• Journal of Microbiology and Biotechnology
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• 제28권10호
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• pp.1723-1729
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• 2018

The aim of this work is to investigate the protective efficacy of emodin, an active, naturally-occurring anthraquinone derivative of several traditional Chinese herbs, against Brucella abortus infection in macrophages. Brucella were incubated with different concentrations of emodin and showed that bacterial survival rates were markedly reduced in a dose-dependent manner at increasing incubation time points. Through bacterial infection assay, the highest non-cytotoxic concentration of emodin demonstrated attenuated invasion of Brucella into macrophages, however it did not inhibit the growth of these pathogens within the host cells. On the other hand, emodin effectively decreased the number of bacteria that adhered to host cells, which indicated its potential as an anti-adhesin agent. Furthermore, using immunoblotting and FACS assay for detecting MAPK signaling proteins and F-actin polymerization, respectively, the results showed that the emodin-incubated cells displayed modest reduction in the phosphorylation levels of ERK1/2 and inhibition of F-actin polymerization as compared to control cells. These findings indicate the potential use of emodin as a naturally-occurring alternative method for the prevention of animal brucellosis although this requires confirmation of safe clinical doses.

• Current Research on Agriculture and Life Sciences
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• 제31권1호
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• pp.18-24
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• 2013

This work attempted to fabricate organic/inorganic nanocomposite by combining organic cellulose nanofibrils (CNFs), isolated by 2,2,6,6-tetramethylpiperidine-1-oxy radical (TEMPO)-mediated oxidation of native cellulose with inorganic nanoclay. The morphology and dimension of CNFs, and tensile properties and thermal stability of CNF/clay nanocomposites were characterized by transmission electron microscope (TEM), tensile test, and thermogravimetry (TG), respectively. TEM observation showed that CNFs were fibrillated structure with a diameter of about $4.86{\pm}1.341nm$. Tensile strength and modulus of the hybrid nanocomposite decreased as the clay content of the nanocomposite increased, indicating a poor dispersion of CNFs or inefficient stress transfer between the CNFs and clay. The elongation at break increased at 1% clay level and then continuously decreased as the clay content increased, suggesting increased brittleness. Analysis of TG and derivative thermogravimetry (DTG) curves of the nanocomposites identified two thermal degradation peak temperatures ($T_{p1}$ and $T_{p2}$), which suggested thermal decomposition of the nanocomposites to be a two steps-process. We think that $T_{p1}$ values from $219.6^{\circ}C$ to $235^{\circ}C$ resulted from the sodium carboxylate groups in the CNFs, and that $T_{p2}$ values from $267^{\circ}C$ to $273.5^{\circ}C$ were mainly responsible for the thermal decomposition of crystalline cellulose in the nanocomposite. An increase in the clay level of the CNF/clay nanocomposite predominately affected $T_{p2}$ values, which continuously increased as the clay content increased. These results indicate that the addition of clay improved thermal stability of the CNF/clay nanocomposite but at the expense of nanocomposite's tensile properties.

• 한국식품위생안전성학회지
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• 제25권4호
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• pp.294-302
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• 2010

연구에서는 식품 중에 bound-MCPD를 측정하기 위해 지방을 추출하고, 메탄올에 녹인 황산으로 $60^{\circ}C$, 4hr 가수분해하여 모두 3-MCPD로 전환시켜 분석등하는 실험법을 개발하였다. 기존의 논문과 비교하였을때 분석시간이 더 빠르고, 현재 식품공전에 등재된 3-MCPD 시험법에 접목시킨 시험법이다. 분석가능한 선형구간은 3-MCPD로서 10ppb(ug/kg)-2ppm(mg/kg), 이며 반복성이 상대표준편차 5%이내, 재현성의 상대표준편차는 선형구간에서 10%이내이다. 기기적인 LOD는 5.4ppb, LOQ 9.0ppb이며 회수율은 3-MCPD 85.53%, bound-MCPD 82.97%이다.

