• 정보처리학회논문지B
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• 제16B권2호
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• pp.165-172
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• 2009

최근 ACS에 따르면 여성에게 유방암은 가장 많이 발병하는 암으로서 그 사망자 수도 두 번째로 많은 암이다. 유방 X선 영상의 종괴나 석회 환부는 진단을 위한 가장 중요한 단서로서 알려져 있으므로 유방암의 조기진단을 위하여 디지털 유방 X선 영상을 컴퓨터에서 처리하는 연구가 진행되고 있다. 본 논문에서는 퍼지 클러스터 지식베이스에 기반을 둔 진단시스템을 제안한다. 제안된 시스템은 듀얼 OFUN-NET에 두 가지 종류의 특징 데이터를 처리하여 진단결과와 그 가능성을 알려준다. 실세계 의료기관으로부터 수집되고 공개적으로 제공되는 유방 X선 데이터베이스 DDSM으로부터 획득한 종괴와 석회 환부의 데이터를 사용하여 실험한다. 실험결과는 제안된 시스템이 기존의 방법보다 높은 분류 정확도와 유방 X선 영상 진단시스템으로서 전문가의 의사 결정을 도울 수 있는 타당한 결과를 보여준다.

• 제어로봇시스템학회논문지
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• 제5권4호
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• pp.427-436
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• 1999

This paper describes an ECG signal labeling algorithm based on fuzzy clustering, which is very useful to the automated ECG diagnosis. The existing labeling methods compares the crosscorrelations of each wave form using IF-THEN binary logic, which tends to recognize the same wave forms such as different things when the wave forms have a little morphological variation. To prevent this error, we have proposed as ECG signal labeling algorithm using fuzzy clustering. The center and the membership function of a cluster is calculated by a cluster validity function. The dominant cluster type is determined by RR interval, and the representative beat of each cluster is determined by MF (Membership Function). The problem of IF-THEN binary logic is solved by FCM (Fuzzy C-Means). The MF and the result of FCM can be effectively used in the automated fuzzy inference -ECG diagnosis.

• Macromolecular Research
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• 제13권3호
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• pp.167-175
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• 2005

This review explores recent works involving the use of the self-assembled nanoparticles of bile acid-modified glycol chitosans (BGCs) as a new drug carrier for cancer therapy. BGC nanoparticles were produced by chemically grafting different bile acids through the use of l-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC). The precise control of the size, structure, and hydrophobicity of the various BGC nanoparticles could be achieved by grafting different amounts of bile acids. The BGC nanoparticles so produced formed nanoparticles ranging in size from 210 to 850 nm in phosphate-buffered saline (PBS, pH=7.4), which exhibited substantially lower critical aggregation concentrations (0.038-0.260 mg/mL) than those of other low-molecular-weight surfactants, indicating that they possess high thermodynamic stability. The SOC nanoparticles could encapsulate small molecular peptides and hydrophobic anticancer drugs with a high loading efficiency and release them in a sustained manner. This review also highlights the biodistribution of the BGC nanoparticles, in order to demonstrate their accumulation in the tumor tissue, by utilizing the enhanced permeability and retention (EPR) effect. The different approaches used to optimize the delivery of drugs to treat cancer are also described in the last section.

• 보건행정학회지
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• 제3권2호
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• pp.100-129
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• 1993

This study is designed to find out some intra-clinic factors affecting the content of practice provided by primary care physicians in Korea, and proposed factors in this study are characteristcs of each private clinc --- physician-related variables(age, sex, specialty), bfed-related variables for inpatient care, laboratory-related variables for precise diagnosis. We have tried to estimate the difference of disease entities cared by each primary care physician according to above factors by analyzin gdisease data claimed during one month(April, 1992) to National Federation of Medical Insurance. The diagnosis codes by ICD-9 in the research disease data were reclassified to 'diagnosis clusters' by virtue of clinical similarities for effective analyses. We have converted frequent-tsing ICD-9 codes to 86 diagnosis clusters, which incorporated 97.4 percents of all ambulatory visits to private clinics. This result means proposed diagnosis-cluster method is effective tool for analysis of the content of ambulatory medical care carried out by primary care physicians. Comparisons and analyses of multiple diagnosis-clusters made on the basis of presented factors were done and the results were as follows; - Major factors affecting the difference between diagnosis-cluster pattern by each variables were phyusician's age, sex, specialty and bed counts of each private clinic for inpatient care and the size of laboratories of each clinic. - Middle aged(30th to 40th) group physicians are providing more comprehensive care than 20th or above 50th aged groups. Male physicians are more adequate for comprehensive care than female physicians, because woman-doctors are providing narrow-spectrum care. The content of practice of obstetricians and gynecologists shows much difference from primary medical practice, and they cannot be included in primary care physician, this study suggested. Pediatricians are also providing short-spectum acre, and nearly all visits to pediatricians were incorporated only 2-3 diagnosis-clusters. General surgeons' practices are very similar to general practioners' or family physicians' practices, the means they are providing primary care rather than special surgical care. And small number of beds(under 5 beds) and only basic(2-3 sorts of)diagnostic apparatuses are sufficient for primary physicians' clinic to carry out primary care. In conclusion, to reinforce primary care department in Korea, there must be support with health policy to expand office-based primary care practice-- with small number of beds for inpatient care and only basic laboratories-- provided by general practitioner of family physician.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권2호
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• pp.536-564
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• 2019

