• Title/Summary/Keyword: diffusion pump

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Buccal Transport of Paclitaxel using Ethanol and Glyceryl Monooleate

  • Lee, Yoon-Jin;Kang, Myung-Joo;Park, Young-Mi;Choi, Young-Wook;Lee, Jae-Hwi
    • Journal of Pharmaceutical Investigation
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    • v.37 no.5
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    • pp.311-314
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    • 2007
  • Paclitaxel (PTX) is an antineoplastic agent approved for the treatment of ovarian and breast carcinomas. However, the use of paclitaxel as an anticancer drug is limited by its extremely poor water solubility (below $0.3\;{\mu}g/mL$). Furthermore, it has very low bioavailability when administered orally because paclitaxel is a substrate of P-glycoprotein (P-gp) efflux pump. In this study, buccal delivery of PTX was investigated as one of the alternatives for PTX delivery. Ethanol and glyceryl monooleate (GMO) were selected as permeation enhancing agents to increase solubility and permeation across buccal mucosa of PTX. At the different concentrations of ethanol solution ($30{\sim}70\;w/w\;%$), PTX permeation was studied, followed effects of GMO in the concentration range of $2.5{\sim}25%$ with ethanol vesicle. The transbuccal ability of PTX was evaluated in vitro using Franz diffusion cells mounted with rabbit buccal mucosa. As a result, incorporation of PTX into ethanol vesicle with GMO significantly enhanced the PTX permeation in rabbit buccal mucosa. Particularly, the mixtures of ethanol:water:GMO at the ratio of 50:47.5:2.5 showed the most excellent enhancing ability. The results showed a promising possibility for buccal delivery of PTX.

Electron Microscopic Studies on Cellular Characteristics and Transport Systems in Tight Epithelia (Tight epithelia의 세포특성과 수송체계에 관한 전자현미경적 연구)

  • Jeon, Jin-Seok
    • Applied Microscopy
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    • v.26 no.1
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    • pp.47-57
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    • 1996
  • This study analysed the transport properties of bladder mucosa known as the typical system of 'tight epithelia' by using TEM observation with both rapid freeze-fracture electron microscopy and thin-section method and mainly analysed the cellular characteristics of turtle bladder epithelial cells. The bladder epithelium, like other tight epithelia, consists of a heterogenous population of cells. The majority of the mucosal cells are the granular cells and may function primarily in the process of active $Na^+$ reabsorption in turtle bladder. The remaining two types of cells are rich in mitochondria and is believed to be res-ponsible for a single major transport system, namely, $H^+$ transport by A-type of cell and urinary $HCO_{3}^-$ secretion by B-type of cell. As viewed in freeze-fracture electron micrograph, the tight junctions form a continuous tight seal around the epithelial cells, thus restricting diffusion in tight epithelia. In addition, the apical surface membranes have a population of rod-shaped intramembranous particles (IMPs). It is believed that these IMPs probably represent the components of the proton pump. However, it is likely that these characteristics of the apical transporter remain to be clarified in tight epithelial cells.

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Dynamic Model of Water Electrolysis for Prediction of Dynamic Characteristics of Cooling System (냉각계통 동적 예측을 위한 수전해 시스템 동적 모사 모델)

  • YUN, SANGHYUN;YUN, JINYON;HWANG, GUNYONG
    • Transactions of the Korean hydrogen and new energy society
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    • v.32 no.1
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    • pp.1-10
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    • 2021
  • Water electrolysis technology, which generates hydrogen using renewable energy resources, has recently attracted great attention. Especially, the polymer electrolyte membrane water electrolysis system has several advantages over other water electrolysis technologies, such as high efficiency, low operating temperature, and optimal operating point. Since research that analyzes performance characteristics using test bench have high cost and long test time, however, model based approach is very important. Therefore, in this study, a system model for water electrolysis dynamics of a polymer electrolyte membrane was developed based on MATLAB/Simulink®. The water electrolysis system developed in this study can take into account the heat and mass transfer characteristics in the cell with the load variation. In particular, the performance of the system according to the stack temperature control can be analyzed and evaluated. As a result, the developed water electrolysis system can analyze water pump dynamics and hydrogen generation according to temperature dynamics by reflecting the dynamics of temperature.

