• Journal of Korean society of Dental Hygiene
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• v.2 no.2
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• pp.175-186
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• 2002

Fluoride has been one of the most widely studied caries-preventive agents. But the effect of prenatal administration had been controversies for many years. The results showed that there were no influence on reproductive rate of rats with administration of fluoride from 0 to 20 ppm during pregnancy(p>0.05). There was a trend towards slightly increased the mean ash weight in the 1, 5 and 20 ppm groups, as compared with the control group. However, there was no significant differences among groups (p>0.05). The contents of calcium, magnesium and phosphorus in the total bone were increased with the administrated fluoride concentration were increased, but there were no statistically significant differences among groups(p>0.05). The mean fluoride level of 1 ppm group was significantly higher than that of control group, but the concentrations of fluoride in total carcass pups of 5 and 20 ppm groups were significantly less than that of 1 ppm group(p>0.05). The results of this study indicate that the amount of fluoride transferred to the offspring, which may produce anticariogenic effects in the primary teeth of their effects in the primary teeth of their offspring.

• Journal of the korean academy of Pediatric Dentistry
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• v.35 no.1
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• pp.144-150
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• 2008

Multimodal cancer therapy including surgery, chemotherapy, and radiotherapy could not only improve the prognosis of malignancy but also reduce the dosage and toxicity of cancer drug for treatment of malignant tumor. The effects of radiotherapy are generally localized, additive, and accumulative, and depend on dosage, site and cell sensitivity. However, in growing individuals, the dental and skeletal sequelae to radiotherapy result in dental or facial abnormalities that are irreversible : arrested root development, disturbances in enamel formation, microdontia, anodontia, altered tooth eruption and mandibular or maxillary hypoplasia. Especially, the teeth which are developing is affected according to the stage. We report three cases of developmental disturbance of permanent teeth after radiotherapy. These children had received radiotherapy for malignant tumor at the age of 3 to 4 years, in which root hypoplasia, short tapered root and early apex closure were observed. For the management of radiation caries and radiotherapy-related teeth, periodic recall check and oral hygiene instruction are required.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.6
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• pp.1270-1276
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• 2002

Compounds 1 - 12 were tested for their growth inhibitory effects against tumor cell lines using two different 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and sulforhodamine B protein (SRB) assays and antimicrobial activity. The cytotoxic activity of methyl-4-[{(2E)-3,7-dimethyl-2,6-octadienyl}oxy]-3-methoxy benzoate (1) exhibit more active than that of 5-fluorouracil (11) on human oral epithelioid carcinoma (KB, ATCC No. OCL 17) cell lines. But this compound (1) on human skin melanoma (SK-MEL-3, HBT 69) cell lines shows less active than that of adriamycin (12). However, compound 9 showed the antimicrobial activity against S. epidermidis (MIC, 15.625 ㎍/㎖), S. aureus, C. albicans (MIC, 31.25 ㎍/㎖), S. mutans, S. typhimurium, P. putida (MIC. 125 ㎍/㎖) and P. aeruginosa (MIC, 500 ㎍/㎖).

• Journal of the Korea Convergence Society
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• v.12 no.3
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• pp.27-34
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• 2021

This study aims to provide basic data to identify the effects of oral health behavior and autologous oral health symptoms on factors that affect quality of life of COVID-19 (coronavirus disease 19) depression. This study collected data from July 2020 to September 2020, the research method was finally analyzed for 89 people in the group of depression non-increase and 86 people in the group of depression due to COVID-19. As an analysis method, oral health behavior, autologous oral health symptom and quality of life were compared, and the hierarchical regression analysis was implemented to check the effect of depression on the quality of life. As a result, the effects of depression (��=-0.155, p=0.012) and autologous oral health symptoms (��=0.524, p<0.001) were significant as a result of controlling demographic characteristics and checking the effects on quality of life. Therefore, it is urgent to develop programs related to the mental health of the community to relieve depression and anxiety with COVID-19, and public relations activities will be needed to relieve anxiety about dental visits so that dental treatment can be received at an appropriate time.

• Journal of dental hygiene science
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• v.7 no.2
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• pp.101-106
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• 2007

This research was based on self-filling survey which 128 dental hygienists who work in dental clinic and dental hospital on May 2006 through July 2006. This survey was analyzed the prevention against virus infection in dental hygienist at medical treatment. As follows analyzed results The experience of get a hand pricked by an infected needle rate is 76.6 percent and the majority of the dental hygienist are sterilize by disinfectant after wash hand and draw blood. The most of dental hygienist are experienced the education of the prevention infection in student and they think that It is necessary to prevention infection in medical treatment. The proportion of use the glove and mask in medical treatment and disuse the glove after medical treatment and the mask when mask get damped is high but the rate of put on the goggle in medical treatment and use the glove in washing and re-treat is low irrespective of age, clinical career, work place. As a result of Independent-sample T Test, the Hygienist who have experience the education of the prevention against virus infection are more excellent work than in-experience group in medical treatment. So we can find that the experience of the education of the prevention infection is very significant to prevention infection in dental hygienist.

