• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.1999-2006
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• 2016

Background: Acute promyelocytic leukemia (APML) is characterized by the reciprocal translocation t(15;17) (p22;p12) resulting in the PML-$RAR{\alpha}$ fusion gene. A dual diagnostic and follow up approach was applied including cytogenetic demonstration of the t(15;17) translocation and detection dg PML-$RAR{\alpha}$ chimeric transcripts by molecular means. Purpose: Conventional cytogenetics involving bone marrow is beset with high probability of poor metaphase index and was substituted with phytohemagglutinin (PHA)-induced peripheral blood culture based cytogenetic analysis as a diagnostic & follow up modality in APML patients of Kashmir (North India). Both qualitative (RT-PCR) and quantitative (Q-PCR) tests were simultaneously carried out to authenticte the modified cytogenetics. Materials and Method: Patient samples were subjected to the said techniques to establish their baseline as well as follow-up status. Results: Initial cytogenetics revealed 30 patients (81%) Positive for t(15;17) whereas 7 (19%) had either cryptic translocation or were negative for t(15;17). Two cases had chromosome 16q deletion and no hallmark translocation t(15;17). Q-PCR status for PML-$RAR{\alpha}$ was found to be positive for all patients. All the APML patients were reassessed at the end of consolidation phase and during maintenance phase of chemotherapy where 6 patients had molecular relapse, wherein 4 also demonstrated cytogenetic relapse. Conclusions: It was found that PHA-induced peripheral blood cytogenetics along with molecular analysis could prove a reliable modality in the diagnosis and assessment of follow up response of APML patients.

• Journal of Veterinary Clinics
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• v.26 no.2
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• pp.130-133
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• 2009

The use of screening tests as part of a diagnostic work-up is common in domestic canine practice, but understanding of the diagnostic test characteristics and factors affecting diagnostic accuracy is not clear among clinicians. This article was aimed to provide clinicians with a better understanding on the selection of test kits and with a proper interpretation of test results using an example from heartworm(Dirofilaria immitis) studies. From the literatures, diagnostic accuracy varied depending on the kits: percent average sensitivity and specificity of ELISA antigen-detecting kits were DiroChek(Synbiotics, USA) 78.1 and 95.2, SNAP(IDEXX, USA) 66.3 and 98.1, and Solo Step(Heska, Switzerland) 69.5 and 97.5, respectively, while the values for three hematological methods(Modified Knott's, direct smear and capillary tube) ranged from 38.4 to 81.8% and from 96.9 to 100%, respectively. Furthermore, it was also reported that the prevalence of heartworm disease in domestic dog populations varied depending on the regions studied: 2.5-22.8% for microfilarial test and 2.2-66.3% by ELISA. The values of predictive values for positive(PPV) and negative(NPV) provide useful information to clinicians on the probability of heartworm infection, but the PPV and NPV are greatly dependent on the heartworm prevalence. This suggests that PPV or NPV values of a test should be interpreted carefully in different clinical settings. Practical methods on the interpretation taking into account heartworm prevalence were discussed.

• Journal of Veterinary Clinics
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• v.30 no.4
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• pp.258-263
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• 2013

The primary goal of this study was to compute sample sizes required to achieve the each aim of a variety of foot-and-mouth disease (FMD) surveillance programs, using a statistically valid technique that takes the following factors into account: sensitivity (Se) and specificity (Sp) of diagnostic test system, desired minimum detectable prevalence, precision, population size, and desired power of the survey. In addition, sample sizes to detect FMD if the disease is present and also as proof of freedom were computed. The current FMD active surveillance programs consist of clinical, virological, and serological surveillance. For the 2012 serological surveillance, annual sample sizes (n = 265,065) are planned at four separate levels: statistical (n = 60,884) and targeted (n = 115,232) at breeding pig farms and slaughter house, in together with the detection of structural proteins (SP) antibodies against FMD (n = 88,949). Overall, the sample size was not designed taking the specific aims of each surveillance stream into account. The sample sizes for statistical surveillance, assuming stratified two-stage sampling technique, was based to detect at least one FMD-infected case in the general population. The resulting sample size can be used to obtain evidence of freedom from FMD infection, not for detecting animals that have antibodies against FMD virus non-structural proteins (NSP). Additionally, sample sizes for targeted surveillance were not aimed for the population at risk, and also without consideration of statistical point of view. To at least the author's knowledge, sampling plan for targeted, breeding pig farms and slaughter house is not necessary and need to be included in the part of statistical surveillance. Assuming design prevalence of 10% in an infinite population, a total of 29 animals are required to detect at least one positive with probability of 95%, using perfect diagnostic test system (Se = Sp = 100%). A total of 57,211 animals needed to be sampled to give 95% confidence of estimating SP prevalence of 80% at the individual animal-level with a precision of ${\pm}5%$, assuming 800 herds with an average 200 heads per farm, within-farm variance of 0.2, between-farm variance of 0.05, cost ratio of 100:1 of farm against animals. Furthermore, 779,736 animals were required to demonstrate FMD freedom, and the sample size can further be reduced depending on the parameters assumed.

