• Korean Journal of Clinical Pharmacy
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• v.8 no.2
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• pp.107-112
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• 1998

Lovastatin is a lipid lowering agent for the treatment of hypercholesterolemia and belongs to a new class of pharmacologic compounds called the 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors. By competitively inhibiting HMG CoA reductase, lovastatin disrupts the biosynthesis of cholesterol in hepatic and peripheral cells and increases the synthesis of high-density-lipoprotein HDL) receptors. Following oral administration, the lactone ring of lovastatin is hydrolysed to the active inhibitor of HMG CoA reductase, lovastatin acid. Lovastatin is known to have poor oral absorption and wide individual variation. In this study, bioequivalence test of two lovastatin formulations, the test drug ($Lovaload^{TM}$, Chong Kun Dang Pharmaceutical Co.) and the reference drug ($Mevacor^{TM}$, Chung Wae Pharmaceutical Co.) were conducted according to the guidelines of Korea Food and Drug Administration (KFDA). A total of 18 healthy male volunteers, $31.90\pm3.60$ years old and $72.17\;7.88$ kg of body weight in average, were evaluated in a randomized crossover manner with a 2-week washout period. Concentrations of lovastatin acid in plasma were measured upto 12 hours following a single oral administration of eight tablets (20 mg of lovastatin per tablet) by high-performance liquid chromatography with UV detection at 238 nm. The area under the concentration-vs-time curve from 0 to 12 hours $(AUC_{0-12h})$ was calculated by the trapezoidal summation method. The statistical analysis showed that there are no significant differences in $AUC_{0-12h),\;C_{max}\;and\;T_{max}$ between the two formulations ($6.72\%,\;1.52\%,\;and\;0.88\$, respectively). The least significant differences between the formulations at $\alpha$=0.05 were less than $20\%\;(11.65\%,\;19.73\%,\;and\;14.81\%\;for\;AUC_{0-12h},\;C_{max}\;and\;T_{max}$, respectively). The $90\%$ confidence intervals for these parameters were also within $\pm20\%\;(-1.50{\leq}{\delta}{\leq}15.00$, $-12.50{\leq}{\delta}{\leq}15.50,\;and\;-9.64{\leq}{\delta]{\leq}11.40{\leq}\;for\;\;AUC_{0-12h}$ ,$C_{max}\;and\;T_{max}$, respectively). In conclusion, the new generic product $Lovaload^{TM}$ was proven to be bioequivalent with the reference drug.

• Journal of the Korea Concrete Institute
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• v.23 no.1
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• pp.39-48
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• 2011

The present investigation evaluates the flexural behavior of pre-tensioned lightweight concrete beams under two-point symmetrical concentrated loads according to the variation of the partial prestressing ratio and the effective prestress of prestressing strands. The designed compressive strength of the lightweight concrete with a dry density of 1,770 $kg/m^3$ was 35 MPa. The deformed bar with a yield strength of 383 MPa and three-wire mono-strands with tensile strength of 2,040 MPa were used for longitudinal tensile reinforcement and prestressing steel reinforcement, respectively. According to the test results, the flexural capacity of pre-tensioned lightweight concrete beams increased with the increase of the partial prestressing ratio and was marginally influenced by the effective prestress of strands. With the same reinforcing index, the normalized flexural capacity of pre-tensioned lightweight concrete beams was similar to that of pre-tensioned normal-weight concrete beams tested by Harajli and Naaman and Bennett. On the other hand, the displacement ductility ratio of pre-tensioned lightweight concrete beams increased with the decrease of the partial prestressing ratio and with the increase of the effective prestress of strands. The load-displacement relationship of pre-tensioned lightweight concrete beam specimens can be suitably predicted by the developed non-linear two-dimensional analysis procedure. In addition, the flexural cracking moment and flexural capacity of pre-tensioned lightweight concrete beams can be conservatively evaluated using the elasticity theorem and the approach specified in ACI 318-08, respectively.

