• 생물정신의학
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• 제19권2호
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• pp.91-98
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• 2012

Objectives : The aim of this study was to examine the effects of brain-derived neurotrophic factor (BDNF) genetic polymorphism and job stress on the severity of alcohol drinking. It was hypothesized that individuals with the Met/Met BDNF genotype would be more vulnerable than those carrying the Val allele. Methods : Participants were 133 healthy Korean adults (mean age $28.2{\pm}1.1$). Job stress and the severity index of drinking were investigated through self-reported questionnaires. BDNF (rs6265) gene was genotyped. Results : There was no significant association between job stress and the severity of alcohol drinking. Although the severity of alcohol drinking was not associated with BDNF genetic polymorphism, there was a significant difference in men according to genotype and job stress. Men with homozygous BDNF Met allele were more severe in alcohol drinking when job stress was high, less severe in alcohol drinking when job stress was low than those carrying the Val allele (F = 4.47, p = 0.038). Also higher level of job stress was correlated with higher severity of alcohol drinking in men homozygous for BDNF Met allele (rs = 0.620, p = 0.005). Conclusions : These findings suggest the possibility that Met allele could have differential susceptibility, with men homozygous for BDNF Met allele being more susceptible to both more adverse and less adverse environmental influences.

• 동의생리병리학회지
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• 제19권5호
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• pp.1303-1310
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• 2005

This study was performed to investigate the effect of Bunsimgieumgagam on the stress due to the maternal separation in rat. In this study, we researched in 'the behavioral observation', 'the changes of body weight', 'quantitative analysis of the number of BrdU-positive cells per section in dentate gyrus of hippocampus', 'free radical scavenging assay' and 'MTT-based cytotoxicity assay of SK-N-SH cell line', in order to figure out the effect on which Bunsimgieumgagam has the increase of neuron in dentate gyrus of hippocampus damaged by the stress due to the maternal separation. In the behavioral Observation, Bunsimgieumgagam was also efficacious against the decline of one's behavior and anorexia derived from the stress by the maternal separation. In the change of body weight, it showed that the Bunsimgieumgagam is effective in the recovery of weight loss caused by heavy stress(p<0.05). Also, Bunsimgieumgagam had an increasing effect, which is similar to a normal state, on DG's neuron in hippocampus (P<0.001). In free radical scavenging assay, Bunsimgieumgagam had a superior free radical scavenging effect. And it showed a significant result with the high cell proliferation effect in MTT-based cytotoxicity assay(P<0.01, p<0.001) This result suggest that Bunsimgieumgagam has an anti-stress effect and a proliferation effect of neuron in dentate gyrus of hippocampus, and it shows the potential of Bunsimgieumgagam in the treatment for the various disorders derived from children's stress.

• 대한기계학회논문집
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• 제18권7호
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• pp.1705-1712
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• 1994

Hilbert problems are derived to evaluate thermal stress intensity factors for a partially insulated crack subjected to vertically uniform heat flow in infinite bonded dissimilar materials. In case of fully insulated crack surface, the present solutions of thermal stress intensity factors are reduced into the same as the previous results. For the homogeneous material, mode II thermal stress intensity factor only exists. However, in the bonded dissimilar materials, both mode I and II thermal stress intensity factors are obtained. Specially, in this case, mode II thermal stress intensity factor is dominent. Also, thermal stress intensity factors are strongly influenced by the material properties. Thermal stress intensity factors decrease when the degree of insulation decreases.

• 한국자동차공학회논문집
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• 제9권6호
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• pp.201-206
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• 2001

The hole-drilling method makes a little hole through the metal surface that has residual stress and measures the relieved stress with a strain gage. It is used widely in measuring the residual stress of surfaces. In this method, the inclined hole is one of the source of error. This paper presents a finite element analysis of influence of the inclined hole for the uniaxial residual stress field. The stress differences between measured and applied residual stress increase proportionally to inclined angle of the hole. The correction equations which easily obtain the residual stress taking account of the inclined angle and direction are derived. The measurement error of stress due to the inclined hole can be reduced to around 1% through this study.

• Tribology and Lubricants
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• 제5권1호
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• pp.64-68
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• 1989

The dynamic characteristics of the annular pressure seal employed in pump have been theoretically deduced with consideration of the effects of elastic deformation due to the centrifugal stress. The deformation of the shaft is governed by the linear theory of elasticity. The results derived herein considering the elastic deformation are compared with the previously published author's results in the stiffness and damping coefficients.

• 대한기계학회논문집A
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• 제41권11호
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• pp.1021-1033
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• 2017

본 연구에서는 매설가스배관의 강 슬리브 보수 용접부에 대한 피로수명에 미치는 보수 용접 공정 변수별 영향을 고찰하여 최적 공정을 수립하였다. 상용 유한요소 해석프로그램인 ABAQUS를 이용한 연계 연성 온도-응력 해석을 통해 강 슬리브 보수용접 시 보수용접부에 발생하는 용접 잔류응력을 도출하였다. 또한, 유한요소 선형탄성 응력해석을 통해 운전응력 변이도 도출하였다. 도출된 용접 잔류응력과 운전응력 변이를 입력값으로써 구조응력/파괴역학 접근법에 대입하여 강 슬리브 보수용접부의 피로수명을 평가하였다. 다양한 보수용접 공정 변수에 대한 유한요소해석과 피로평가를 수행하여 공정변수별 피로수명에 미치는 영향을 고찰하였다. 최종적으로는 고찰한 피로수명에 미치는 공정변수별 영항 결과를 토대로 공정 및 경제적 비용을 최소화하고 피로수명을 적절히 향상시킬 수 있는 최적 방안을 도출하였다.

