• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.213.2-213.2
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• 2003

A simple analytical procedure using FT-NIR for the rapid determination of individual ingredients was evaluated. Direct measurements were made by reflection using a reflectance accessory, by transmittance using tablet accessory and turn table. FT-NIR spectral data were transformed to the first derivative. Partial Least Square Regression(PLSR) was applied to quantify near-infrared (NIR) spectra of 2 ingredients. These calibration models were cross-validated (leave-one-out approach). The prediction ability of the models was evaluated on ambroxol tablets and compared with the real values in manufacturing procedure. (omitted)

• Nonlinear Functional Analysis and Applications
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• 제29권1호
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• pp.165-177
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• 2024

In this paper, we investigate the suitable conditions for the existence results for a class of 𝔍-Hilfer fractional nonlinear Fredholm-Volterra models with new conditions. The findings are based on Banach contraction principle and Schauder's fixed point theorem. Also, the generalized Hyers-Ulam stability and generalized Hyers-Ulam-Rassias stability for solutions of the given problem are provided.

• 한국신뢰성학회지:신뢰성응용연구
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• 제10권3호
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• pp.183-197
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• 2010

Web businesses are one of the most dynamic industries where lots of new business models are emerging while the other obsoleted ones are fading away almost every day. It is, therefore, difficult to establish a classification scheme for ever-changing web businesses. Previous researches on business models focus on classifying web businesses in one dimension which made some web sites difficult to fit into one category. We propose two dimensional classification scheme based on the means and the sources of revenue. The two dimensional classification provides more clear and broad perspectives of the web businesses and ways to identify web sites in combinations of several business models.

• Journal of the Korean Data and Information Science Society
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• 제21권6호
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• pp.1171-1180
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• 2010

회귀함수의 비모수적 적합에서 공변량의 차원이 증가함에 따라 추정량의 극한성질이 좋지 않음이 잘 알려져 있다. 이러한 문제점을 극복하기 위한 방법중의 하나는 단일지표모형의 추정을 이용하여 공변량의 차원을 1차원으로 줄이는 것이다. 단일지표모형에서 계수 추정 방법으로는 반복적으로 해를 계산하여 근사치를 구하는 방법인 준모수적 최소제곱법과 비반복적으로 계산하여 구하는 도함수 가중평균법이 있다. 두 추정 방법 모두 모수적인 방법과 같은 수렴비율로 정규근사한다고 알려져 있지만 실질적인 성능에 관한 비교는 이루어지지 않았다. 본 논문에서는 모의실험을 통해 두 방법에 의한 추정치의 분산을 비교하여 어떠한 방법이 좋은지를 파악하고자 한다.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.1041-1041
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• 2001

Removal of variability in spectra data before the application of chemometric modeling will generally result in simpler (and presumably more robust) models. Particularly for sparsely sampled data, such as typically encountered in diode array instruments, the use of Savitzky-Golay (S-G) derivatives offers an effective method to remove effects of shifting baselines and sloping or curving apparent baselines often observed with scattering samples. The application of these convolution functions is equivalent to fitting a selected polynomial to a number of points in the spectrum, usually 5 to 25 points. The value of the polynomial evaluated at its mid-point, or its derivative, is taken as the (smoothed) spectrum or its derivative at the mid-point of the wavelength window. The process is continued for successive windows along the spectrum. The original paper, published in 1964 [1] presented these convolution functions as integers to be used as multipliers for the spectral values at equal intervals in the window, with a normalization integer to divide the sum of the products, to determine the result for each point. Steinier et al. [2] published corrections to errors in the original presentation [1], and a vector formulation for obtaining the coefficients. The actual selection of the degree of polynomial and number of points in the window determines whether closely situated bands and shoulders are resolved in the derivatives. Furthermore, the actual noise reduction in the derivatives may be estimated from the square root of the sums of the coefficients, divided by the NORM value. A simple technique to evaluate the actual convolution factors employed in the calculation by the software will be presented. It has been found that some software packages do not properly account for the sampling interval of the spectral data (Equation Ⅶ in [1]). While this is not a problem in the construction and implementation of chemometric models, it may be noticed in comparing models at differing spectral resolutions. Also, the effects on parameters of PLS models of choosing various polynomials and numbers of points in the window will be presented.

• Biomolecules & Therapeutics
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• 제5권2호
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• pp.117-124
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• 1997

