• 한국발생생물학회지:발생과생식
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• 제14권4호
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• pp.253-259
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• 2010

DNA 메틸화 (DNA methylation)는 유전자의 발현을 조절하는 대표적인 후생학적 조절기작 (epigenetic regulation) 중에 하나이다. DNA 메틸화 양상은 생식세포 형성과정 및 배 발생단계에서 탈메틸화 (demethylation)와 de novo 메틸화의 드라마틱한 변화가 일어난다. 또한 이러한 DNA 메틸화는 배아줄기세포 (embryonic stem cells, ESCs)에서 특징적인 양상을 보이는 것으로 알려져 있다. 본 연구에서는 생쥐 수정란 유래 배아줄기세포와 체세포핵이식 배아줄기세포 (nuclear transplanted ESCs)를 이용해서 대표적 각인유전자 (imprinting genes)로 알려진 Snrpn, Igf2r, H19 유전자들에 대한 메틸화 양상을 알아보고자 하였다. 연구 결과 H19 유전자에 대해서는 DNA 메틸화 양상은 수정란 유래 배아줄기세포와 체세포핵이식 배아줄기세포에서 비슷한 경향을 보였으나, Snrpn과 Igf2r의 경우에는 체세포핵이식 배아줄기세포에서 과메틸화 (hypermethylation) 경향을 보였다.

• Plant Resources
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• 제2권1호
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• pp.1-9
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• 1999

The callus from the hypocotyl region of immature embryo of Citrus junos Sieb. was efficiently induced in the $\frac{1}{2}$ MS medium containing 45uM BA after 8 weeks culture. The callus was developed into the two callus type, embryogenic callus and nonembryogenic callus, which can be distinguished by visual examination depending on color and appearence. In vitro regeneration of callus established efficiently in the hormone-free MS medium from the embryogenic callus. In order to investigate the physiological changes depending on the developmental stage of embryo, the embryo was formed in the MS medium. The embryogenic and nonembryogenic callus, and the various stages of the somatic embryo were examimed the changes of esterase activity, and their isozyme patterns as well. The protein content and esterase activities was gradually increased on the developmental stages of embryo. Total protein pattern were different by the SDS-PAGE and were appeared strong band of 23 KD in the torpedo stage. The pattern of the esterase isozyme was exhibited a difference between embryogenic callus and nonembryogenic callus. It was appered pI 6.0, 8.0, 8.2 in the embryogenic callus. Also the new band of pI 4.75 was appeared in the cotyledon. These results suggest that the changes of esterase activities and isozyme patterns are importent factor in the differentiation and development of citrus.

• 패션비즈니스
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• 제8권4호
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• pp.68-79
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• 2004

This study aims to understand the history of the Victorian age that attached importance to various designs and aesthetic aspects by art and craft movement, and to present that the Victorian pattern is a factor with unlimited possibility in application and development of the modern textile product designs. Therefore, through documents research home and abroad, I considered the periodical background of the Victorian style, a change course of textile, and the theoretical backing of the Victorian pattern, and I studied and analyzed the cases of being applied in the modern textile product designs by classifying apparel, home interior, and fashion accessories. First of all, in apparel, the Victorian pattern transformed into geometrical form had much relative importance, and secondly, in the home interior, the Victorian pattern was expressed realistically or it was represented more boldly and complexly with new materials or techniques introduced. Thirdly, in fashion accessories, decorative nature was shown in intense design with the real description of the Victorian flower pattern and brilliant colors. With these results, it was found out that when the Victorian pattern was applied in the modern textile product designs, it was the factor that could be expected to make a high value added suitable with the modern sense, and it was the pattern with developmental potential with its unlimited use range. Therefore, based on this study, it is considered that the development of textile product designs utilizing the Victorian pattern and academic research, reorganizing the Victorian pattern in accordance with the modern design should be continued.

• Archives of Plastic Surgery
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• 제38권5호
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• pp.683-686
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• 2011

Purpose: Craniosynostosis of three or more cranial sutures was not common. "Mercedes Benz pattern," named by Moore1 was a rare form of craniosynostosis and had an atypical pattern of premature closure of cranial suture. It was not reported in Republic of Korea. We report this case with literature review. Methods: A 13-months-old male patient visited our clinic due to exophthalmos. He showed normal developmental course. Other neurological tests were normal but he was Crouzon syndrome patient. CT scans showed bilateral lambdoid and posterior sagittal sutures were fused and the length of the skull was extended. Cranioplasty with pi craniotomy & Barrel-Stave osteotomy and recombination of the bone flap was performed. Results: The patient was discharged after post operative 10 days without any complications. In follow up visit after 2.7 years, he was in good state without recurrence and functional abnormality of skull. Conclusion: This was the first case of Mercedes Benz pattern craniosynostosis with Crouzon syndrome in Korea. This type of craniosynostosis has to be considered differently from single type of craniosynostosis or typical syndromic craniosynostosis clinically and surgically.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
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• pp.76-76
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• 2003