Development and validation of the lead-bismuth cooled reactor system code based on a fully implicit homogeneous flow model

  • Ge Li;Wang Jingxin;Fan Kun;Zhang Jie;Shan Jianqiang
    • Nuclear Engineering and Technology
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    • v.56 no.4
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    • pp.1213-1224
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    • 2024
  • The liquid lead-bismuth cooled fast reactor has been in a single-phase, low-pressure, and high-temperature state for a long time during operation. Considering the requirement of calculation efficiency for long-term transient accident calculation, based on a homogeneous hydrodynamic model, one-dimensional heat conduction model, coolant flow and heat transfer model, neutron kinetics model, coolant and material properties model, this study used the fully implicit difference scheme algorithm of the convection-diffusion term to solve the basic conservation equation, to develop the transient analysis program NUSOL-LMR 2.0 for the lead-bismuth fast reactor system. The steady-state and typical design basis accidents (including reactivity introduction, loss of flow caused by main pump idling, excessive cooling, and plant power outage accidents) for the ABR have been analyzed. The results are compared with the international system analysis software ATHENA. The results indicate that the developed program can stably, accurately, and efficiently predict the transient accident response and safety characteristics of the lead-bismuth fast reactor system.

Dry Etching of GaAs and AlGaAs in Diffuion Pump-Based Capacitively Coupled BCl3 Plasmas (확산펌프 기반의 BCl3 축전결합 플라즈마를 이용한 GaAs와 AlGaAs의 건식 식각)

  • Lee, S.H.;Park, J.H.;Noh, H.S.;Choi, K.H.;Song, H.J.;Cho, G.S.;Lee, J.W.
    • Journal of the Korean Vacuum Society
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    • v.18 no.4
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    • pp.288-295
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    • 2009
  • We report the etch characteristics of GaAs and AlGaAs in the diffusion pump-based capacitively coupled $BCl_3$ plasma. Process variables were chamber pressure ($50{\sim}180$ mTorr), CCP power ($50{\sim}200\;W$) and $BCl_3$ gas flow rate ($2.5{\sim}10$ sccm). Surface profilometry was used for etch rate and surface roughness measurement after etching. Scanning electron microscopy was used to analyze the etched sidewall and surface morphology. Optical emission spectroscopy was used in order to characterize the emission peaks of the $BCl_3$ plasma during etching. We have achieved $0.25{\mu}m$/min of GaAs etch rate with only 5 sccm $BCl_3$ flow rate when the chamber pressure was in the range of 50{\sim}130 mTorr. The etch rates of AlGaAs were a little lower than those of GaAs at the conditions. However, the etch rates of GaAs and AlGaAs decreased significantly when the chamber pressure increased to 180 mTorr. GaAs and AlGaAs were not etched with 50 W CCP power. With $100{\sim}200\;W$ CCP power, etch rates of the materials increased over $0.3{\mu}m$/min. It was found that the etch rates of GaAs and AlGaAs were not always proportional to the increase of CCP power. We also found the interesting result that AlGaAs did not etched at 2.5 sccm $BCl_3$ flow rate at 75 mTorr and 100 W CCP power even though it was etched fast like GaAs with more $BCl_3$ gas flow rates. By contrast, GaAs was etched at ${{\sim}}0.3{\mu}m$/min at the 2.5 sccm $BCl_3$ flow rate condition. A broad molecular peak was noticed in the range of $500{\sim}700\;mm$ wavelength during the $BCl_3$ plasma etching. SEM photos showed that 10 sccm $BCl_3$ plama produced more undercutting on GaAs sidewall than 5 sccm $BCl_3$ plasma.

