• Parasites, Hosts and Diseases
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• 제57권4호
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• pp.445-450
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• 2019

Human infections due to the monkey malaria parasite Plasmodium knowlesi is increasingly being reported from most Southeast Asian countries specifically Malaysia. The parasite causes severe and fatal malaria thus there is a need for urgent measures for its control. In this study, the level of polymorphisms, haplotypes and natural selection of full-length pkmsp8 in 37 clinical samples from Malaysian Borneo along with 6 lab-adapted strains were investigated. Low levels of polymorphism were observed across the full-length gene, the double epidermal growth factor (EGF) domains were mostly conserved, and non-synonymous substitutions were absent. Evidence of strong negative selection pressure in the non-EGF regions were found indicating functional constrains acting at different domains. Phylogenetic haplotype network analysis identified shared haplotypes and indicated geographical clustering of samples originating from Peninsular Malaysia and Malaysian Borneo. This is the first study to genetically characterize the full-length msp8 gene from clinical isolates of P. knowlesi from Malaysia; however, further functional characterization would be useful for future rational vaccine design.

• 한국환경과학회지
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• 제28권2호
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• pp.267-276
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• 2019

Elevated linear parks have the potential to support the ecological stability, city amenity, cultural opportunity, and health benefits of urban dwellers; these are increasingly becoming an integral part of the urban infrastructure. Due to structural limitations in space, linear parks need to be planned to increase the value of green space. This study was aimed at advancing urban planning techniques for increasing the value of elevated linear parks, by comparing the Seoullo7017 with the Promenade $plant{\acute{e}}e$ and the Highline. Planning characteristics of these green spaces were analyzed from the perspectives of physical planning factors, amenity values for users, and management systems. Field surveys and virtual tools were used to investigate the current characteristics of these parks, in addition to the literature survey. From the analysis of planning factors, amenity values, and management in the three linear parks, following important recommendations were made in order to promote the values of these parks: (a) diversify planting design for increasing the diversity of green space in a narrow area; (b) bring in various forms of amenities to promote the quality of users' experience; and (c) establish community-based management systems for enhancing regional competitiveness and profit sharing in urban regeneration projects.

• Child Health Nursing Research
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• 제25권2호
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• pp.214-222
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• 2019

Purpose: This study examined the mediating and moderating effects of multicultural efficacy in the relationship between cultural empathy and cultural competence in child care teachers. Methods: A cross-sectional descriptive survey design was used. The participants were 277 child care teachers at private and public daycare centers in G and S districts of Seoul. The survey instruments included a cultural empathy questionnaire, a multicultural efficacy scale, and a cultural competence scale. Data were analyzed using the SPSS and AMOS programs. For data analysis, descriptive statistics, correlation, and mediating and moderating effect analyses were performed. Bootstrapping was implemented to verify the mediating effect of the model developed herein. Results: Positive correlations among cultural empathy, multicultural efficacy, and cultural competence were noted. Multicultural efficacy showed a significant mediating effect on the relationships between cultural empathy and cultural competence. However, there was no moderating effect. Conclusion: In order to enhance the cultural competence of child care teachers, it is necessary to develop a strategy that can promote their cultural empathy and multicultural efficacy. Furthermore, these results will ultimately enhance the role of child care teachers, thus contributing to the normal growth and development of multicultural children.

• Journal of Microbiology and Biotechnology
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• 제29권5호
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• pp.667-686
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• 2019

Streptomyces are attractive microbial cell factories that have industrial capability to produce a wide array of bioactive secondary metabolites. However, the genetic potential of the Streptomyces species has not been fully utilized because most of their secondary metabolite biosynthetic gene clusters (SM-BGCs) are silent under laboratory culture conditions. In an effort to activate SM-BGCs encoded in Streptomyces genomes, synthetic biology has emerged as a robust strategy to understand, design, and engineer the biosynthetic capability of Streptomyces secondary metabolites. In this regard, diverse synthetic biology tools have been developed for Streptomyces species with technical advances in DNA synthesis, sequencing, and editing. Here, we review recent progress in the development of synthetic biology tools for the production of novel secondary metabolites in Streptomyces, including genomic elements and genome engineering tools for Streptomyces, the heterologous gene expression strategy of designed biosynthetic gene clusters in the Streptomyces chassis strain, and future directions to expand diversity of novel secondary metabolites.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제26권4호
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• pp.29-38
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• 2020

Purpose: The first thing to be done in promoting community care is local diagnosis. Therefore, this study attempted to derive the physical infrastructure to be diagnosed, and to develop diagnostic items and diagnostic indicators applicable to this. Methods:: First, the physical infrastructure related to the community care is derived. And the diagnosis items are derived using the checklist of 'community support and health services' in the WHO Guide for Global age-friendly cities. Next, by analyzing previous studies, we develop diagnostic indicators for each diagnostic item and explore their applicability. Results: As a result of deriving the physical infrastructure for each area of housing, health service, and nursing care for community care, 22 facilities were derived for 9 types. Diagnosis items for the facilities are 1)regional equity, 2)proximity between facilities, 3)transportation access, 4)regional use, 5)barrier-free design, 6)diversity of facilities, and a total of 14 diagnostic indicators was derived. We reviewed and suggested the applicability of diagnostic items and indicators by each physical infrastructure. Implications: For the realization of community care, local diagnosis should not be limited to sim- ply grasping the presence or absence of facilities and the total amount. Instead it should strengthen capabilities by conducting diagnosis to understand the performance of facilities.