• 한국전산구조공학회논문집
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• 제21권4호
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• pp.391-399
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• 2008

본 논문에서는 다중 균열 구조물에서의 균열 진전에 따른 에너지 해방을 및 고차 미분값을 구할 수 있는 가상균열 진전법을 제시한다. 이 방법은 다중 균열 체계의 에너지 해방율과 고차 미분값이 단 한번의 해석으로 수행될 수 있는 장점이 있다. 예제에서 얻어진 해의 최대 오차는 에너지 해방율 0.2%, 일차 미분값 $2\sim3%$, 이차 미분값 $5\sim10%$이다 이 방법으로 구한 에너지 해방률의 미분값들은 파괴 확률을 구하거나, sire effect law에 적용될 수 있다.

• Korean Chemical Engineering Research
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• 제53권4호
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• pp.457-462
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• 2015

헤미셀룰로오스 가수분해액은 당은 물론 카르복시산, 푸란유도체 및 페놀화합물과 같은 여러 종류의 에탄올 발효 저해물질을 포함한다. 본 연구에서는 이런 저해물질들을 제거할 수 있는 분리 기술로서 에멀젼형 액막법이 적용되었다. 기본 모사 헤미셀룰로오스 가수분해액은 당인 자일로스, 용매인 묽은 황산 수용액과 카르복시산인 초산으로 구성되었으며, 필요에 따라 푸란유도체인 푸르푸랄 또는 페놀화합물인 p-hydroxybenzoic acid(HBA)가 그 가수분해액에 추가되었다. 본 연구에서 고려된 모든 에멀젼형 액막계에서 약산인 초산과 HBA는 선택적으로 제거가 가능하였지만, 알데히드인 푸르푸랄은 상당히 제거하기가 어려웠다. 또한, 기본 모사 가수분해액에 HBA가 추가된 에멀젼형 액막계에서 추출제로 tributyl phosphate를 사용하여 원료상에 있는 초산과 HBA를 99%까지 동시에 선택적으로 제거할 수 있었다.

• Smart Structures and Systems
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• 제21권3호
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• pp.279-286
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• 2018

The free longitudinal vibration of a circular truncated nanocone is investigated based on the nonlocal elasticity theory. Exact analytical formulations for tapered nanostructures are derived and the nonlinear differential governing equation of motion is developed. The nonlocal small scale effect unavailable in classical continuum theory is addressed to reveal the long-range interaction of atoms implicated in nonlocal constitutive relation. Unlike most previous studies applying the truncation method to the infinite higher-order differential equation, this paper aims to consider all higher-order terms to show the overall nonlocality. The explicit solution of nonlocal stress for longitudinal deformation is determined and it is an infinite series incorporating the classical stress derived in classical mechanics of materials and the infinite higher-order derivative of longitudinal displacement. Subsequently, the first three modes natural frequencies are calculated numerically and the significant effects of nonlocal small scale and vertex angle on natural frequencies are examined. The coupling phenomenon of natural frequency is observed and it is induced by the combined effects of nonlocal small scale and vertex angle. The critical value of nonlocal small scale is defined, and after that a new proposal for determining the range of nonlocal small scale is put forward since the principle of choosing the nonlocal small scale is still unclear at present. Additionally, two different types of nonlocal effects, namely the nonlocal stiffness weakening and strengthening, reversed phenomena existing in nanostructures are observed and verified. Hence the opposite nonlocal effects are resolved again clearly. The nano-engineers dealing with a circular truncated nanocone-based sensors and oscillators may benefit from the present work.

• Advances in nano research
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• 제10권4호
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• pp.359-371
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• 2021

A tumor immune interaction is a main topic of interest in the last couple of decades because majority of human population suffered by tumor, formed by the abnormal growth of cells and is continuously interacted with the immune system. Because of its wide range of applications, many researchers have modeled this tumor immune interaction in the form of ordinary, delay and fractional order differential equations as the majority of biological models have a long range temporal memory. So in the present work, tumor immune interaction in fractional form provides an excellent tool for the description of memory and hereditary properties of inter and intra cells. So the interaction between effector-cells, tumor cells and interleukin-2 (IL-2) are modeled by using the definition of Caputo fractional order derivative that provides the system with long-time memory and gives extra degree of freedom. Moreover, in order to achieve more efficient computational results of fractional-order system, a discretization process is performed to obtain its discrete counterpart. Furthermore, existence and local stability of fixed points are investigated for discrete model. Moreover, it is proved that two types of bifurcations such as Neimark-Sacker and flip bifurcations are studied. Finally, numerical examples are presented to support our analytical results.

