The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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Evaluation of Sympathetic Innervation in Cardiomyopathy with $^{123}I-MIBG$

심근병에서 $^{123}I-MIBG$ 영상을 이용한 교감신경기능의 평가

  • Kim, Sun-Jung (Department of Diagnostic Radiology, College of Medicine, Yonsei University) ;
  • Lee, Jong-Doo (Department of Diagnostic Radiology, College of Medicine, Yonsei University) ;
  • Lee, Do-Yun (Department of Diagnostic Radiology, College of Medicine, Yonsei University) ;
  • Park, Chang-Yoon (Department of Diagnostic Radiology, College of Medicine, Yonsei University) ;
  • Ham, Jin-Kyung (Department of Diagnostic Radiology, College of Medicine, Yonsei University) ;
  • Chung, Nam-Sik (Department of Cardioloay, College of Medicine, Yonsei University) ;
  • Cho, Seung-Yun (Department of Cardioloay, College of Medicine, Yonsei University) ;
  • Lee, Sung-Sook (Department of Diagnostic Radiology, Inje University College of Medicine) ;
  • Kim, Young-Soo (Department of Diagnostic Radiology, Inje University College of Medicine)
  • 김선정 (연세대학교 의과대학 진단방사선과학교실) ;
  • 이종두 (연세대학교 의과대학 진단방사선과학교실) ;
  • 이도연 (연세대학교 의과대학 진단방사선과학교실) ;
  • 박창윤 (연세대학교 의과대학 진단방사선과학교실) ;
  • 함진경 (연세대학교 의과대학 진단방사선과학교실) ;
  • 정남식 (연세대학교 의과대학 심장내과학교실) ;
  • 조승연 (연세대학교 의과대학 심장내과학교실) ;
  • 이성숙 (인제대학교 의과대학 진단방사선과학교실) ;
  • 김용수 (인제대학교 의과대학 진단방사선과학교실)
  • Published : 1993.11.15
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Abstract

$^{123}Iodine$-metaiodobenzylguanidine (MIBG) which is a norepinephrine analogue, can be used to evaluate the sympathetic innervation of the heart. In this study, cardiac imaging with $^{123}I-MIBG$ was performed in patients with 9 dilated cardiomyopathy, 2 ischemic cardiomyopathy and 1 acute myocardial infarction to evaluate the sympathetic nervous function. $^{123}I-MIBG$ imaging showed multifocal defects (8), diffuse defect (2), near non-visualization (2). The defects of MIBG scans were found to be larger and more severe on 4 hours image than 30 minutes. Heart to lung, heart to mediastinum ratios were decreased at 4 hours than those at 30 minutes. Measured LVEF values were not correlated with the severity of MIBG uptake. $^{99m}Tc-MIBI$ imaging was also performed in all patients to find the relationship with $^{123}I-MIBG$ scan. $^{99m}Tc-MIBI$ scan showed multifocal defects in 9 patients, diffuse defects in 1 patient and no defect in 2 patients. The defects are similar in size, severity and extent, but more larger and severe on $^{123}I-MIBG$ imaging. Therefore, cardiac $^{123}I-MIBG$ imaging is a useful method to evaluate the sympathetic nervous function in cardiomyopathy.

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