• Molecules and Cells
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• 제26권1호
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• pp.1-4
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• 2008

A gene's influence on an organism's Darwinian fitness ultimately determines whether it will be lost, maintained or modified by natural selection, yet biologists have few gene expression systems in which to measure whole-organism gene function. In the Department of Molecular Ecology at the Max Planck Institute for Chemical Ecology we are training "molecularly enabled field biologists" to use transformed plants silenced in the expression of environmentally regulated genes and the plant's native habitats as "laboratories." Research done in these natural laboratories will, we hope, increase our understanding of the function of genes at the level of the organism. Examples of the role of threonine deaminase and RNA-directed RNA polymerases illustrate the process.

• IMMUNE NETWORK
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• 제13권1호
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• pp.1-9
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• 2013

Autophagy is a fundamental cellular process in eukaryotic cells for maintaining homeostasis by degrading cellular proteins and organelles. Recently, the roles of autophagy have been expanded to immune systems, which in turn modulate innate immune responses. More specifically, autophagy acts as a direct effector for protection against pathogens, as well as a modulator of pathogen recognition and downstream signaling in innate immune responses. In addition, autophagy controls autoimmunity and inflammatory disorders by negative regulation of immune signaling. In this review, we focus on recent advances in the role of autophagy in innate immune systems.

• IMMUNE NETWORK
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• 제9권4호
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• pp.115-121
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• 2009

Natural killer (NK) cells play key roles in innate and adaptive immune defenses. NK cell responses are mediated by two major mechanisms: the direct cytolysis of target cells, and immune regulation by production of various cytokines. Many previous reports show that the complex NK cell activation process requires de novo gene expression regulated at both transcriptional and post-transcriptional levels. Specialized un-translated regions (UTR) of mRNAs are the main mechanisms of post-transcriptional regulation. Analysis of posttranscriptional regulation is needed to clearly understand NK cell biology and, furthermore, harness the power of NK cells for therapeutic aims. This review summarizes the current understanding of mRNA metabolism during NK cell activation, focusing primarily on post-transcriptional regulation.

• 미술이론과 현장
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• 제8호
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• pp.185-215
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• 2009

In Malaysia, figurative painting has increasingly become a means for artists to pose questions about presumptions of power and assumptions of history. The body, its potentially breached boundaries and defenses, forms an integral component of the battle for political influence. The degree of control over one's own and other people's bodies has become a measuring stick to determine the power of potential political leaders. Anxiety about boundaries and access to powerful bodies is intertwined with the questions of who has the right to hold power; the relevance of moral bodies and of what comprises an ideal self or selves. These questions are raised in intriguing ways in contemporary Malaysian art. While eschewing a direct take on current politics, Malaysian artists have increasingly turned to the body to address issues in Malaysian history, culture and the distribution of power. This paper will explore some works by three artists in particular, Wong Hoy Cheong, Nadiah Bamadhaj and Ahmad Fuad Osman use the figure to problematise dominant narratives in Malaysian history. Their work variously challenge political, racial and gender hierarchies and in so doing, reveal them as social constructions.

• 한국식품과학회지
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• 제39권5호
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• pp.481-487
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• 2007

Toll-like receptors (TLRs) induce innate immune responses that are essential for host defenses against invading microbial pathogens, thus leading to the activation of adaptive immune responses. In general, TLRs have two major downstream signaling pathways: the MyD88- and TRIF-dependent pathways, which lead to the activation of $NF-{\kappa}B$ and IRF3. Numerous studies have demonstrated that certain phytochemicals possessing anti-inflammatory effects inhibit $NF-{\kappa}B$ activation induced by pro-inflammatory stimuli, including lipopolysaccharides and $TNF{\alpha}$. However, the direct molecular targets for such anti-inflammatory phytochemicals have not been fully identified. Identifying the direct targets of phytochemicals within the TLR pathways is important because the activation of TLRs by pro-inflammatory stimuli can induce inflammatory responses that are the key etiological conditions in the development of many chronic inflammatory diseases. In this paper we discuss the molecular targets of resveratrol, (-)-epigallocatechin-3-gallate (EGCG), and curcumin in the TLR signaling pathways. Resveratrol specifically inhibited the TRIF pathway in TLR3 and TLR4 signaling, by targetting TBK1 and RIP1 in the TRIF complex. Furthermore, EGCG suppressed the activation of IRF3 by targetting TBK1 in the TRIF-dependent signaling pathways. In contrast, the molecular target of curcumin within the TLR signaling pathways is the receptor itself, in addition to $IKK{\beta}$. Together, certain dietary phytochemicals can modulate TLR-derived signaling and inflammatory target gene expression, and in turn, alter susceptibility to microbial infection and chronic inflammatory diseases.

• 한국자원식물학회지
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• 제29권6호
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• pp.704-711
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• 2016

Tomatoes are considered as one of the main components of daily meals in most households. Thus, it is important to invest in studies enhancing their yield and nutritional value. The study evaluated the effect of wood vinegar (WV) on tomato under greenhouse conditions. Data on fruit number, fruit weight, and plant height were recorded. Total phenolic content (TPC) and antioxidant activity of tomato were determined using the Folin-Ciocalteu reagent and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, respectively. FRR-CF+500x-WV significantly increased the fruit number (86.11%) and fruit weight (81.78%) over the control. Results were comparable to HRR-CF+250x-WV, indicating that conventional fertilizer and WV may have synergistic effect on each other. TPC and scavenging effect on DPPH radical was improved by 250x-WV application. The increase in the phenolic compounds can be attributed to WV as a direct source or as a factor triggering the plants to produce more secondary metabolites with the purpose of increasing natural defenses. The significant effect obtained by applying the full recommended rate of conventional fertilizer on the carotenoid content was due to the availability of the major nutrients needed by the plant. Correlation analysis showed that carotenoids have negative correlation with TPC and DPPH. However, TPC and DPPH showed that these are positively correlated with each other. Tomatoes are excellent source of antioxidants associated with the reduction of some human diseases and improved health. The results provided evidence that WV alone and/or its combination with conventional fertilizers has favorable effects on the quality of tomato.

