[KSCI] Korea Science Citation Index Service

Cytotoxic and Antimicrobial Activities of Bioactive Monoterpenophenols

Oh In Kio (Department of Environmental Hygiene, Wonkwang Health Science College)
Lee Hyun Ok (Department of Dental Hygiene, Wonkwang Health Science College)
Ahn Jong Woong (Medicinal Science Division, Korea Research Institute of Chemical Technology)
Kim Hyung Min (Department of Oriental Pharmacy, School of Pharmacy, Wonkwang University)
Shin Ji Hee (Department of Herbal Resources, Professional Graduate School of Oriental Medicine Wonkwang University)
Lim Jin A (Department of Herbal Resources, Professional Graduate School of Oriental Medicine Wonkwang University)
Chun Hyun Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine Wonkwang University)
Baek Seung Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine Wonkwang University)

Publication Information

Journal of Physiology & Pathology in Korean Medicine / v.16, no.6, 2002 , pp. 1270-1276 More about this Journal

Abstract

Compounds 1 - 12 were tested for their growth inhibitory effects against tumor cell lines using two different 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and sulforhodamine B protein (SRB) assays and antimicrobial activity. The cytotoxic activity of methyl-4-[{(2E)-3,7-dimethyl-2,6-octadienyl}oxy]-3-methoxy benzoate (1) exhibit more active than that of 5-fluorouracil (11) on human oral epithelioid carcinoma (KB, ATCC No. OCL 17) cell lines. But this compound (1) on human skin melanoma (SK-MEL-3, HBT 69) cell lines shows less active than that of adriamycin (12). However, compound 9 showed the antimicrobial activity against S. epidermidis (MIC, 15.625 ㎍/㎖), S. aureus, C. albicans (MIC, 31.25 ㎍/㎖), S. mutans, S. typhimurium, P. putida (MIC. 125 ㎍/㎖) and P. aeruginosa (MIC, 500 ㎍/㎖).

Keywords

Growth inhibitory effects; MTT; SRB; KB; SK-MEL-3;

Citations & Related Records

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