• 대한건축학회논문집:계획계
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• 제34권3호
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• pp.3-10
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• 2018

The purpose of this study is to suggest the direction and recognition for applying to component of Emotion of the elementary school space with characteristics of child development. For the accomplishment of the study is to deduce types of emotional component and characteristics of child development based on literature and advanced research related to 'Child development and behavior', 'The elementary school space', and concept of 'children' and 'emotion'. In addition, The level of recognition of teachers and students about creation plan of school space by types of emotion component and preference and relationships of students on emotion component of elementary school space is investigated. The space environment has great influence in childhood going through big changes in physical, cognitive, emotional and social ways, Providing space environment built with emotion component such as 'affordance', 'diversity', 'territoriality', and 'relationships' considering characteristics of child development is most important of all, In particular, when building indoor space in elementary schools where students going through various development stages live, providing friendly environments for emotion of children put top priority on students in the decision-making process and guaranteed the participation of students is expected.

• 대한건축학회논문집:계획계
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• 제34권7호
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• pp.13-20
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• 2018

In this study, it was started with the research for improving the housing plan of the elderly and the aged housing environment. The spatial extent of the study is in Haedoji Village, Yeongdo, Busan, and the time ranged from the mid-1950s, when the Korean war broke out and the refugees started to settle, to the present as of August 2017. As Result, the size of the residential space per capita was overcrowded at $9.2m^2$ in the 1970s and 1980s, when the number of families was high, but since 2010, the size of the residential space currently living alone with only one elderly or couple was $29.2m^2$. In the future, it can be judged that the size of elderly housing can be expected to be envisioned within about $35{\sim}40m^2$ in consideration of the diversity of housing including table space in the 2LDK type.

• 대한건축학회논문집:계획계
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• 제35권3호
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• pp.21-30
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• 2019

The purpose of this study is to investigate how Pritzker Architecture Prize as a social act has maintained an organic relationship with the architecture, the urban society through the speakings and writings of the laureates of the Pritzker Architecture Prize. The composition of this research is to grasp the background of the establishment of Pritzker Architecture Prize and the examination process, to examine its social meaning, and to identify the main flow of words from writings about the laureates through the literature survey and text frequency analysis. And is to interpret the meaning of urban society change and words about the laureates. As a result of the analysis of the flow, it is a tendency to move from ideology and style to newness and innovation, and now to publicity and sociality. Especially in recent years, a wide range of values are floated as much as the complicated issues of urban society and the natural environment. The various architectural activities that make up the urban life became more important than the building units existing like an icon. It is considered possible because the Pritzker Architecture Prize has been awarded for a sustainable common social act. In addition, through literature surveys, have also seen changes in the value of individual laureates, the mixing of styles, and the eclectic aspect. Therefore, the task of reading change should not be a process of finding a new style for a new age, but a task of acknowledging heterogeneity of each architect and recognizing diversity through pluralization.

• 동아시아경상학회지
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• 제10권4호
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• pp.39-45
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• 2022

Purpose - This short paper reviews the debate dealing with the relationship between strategy and traditional strategy approach on the one hand, and business models and new business model approach on the other hand and tries to offer useful direction to be more helpful to theoretical discussions. Research design, data, and methodology - This paper makes a theoretical analysis to explain the confusion surrounding the debate, reviewing mainly literature survey papers and finds theoretical conjecture and its limitations in order to present useful direction to the future theoretical work. Result - In order to comprise its diversity, business model studies should consider the characteristics of each firm, sector, and market. Adding further elements which are related to each sector or market, theoretical studies can capture the diverse phenomena related to business model and business model innovation. Conclusion - The traditional strategy perspective can be utilized to the Business model phenomenon in the case of incumbent firms and non-digital sector and existing markets. Meanwhile the new business model perspective can be utilized to business model phenomena in case of start-ups and digital sector and emerging markets. Reconciling two perspectives, the studies dealing with the business model should focus on the characteristics of firms, markets, and knowledge from the perspective of business model innovation.

• 융합경영연구
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• 제10권6호
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• pp.47-57
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• 2022

Purpose: This study explored the relationship between product characteristics and customer purchase intention in cross-border online shopping. Research design, data, and methodology: Through literature review, the research model of product characteristics and consumers' purchase intention is constructed, and trust is taken as a medium variable. Based on the survey data of Chinese consumers, empirical analysis and hypothesis verification are conducted. This study used SPSS version 21 to confirm the reliability and validity of the research model. To confirm the media effect of the model in this study, the Sobel Test was used. Results: The results of hypothesis identification of this research model showed that 8 of the 11 hypotheses were adopted and 3 were rejected. Results confirmed the relationship between product characteristics (specification, diversity, reputation, novelty, quality) and customer purchase intention. Conclusions: The result from this study had particular theoretical significance for improving the research on cross-border online shopping systems to improve the safety and satisfaction of customers in cross-border online shopping.