expression and subcellular localization of NO in muscle development and myoblast differentiation are largely unknown. In this study, we examined effects of the nitric oxide generated by a microwave plasma torch, on proliferation/differentiation of rat myoblastic L6 cells. Experimental data pertaining to nitric oxide production are presented in terms of the oxygen input in units of cubic centimetres per minute. The various levels of nitric oxide are observed depending on the flow rate of nitrogen gas, the ratio of oxygen gas, and the microwave power4. In order to evaluate the potential of nitric oxide as an activator of cell differentiation, we applied nitric oxide generated from the microwave plasma torch to L6 skeletal muscles. Differentiation of L6 cells into myotubes was significantly enhanced the differentiation after nitric oxide treatment. Nitric oxide treatment also increase the expression of myogenesis marker proteins and mRNA level, such as myogenin and myosin heavy chain (MHC), as well as cyclic guanosine monophosphate (cGMP), However during the myotube differentiation we found that NO activate oxidative stress signaling erks expression. Therefore, these results establish a role of NO and cGMP in regulating myoblast differentiation and elucidate their mechanism of action, providing a direct link with oxidative stress signalling, which is a key player in myogenesis. Based on these findings, nitric oxide generated by plasma can be used as a possible activator of cell differentiation and tissue regeneration.