• Journal of the Korean Society of Radiology
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• v.11 no.3
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• pp.171-175
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• 2017

In the non-destructive inspection field, we invest a lot of time and resources in developing the radiation source system to ensure the safety of the workers. However, the probability of accidents is still high. In order to prevent potential radiation accidents in advance, it is necessary to directly verify the position of the radiation source, but the research is still insufficient. In this study, we developed a monitoring system that can detect the position of the radiation source in the source guide tube in the gamma-ray irradiator. The characteristics of the radiation detector are estimated by monte carlo simulation. As a result, the radiation detector for Ir-192 gamma-ray energy was analyzed to have secondary electron equilibrium at $150{\mu}m$ regardless of the semiconductor material. Also, it is expected that the gamma ray response characteristic is the best in $HgI_2$. These results are expected to be used as a basis for determining the optimal thickness of the radiation detector located in the detection part of the future monitoring system. In addition, when developing a monitoring system based on this, radiation workers can easily recognize the danger and secure safety, as well as prevent and preemptively respond to potential radiation accidents.

• Journal of the Korean Society of Radiology
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• v.6 no.6
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• pp.483-487
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• 2012

In 1895, the discovered X-ray is used for not only in this field of medicine wide but also field. The detection of radiation after, people realized the risk of the radiation exposured recommended the principle about the protection of radiation by the part of the effort for lowering the radiation exposure. In this recommendation, all unnecessary radiation exposure have to be prevented by All doses include the protection of radiation, general idea of applicable two kinds of that it has to low maintain. Presently, in the General X-ray room of the clinical, the lead (Pb) was used for the shielding, However, because it had the problem of the lead poisoning which is fatal in the human body, the alternatives was showed. and Among them, the material that it is the tungsten was presented. in this research, the absorbed spectrum according to the thickness in the continuous X-ray energy of the tungsten which is not harmful to the human body through the Monte Carlo simulation, tried to compare with the absorbed spectrum of the lead (Pb). The tungsten confirmed that simulation presumption than result lead in the whole domain that absorbed probability was higher and it is considered that tungsten shows the absorbed efficiency higher than the lead in particularly, 70 keV ~ 90 keV and the tungsten is more useful to the X-ray energy cover of the high energy diagnostic area.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.23 no.7
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• pp.1797-1806
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• 1998

Future satellite communication systems will be developed at Ka-band (20/30 GHz) owing to the relatively wide frequency allocation and current freedom from terrestrial interference for multimedia services. A serious disadvantage of the Ka-band, however, is the very high atmospheric attenuation in rainy weather. Synchronous CDMA drastically redces the effect of self-noise with several interesting features of CDMA for mobile communications such as fixible freuqncy rese, the capability of performin soft-handover and a lower sensitivity to interference. This paper evaluates the performance of a synchronous CDMA reture link for a Ka-band geostationary satellite communication system. For a fixed satellite channel whose characteristics depend on weather conditions, the signal envelope and phase for this channel is modelled as Gaussian. The bit error and outage probability, and the detection loss due to imperfect chip timing synchronization is analytically evaluated and the system capacity degaradation due to the weather condition is estimated. The two cases consist of the general case in which all users are affected by rain condition, and the worst case in which the reference user is only affected by rain attenuation. the results for two cases of rain condition clearly show that synchronous CDMA eases the power control requirements and has less sensitivity to imperfect power control.