• Geomechanics and Engineering
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• 제28권1호
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• pp.49-64
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• 2022

In this work, the bending and dynamic behaviors of advanced composite plates resting on variable visco-Pasternak foundations are studied using a simple shear deformation integral plate model. The research is carried out with a view to a three-parameter foundation including the influences of the variable Winkler coefficient, the constant Pasternak coefficient and the damping coefficient of the elastic medium. The present theory uses a displacement field with integral terms instead of derivative terms by including also the shear deformation effect without introducing the shear correction factors. The equations of motion for advanced composite plates are obtained using the Hamilton principle. Analytical solutions for the bending and dynamic analysis are deduced for simply supported plates resting on variable visco-Pasternak foundations. Some numerical results are presented to demonstrate the impact of material index, elastic foundation type, and damping coefficient of the foundation, on the bending and dynamic responses of advanced composite plates.

• 드라이브 ㆍ 컨트롤
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• 제20권4호
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• pp.1-8
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• 2023

In recent years, robots have been utilized in various industries to reduce workload and enhance work efficiency. The following mobility offers users convenience by autonomously tracking specific locations and targets without the need for additional equipment such as forklifts or carts. In this paper, deep learning techniques were employed to recognize individuals and assign each of them a unique identifier to enable the recognition of a specific person even among multiple individuals. To achieve this, the distance and angle between the robot and the targeted individual are transmitted to respective controllers. Furthermore, this study explored the control methodology for mobility that tracks a specific person, utilizing Simultaneous Localization and Mapping (SLAM) and Proportional-Integral-Derivative (PID) control techniques. In the PID control method, a genetic algorithm is employed to extract the optimal gain value, subsequently evaluating PID performance through simulation. The SLAM method involves generating a map by synchronizing data from a 2D LiDAR and a depth camera using Real-Time Appearance-Based Mapping (RTAB-MAP). Experiments are conducted to compare and analyze the performance of the two control methods, visualizing the paths of both the human and the following mobility.

• 문화기술의 융합
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• 제7권3호
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• pp.599-604
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• 2021

AI 인공지능으로 각 분야가 융합된 시대에 디자인에서는 AI-CARE 기능의 디자인과 UI UX 디자인이 각광 받는 시기에 들어와 있다. 새로운 기능에 맞는 시각 효과는 형태 디자인의 적용과 색의 트랜드가 중요하다. 본 논문에서는 이를 활용하여 형태 트랜드의 정리와 적용에 관한 사례를 제시하고, 디자인 방향을 제시하고자 한다. 도입부에서는 최신 디자인 환경 요인을 분석하여 새로운 제안의 방향으로 연구하였다. 본문에서는 기능 디자인 형태를 분리하여 기획에서의 디자인 방향과 고려사항 대한 부분을 연구하였으며, 디자인 작업의 방향성을 제시하였다. 형태와 색채 부분의 단계에서 미니멀리즘과 유니버셜 디자인, 어포던스 디자인의 흐름에 맞는 계획서를 제안하였다. 사례 실습을 바탕으로 한 본론의 연구 방법은 부분별 디자인 작업에 특화된 형태와 색채에 관한 콘텐츠를 어떻게 고려할 것인가에 대한 고찰이며, 콘텐츠 이미지에서 새로운 영역의 UI UX 분야 그래픽 제작이 실현 가능하도록 제안하였다. 본 연구를 통해 AI CARE 베드 PART별로, 디자인 방향성과 타당성을 제안함으로써 형태와 색의 도출 방법의 디자인 방향성과 기획에 도달했다.