• Title/Summary/Keyword: diagnostic evaluation

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Diagnostic Value of Flow Cytometric DNA Analysis in the Evaluation of Effusions (체강삼출액의 진단에 있어서 유세포분석에 의한 DNA 함량 측정의 유용성)

  • Lee, Ji-Shin;Juhang, Sang-Woo
    • The Korean Journal of Cytopathology
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    • v.8 no.1
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    • pp.20-26
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    • 1997
  • The specificity of cytologic examination in effusions is high but the sensitivity is low. Therefore, various ancillary methods for the detection of malignant cells in effusions have been proposed. The presence of an aneuploid cell population is generally considered diagnostic of malignancy. The purpose of this study is to determine whether the routine use of flow cytometry adds to standard cytologic evaluation in effusions. We did flow cytometric DNA analysis in 76 effusions(28 malignant and 48 benign fluids). All the 48 benign effusions were diploid. There were 12(42.9%) aneuploid and 16(67.1%) diploid malignant effusions. Based on these results flow cytometric DNA analysis had a sensitivity of 42.9% and a specificity of 100%. These results suggest that flow cytometric DNA analysis may be a useful adjunct to conventional cytology, but its principal limitation is us relatively low sensitivity.

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A Study on Heat-Flux Evaluation for Cable Fire Including Diagnostic Methodology for Degradation in Nuclear Power Plants (원전 케이블 화재 열속평가 및 열화 진단방법에 관한 연구)

  • Lim, Hyuk-Soon;Kim, Doo-Hyun
    • Journal of the Korean Society of Safety
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    • v.26 no.2
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    • pp.20-25
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    • 2011
  • The fire event occurred in fire proof zone often causes serious electrical problems such as shorts, ground faults, or open circuits in nuclear power plants. These would be directed to the loss of safe shutdown capabilities performed by safety related systems and equipments. The fire event can treat the basic design principle that safety systems should keep their functions with redundancy and independency. In case of a multi-core cable fire, operators can not perform their mission properly and can misjudge the situation because of spurious operation, wrong indication or instrument. These would deteriorate the plant capabilities of safety shutdown and make disastrous conditions. In this paper, the characteristic of cable fire is investigated and the heat-flux evaluation for cable fire is studied. Moreover, a diagnostic methodology for degraded cable in nuclear power plants is presented.

A Evaluation Method of Operational Performance for Air-operated Gate Valve (공기구동 게이트밸브의 운전 성능평가 방법에 관한 연구)

  • Kim, Dae-Woong;Park, Sung-Keun;Kang, Shin-Cheul;Kim, Yang-Suk
    • The KSFM Journal of Fluid Machinery
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    • v.12 no.2
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    • pp.31-38
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    • 2009
  • The valve performance has been evaluated from the theoretical equation based on design information such as packing thrust, spring preload and friction coefficient(${\mu}$). The accuracy of those data can be lower than that of vendor's initial design data. Especially, the friction coefficient can be degraded with time than the original condition and the valve performance calculated using the previous friction coefficient can not be available. Accordingly, this paper is describing a new performance evaluation method of valve based on diagnostic test data which are acquired from a site valve tested in static and dynamic conditions. Especially, this paper provides a new method using friction coefficient(${\mu}$) which is derived from the diagnostic test data acquired in the valve's design basis condition.

Evaluation of Sympathetic Innervation in Cardiomyopathy with $^{123}I-MIBG$ (심근병에서 $^{123}I-MIBG$ 영상을 이용한 교감신경기능의 평가)

  • Kim, Sun-Jung;Lee, Jong-Doo;Lee, Do-Yun;Park, Chang-Yoon;Ham, Jin-Kyung;Chung, Nam-Sik;Cho, Seung-Yun;Lee, Sung-Sook;Kim, Young-Soo
    • The Korean Journal of Nuclear Medicine
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    • v.27 no.2
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    • pp.195-202
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    • 1993
  • $^{123}Iodine$-metaiodobenzylguanidine (MIBG) which is a norepinephrine analogue, can be used to evaluate the sympathetic innervation of the heart. In this study, cardiac imaging with $^{123}I-MIBG$ was performed in patients with 9 dilated cardiomyopathy, 2 ischemic cardiomyopathy and 1 acute myocardial infarction to evaluate the sympathetic nervous function. $^{123}I-MIBG$ imaging showed multifocal defects (8), diffuse defect (2), near non-visualization (2). The defects of MIBG scans were found to be larger and more severe on 4 hours image than 30 minutes. Heart to lung, heart to mediastinum ratios were decreased at 4 hours than those at 30 minutes. Measured LVEF values were not correlated with the severity of MIBG uptake. $^{99m}Tc-MIBI$ imaging was also performed in all patients to find the relationship with $^{123}I-MIBG$ scan. $^{99m}Tc-MIBI$ scan showed multifocal defects in 9 patients, diffuse defects in 1 patient and no defect in 2 patients. The defects are similar in size, severity and extent, but more larger and severe on $^{123}I-MIBG$ imaging. Therefore, cardiac $^{123}I-MIBG$ imaging is a useful method to evaluate the sympathetic nervous function in cardiomyopathy.

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Evaluation by Contrast-Enhanced MR Imaging of the Lateral Border Zone in Reperfused Myocardial Infarction in a Cat Model

  • Ae Kyung Jeong;Sang Il Choi;Dong Hun Kim;Sung Bin Park;Seoung Soo Lee;Seong Hoon Choi;Tae-Hwan Lim
    • Korean Journal of Radiology
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    • v.2 no.1
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    • pp.21-27
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    • 2001
  • Objective: To identify and evaluate the lateral border zone by comparing the size and distribution of the abnormal signal area demonstrated by MR imaging with the infarct area revealed by pathological examination in a reperfused myocardial infarction cat model. Materials and Methods: In eight cats, the left anterior descending coronary artery was occluded for 90 minutes, and this was followed by 90 minutes of reperfusion. ECG-triggered breath-hold turbo spin-echo T2-weighted MR images were initially obtained along the short axis of the heart before the administration of contrast media. After the injection of Gadomer-17 and Gadophrin-2, contrast-enhanced T1-weighted MR images were obtained for three hours. The size of the abnormal signal area seen on each image was compared with that of the infarct area after TTC staining. To assess ultrastructural changes in the myocardium at the infarct area, lateral border zone and normal myocardium, electron microscopic examination was performed. Results: The high signal area seen on T2-weighted images and the enhanced area seen on Gadomer-17-enhanced T1WI were larger than the enhanced area on Gadophrin-2-enhanced T1WI and the infarct area revealed by TTC staining; the difference was expressed as a percentage of the size of the total left ventricle mass (T2= 39.2 %; Gadomer-17 =37.25 % vs Gadophrin-2 = 29.6 %; TTC staining = 28.2 %; p < 0.05). The ultrastructural changes seen at the lateral border zone were compatible with reversible myocardial damage. Conclusion: In a reperfused myocardial infarction cat model, the presence and size of the lateral border zone can be determined by means of Gadomer-17- and Gadophrin-2-enhanced MR imaging.

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