• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1749-1752
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• 2012

Colorectal cancer (CRC), now the third most common cancer across the world, is known to aggregate in families. USP7 is a very important protein with an important role in regulating the p53 pathway, which is critical for genomic stability and tumor suppression. We here genotyped eight SNPs within the USP7 gene and conducted a case-control study in 312 CRC patients and 270 healthy subjects in the Chinese Han population. No significant associations were found for any single SNP and CRC risk. Our data eliminate USP7 as a potential candidate gene towards for CRC in the Han Chinese population.

• 재활복지
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• 제15권4호
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• pp.27-47
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• 2011

본 논문은 발달장애인의 역량강화를 통해 지역사회로의 자연스러운 전환을 목표로 한 전환과정과 프로그램을 개발하기 위한 연구이다. 연구목적을 달성하기 위하여 문헌연구, 관련 프로그램 사례조사, 전문가 심층면접 방법을 활용하였으며 연구의 결과는 다음과 같다. 첫째, 현재 발달장애인들을 고려한 전환과정은 지나치게 제한되어 있고 이들의 특성을 고려하지 못하고 있다. 둘째, 발달장애인을 위한 새로운 고등교육프로그램이 새로운 전환과정으로 시작되고 있으나 중등학교와 연계가 부족하다. 셋째, 중등학교 이후 발달장애인을 위한 대학프로그램에서 중요하게 고려되어야 하는 요인은 자기인지와 자기이해이다. 이 결과를 중심으로 한국에서 발달장애인을 위한 대학 내 전환과정과 프로그램을 제안하면 첫째, 발달장애인을 위한 중등학교 이후 전환과정은 최소한 발달장애인의 특성과 자기이해와 자기인지가 이루어질 수 있도록 주류화교육이 이루어져야 하며, 이를 고려할 때 대학 내에서의 전환과정 구성은 하나의 대안이 될수 있다. 둘째, 대학 내 구성되는 고등교육프로그램은 다음과 같은 측면이 고려되어 구성될 필요가 있다. ① 대학 내의 많은 고등교육 관련 프로그램의 지원을 받을 수 있도록 연계되거나 지원망이 구축될 필요가 있다. ② 대학 내의 모든 프로그램에 발달장애학생들이 참여할 수 있도록 문호가 개방되어야 한다. ③ 대학 내의 전문 인력들이 필요에 따라 참여할 수 있도록 인적구성이 체계화되고 연계될 수 있어야 한다. ④ 대학 내의 비장애학생들이 발달장애학생들의 프로그램에 참여할 수 있도록 통합학습이나 활동이 자연스럽게 이루어질 수 있도록 해야 한다.

• 한국정보통신학회논문지
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• 제20권8호
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• pp.1561-1568
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• 2016

발달장애청소년은 지적기능과 적응행동에 현저히 제한이 있기 때문에 이들이 고등학교 졸업 후 지역사회의 한 구성원으로서 독립적으로 살아가기 위해서는 개인의 다양성 및 환경적인 차이를 고려한 지속적인 교육이 병행되어야 한다. 컴퓨터교육은 '교육의 평등과 보편성의 확대'라는 측면에서 지역사회적응에 있어 유용한 도구로 활용될 수 있다. 특히, 전환기교육과정으로서의 컴퓨터교육은 성인사회에서 독립적이고 일상적인 삶을 지속하는데 있어 실질적 도움이 된다. 따라서 이 논문은 1)발달장애청소년의 지역사회 적응과 전환기 교육 2) 발달장애청소년을 위한 컴퓨터교육의 중요성과 의의 3)발달장애청소년을 위한 컴퓨터교육의 현황을 살펴보았으며, 이를 통해 발달장애인을 위한 컴퓨터교육의 개선방안을 제시하였다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제18권2호
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• pp.88-96
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• 2007

Pervasive developmental disorders are characterized by lifelong impairments in fundamental social and/or communication skills and by the presence of seemingly purposeless and repetitive behaviors, interests, or activities. A number of possible biological etiologies, including genetic, structural and functional brain abnormalities, have been identified in patients with pervasive developmental disorders. In addition, clinicians should take the possibility of comorbid psychiatric conditions into consideration when making the differential diagnosis of pervasive developmental disorders.