Effect of Pulsatile Versus Nonpulsatile Blood Flow on Renal Tissue Perfusion in Extracorporeal Circulation (체외순환에서 박동 혈류와 비박동 혈류가 신장의 조직관류에 미치는 영향)

  • Kim Hyun Koo;Son Ho Sung;Fang Yang Hu;Park Sung Young;Kim Kwang Taik;Kim Hark Jei;Sun Kyung
    • Journal of Chest Surgery
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    • v.38 no.1 s.246
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    • pp.13-22
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    • 2005
  • It has been known that pulsatile flow is physiologic and more favorable to tissue perfusion than nonpulsatile flow. The purpose of this study is to directly compare the effect of pulsatile versus nonpulsatile blood flow to renal tissue perfusion in extracorporeal circulation by using a tissue perfusion measurement system. Material and Method: Total cardiopulmonary bypass circuit was constructed to twelve Yorkshire swines, weighing 20$\~ $30 kg. Animals were randomly assigned to group 1 (n=6, non pulsatile centrifugal pump) or group 2 (n=6, pulsatile T-PLS pump). A probe of the tissue perfusion measurement system $(QFlow^{TM}-500)$ was inserted into the renal pa­renchymal tissue. Extracorporeal circulation was maintained for an hour at a pump flow of 2 L/min after aortic cross-clamping. Tissue perfusion flow of the kidney was measured at baseline (before bypass) and every 10 minutes after bypass. Serologic parameters were collected at baseline and 60 minutes after bypass. Result: Baseline parameters were not different between the groups. Renal tissue perfusion flow was substantially higher in the pulsatile group throughout the bypass (ranged 48.5$\~$ 64 in group 1 vs. 65.8$\~$88.3 mL/min/100 g in group 2, p=0.026$\~$ 0.45) The difference was significant at 30 minutes bypass $(47.5{\pm}18.3\;in\;group\;1\;vs.\;83.4{\pm}28.5$ mL/min/100 g in group 2, p=0.026). Serologic parameters including plasma free hemoglobin, blood urea nitrogen, and creatinine showed no differences between the groups at 60 minutes after bypass (p=NS). Conclusion: Pulsatile flow is more beneficial to tissue perfusion of the kidney in short-term extracorporeal circulation. Further study is suggested to observe the effects to other vital organs or long-term significance.

A Study on Industries's Leading at the Stock Market in Korea - Gradual Diffusion of Information and Cross-Asset Return Predictability- (산업의 주식시장 선행성에 관한 실증분석 - 자산간 수익률 예측 가능성 -)

  • Kim Jong-Kwon
    • Proceedings of the Safety Management and Science Conference
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    • 2004.11a
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    • pp.355-380
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    • 2004
  • I test the hypothesis that the gradual diffusion of information across asset markets leads to cross-asset return predictability in Korea. Using thirty-six industry portfolios and the broad market index as our test assets, I establish several key results. First, a number of industries such as semiconductor, electronics, metal, and petroleum lead the stock market by up to one month. In contrast, the market, which is widely followed, only leads a few industries. Importantly, an industry's ability to lead the market is correlated with its propensity to forecast various indicators of economic activity such as industrial production growth. Consistent with our hypothesis, these findings indicate that the market reacts with a delay to information in industry returns about its fundamentals because information diffuses only gradually across asset markets. Traditional theories of asset pricing assume that investors have unlimited information-processing capacity. However, this assumption does not hold for many traders, even the most sophisticated ones. Many economists recognize that investors are better characterized as being only boundedly rational(see Shiller(2000), Sims(2201)). Even from casual observation, few traders can pay attention to all sources of information much less understand their impact on the prices of assets that they trade. Indeed, a large literature in psychology documents the extent to which even attention is a precious cognitive resource(see, eg., Kahneman(1973), Nisbett and Ross(1980), Fiske and Taylor(1991)). A number of papers have explored the implications of limited information- processing capacity for asset prices. I will review this literature in Section II. For instance, Merton(1987) develops a static model of multiple stocks in which investors only have information about a limited number of stocks and only trade those that they have information about. Related models of limited market participation include brennan(1975) and Allen and Gale(1994). As a result, stocks that are less recognized by investors have a smaller investor base(neglected stocks) and trade at a greater discount because of limited risk sharing. More recently, Hong and Stein(1999) develop a dynamic model of a single asset in which information gradually diffuses across the investment public and investors are unable to perform the rational expectations trick of extracting information from prices. Hong and Stein(1999). My hypothesis is that the gradual diffusion of information across asset markets leads to cross-asset return predictability. This hypothesis relies on two key assumptions. The first is that valuable information that originates in one asset reaches investors in other markets only with a lag, i.e. news travels slowly across markets. The second assumption is that because of limited information-processing capacity, many (though not necessarily all) investors may not pay attention or be able to extract the information from the asset prices of markets that they do not participate in. These two assumptions taken together leads to cross-asset return predictability. My hypothesis would appear to be a very plausible one for a few reasons. To begin with, as pointed out by Merton(1987) and the subsequent literature on segmented markets and limited market participation, few investors trade all assets. Put another way, limited participation is a pervasive feature of financial markets. Indeed, even among equity money managers, there is specialization along industries such as sector or market timing funds. Some reasons for this limited market participation include tax, regulatory or liquidity constraints. More plausibly, investors have to specialize because they have their hands full trying to understand the markets that they do participate in