• International Journal of Oral Biology
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• v.37 no.3
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• pp.146-152
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• 2012

MicroRNAs (miRNAs, miRs) are about 21-25 nucleotides in length and regulate mRNA translation by base pairing to partially complementary sites, predominantly in the 3'-untranslated region (3'-UTR) of the target mRNA. In this study, the expression profile of miRNAs was compared and analyzed for the establishment of miRNA-related odontoblast differentiation using MDPC-23 cells derived from mouse dental papilla cells. To determine the expression profile of miRNAs during the differentiation of MDPC-23 cells, we employed miRNA microarray analysis, quantitative real-time PCR (qRT-PCR) and Alizaline red-S staining. In the miRNA microarray analysis, 11 miRNAs were found to be up- or down-regulated more than 3-fold between day 0 (control) and day 5 of MDPC-23 cell differentiation among the 1,769 miRNAs examined. In qRT-PCR analysis, the expression levels of two of these molecules, miR-194 and miR-126, were increased and decreased in the control MDPC-23 cells compared with the MDPC-23 cells at day 5 of differentiation, respectively. Importantly, the overexpression of miR-194 significantly accelerated mineralization compared with the control cultures during the differentiation of MDPC-23 cells. These results suggest that the miR-194 augments MDPC-23 cell differentiation, and potently accelerates the mineralization process. Moreover, these in vitro results show that different miRNAs are deregulated during the differentiation of MDPC-23 cells, suggesting the involvement of these genes in the differentiation and mineralization of odontoblasts.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.1
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• pp.230-233
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• 2005

The cytotoxic activity of $13(E)-labd-13-ene-8{\alpha}$, 15-diol (1), isolated from the ethanol extract of Brachyglottis monroi, was evaluated against human oral epithelioid carcinoma cells(KB).

• Journal of Microbiology and Biotechnology
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• v.12 no.6
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• pp.993-997
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• 2002

A glucanhydrolase (a DXAMase exhibiting both dextranolytic and amylolytic activities) from Lipomyces starkeyi KSM 22 hydrolyzed polysaccharides having ${\alpha}-(1{\rightarrow}3)-,\;{\alpha}(1{\rightarrow}4)-,\;and\;{\alpha}-(1{\rightarrow}6)$-D-glucosidic linkages. The oral hygiene benefits of DXAMase-containing mouthwash were examined in relation to human experimental gingivitis during a 3-week period without brushing. The DXAMase-treated group exhibited a lower increase in plaque accumulation and gingival index score than the chlorhexidine-treated group. The DXAMase-treated group also showed less tongue accumulation, bad taste, and tooth staining, thus indicating a positive role for DXAMase as an antiplaque agent ingredient.

• Journal of environmental and Sanitary engineering
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• v.21 no.2 s.60
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• pp.1-10
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• 2006

Codonopsis pilosula and Adenophora triphylla were cultivated by sawing seeds, but the germination rate were low. To cultivate these two wild plants was very difficult. The marketable roots of the plants had low quality. The plant pathogens were very difficulty to prevent the diseases (Rhizoctonia, Pythium, Fusarium, Erwinia, Botrytis, Phythophthora) appeared in cultural state. For the extermination of the disease needs a lot of agricultural chemicals, the effect of remain behind an insecticides was high of a hazardous rate after harvest. On this studies, for the safe prevention of the diseases and the promote of seeds germination, we used Bacillus subtilis, B. liquefaciens, Paenibacillus polymixa, Pseudomonas putida separated in our research, these results would bring us harmless products of medicinal herbs for human.

• The Journal of Korean Society for School & Community Health Education
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• v.13 no.3
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• pp.33-42
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• 2012

Purpose: This research targeted the high school students to analysis the behavior leading to oral health following the level of knowledge of and attitude towards oral health. Going steps further, this research examines the effect of the education on the oral cavity's health on the behavior leading to oral health to provide the need to conduct education on the oral cavity's health. Methods: High school students in the 1st to the 3rd grades in two high schools in Gyeongsangnamdo were targeted to conduct survey on 444 students. Collected data was subjected to the SPSS statistical program to obtain the frequency, percentage and average. Moreover, standard deviation, t-verification, one-way ANOVA, correlation analysis and logistics regression analysis were conducted. Results: First, average of the high school students' knowledge of and attitude towards oral cavity's health was higher when the education on the oral cavity's health was received compared to when education on the oral cavity's health was not received. Second, knowledge of and attitude towards oral cavity's health were high when there was the willingness to participate in the education on the oral health. In case education on the oral cavity's health was received, average of the knowledge of oral cavity's health was high, which manifested statistically significant difference. Average of the knowledge of oral cavity's health was high as well in case there is a perception that the need for the education on oral cavity exists. Third, the probability of having had their teeth scaled was higher when the total score for the knowledge of oral cavity's health was higher. The probability of having had their teeth scaled was higher when the score on the attitude for preventing periodontal disease was higher. Conculsion: These results demonstrate that the existence of high school students' education on the oral cavity's health, and knowledge of and attitude towards oral cavity's health exert significant influence on the behavior leading to oral cavity's health.