The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effect of Cervi Cornu On treatment of Osteoporosis in Ovariectomized Rats

녹각(鹿角)이 난소적출로 유발된 흰쥐의 골다공증 치료효과에 미치는 영향

  • Hwang, Jeong-Soo (Department of Oriental Medicine, Daegu Haany University) ;
  • Seo, Bu-Il (Department of Oriental Medicine, Daegu Haany University) ;
  • Park, Ji-Ha (Department of Oriental Medicine, Daegu Haany University) ;
  • Roh, Seong-Soo (Department of Oriental Medicine, Daegu Haany University) ;
  • Kim, Mi-Ryeo (Department of Oriental Medicine, Daegu Haany University) ;
  • Kim, Seong-Mo (Department of Oriental Medicine, Daegu Haany University) ;
  • Koo, Jin-Suk (Couple Oriental Medical Hospital)
  • Received : 2010.04.19
  • Accepted : 2010.06.22
  • Published : 2010.06.30
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Abstract

Objectives : The present study has been undertaken to investigate the effects of Cervi Cornu on treatment of osteoporosis in ovariectomized rats. Method : In this experiment, the rats were ovariectomized. Rats were administered by Cervi Cornu. The levels of bone mineral density, osteocalcin, ALP, calcium, phosphorus in serum, calcium, phosphorus, deoxypyridinoline in urine, ash weight of bone, body weight and uterus weight were measured. Results : 1. The levels of fibula-tibial bone mineral density were significantly increased in comparison with OVX group at 8 weeks in Cervi Cornu group. 2. The levels of serum osteocalcin showed significant decrease in comparison with OVX group at 4 weeks in Cervi Cornu group. The levels of serum ALP and phosphorus showed significant decrease in comparison with OVX group at 4, 8 weeks in Cervi Cornu group group. The levels of serum calcium showed significant increase in comparison with OVX group at 4, 8 weeks in Cervi Cornu group. 3. The levels of urine calcium, phosphorus and deoxypyridinoline showed significant decrease in comparison with OVX group in Cervi Cornu group. 4. The levels of fibula-tibial ash weight showed significant increase in comparison with OVX group in Cervi Cornu group. 5. The levels of body weight were significantly decreased in comparison with OVX group at 4, 8 weeks in Cervi Cornu group. 6. The levels of uterus weight were significantly increased in comparison with OVX group in Cervi Cornu group. Conclusion : Reviewing these experimetal results, it appeared that Cervi Cornu had efficacy on treatment of osteoporosis.

Keywords

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