• Molecules and Cells
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• 제42권7호
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• pp.503-511
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• 2019

As sessile organisms, plants have developed sophisticated system to defend themselves against microbial attack. Since plants do not have specialized immune cells, all plant cells appear to have the innate ability to recognize pathogens and turn on an appropriate defense response. The plant innate immune system has two major branches: PAMPs (pathogen associated molecular patterns)-triggered immunity (PTI) and effector-triggered immunity (ETI). The ability to discriminate between self and non-self is a fundamental feature of living organisms, and it is a prerequisite for the activation of plant defenses specific to microbial infection. Arabidopsis cells express receptors that detect extracellular molecules or structures of the microbes, which are called collectively PAMPs and activate PTI. However, nucleotidebinding site leucine-rich repeats (NB-LRR) proteins mediated ETI is induced by direct or indirect recognition of effector molecules encoded by avr genes. In Arabidopsis, plasmamembrane localized multifunctional protein RIN4 (RPM1-interacting protein 4) plays important role in both PTI and ETI. Previous studies have suggested that RIN4 functions as a negative regulator of PTI. In addition, many different bacterial effector proteins modify RIN4 to destabilize plant immunity and several NB-LRR proteins, including RPM1 (resistance to Pseudomonas syringae pv. maculicola 1), RPS2 (resistance to P. syringae 2) guard RIN4. This review summarizes the current studies that have described signaling mechanism of RIN4 function, modification of RIN4 by bacterial effectors and different interacting partner of RIN4 in defense related pathway. In addition, the emerging role of the RIN4 in plant physiology and intercellular signaling as it presents in exosomes will be discussed.

• 한국산학기술학회논문지
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• 제18권11호
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• pp.94-103
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• 2017

자동으로 해킹을 수행하는 도구 및 기법의 발전으로 인해 최근 신규 보안 취약점들이 증가하고 있다. 대표적인 취약점 DB인 CVE를 기준으로 2010년부터 2015년까지 신규 취약점이 약 8만건이 등록되었고, 최근에도 점차 증가하는 추세이다. 그러나 이에 대응하는 방법은 많은 시간이 소요되는 전문가의 수동 분석에 의존하고 있다. 수동 분석의 경우 취약점을 발견하고, 패치를 생성하기까지 약 9개월의 시간이 소요된다. 제로데이와 같은 빠른 대응이 필요한 취약점에 대한 위험성이 더 부각되는 이유이다. 이와 같은 문제로 인해 최근 자동화된 SW보안 취약점 탐색 및 대응 기술에 대한 관심이 증가하고 있다. 2016년에는 바이너리를 대상으로 사람의 개입을 최소화하여 자동화된 취약점 분석 및 패치를 수행하는 최초의 대회인 CGC가 개최 되었다. 이 외에도 세계적으로 Darktrace, Cylance 등의 프로젝트를 통해 인공지능과 머신러닝을 활용하여 자동화된 대응 기술들을 발표하고 있다. 그러나 이러한 흐름과는 달리 국내에서는 자동화에 대한 기술 연구가 미비한 상황이다. 이에 본 논문에서는 자동화된 SW 보안 취약점 탐색 및 대응 기술을 개발하기 위한 선행 연구로서 취약점 탐색과 대응 기술에 대한 선행 연구 및 관련 도구들을 분석하고, 각 기술들을 비교하여 자동화에 용이한 기술 선정과 자동화를 위해 보완해야 할 요소를 제안한다.

• 한국항행학회논문지
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• 제26권5호
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• pp.304-311
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• 2022

적 방공망 제압 임무는 현대전에서 전략적으로 중요한 임무이지만 적 방공자산에 직접적으로 노출될 위험이 높아 위험 부담이 크다. 따라서, 무인기를 활용하여 임무를 수행하는 것이 하나의 대안으로 제시된다. 본 논문에서는 무인기의 적 방공망 제압 임무 수행을 위한 경로 생성 기법과 생성된 경로에 대한 임무 효과도 산출 기법을 제안한다. 먼저, RRT 기반의 경로 탐색 알고리즘을 기반으로 적의 단거리 대공 위협을 고려할 수 있는 저공 침투/이탈 비행 경로 기법을 다룬다. 또한, 최단의 경로이면서 동시에 적의 단거리 대공 위협을 최대한 회피하는 표적 타격 경로를 생성하기 위해 Dubins 경로 기반의 타격 경로 생성 기법이 사용된다. 이를 통해 생성된 침투/타격/이탈 경로를 순서에 따라 통합한다. 통합된 경로를 기반으로 연료소모량, 무인기의 생존 확률, 임무 수행 소요 시간, 그리고 표적 파괴 확률로 이루어진 임무 효과도를 산출한다. 마지막으로, 제안된 적 방공망 제압 임무 경로 생성 기법 및 임무 효과도 산출 기법을 가상 시나리오를 통해 검증한다.