• 아동학회지
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• 제29권5호
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• pp.197-214
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• 2008

The purpose of this study was to investigate clinical characteristics and the attribution of children having play therapy by developmental, behavioral, and emotional disorders. Subjects of this study were 118 3- to 9-year-old children randomly selected from children who were receiving or who already finished play therapy at one of the child and family counseling centers in Cheong-Ju City. Results showed that children with developmental disorders had lower levels of relationship during play, and their relationships were more disorganized or separated than children with emotional or with behavioral disorders. This study has significance by providing psychological information on play characteristics of children by type of disorder.

• 대한한방소아과학회지
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• 제33권4호
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• pp.60-73
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• 2019

Objectives This study reviewed the effects of a combined treatment with Kampo and Western medicine for Developmental disability in Japan, and the provision of education programs in clinical care. Methods The search database includes J-STAGE. To narrow the search, the following key words were used: 'pervasive developmental disorders, Attention-Deficit/Hyperactivity Disorder, Learning Disorders or Learning Disabilities, Intellectual Disability, and Kampo'. The search was limited to the publication date from 2001 to 2019. Results 1. Japan analyzed five sections: The usage of the Kampo medicine ranges from 25.2% to 71.6%, and the Kampo medicine was highly used in large cities. 2. In Japan, the educational programs were provided for the caregiver and special educational programs were available for children with disabilities. 3. In Japan, there were 9 studies regarding developmental disability treating with herbal remedies. There were seven clinical trial reports, and two were published in a review or report form. 4. The results showed benefits of using Kampo for patients with lack of Yin in blood in treatment of developmental disorder. It is also important to control the liver qi and Yin in blood. 5. Seven papers reported no side effects or abnormal findings. They have reduced the use of antipsychotics. Conclusions These review studies in regards to the combined treatment of Kampo and Western medicines can be helpful to improve long term side effects of the antipsychotics used in developmental disorders.

• Clinical and Experimental Pediatrics
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• 제58권1호
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• pp.8-14
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• 2015

In patients with a language developmental delay, it is necessary to make a differential diagnosis for autism spectrum disorders (ASDs), specific language impairment, and mental retardation. It is important that pediatricians recognize the signs and symptoms of ASDs, as many patients with language developmental delays are ultimately diagnosed with ASDs. Pediatricians play an important role in the early recognition of ASDs, because they are usually the first point of contact for children with ASDs. A revision of the diagnostic criteria of ASDs was proposed in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) that was released in May 2013. The autism spectrum describes a range of conditions classified as neurodevelopmental disorders in the fifth edition of the DSM. The new diagnostic criteria encompasses previous elements from the diagnosis of autistic disorder, Asperger disorder, childhood disintegrative disorder, and pervasive developmental disorder-not otherwise specified. An additional change to the DSM includes synthesizing the section on social and communication deficits into one domain. In ASD patients, the appropriate behavioral therapies and rehabilitation treatments significantly affect the prognosis. Therefore, this makes early diagnosis and treatment very important. In conclusion, pediatricians need to be able to recognize the signs and symptoms of ASDs and be attentive to them in order to make an early diagnosis and provide treatment.

