• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.286-286
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• 1996

In order to elucidate the mechanism of action of transdermal absorption-enhancing compounds, i.e., pyrrolidone derivatives (2-pyrrolidone, 1-methyl-2-pyrrolidone, 1-ethyl-2-pyrrolidone, 1,5-dimethyl-pyrrolidone and 5-methyl-2-pyrrolidone), multilamellar liposome was prepared from the simulated stratum corneum lipid and employed as a model system for the barrier function of the stratum corneum. The liposomal membrane of the stratum corneum lipid liposome (SCLL) behaves as an osmometer and has an excellent barrier function. In addition, its phase transition temperatures are similar to those of human stratum corneum intercellular lipid region. Therefore, SCLL seems to be a useful skin model. To estimate the barrier function of SCLL, the osmotic behavior of SCLL was measured in the presence of pyrrolidone derivatives and the effect on the phase transition temperature of SCLL was also investigated using differential calorimetry. Above a certain concentration (MLAC), enhances perturb the barrier function of the liposome. The relationship between MLACs and the partition coefficient of the pyrrolidone derivatives was observed; the greater the partition coefficients, the smaller the MLAC. This suggests that the more hydrophobic enhancers penetrate into the lipid layer more easily and reduce the barrier function of membrane more effectively. The results of differential scanning thermograms of the SCLL suggest that the pyrrolidone derivatives had incorporated into the lipid layer in the liposome and increased the fluidity of the lipid layer in the liposome. Such activity might have some correlation with the transdermal absorption-enhancing activity these compounds.

• Structural Engineering and Mechanics
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• v.35 no.2
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• pp.191-203
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• 2010

To investigate the critical buckling load and post-buckling behavior of an axially loaded pile entirely embedded in soil, the non-linear large deflection differential equation for a pinned pile, based on the Winkler-model and the discretionary distribution function of the foundation coefficient along pile shaft, was established by energy method. Assuming that the deflection function was a power series of some perturbation parameter according to the boundary condition and load in the pile, the non-linear large deflection differential equation was transformed to a series of linear differential equations by using perturbation approach. By taking the perturbation parameter at middle deflection, the higher-order asymptotic solution of load-deflection was then found. Effect of ratios of soil depth to pile length, and ratios of pile stiffness to soil stiffness on the critical buckling load and performance of piles (entirely embedded and partially embedded) after flexural buckling were analyzed. Results show that the buckling load capacity increases as the ratios of pile stiffness to soil stiffness increasing. The pile performance will be more stable when ratios of soil depth to pile length, and soil stiffness to pile stiffness decrease.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.19 no.2
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• pp.204-210
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• 2010

The inner structure of the triangular separate bar (TSB) was improved to enhance the productivity of the TSB flow meter by simplifying the machining process for making the flow meter. The cross section of upstream and downstream pressure chamber in the TSB was changed from triangle to circle, which make it possible to substitute the wire cutting by drilling in the process of machining the pressure chamber. The flow rate characteristics of the flow meters was calibrated with a laminar flow meter. Six kinds of flow meters whose diameters of pressure tap for measuring pressure of both upsteam and downstream pressure chamber were different one another were made. The effects of the pressure tap diameter on the flow rate characteristics of the TSB flow meter was little. The mass flow rate characteristics of the flow meters with increasing a non-dimensional parameter which includes the gas temperature, exhaust gas pressure and differential pressure at the flow meters and atmospheric pressure shows nearly linear relationship with a correlation coefficient of R=0.998.

• Archives of Pharmacal Research
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• v.24 no.2
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• pp.100-104
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• 2001

Differential pulse polarographic(DPP) analytical procedure for the rifampicin antibiotic, which can be applied to monitor its synthetic process from the starting antibiotic of rifamycin B or rifamycin SV has been developed based on the electrochemical reduction of an azomethine group. Rifampicin exhibited a cathodic peak due to the azomethine group in the side chain of 3-[(4-methyl-1-piperazinyl)imino]methyl moiety and another cathodic peak due to the carbonyl group in rifamycin SV by DPP. The experimental peak potential shift of an azomethine reduction was -73 mV/pH in the pH range between 3.0 and 7.5, agreeing with involvement of 4 e-and 5 $H^5$ in its reduction. By the cyclic voltammetric(CV) studies, the azomethine and the carbonyl reductions in rifampicin were processed irreversibly on the mercury electrode. The plot of peak currents vs. concentrations of rifampicin ranging $1.0{\times}10^{-7} M~$1.0{\times}10^{-5} M yielded a straight line with a correlation coefficient of 0.9996. The detection limit was $1.0{\times}10^{-8} M with a modulation amplitude of 50 mV DPP has been successfully applied for the determination of rifampicin in the pharmaceutical preparations.

