• 대한간호학회지
• /
• 제36권6호
• /
• pp.933-941
• /
• 2006

Objective: The purpose of this study was to evaluate the effects of soybean intake on bone mineral density and bone turnover markers in postmenopausal rural Korean women. Method: This study was carried out during nine months from Oct. 25 2004 to Aug. 31 2005. The subjects of this study were female patients over 50 living in rural areas diagnosed with osteoporosis. There were 18 women in the experimental group and 20 in the control group. In this study, the experimental group received 100 mg of isoflavone (soybean) and calcium 1,500 mg for nine months while the control group received 1,500mg of calcium only. Results: After the soybean intake, the change of bone mineral density between the experimental group and control group was statistically significant. However, the bone turnover markers of osteocalcin and deoxypyridinoline between the experimental group and control group were not significantly different statistically. In the Pearson Correlation between bone mineral density and bone turnover markers, the osteocalcin and deoxypyridinoline of the experimental group had a positive correlation, and osteocalcin and DPD/osteocalcin ratio had anegative correlation. In the control group, osteocalcin and DPD/osteocalcin ratio had a negative correlation. Conclusions: This result showed that soybean intake changed bone mineral density in postmenopausal woman.

• 농촌의학ㆍ지역보건
• /
• 제32권1호
• /
• pp.41-51
• /
• 2007

Objectives: The aim of this study was to evaluate the effects of exercise on the cardiovascular and musculoskeletal variables and quality of life in elderly women. Methods: The study subjects were 22 in experimental group and 21 in the control group, all of who were aged 65 years and over. The subjects in the experimental group were under an exercise program 3 times a week for one year. To assess the effects of exercise in the study group, blood pressure, heart rate, lipid profile, bony metabolism, grip strength, flexibility, reaction time, and quality of life were measured. Results: Exercise showed the significant differences between experimental and control groups on the variables of the diastolic blood pressure, HDL-cholesterol, urinary deoxypyridinoline, flexibility, and quality of life. Compared to before the exercise in the study group, the urinary DPD level and quality of life were significantly improved at 3 months, and diastolic blood pressure, serum HDL-cholesterol, and flexibility were significantly improved by 1 year. Conclusions: The study results underscore the efficacy of exercise and the need for regular exercise programs that are designed for older persons.

• Archives of Pharmacal Research
• /
• 제28권1호
• /
• pp.106-110
• /
• 2005

The preventive effects of Sophorae Fructus extracts (I: hot water extract and II: combination product using I) on bone loss in ovariectomized (OVX) rats were investigated. Sophorae Fructus extracts were orally administrated to OVX rats for 9 weeks. Ovariectomy caused the increase of body weight and deoxypyridinoline (Dpd: bone resorption marker) and decrease of calcium (Ca: bone formation marker) level in serum. Dpd level were significantly decreased and Ca levels were elevated at 9 weeks in Sophorae Fructus extracts administered groups after ovariectomy at a dose of 0.556 g/kg/day compared with control group. In administered groups, trabecular bone area (TBA) in the tibia and lumbar were also increased compared with control group in histomorphological analysis. The preventive or treatment effects of Sophorae Fructus extracts on bone loss in OVX rats appears to be due to suppression of bone turnover.