• 말소리와 음성과학
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• 제7권3호
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• pp.165-173
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• 2015

This study was aim to compare the phonological error patterns and PCC(Percentage of Correct Consonants) derived from the single word and spontaneous speech contexts of the speech sound disorders with unknown origin(SSD). The present study suggest that the development phonological error patterns and non-developmental error patterns of the target children, in according to speech context. The subjects were 15 children with SSD up to the age of 5 from 3 years of age. This research use 37 words of APAC(Assessment of Phonology & Articulation for Children) in the single word context and 100 eojeol in the spontaneous speech context. There was no difference of PCC between the single word and the spontaneous speech contexts. Significantly different developmental phonological error patterns between the single word and the spontaneous speech contexts were syllable deletion, word-medial onset deletion, liquid deletion, gliding, affrication, fricative other error, tensing, regressive assimilation. Significantly different non-developmental phonological error patterns were backing, addtion of phoneme, aspirating. The study showed that there was no difference of PCC between elicited single word and spontaneous conversational context. And there were some different phonological error patterns derived from the two contexts of the speech sound disorders. The more important interventions target is the error patterns of the spontaneous speech contexts for the immediate generalization and rising overall intelligibility.

• Biomolecules & Therapeutics
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• 제32권2호
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• pp.183-191
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• 2024

The Unfolded Protein Response (UPR) serves as a critical cellular mechanism dedicated to maintaining protein homeostasis, primarily within the endoplasmic reticulum (ER). This pathway diligently responds to a variety of intracellular indicators of ER stress with the objective of reinstating balance by diminishing the accumulation of unfolded proteins, amplifying the ER's folding capacity, and eliminating slow-folding proteins. Prolonged ER stress and UPR irregularities have been linked to a range of neuropsychiatric disorders, including major depressive disorder, bipolar disorder, and schizophrenia. This review offers a comprehensive overview of the UPR pathway, delineating its activation mechanisms and its role in the pathophysiology of neuropsychiatric disorders. It highlights the intricate interplay within the UPR and its profound influence on brain function, synaptic perturbations, and neural developmental processes. Additionally, it explores evolving therapeutic strategies targeting the UPR within the context of these disorders, underscoring the necessity for precision and further research to effective treatments. The research findings presented in this work underscore the promising potential of UPR-focused therapeutic approaches to address the complex landscape of neuropsychiatric disorders, giving rise to optimism for improving outcomes for individuals facing these complex conditions.

• 재활치료과학
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• 제12권1호
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• pp.37-49
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• 2023

목적 : 본 연구의 목적은 정신장애 영유아의 K-CBCL 1.5-5(Korean-Child Behavior Checklist 1.5-5) DP(Dysregulation Profile)의 요인구조를 확인하고, 정신장애 진단 집단 간 차이를 검증하였다. 연구방법 : 서울 소재의 종합병원 소아정신과, 발달장애 클리닉 등에서 2010년에서 2015년까지 수집된 자료를 활용하였다. DSM-IV에 근거하여 정신장애로 진단된 영유아 265명의 어머니에게 실시된 K-CBCL 1.5-5 자료를 최종분석에 사용하였다. 결과 : 정신장애 영유아의 K-CBCL 1.5-5 DP의 요인구조는 이중요인 모형(Bifactor)이 상대적으로 가장 적합하였다(χ² = 893.722, TLI = .782, CFI = .822, RMSEA = .064). 또한 의사소통장애, 전반적 발달장애, 정서장애, 발달지체 등 영유아의 정신장애 진단 집단 간 차이가 유의하였다(F(3, 259) = 9.780, p < .001). 그 중 전반적 발달장애 집단과 정서장애 집단이 의사소통장애 집단보다 높은 조절곤란을 보이는 것으로 확인되었다. 결론 : 본 연구에서는 정신장애 영유아의 조절곤란 문제의 존재를 확인하였다. 이중요인 모형을 통해 K-CBCL 1.5-5 DP가 불안/우울, 공격행동, 주의집중문제의 특정요인과 특정요인 이상의 일반요인으로 구성된다는 것을 확인하였고, K-CBCL 1.5-5 DP의 다차원성을 규명하였다. 또한 정신장애 집단 간 유의한 차이가 있었고 조절곤란 문제는 영유아기부터 전반적 발달장애와 정서장애의 증상 발현과 심화에 기여하는 것으로 사료된다.