• The Journal of the Acoustical Society of Korea
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• v.21 no.4
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• pp.380-386
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• 2002

Conventional post-processing as like confidence measure (CM) proposed by Rahim calculates phones' CM using the likelihood between phoneme model and anti-model, and then word's CM is obtained by averaging phone-level CMs[1]. In conventional method, CMs of some specific keywords are tory low and they are usually rejected. The reason is that statistics of phone-level CMs are not consistent. In other words, phone-level CMs have different probability density functions (pdf) for each phone, especially sri-phone. To overcome this problem, in this paper, we propose normalized confidence measure. Our approach is to transform CM pdf of each tri-phone to the same pdf under the assumption that CM pdfs are Gaussian. For evaluating our method we use common keyword spotting system. In that system context-dependent HMM models are used for modeling keyword utterance and contort-independent HMM models are applied to non-keyword utterance. The experiment results show that the proposed NCM reduced FAR (false alarm rate) from 0.44 to 0.33 FA/KW/HR (false alarm/keyword/hour) when MDR is about 8%. It achieves 25% improvement of FAR.

• Korean Journal of Environmental Biology
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• v.25 no.2
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• pp.94-99
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• 2007

To investigate the spatial distribution and daily calling pattern of the Gold-spotted pond frog, Rana chosenica, in Chungju city and Chungwon gun, Chungbuk province, Korea, we divided the study area into 226 plots with a $2{\times}2km^2$ plot on the map, of which we assigned 32 plots for monitoring populations. Call monitoring on whether the species are present or not were conducted for 5 minutes in between sunset and the midnight from at the end of May to July in 2006. Gold-spotted pond frogs were detected at least once four out of 32 plots. Using program Presence, we obtained site occupancy rate as 0.170 which was quite low compared with other species, while detection probability was 0.66 that propose at least three times to visit the monitoring site to confirm the absence of the frogs. The frogs were actively calling from 21:00 to 02:00, and the number of calling male was significantly and highly correlated with water temperature and humidity. This study shows the present status of the Gold-spotted pond frogs in Chungju city and Chungwon gun and we suggests various effective monitoring methods based on the this study.

• The Korean Journal of Pesticide Science
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• v.15 no.1
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• pp.48-54
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• 2011

Risk assessments of pesticides detected in six major rivers during peak season were estimated for algae, Daphnia, and fish using hazard quotient (HQ) indexes. The eight pesticides (isoprothiolane, hexaconazole, diazinon, chlorpyrifos, prothiofos, alachlor, butachlor, molinate) were detected within the range of 0.027~12.871 ${\mu}g/L$. Detection frequency of isoprothiolate was estimated to be high at 67.5%, and those of the others varied from 15.0 to 37.5%, Hazard Quotients (HQ) indexes varied by freshwater organisms (algae, Daphnia, and fish). Overall, the ecological risk probability due to exposure of pesticides detected in major rivers did not reveal based on HQ indexes below 1.0. Particularly, butachlor and molinate for algae, chlorpyrifos, diazinon, prothiofos for Daphnia, and chlorpyrifos for fish acted as dominant contributors in increasing the ecological risk in six major rivers. This implied that integrated ecological risk assessment is required using various biological species, reflecting toxicity sensitivity. This study may provide the essential data in establishing the priority for pesticides management in major rivers, Korea.

• Korean Journal of Remote Sensing
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• v.33 no.3
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• pp.287-299
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• 2017

The Southern Volcanic Zone (SVZ) of Chile consists of many volcanoes, including the Mt.Villarrica and Mt.Llaima, and the two volcanoes are covered with snow at the top of Mountain. The purpose of this study is to analyze the relationship between the ice caps and the volcanic activity of the two volcanoes for 25 years by using the satellite image data are available in a time series. A total of 60 Landsat-5 TM and Landsat-7 ETM + data were used for the study from September 1986 to February 2011. Using NDSI (Normalized Difference Snow Index) algorithm and SRTM DEM, snow cover and snowline were extracted. Finally, the snow cover area, lower-snowline, and upper-snowline, which are quantitative indicators of snow cover change, were directly or indirectly affected by volcanic activity, were extracted from the satellite images. The results show that the volcanic activity of Villarrica volcano is more than 55% when the snow cover is less than 20 and the lower-snowline is 1,880 m in Llaima volcano. In addition, when the upper-snowline of the two volcanoes is below -170m, it can be confirmed that the volcano is differentiated with a probability of about 90%. Therefore, the changes in volcanic snowfall are closely correlated with volcanic activity, and it is possible to indirectly deduce volcanic activity by monitoring the snow.