• Journal of Power System Engineering
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• v.12 no.2
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• pp.35-40
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• 2008

This paper deals with the free vibrations of conical shells with linearly variable thickness by the transfer influence coefficient method. The classical thin shell theory based upon the Flugge theory is assumed and the governing equations of a conical shell are written as a coupled set of first order matrix differential equations using the transfer matrix. The Runge-Kutta-Gill integration method is used to solve the governing differential equation. The natural frequencies and corresponding mode shapes are calculated numerically for the conical shells with linearly variable thickness and various boundary conditions at the edges. The present method is applied to conical shells with linearly varying thickness, and the effects of the semi-vertex angle, the number of circumferential waves and thickness ratio on vibration are studied.

• Advances in materials Research
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• v.6 no.1
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• pp.27-43
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• 2017

The transient thermo-mechanical behavior of a simply-supported beam made of a functionally graded material (FGM) under the effect of a moving heat source is investigated. The FGM consists of a ceramic part (on the top), which is the hot side of the beam as the heat source motion takes place along this side, and a metal part (in the bottom), which is considered the cold side. Grading is in the transverse direction, with the properties being temperature-dependent. The main steps of the thermo-elastic modeling included deriving the partial differential equations for the temperatures and deflections in time and space, transforming them into ordinary differential equations using Laplace transformation, and finally using the inverse Laplace transformation to find the solutions. The effects of different parameters on the thermo-mechanical behavior of the beam are investigated, such as the convection coefficient and the heat source intensity and speed. The results show that temperatures, and hence the deflections and stresses increase with less heat convection from the beam surface, higher heat source intensity and low speeds.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.18 no.3
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• pp.245-256
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• 2014

This work is focused on the boundary layer and heat transfer characteristics of hydromagnetic flow over a stretching sheet with variable thickness. Steady, two dimensional, nonlinear, laminar flow of an incompressible, viscous and electrically conducting fluid over a stretching sheet with variable thickness and power law velocity in the presence of variable magnetic field and variable temperature is considered. Governing equations of the problem are converted into ordinary differential equations utilizing similarity transformations. The resulting non-linear differential equations are solved numerically by utilizing Nachtsheim-Swigert shooting iterative scheme for satisfaction of asymptotic boundary conditions along with fourth order Runge-Kutta integration method. Numerical computations are carried out for various values of the physical parameters and the effects over the velocity and temperature are analyzed. Numerical values of dimensionless skin friction coefficient and non-dimensional rate of heat transfer are also obtained.

• Geomechanics and Engineering
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• v.4 no.4
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• pp.229-241
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• 2012

In this paper, utilizing void ratio-effective stress and void ratio-permeability relationships, a system of two nonlinear partial differential equations is derived to predict the consolidation characteristics of normally consolidated (NC) and overconsolidated (OC) soft clays subjected to cyclic loading. A developed feature of the coefficient of consolidation containing two key parameters is emerged from the differential equations. Effect of these parameters on the consolidation characteristics of soft clays is analytically discussed. It is shown that the ratios between the slopes of e-$log{\sigma}^{\prime}$ and e-log k lines in the NC and OC states play a major role in the consolidation process. In the companion paper, the critical assumptions made in the analytical discussion are experimentally verified and a numerical study is carried out in order to examine the proposed theory.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.5 no.4
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• pp.243-248
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• 1993

In this research, unsteady groundwater flow in unconfined and homogeneous three layer aquifers is studied theoretically and experimentally. Numerical solutions are obtained by Runge Kutta and Runge Kutta Gill method after transforming the governing nonlinear partial differential equations to nonlinear ordinary differential equations. Experimental apparatus includes a test section filled with fine, medium and coarse sands. Experimental results are compared with the numerical solutions and both experimental and numerical results correspond well with each other. This numerical approach may be also applied to the cases which have more aquifers.

• Bulletin of the Korean Chemical Society
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• v.29 no.1
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• pp.38-42
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• 2008

The voltammetic behavior of Vitamin B6 (VB6) was studied at a glassy carbon electrode in phosphate buffers using cyclic, linear sweep and differential pulse voltammetry. The oxidation process was shown to be irreversible over the entire pH range studied (4.0-10.0) and was adsorption controlled. The adsorption amount of VB6 on the glassy carbon electrode was examined by chronocoulometry and the value of n, product of transfer coefficient and number of electrons transferred in the rate determining step, was determined from Tafel plot. VB6 was determined by differential pulse voltammetry and the peak current was found linearly with its concentration in the range of 3 10-7-2 10-4 mol L-1. The detection limit was 1 10-7 mol L-1. The procedure was successfully applied for the assay of VB6 in tablets.