Soft faults are inherent in wireless sensor networks (WSNs) due to external and internal errors. The failure of processes in a protocol stack are caused by errors on various layers. In this work, impact of errors and channel misbehavior on process execution is investigated to provide an error classification mechanism. Considering implementation of WSN protocol stack, inter-process correlations of stacked and peer layer processes are modeled. The proposed model is realized through local and global decision trees for fault diagnosis. A hybrid framework is proposed to implement local decision tree on sensor nodes and global decision tree on diagnostic cluster head. Local decision tree is employed to diagnose critical failures due to errors in stacked processes at node level. Global decision tree, diagnoses critical failures due to errors in peer layer processes at network level. The proposed model has been analyzed using fault tree analysis. The framework implementation has been done in Castalia. Simulation results validate the inter-process correlation model-based fault diagnosis. The hybrid framework distributes processing load on sensor nodes and diagnostic cluster head in a decentralized way, reducing communication overhead.

• Korean Journal of Radiology
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• 제24권10호
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• pp.941-943
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• 2023

• 한국전자통신학회논문지
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• 제15권3호
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• pp.611-616
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• 2020

본 논문은 대도시에서의 COVID-19 바이러스 확산을 막기 위해, 대한민국 서울의 감염 상황에 대한 클러스터 분석을 통한 링크드 데이터 기반 시맨틱 진단 및 추적 시스템을 제안한다. 본 논문은 크게 3개의 섹션으로 구성되어 있는데, 클러스터 분석을 위해 서울의 감염자 정보를 수집하고, 중요한 감염 환자 속성을 추출하여 랜덤 포레스트를 기반으로 한 진단 모델을 구축하고, 그리고 링크드 데이터를 기반으로 한 추적 시스템을 설계하고 구현한다. 실험 결과 진단 모델의 정확도가 80% 이상으로 나타났으며, 더군다나 본 논문에서 제안한 추적 시스템은 기존 시스템들보다 더 유연하고 개방적이며 시맨틱 쿼리도 지원한다.

• 대한방사선기술학회지:방사선기술과학
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• 제32권1호
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• pp.45-52
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• 2009

유방 촬영술(Digital mammography)은 유방암의 조기 진단에서 매우 중요한 진단 방법으로서 비촉지성 유방암의 조기 발견율을 높여 유방암에 따른 여성의 사망률을 감소시키고 있다. 그 중에서도 유방 병변의 미세석회화(Microcalcification)는 조기 유방암의 진단에 있어서 중요한 병변으로 보고 되고 있으며, 선별 검사로 임상적 유용성이 확립된 상태이다. 유방 촬영술에서 미세석회화 소견은 영상의학과 전문의가 판독하여 조직 검사에서 양성 및 악성 병변에 대하여 각각 군집의 개수, 군집 당 석회화 수, 미세석회화 크기와 범위, 미세석회화 형태, 동반 종괴의 유무 등을 분석하여 최종적으로 진단을 확정한다. 그러므로 군집화된 미세석회화의 정보는 유방암 예측에 있어 임상적인 실질 정보를 가지고 있으며, 의사에게 진단을 위한 검사의 기본적인 가이드라인을 제시한다. 따라서 본 연구에서는 유방 촬영술의 디지털 영상에 나타난 미세석회화의 정량적인 계산을 위해서 DoG filter, Adaptive thresholding, Expectation Maximization의 3단계를 제안한다. 제안한 알고리듬을 실험을 통하여 군집화 및 각 클러스터 내의 미세석회화의 분포 개수, 길이를 측정하였으며, 임상의 사에게 디지털 유방영상의 분석을 통하여 초기 유방암 진단의 지표를 제시할 것으로 사료된다. 그리고 이는 객관적인 유방암 컴퓨터자동검출(CAD)에 사용될 수 있는 병변의 정보로서 가능성을 보였다.

• 지능정보연구
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• 제6권1호
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• pp.97-112
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• 2000

The basic idea of case-based reasoning is to solve a new problem using the previous problem-solving experiences. In this research we develop a case-based reasoning system for equipment malfunction diagnosis. We first divide the case base into clusters using the case-based clustering technique. Then we develop an appropriate case-based diagnostic system for each cluster. In other words for individual cluster a different case-based diagnostic system which uses different weights for attributes is developed. As a result multiple case-based reasoning system are operating to solve a diagnostic problem. In comparison to the performance of the single case-based reasoning system our system reduces the computation time by 50% and increases the accuracy by 5% point.

• 한국컴퓨터정보학회논문지
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• 제21권1호
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• pp.9-16
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• 2016

In this paper, we present a performance evaluation agent based on fuzzy cluster analysis and validity measures. The proposed agent is consists of three modules, fuzzy cluster analyzer, performance evaluation measures, and feature ranking algorithm for feature selection step in CAD system. Feature selection is an important step commonly used to create more accurate system to help human experts. Through this agent, we get the feature ranking on the dataset of mass and calcification lesions extracted from the public real world mammogram database DDSM. Also we design a CAD system incorporating the agent and apply five different feature combinations to the system. Experimental results proposed approach has higher classification accuracy and shows the feasibility as a diagnosis supporting tool.