Eleven wrasse species inhabit the coastal waters of Jeju Island, Korea. They are the target of leisure fishing and are considered good eating. We investigated the distribution of standard length (SL) by sex of wrasse in Jeju coastal waters for Halichores poecilopterus, H. tenuispinis, Pseudolabrus japonicus, and Pteragogus flagellifera. A cross-section of the ovary showed the ovarian cavity and ovarian lamellae containing oocytes. A cross-section of the testis showed many lobules containing spermatogonia and spermatocytes. A cross-section of a gonad undergoing sex reversal showed the regression or reduction of oocytes and some spermatocytes located in the ovarian lamellae. A cross-section of a sex-reversed testis showed the primary structure of the ovary, with spermatocytes distributed in the epithelium of the lamellae, and reformed seminiferous ducts in the basement lamellae. (중략)

• 한국초등과학교육학회지:초등과학교육
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• 제17권2호
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• pp.23-31
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• 1998

The purpose of the present study was to investigate the development of elementary school student's reasoning strategies used in proportional tasks. Three hundred and ninety elementary students were sampled to investigate their reasoning strategies used in Pouring Water Tasks. Results showed that 4 percentage of students used proportional reasoning strategy. By the way, about 80 % of students used qualitative guess or additive strategies to solve proportion tasks. Further, about fifth-grade or 11-year-old students began to use proportional reasoning strategy. Also, female and malt students' development of reasoning strategies improved from 1st grade across 5th grade and from 6-year-old across 11-year-old. However, female did not show the improvement of strategy development after 5th-grade or 11-year-old. However, male students showed a continuous improvement after the grade or age. In addition, students showed developmental patterns of spurts and plateau, ra thor than a linear developmental pattern. The present study also discussed educational implications of this findings in school curriculum.

• BMB Reports
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• 제32권2호
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• pp.103-111
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• 1999

Hh proteins represent a new signaling paradigm in metazoan development. In species ranging from fruit flies to humans, Hh proteins mediate multiple processes vital to appropriate pattern formation in the developing embryo. Hh proteins undergo an autoprocessing event in which the full-length protein is cleaved into N-terminal and C-terminal domains (Hh-N and Hh-C, respectively), and a cholesterol moiety becomes covalently attached to Hh-N. All known signaling activities of Hh proteins are mediated by Hh-N while both the cleavage and cholesterol transfer reactions are mediated by Hh-C. The cholesterol attached to Hh-N is required to retrict the range of Hh signaling and may be involved in ensuring appropriate reception of the Hh signal in target tissues. Disruptions of Hh signaling pathways lead to severe developmental defects in newborns and cancers in adults. While studies of Hh proteins have yielded a wealth of new insight into the molecular mechanisms of metazoan development, many outstanding questions concerning Hh signaling mechanisms ensure that unraveling the secrets of this molecule will keep scientists well entertained for the foreseeable future.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2005년도 제5회 발생공학 국제심포지엄 및 학술대회
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• pp.57-58
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• 2005

• 대한치과교정학회지
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• 제11권2호
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• pp.77-83
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• 1981

The author analyzed the morphological pattern of mandibles and lower third molars in order to study and predict the impaction of the developmental third molars. The subjects consisted of 37 males and 87 females with malocclusion. The following results were obtained: 1. The mandible was shown to be shorter in the impacted third molar group than in the erupted group, both in over-all length and in body length. 2. The developmental mesial angulation of the third molar to the mandibular plane was higher in the impacted third molar group. 3. There was a tendency for impacted third molars to be slightly larger than those which erupted except Class II malocclusion in female. 4. In the available space for the eruption of the third molar, significant space deficiency was found in association with the impacted third molar group compared with the erupted group.

• 아동학회지
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• 제19권2호
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• pp.133-146
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• 1998

This study was designed to assess the developmental sequence of children's understanding of social interaction and to test the effects of support conditions and behavioral domains on the understanding of social interaction. The subjects were one hundred 4- to 8-year-old children. The method was a doll play situation, composed of three different support conditions. Scalogram analysis was used to test the developmental sequence, and ANOVA and paired t-test were used to test the significance of differences in stages. The results of this study evidenced a sequential pattern in the 4- to 8-year-old children's understanding of social interaction. There were also significant differences between stages in the understanding of social interaction according to support conditions and behavioral domains. Higher levels of support produced higher stages of understanding and the understanding of positive social interactions were higher than those of negative social interactions at ages 4 and 5.