• 제목/요약/키워드: dermal

검색결과 1,063건 처리시간 0.032초

동종사체진피와 배양한 자가상피세포를 이용한 선천성 피부 형성 부전증 환자의 치험례 (Treatment of Aplasia Cuti Congenita Using Allogenic Dermal matrix and Cultured Epithelial Autograft: A Case Report)

  • 이진화;김용규;이상준
    • Archives of Plastic Surgery
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    • 제33권5호
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    • pp.672-675
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    • 2006
  • Purpose: The purpose of this study is to document the surgical methods used in infants with aplasia cutis congenita treated with allogenic dermal matrix and cultured epithelial autografts. Methods: The large defects in both lower legs were replaced with allogenic dermal matrix to avoid the postoperative hypertrophic scar contracture and a full-thickness skin biopsy was taken from right groin area simultaneously. We sent the specimen to a commercial laboratory for culture and obtained cultured epithelial autografts($Holoderm^{(R)}$) after 2 weeks, placed it over the allogenic dermal matrix. Results: The skin-defected area were nearly epithelialized after 2 weeks and there were no significant problem on during 6 months follow-up. Conclusion: The surgical method using allogenic dermal matrix and cultured epithelial autograft provided an excellent coverage of large skin defects of infant with aplasia cutis congenita.

Protective actions of Rubus coreanus ethanol extract on collagenous extracellular matrix in ultraviolet-B irradiation-induced human dermal fibroblasts

  • Bae, Ji-Young;Lim, Soon-Sung;Choi, Jung-Suk;Kang, Young-Hee
    • Nutrition Research and Practice
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    • 제1권4호
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    • pp.279-284
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    • 2007
  • Solar ultraviolet (UV) irradiation leads to distinct changes in the skin connective tissues by degradation of collagen, which is a major structural component in the extracellular matrix. UV irradiation induces the production of matrix metalloproteinases (MMP) capable of attacking native fibrillar collagen and responsible for inhibiting the construction of collagenous extracellular matrix. In this study, we attempted to investigate the protective actions of Rubus coreanus ethanol extract (RCE) on the MMP production and the consequent procollagen/collagen degradation in UV-B-irradiated human dermal fibroblasts. The analytical data showed that Rubus coreanus ethanol extract was mostly comprised of cyanidin 3-rutinoside. Pre-treatment of fibroblasts with this extract inhibited UV-B-induced production of MMP-1, MMP-8 and MMP-13 in dose-dependent manners. In addition, Western blot analysis and immunocytochemical staining assay revealed that RCE markedly augmented the cellular levels of procollagen/collagen declined in UV-B-exposed dermal fibroblasts. These results demonstrate that RCE blocks UV-B-induced increase of the collagen degradation by inhibiting MMP production. Thus, RCE may act as an agent inhibiting excessive dermal collagen degradation leading to the skin photoaging.

Radiographic study of dermal fillers in the facial area: A series of 3 cases

  • Kwon, Young-Eun;An, Chang-Hyeon;Choi, Karp-Shik;Lee, Du-Hyeong;An, Seo-Young
    • Imaging Science in Dentistry
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    • 제48권3호
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    • pp.227-231
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    • 2018
  • In recent years, as interest in maintaining beauty and a youthful appearance has grown, filler procedures such as soft tissue augmentation have become more popular. These fillers are sometimes seen as radiopaque shadows on radiographic images, either due to the fillers themselves or because of secondary reactions; such findings may present a diagnostic challenge to dentists. The present report describes 3 cases of dermal fillers observed in panoramic and cone-beam computed tomographic (CBCT) images. All 3 elderly female patients had filler injected into their cheeks and chin area for cosmetic purposes decades ago. On panoramic images, multiple symmetric radiopacities were observed in the facial area; on CBCT, these calcifications were seen in the subcutaneous tissue in various shapes and with varying density. In conclusion, dentists should be aware of the imaging characteristics of dermal filler, and should be able to differentiate dermal filler from other pathological findings.

Basic rheology of dermal filler

  • Choi, Moon Seop
    • Archives of Plastic Surgery
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    • 제47권4호
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    • pp.301-304
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    • 2020
  • Dermal injectables are the most popular material for facial enhancement, including volumizing and wrinkle correction. However, although hyaluronic acid is the most common component of dermal injectables, the character of hyaluronic acid products is quite variable. These materials can be described in terms of their viscoelastic properties using four parameters. In this article, the author would like to describe these properties in detail. Although many physicians consider this material to be convoluted, thoroughly understanding the characteristics of various injectables enables us to tailor procedures accordingly and to enhance the final results.

흰쥐에 대한 생모수의 아급성 경피독성시험 (Subacute Dermal Toxicity Study of Sangmosu in Rats)

  • 박현선
    • 약학회지
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    • 제43권3호
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    • pp.358-368
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    • 1999
  • Subacute toxicity study was performed in Sprague-Dawley rats after daily dermal administration of Sangmosu (0.2, 1.0 and 5.0 g/kg) for one month. There were no clinical signs and pathological changes compared with control group. Bodyweights were not significantly changed between control and Sangmosu treatment groups. In histopathological examinations, there were some pneumonia in lung tissues at all groups of Sangmosu treatment including control, but it was not considered to be caused by Sangmosu. These results suggest that Sangmosu does not induce any significant subacute dermal toxicities in Sprague-Dawley rats.

