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Bone Loss Preventing Effect of Sophorae Fructus On Ovariectomized Rats  

Shim Jae Geul (College of Pharmacy, Chung-Ang University)
Yeom Seung Hwan (College of Pharmacy, Chung-Ang University)
Kim Hyun Jung (College of Pharmacy, Chung-Ang University)
Choi Young Wook (College of Pharmacy, Chung-Ang University)
Lee Do Ik (College of Pharmacy, Chung-Ang University)
Song Kye Yong (College of Medicine, Chung-Ang University)
Kwon Suk Hyung (Rexgene Biotech Co., Ltd.)
Lee Min Won (College of Pharmacy, Chung-Ang University)
Publication Information
Archives of Pharmacal Research / v.28, no.1, 2005 , pp. 106-110 More about this Journal
Abstract
The preventive effects of Sophorae Fructus extracts (I: hot water extract and II: combination product using I) on bone loss in ovariectomized (OVX) rats were investigated. Sophorae Fructus extracts were orally administrated to OVX rats for 9 weeks. Ovariectomy caused the increase of body weight and deoxypyridinoline (Dpd: bone resorption marker) and decrease of calcium (Ca: bone formation marker) level in serum. Dpd level were significantly decreased and Ca levels were elevated at 9 weeks in Sophorae Fructus extracts administered groups after ovariectomy at a dose of 0.556 g/kg/day compared with control group. In administered groups, trabecular bone area (TBA) in the tibia and lumbar were also increased compared with control group in histomorphological analysis. The preventive or treatment effects of Sophorae Fructus extracts on bone loss in OVX rats appears to be due to suppression of bone turnover.
Keywords
Sophorae fructus; Osteoporosis; Ovariectomy; Deoxypyridinoline; Calcium level; Trabecular bone area;
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1 Balbaa, S. I., Zaki, A., Y., and Eln Shamy, A. M., Qualitative and quantitative study of the flavonoid content of the different organs of Sophora japonica at different stages of development. Planta Medica, 25, 325-330 (1974)   DOI   ScienceOn
2 Han, B. H., Takeatsu, K., Paul, P. H. But, Guo, J.-X., and Sung, C. K., International Collation of Traditional and Folk Medicine: Northeast Asia-Part I, World Scientific Publishing Co., Singapore, p.p. 68-69 (1996)
3 Hesley, R. P., Shepard, K. A., Henkins, D. K., and Riggs, B. L., Monitoring estrogen replacement therapy and identifying rapid bone losers with an immunoassay for deoxypyridinoline. Osteoporosis int., 8, 159-164 (1998)   DOI   ScienceOn
4 Kariyone, T., Ishimasa, S., and Shiomi, T., Triterpenoids. VIII. Triterpenoids contained in Sophora japonica. Yakugaku Zasshi., 76, 1210-1211 (1956)
5 Kim, H. J., Kim, M. G., Shim, J. G., Yeom, S. H., and Lee, M. W., Quantitative Determination of Isoflavonoids and Flavonoids from Sophorae Fructus. Chung-Ang Journal of Pharmacal Sciences, 18, 37-43 (2004)
6 Omi, N. and Ezawa, I., The effect of ovariectomy on bone metabolism in rats. Bone, 17, 163S-168S (1995)
7 Riggs, B. L., Overview of osteoporosis. West J. Med., 154, 63- 77 (1991)
8 Takahashi, M., Ishimasa, S., and Koyama, Y., Components of Sophora japonica. IV. Optical rotary dispersion curve of the derivative of sophoradiol. Yakugaku Zasshi., 80, 698-699 (1960)
9 Kimura, M. and Yamada, H., Interaction in the antibacterial activity of flavonoids from Sophora japonica L. to Propionibacterium. Yakugaku zasshi., 104, 340-346 (1984)
10 Stark, A. and Madar, Z., Phytoestrogens: a review of recent findings. J. Pediatr. Endocrinol. Metab., 15, 561-572 (2002)
11 Belcher, S. M. and Zasrnovszky, A., Estogenic actions in the brain: estrogen, phytoestrogen, and rapid intracellular mechanisms. J. Pharmacol. Exp. Ther., 299, 408-414 (2001)
12 Setchell, K. D. R., Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. AM. J. Clin. Nutr., 68, 1333S-1346S (1998)
13 Wang, L.-Q., Mammalian phytoestrogens: enterodiol and enterolactone. J. Chromatoar., B 777, 289-309 (2002)
14 Garnero, P. and Delmas, P. D., New developments in biochemical markers for osteoporosis. Calcified tissue international, 59, S2-9, (1996)   DOI   PUBMED
15 Bhathena, S. M. and Velasquez, M. T., Beneficial role of dietary phytoestrogens in obesity and diabetes. AM. J. Clin. Nutr., 76, 1191-1201 (2002)
16 Seyedin, S. M. and Rosen, D. M., Matrix Proteins of the Skeleton. Curr. Opin. Cell Biol., 2, 914-919 (1990)   DOI   ScienceOn
17 Riley, J. P., The use of continuous extraction for the removal of interfering elements in the determination of calcium and magnesium. Analytica Chimica Acta, 21, 317-323 (1959 )   DOI   ScienceOn
18 Akhmedkhodzhaeva, N. M., Svechnikova, A. N., Bandyukova, V. A., and Kambarova, D. M., Determination of flavones in Sophora japonica fruits. Farmatsiya, 35, 60-61 (1986)
19 Genant, H. K., Bay link, D. J., and Gallagher, J. C., Estrogens in the prevention of osteoporosis in post menopausal women. American Journal of Obsteterics and Gynaecology, 161, 1842-1846 (1998)
20 Eastell, R., Colwell, A., Hampton, L., and Reeve, J., Biochemical markers of bone resorption compared with estimates of bone resorption from radiotracer kinetic studies in osteoporosis. J. Bone Miner. Res., 12, 59-65 (1997)   DOI   ScienceOn
21 Van Staveren, W. A., de Groot, L. C., Blanco, Y. H., and Van der Wilen, R. P., Assessing diets of elderly people: problems and approaches. Am. J. Clin. Nutr., 59, 2215-2235 (1999)
22 Kim, T. W., The Woody Plants of Korea in Color, Kyo-Hak Publishing Co., Seoul, Korea, p. 399 (1995)
23 Glazier, M. G. and Bowman, M. A., A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch. Intern. Med., 161, 1161- 1172 (2001)   DOI   ScienceOn
24 Gruber, H. E., Ivey, J. L., Baylink, D. L., Mathews, M., Nelp, W. B., Sison, K., and Chestnut, C. H., Lomg-term calcitonin therapy in postmenopaual osteoporosis. Metabolism, 33, 295-303 (1984)   DOI   ScienceOn