• 생명과학회지
• /
• 제18권11호
• /
• pp.1578-1583
• /
• 2008

폐경을 앞둔 여성에게는 폐경을 전후하여 지속되는 골 손실 가속화 등의 문제점을 가지고 있다. 그러므로 본 연구에서는 인위적 폐경을 유발시킨 난소 절제 쥐에서의 골 손실의 유무를 결합조직 중의 collagen 함량 변화를 통하여 그 효과를 검토하였다. 그 결과 생화학적 골 대사 지표인 혈 중 ALP 활성은 난소 절제(OVX-control)로 인하여 증가하는 반면, 난소 절제 후 다시마 추출물 투여(OVX-ST50, OVX-ST200)로 혈중 ALP 활성은 감소하는 경향을 보여 골 흡수를 저하시킬 수 있는 가능성을 나타내었다. 한편 난소 절제 후 collagen 함량이 감소하였으나, 다시마 추출물 투여에 의해 피부조직과 골.연골 조직에서 collagen 함량이 증가하는 경향을 보였고, 특히 OVX-ST200군은 각 조직 모두 OVX-control에 비하여 유의적으로 증가하였다(p<0.05). Collagen의 성숙 가교물질인 pyridinoline 함량 또한 난소 절제 후 골, 연골 조직 중에서 감소하였으나 다시마 추출물을 투여한 군에서 증가하는 경향을 나타내었다. 골에서의 deoxypylidinoline 함량은 난소를 절제하지 않은 Sham군이 OVX-control군에 비해서 유의적으로 높은 값을 나타냈고(p<0.05), 난소 절제 후 다시마 추출물을 농도별로 투여한 군(OVX-ST50 및 OVX-ST200)에서 유의 적으로 높은 값을 나타내어(p<0.05), 난소 절제 시 합성이 감소되는 deoxypyridinoline 생성량을증가시켰다. 에스트로겐 감소로 인한 결합조직 중 collagen 함량 저하가 다시마 추출물 투여에 의해 증가된 본 실험 결과로 미루어 보아 다시마 중의 phytoestrogen이 에스트로겐 유사효과를 나타냄을 알 수 있었다. 이상과 같이 폐경으로 인한 장애를 감소시키기 위하여 에스트로겐의 장기간 복용에 의한 부작용을 다시마 중의 phytoestrogen이 estrogen 대체 작용을 함으로써 그 부작용을 감소시켜 줄 것으로 사료되며, 이들의 구조 및 기전에 대해서는 앞으로 연구가 더 필요 한 것으로 생각된다.

• 대한지역사회영양학회지
• /
• 제4권3호
• /
• pp.412-420
• /
• 1999

The amount and type of dietary protein that effects affect bone mineral loss after menopause and different dietary patterns may influence anthropometric measurements, biochemical values, and bone metabolism. Objective : Our objective was to investigate bone metabolism and chronic disease factors in two different dietary patterns. Design: The sample consisted of 40 lacto-ove-vegetarians(LOV) and 49 omnivores aged from 47 to 85 years in good condition without any medical problems. Results : The average energy intake of LOV was 1414.0kcal and omnivores, 1403.2kcal. The difference between means was not statistically significant. The differences of means of body weight and BMI between the two groups were not significant but the systolic blood pressure of LOV group was significantly lower than omniovores(p<0.05). The values of serum cholesterol(p<0.05) and glucose(p<0.05) of LOV were signifcantly lower than that of omnivores. The serum albumin level(p<0.01) of LOV was lower than it'scounterpart but in a normal range. The intake of crude fiber(p<0.05) of LOV group was significantly higher. The urinary pH of LOV was 7.4 and that of omnivores was 6.3(p<0.001). Plant calcium(p>0.05) and plant iron(p<0.001) had positive correlations with the uninary pH but animal protein(p>0.05) and animal iron(p>0.05) had negative correlations with the urinary pH. The level of urinary biochemical marker of bone resorption, deoxypyridinoline(DPD) of LOV was significantly lower than the other group(p>0.05). The T-scores of bone mineral density for the two sites in the two groups were not significantly different. Conclusions : The DPD level and urinary pH value of LOV were more desirable for the bone metabolism that the omnivores. The diet of LOV had lower risk factors of chronic diseases than the other group.