• 한국세라믹학회지
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• 제33권5호
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• pp.583-589
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• 1996

In this study a new analytical model which can describe the relationship between the bridging stress and microstructure has beenproposed in order to investigate the microstructural effect on the R-curve behavior in polycrystalline aluminas since the R-curve can be derived via the bridging stress function. In the currently developed model function the distribution of grain size is considered as a microstructural factor in modeling of bridging stress function and thus the bridging stress function including three constants PM, n, and Cx, can be established analytically and quantitatively. The results indicate that the n value is closely related to the grain size distribution thereby providing a reliability of the current model for the bridging stress analysis. Thus this model which explains the correlation of the bridging stress distribution and microstructual parame-ters is useful for the systematic interpretation of microfracture mechanism including the R-curve behavior in polycrystalline aluminas.

• Structural Engineering and Mechanics
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• 제52권1호
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• pp.75-87
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• 2014

To analyze the tension performance of laminated rubber bearings under tensile loading, a theoretical tension model for analyzing the rubber bearings is proposed based on the theory of elasticity. Applying the boundary restraint condition and the assumption of incompressibility of the rubber (Poisson's ratio of the rubber material is about 0.5 according the existing research results), the stress and deformation expressions for the tensile rubber layer are derived. Based on the derived expressions, the stress distribution and deformation pattern especially for the deformation shapers of the free edges of the rubber layer are analyzed and validated with the numerical results, and the theory of cracking energy is applied to analyze the distributions of prediction cracking energy density and gradient direction. The prediction of crack initiation and crack propagation direction of the rubber layers is investigated. The analysis results show that the stress and deformation expressions can be used to simulate the stress distribution and deformation pattern of the rubber layer for laminated rubber bearings in the elastic range, and the crack energy method of predicting failure mechanism are feasible according to the experimental phenomenon.

• Journal of Ginseng Research
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• 제48권2호
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• pp.211-219
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• 2024

Background: Recently, plant-derived exosome-like nanoparticles (PDENs) have been isolated, and active research was focusing on understanding their properties and functions. In this study, the characteristics and molecular properties of ginseng root-derived exosome-like nanoparticles (GrDENs) were examined in terms of skin protection. Methods: HPLC-MS protocols were used to analyze the ginsenoside contents in GrDENs. To investigate the beneficial effect of GrDENs on skin, HaCaT cells were pre-treated with GrDENs (0-2 × 10⁹ particles/mL), and followed by UVB irradiation or H₂O₂ exposure. In addition, the antioxidant activity of GrDENs was measured using a fluorescence microscope or flow cytometry. Finally, molecular mechanisms were examined with immunoblotting analysis. Results: GrDENs contained detectable levels of ginsenosides (Re, Rg1, Rb1, Rf, Rg2 (S), Gyp17, Rd, C-Mc1, C-O, and F2). In UVB-irradiated HaCaT cells, GrDENs protected cells from death and reduced ROS production. GrDENs downregulated the mRNA expression of proapoptotic genes, including BAX, caspase-1, -3, -6, -7, and -8 and the ratio of cleaved caspase-8, -9, and -3 in a dose-dependent manner. In addition, GrDENs reduced the mRNA levels of aging-related genes (MMP2 and 3), proinflammatory genes (COX-2 and IL-6), and cellular senescence biomarker p21, possibly by suppressing activator protein-1 signaling. Conclusions: This study demonstrates the protective effects of GrDENs against skin damage caused by UV and oxidative stress, providing new insights into beneficial uses of ginseng. In particular, our results suggest GrDENs as a potential active ingredient in cosmeceuticals to promote skin health.

• Journal of Power Electronics
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• 제19권5호
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• pp.1108-1121
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• 2019

The non-inverting buck-boost converter (NIBB) is a step-up and step-down DC-DC converter suitable for wide-input-voltage-range applications. However, when the input voltage is close to the output voltage, the NIBB needs to operate in the buck-boost mode, causing a significant efficiency reduction since all four switches operates in the PWM mode. Considering both the current stress limitation and the efficiency optimization, a novel design methodology for the optimal phase-shift modulation of a NIBB in the buck-boost mode is proposed in this paper. Since the four switches in the NIBB form two bridges, the shifted phase between the two bridges can serve as an extra degree of freedom for performance optimization. With general phase-shift modulation, the analytic current expressions for every duty ratio, shifted phase and input voltage are derived. Then with the two key factors in the NIBB, the converter efficiency and the switch current stress, taken into account, an objective function with constraints is derived. By optimizing the derived objective function over the full input voltage range, an offline design methodology for the optimal modulation scheme is proposed for efficiency optimization on the premise of current stress limitation. Finally, the designed optimal modulation scheme is implemented on a DSPs and the design methodology is verified with experimental results on a 300V-1.5kW NIBB prototype.