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Coolant Leak Effect on Polymer Electrolyte Membrane Fuel Cell (고분자전해질연료전지의 냉각수 누설에 대한 연구)

  • Song, Hyun-Do;Kang, Jung-Tak;Kim, Jun-Bom
    • Journal of the Korean Electrochemical Society
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    • v.10 no.4
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    • pp.301-305
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    • 2007
  • The performance of polymer electrolyte membrane fuel cell could be decreased due to coolant leaked from connection part. Micro pump was used to put small amount of coolant and investigate the effect on fuel cell. The stoichiometric ratio of hydrogen/air was 1.5/2.0, both side of gas was fully humidified, and current density of $400mA/cm^2$ was used as standard condition in this experiment. Constant current method was used to check performance recovery from coolant effect in 3 cell stack. The performance was recovered when coolant was injected in cathode side. On the other hand, the performance was not recovered when coolant was injected in anode side. Ethylene glycol could be converted to CO in oxidation process and cause poisoning effect on platinum catalyst or be adhered on GDL and cause gas diffusion block effect resulting performance decrease. Water with nitrogen gas was supplied in anode side to check performance recovery. Polarization curve, cyclic voltammetry, electrochemical impedance spectroscopy was used to check performance, and gas chromatography was used to check coolant concentration. Constant current method was not enough in full recovery of performance. However, water injection method was proved good method in full recovery of performance.

Oceanic Diffusion Characteristics in Jinhae Bay (진해만의 해양확산특성연구)

  • An, Yu-Sin;Kim, Yeong-Seop;Han, Yeong-Ho
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.18 no.1
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    • pp.1-10
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    • 1982
  • Diffusion processes in tidal swinging coastal waters are studied by releasing one hundred liters of Rhodamine B four times. Dye patches were formed from instantaneous point sources. The patches were sampled with a pump on a tracking boat, and samples were analyzed with fluorospectro-photometer. The patterns of patches were reconstructed and their characteristics were analyzed in terms of variance of concentration, area estimation, and decrease rate of peak concentration. In all of the four experiments, the dye patches were mos시 elongated to the direction of current axis. the elongation rate was 0.34 on the average. Apparent diffusivities were 620 to 3,000 cm super(2) /sec during initial period of 90 minutes. The variance increased by exp(0.047t) on the average, and peak concentration deceased by exp(-0.044t) on the average.

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Sampling and Analysis of Soil Pore Water for Predicting the Diffusion and Behavior of Soil Pollutant Using Soil Lysimeter (토양라이시미터를 이용한 토양오염확산.거동 예측을 위한 토양공극수 채취와 분석)

  • Ko, Il-Won;Lee, Se-Yong;Kim, Kyoung-Woong;Lee, Jin-Soo
    • Economic and Environmental Geology
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    • v.40 no.5
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    • pp.551-561
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    • 2007
  • This case study is about the sampling and interpretation of soil pore water in order to understand and to predict the diffusion and behavior of soil pollution. For the measurement of polycyclic aromatic hydrocarbons(PAHs) in two representative hydrocarbon-contaminated sites, the extraction system of the soil pore water was set up with respect to soil depths and the behavior of contaminants was interpreted. The soil solution extraction system consisted of peristaltic pump, and extraction and sampling compartment, and can measure simultaneously the soil water pressure. The concentration of PAHs with respect to extraction pressure and time decreased due to dilution through soil pore water. Particularly, the concentration of PAHs was more reduced under the unsaturated oxic condition than saturated anoxic condition. Therefore, the soil solution extraction with respect to soil water pressure can interpret the extent of equilibrium between porewater and soil surface.