• 한국식품영양학회지
• /
• 제21권1호
• /
• pp.71-78
• /
• 2008

This study examined the effects of mulberry-leaf powder Tofu(MPT) on the anthropometric measurements, bone mineral density(BMD), biochemical markers of bone turnover, serum lipid levels of and macrominerals status in 30 female university students living in Choongnam with low dietary Ca intake was low(mean daily $intake=524.66{\pm}21.47$ mg/day). The subjects received the MPT supplemented(100 g/day) for 4 weeks. The nutrient content per 100 g MPT was 84.10 kcal(energy), 8.98 g(protein), 0.53 mg(fiber), 211.33 mg(Ca) and 1.59 g(fat). Anthropometric measurements, 24-hour dietary recall, carpus BMD using DEXA, select BMD biomarckers(serum alkaline phophatase activity, osteocalcin, urinary deoxypyridinoline), serum protein levels, albumin, and glucose levels, lipid profiles(cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol) and serum macrominerals(Ca, Ca/P ratio, Mg) were analyzed before and after MPT supplementation. Following MPT supplementation, there was no significant differences in anthropometric measurements, nutrient intakes, carpus BMD, serum alkaline phosphatase activity, osteocalcin, and urinary deoxypyridinoline, serum levels of protein, albumin, and glucose or lipid profiles with AI, HTR, LHR and CRF. However, there were significant increases in dietary calcium as well as decreases in serum triglycerides with MPT supplementation. Although further research is needed, these results that regular intake MPT could prevent bone and cardiovascular diseases.

• 대한본초학회지
• /
• 제25권2호
• /
• pp.1-10
• /
• 2010

Objectives : The present study has been undertaken to investigate the effects of Cervi Cornu on treatment of osteoporosis in ovariectomized rats. Method : In this experiment, the rats were ovariectomized. Rats were administered by Cervi Cornu. The levels of bone mineral density, osteocalcin, ALP, calcium, phosphorus in serum, calcium, phosphorus, deoxypyridinoline in urine, ash weight of bone, body weight and uterus weight were measured. Results : 1. The levels of fibula-tibial bone mineral density were significantly increased in comparison with OVX group at 8 weeks in Cervi Cornu group. 2. The levels of serum osteocalcin showed significant decrease in comparison with OVX group at 4 weeks in Cervi Cornu group. The levels of serum ALP and phosphorus showed significant decrease in comparison with OVX group at 4, 8 weeks in Cervi Cornu group group. The levels of serum calcium showed significant increase in comparison with OVX group at 4, 8 weeks in Cervi Cornu group. 3. The levels of urine calcium, phosphorus and deoxypyridinoline showed significant decrease in comparison with OVX group in Cervi Cornu group. 4. The levels of fibula-tibial ash weight showed significant increase in comparison with OVX group in Cervi Cornu group. 5. The levels of body weight were significantly decreased in comparison with OVX group at 4, 8 weeks in Cervi Cornu group. 6. The levels of uterus weight were significantly increased in comparison with OVX group in Cervi Cornu group. Conclusion : Reviewing these experimetal results, it appeared that Cervi Cornu had efficacy on treatment of osteoporosis.

• 대한본초학회지
• /
• 제24권1호
• /
• pp.59-71
• /
• 2009

본 연구는 상표소와 상심자가 난소적출로 유발된 흰쥐의 골다공증 치료효과에 미치는 영향에 관한 것으로서 주요 내용은 다음과 같다. 본 연구에서는 상표소와 상심자 물 추출물을 난소를 절제한 흰쥐에 투여하여 대퇴골, 비골경골의 골밀도, 혈청 중 오스테오칼신 함량, 알칼리성 인산가수분해효소 활성도, 칼슘 함량, 인 함량, 소변 중 무기성분의 변화, deoxypyridinoline 함량 등과 뼈의 함량, 인 함량, ash 무게에 미치는 영향을 살펴보았다. 본 실험 결과 상표소와 상심자 물 추출물은 폐경기 이후 골다공증에 대한 치료에 효과적이라고 판단된다는 내용이다.