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Keratinocytic Vascular Endothelial Growth Factor as a Novel Biomarker for Pathological Skin Condition

  • Bae, Ok-Nam;Noh, Minsoo;Chun, Young-Jin;Jeong, Tae Cheon
    • Biomolecules & Therapeutics
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    • 제23권1호
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    • pp.12-18
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    • 2015
  • Skin is an emerging target tissue in pharmaceutical and cosmetic science. Safety assessment for dermal toxicity is a critical step for development of topically applicable pharmaceutical agents and ingredients in cosmetics. Urgent needs exist to set up toxicity testing methods for dermal safety, and identification of novel biomarkers for pathological cutaneous alteration is highly required. Here we will discuss if vascular endothelial growth factor (VEGF) has a potential as a biomarker for dermal impairment. Experimental and clinical evidences for induction of keratinocytic VEGF under pathological conditions will be reviewed.

Development of in vitro 3D hair growth model using tissue engineering technology

  • Park, Jung-Keug
    • 한국생물공학회:학술대회논문집
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    • 한국생물공학회 2003년도 생물공학의 동향(XIII)
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    • pp.113-117
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    • 2003
  • 모낭은 복잡한 상호작용을 통하여 성장 및 주기가 조절되며 다양한 세포들로 구성진 기관이다. 본 연구에서는 조직공학적 방법을 이용하여 모낭을 구성하는 세포들을 분리 및 배양하였고 세포들의 형태와 증식양상을 관찰할 수 있었고, 기관배양의 방법을 통하여 in vitro에서 첨가물에 대한 모발의 성장 및 주기의 변화를 살펴보았다.

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FEM APPROACH TO ONE DIMENSIONAL UNSTEADY STATE TEMPERATURE DISTRIBUTION IN HUMAN DERMAL PARTS WITH QUADRATIC SHAPE FUNCTIONS

  • Gurung, D. B.;Saxena, V. P.;Adhikary, P. R.
    • Journal of applied mathematics & informatics
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    • 제27권1_2호
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    • pp.301-313
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    • 2009
  • This paper presents a Finite Element Method (FEM) application to thermal study of natural three layers of human dermal parts of varying properties. This paper carries out investigation of temperature distributions in these layers namely epidermis, dermis and under lying tissue layer. It is assumed that the outer skin is exposed to atmosphere and the loss of heat due to convection, radiation and evaporation of water have also been taken into account. The computations are carried out for one dimensional unsteady state case and the shape functions in dermal parts have been considered to be quadratic. A Finite Element scheme that uses the Crank-Nicolson method is used to solve the problem and the results computed have been exhibited graphically.

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진행성 반안면위축환자의 치험례 (A Case Report of Progressive Hemifacial Atrophy)

  • 최문기
    • Maxillofacial Plastic and Reconstructive Surgery
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    • 제32권4호
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    • pp.344-350
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    • 2010
  • A progressive hemifacial atrophy is characterized by progressive atrophy of subcutaneous fat and rarely muscle and bone. Its contour follows the underlying muscle. Unilateral involvement is common. The treatment goal has been focused on the augmentation of the soft tissue. Many materials such as implants, collagen, fat graft, fat injection, dermal fat graft, filler and vascualized autogenous graft have been used. Although these materials have been used, the best treatment hasn't been achived. In severe cases underlying soft tissue, muscle and bone may be atrophied and massive soft tissue graft, implant and orthognathic surgery must be used. The author used the dermal-fat tissue for the pupose of soft tissue augmentation. We can get the massive soft tissue by the dermolipectomy procedure through the mini-abdominoplsty. The facial augmentation was done by augmentation of the dermal-fat tissue. The progressive hemifacial atrophy is hard to treat by only one procedure and many modalites must be considered.

Midface Infection after COVID-19 Vaccination in a Patient with Calcium Hydroxylapatite Dermal Filler: A Case Report and Literature Review

  • Jeon, Hong Bae;Yoon, Jae Hee;Lim, Nam Kyu
    • Archives of Plastic Surgery
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    • 제49권3호
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    • pp.310-314
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    • 2022
  • The emergence of vaccines for coronavirus disease 2019 (COVID-19) raises risk of possible adverse events from interaction between the vaccines and facial aesthetic care. A 47-year-old female with no medical comorbidities visited our emergency room due to midface painful swelling after 3 hours following receiving the second dose of the messenger RNA BNT162b2 COVID-19 vaccine. About 14 years ago, she underwent nonsurgical augmentation on the nasojugal groove with a calcium hydroxylapatite dermal filler. We performed incision and drainage under general anesthesia on the next day. During operation, yellowish pus-like materials bulged out. After an operation, we performed a combination therapy with antibiotics and methylprednisolone. Her symptoms improved day by day after surgery, and then a complete recovery was achieved at 3 weeks after the treatment. In conclusion, providers of aesthetic procedures are to be aware of the potential risks of such vaccines for patients who already had or seek to receive dermal filler injections.