The analgesic effects of DA-5018, a new caosaucin derivative, were evaluated in various experimental pain models. Drugs were administered subcutaneously or topically. When drugs were administered subcutaneously, 1) the $ED_{50}$ of DA-5018, morphine . HCI, capsaicin and acetaminophen were 0.091-2.0, 0.3-4.3, 1.4-26.5 and 45.4-643 mg/kg, respectively in various pain or inflammatory models including acetic acid writhing, formalin, tail flick, Randall-Selitto, hot plate and crouton oil-induced ear edema test, 2) the AD2 values (the dose for doubling of pain threshold of vehicle control) of DA-5018, capsaicin and ketoprpgin were 1.07 $\pm$ 0. 18, 23.47$\pm$4.46 and 2.97$\pm$0.43 mg/kg in Freund's complete adjuvant (FCA)-induced arthritic pain model. And by topical application, 1) neither DA-5018 0.3% cream nor Zostrix-HP (capsaicin 0.075%) were effective in formalin test, 2) although DA-5018 0.3% cream significantly inhibited the croton oil-induced ear edema being better than Zostrix-HP and Kenofen (ketoprofen 3%). 3) In FCA model, DA-5018 0.3% cream reversed the decreased pain threshold of arthritic rat from 136.4 g (day 0) to 289.0 g (day 5) and 250.1 g (day 10), which was similar to Zostrix-HP. These results suggest that DA-5018 administered subcutaneously has a potent and broad analgesic spectrum than nonsteroidal antiinflammatory drugs against acute and chronic pain, and by topical application it exerts comparable analgesic and antiinglammaatory effects to capsaicin cream.

• 한국전자통신학회논문지
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• 제16권3호
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• pp.401-406
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• 2021

최근 들어, 음향 이벤트 검출을 위하여 CRNN(: Convolutional Recurrent Neural Network) 구조에 기반 한 평균-교사 모델이 대표적으로 사용되고 있다. 평균-교사 모델은 두 개의 병렬 형태의 CRNN을 가진 구조이며, 이들의 출력들의 일치성을 학습 기준으로 사용함으로서 약-전사 레이블(label)과 비-전사 레이블 음향 데이터에 대해서도 효과적인 학습이 가능하다. 본 연구에서는 최신의 평균-교사 모델에 로그-멜 스펙트럼에 대한 차분 특징을 추가적으로 사용함으로서 보다 나은 성능을 이루고자 하였다. DCASE 2018/2019 Challenge Task 4용 학습 및 테스트 데이터를 이용한 음향 이벤트 검출 실험에서 제안된 차분특징을 이용한 평균-교사모델은 기존의 방식에 비해서 최대 8.1%의 상대적 ER(: Error Rate)의 향상을 얻을 수 있었다.

• 제어로봇시스템학회논문지
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• 제21권8호
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• pp.718-722
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• 2015

This paper proposes a fractional-order PID (Proportional-Integral-Derivative) control used electromagnetic strip stabilization controller in a continuous galvanizing line. Compared to a conventional PID controller, a fractional-order PID controller has integration-fractional-order and derivation-fractional-order as additional control parameters. Thanks to increased control parameters, more precise controller adjustment is available. In addition, accurate transfer function of a real system generally has a fractional-order form. Therefore, it is more adequate to use a fractional-order PID controller than a conventional PID controller for a real world system. Finite element models of a $1200{\times}2000{\times}0.8mm$ strip, which were extracted using a commercial software ANSYS were used as simulation plants, and Gaussian mixture models were used to find optimized control parameters that can reduce the strip vibrations to the lowest amplitude. Simulation results show that a fractional-order PID controller significantly reduces strip vibration and transient response time than a conventional PID controller.

• 응용통계연구
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• 제6권2호
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• pp.393-399
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• 1993

반응이 두 가지로 나타나는 자료에서 설명변수와 반응변수와의 관계를 연구할 때 많이 사용되는 로지스틱 회귀모형에 대하여 그 모수들을 최우추정법으로 구할 때 추정량의 표준오차는 보통 로그우도함수의 2차도함수에 바탕을 두어 계산하게 된다. 한편 피셔정보량이 로그우도함수의 1차도함수를 제곱한 통계량의 기대값으로도 계산된다는 점에 착안하여 얻어지는 피셔정보량의 추정량도 이와 거의 비슷한 대표본 성질을 갖는 것으로 알려져 있다. 이러한 피셔정보량의 추정량들은 최우추정량을 구할 때의 반복 알고리즘과 깊은 관련을 갖고 있다. 어느 방법이 더 효과적으로 최우추정량을 계산하는 지 평균반복횟수를 비교하고 대표본분산의 추정량으로서 각 방법에서 계산되는 분산의 추정량들을 비교하였다.

• Journal of the Korean Wood Science and Technology
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• 제47권1호
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• pp.101-109
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• 2019

This paper examines the classification of five coniferous species, including larch (Larix kaempferi), red pine (Pinus densiflora), Korean pine (Pinus koraiensis), cedar (Cryptomeria japonica), and cypress (Chamaecyparis obtusa), using near-infrared (NIR) spectra. Fifty lumber samples were collected for each species. After air-drying the lumber, the NIR spectra (wavelength = 780-2500 nm) were acquired on the wide face of the lumber samples. Soft independent modeling of class analogy (SIMCA) was performed to classify the five species using their NIR spectra. Three types of spectra (raw, standard normal variated, and Savitzky-Golay $2^{nd}$ derivative) were used to compare the classification reliability of the SIMCA models. The SIMCA model based on Savitzky-Golay $2^{nd}$ derivatives preprocessing was determined as the best classification model in this study. The accuracy, minimum precision, and minimum recall of the best model (PCA models using Savitzky-Golay $2^{nd}$ derivative preprocessed spectra) were evaluated as 73.00%, 98.54% (Korean pine), and 67.50% (Korean pine), respectively.