• Journal of Community Nutrition
• /
• 제5권3호
• /
• pp.132-140
• /
• 2003

The objective of this study was to investigate the effect of soymilk and exercise on bone mineral density (BMD) in underweight college women of 19-22 years of age, who had lower bone mass. The BMD of the lumbar spine and femoral neck was measured for 52 underweight college women. Among them, 33 subjects, whose t-score value was below -1, were selected. Questionnaire survey, anthropometrical measurements, dietary recall, analysis of BMD, fasting serum osteocalcin and urinary deoxypyridinoline (DPD) were conducted before and after the 10 week study. The 33 subjects were divided into 2 groups： soymilk group (n=19), and soymilk ＋ exercise group (n=14). The soymilk group was given 400$m\ell$ soymilk containing 60mg of isoflavones on a daily basis and the soymilk ＋ exercise group exercised three times a week with a daily intake of 400$m\ell$ soymilk for 10 weeks. The average ages of the soymilk group and the soymilk ＋ exercise group were 21.1 years and 20.4 years, respectively and, there were no significant differences between the soymilk group and the soymilk ＋ exercise group in the areas of height, weight or Body Mass Index (BMI). At the baseline, the mean daily energy intake of the soymilk group and the soymilk ＋ exercise group was 1,597.9kcal (79.43％ of RDA) and 1,704.2kcal (85.2％ of RDA), respectively. The mean calcium intake of the soymilk group (408.3mg) was not significantly different from that of the soymilk ＋ exercise group (389.4mg). Despite the 400$m\ell$ soymilk supplementation, there were no significant changes of nutrient intake in either group after treatment. However, there were significant increases in BMD's of lumbar spine and femoral neck in both groups. There were some increases in the serum osteocalcin level and decreases in the urinary deoxypyridinoline level as well. BMD change of the soymilk group was not significantly different from that of the soymilk ＋ exercise group. In conclusion, supplementary intake of soymilk (containing 60mg of isoflavones) resulted in a significant increase in the BMD's of the lumbar spine and femoral neck in underweight college women with low bone mass. However, exercise did not result in any significant changes in the BMD's, implying the necessity for more intensive and specific long-term physical training for any substantial changes. Further investigation is necessary to determine the exercise that most strongly affects BMD.

• Journal of Nutrition and Health
• /
• 제45권2호
• /
• pp.121-126
• /
• 2012

본 연구는 n-3 장쇄지방산이 풍부한 어유가 골격대사에 미치는 영향을 알아보고자 이유한 Sprague-Dawley 종 흰쥐 (수컷)에게 4주 동안 FO군, FICO군, SO군의 실험식이를 공급한 후, 혈액과 뇨에서 생화학적 골격대사지표와 대퇴골의 무기질함량 및 골밀도를 측정하였다. 부갑상선호르몬, 칼시토닌, 오스테오 칼신은 세 그룹 사이에 차이를 보이지 않았으며, 뼈흡수지표인 deoxypyridinoline도 그룹 간에 차이가 없는 것으로 나타났다. 반면에 골격형성지표인 ALP의 활성은 FO군에서 SO군에 비해 유의하게 높았고, 대퇴골의 골밀도 또한 SO군에 비해 FO군에서 유의하게 높은 값을 보였다. 그러나 FICO군과 SO군 간에는 차이가 없는 것으로 나타났다. 이러한 결과로 볼 때, 본 연구에서 DHA, EPA 급원의 어유 함량이 높은 식이는 ALP활성을 높이고 골밀도를 증대시킴으로써 성장기 흰쥐의 골격형성에 보호적인 효과가 있음을 알 수 있다. 그러나 식이 n-3 장쇄지방산이 골격대사에 미치는 효과를 규정하기 위해서는 적정식이수준이나 적정 n6/n3 비율과 관련된 많은 연구가 요구되며, n-3계 내의 각 지방산이 골격에 주는 작용양상에도 차이가 있을 수 있으므로 이에 대한 다양한 연구의 병행이 필요할 것으로 본다.