• Journal of the Korean Geographical Society
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• v.47 no.1
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• pp.79-97
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• 2012

This study examines on the impact of biodiversity in circular greenspace of Cheongju city since 2002 greenbelt release. Research has carried out to investigate the biotope pattern change with landscape fragmentation. Major landscape fragmentation has occurred with development of residential sector and build-up of major highways. Settlement has been expanded to the entire area connected to urban district excluding the eastern forest. North-south district shows high road density, where inter-regional roads meet in the cross-section. It is found that landscape fragmentation impact on species richness as well as population size of the species varies depending on the animal species. The birds show high species richness in N2, N3, N4, S2(north-south zone) even with high fragmentation rate. This can be explained that birds can access to aquatic environment where they can find abundant food resources. The amphibians and the reptiles show almost no zonal variation in species richness than the birds. The more a zone fragmented in small patches, the species richness of the amphibians and the reptiles also tends to be declined. Information accumulation on biodiversity for integrating landscape planning in urban planning, various level of community participation in decision making process, and cross border cooperation with neighbouring Cheongwon-gun will be required for sustainable greenspace management of Cheongju City.

• Journal of the Korean Geotechnical Society
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• v.21 no.7
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• pp.55-62
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• 2005

The use of the bearing capacity equation is subjected to several uncertainties. In this study, estimation of the bearing capacity of footings based on the cone resistance q$_{c}$ is investigated. Non-linear finite element analyses based on a state-dependent stress-strain model were performed to obtain the load-settlement responses of axially loaded circular footings. Various soil and footing conditions, including different relative densities, depths of embedment, and footing diameters were considered in the analyses. Based on the finite element results, load-settlement curves were obtained and used to determine the unit limit bearing capacity in terms of the cone resistance q$_{c}$ for footings subjected to surcharge. Values of the unit bearing capacity for different embedment depths were in a narrow range, while considerable variation was observed with relative density D$_{R}$. It was observed that the unit limit bearing capacity normalized with respect to q$_{c}$ decreases as D$_{R}$ increases for a given surcharge.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.5
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• pp.819-824
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• 2016

The accelerated thermal aging of CSPE (chlorosulfonated polyethylene) was carried out for 33.64 and 67.27 days at 110[$^{\circ}C$], equivalent to 40 and 80 years of aging at 50[$^{\circ}C$], respectively. These samples were referred to as CSPE-0y, CSPE-40y and CSPE-80y, respectively. As the accelerated thermally aged years of the CSPE increase, the insulation resistance[$\Omega$] at 20[Hz], 500[Hz], and 2[KHz], and the percent elongation [%EL] of the CSPE decrease. However, the dissipation factor($tan{\delta}$) at 20[Hz], 500[Hz], and 2[KHz], the apparent density[$g/cm^3$], the glass transition temperature and the melting temperature of the CSPE were increased. The period of time that the voltage has to be applied until electric breakdown of the CSPE-0y is longer than that of the CSPE-40y, and the CSPE-80y, but the dielectric strength of the CSPE-80y is lower than that of the CSPE-0y and the CSPE-40y. The differential temperatures after the AC and DC voltages are applied to CSPE-0y, CSPE-40y and CSPE-80y are 0.026~0.028[$^{\circ}C$], 0.030~0.042[$^{\circ}C$], 0.018~0.045[$^{\circ}C$], respectively. The variations of temperature for the AC voltage are higher than those for the DC voltage when an AC voltage is applied to CSPE-0y, CSPE-40y and CSPE-80y. It is found that the dielectric loss owing to the dissipation factor[$tan{\delta}$] is related to the electric dipole conduction current. It is ascertained that the ionic (electron or hole) leakage current is increased by the separation of the branch chain of CSPE polymer from the main chain of the polyethylene as a result of thermal stress due to accelerated thermal aging as well as by conducting ions such as $Na^+$, $Cl^-$, $Mg^{2+}$, $SO_4^{2-}$, $Ca^{2+}$ and $K^+$ after seawater soaking.

• KIEE International Transaction on Systems and Control
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• v.2D no.2
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• pp.78-91
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• 2002

In the thermal power plant, there are six manipulated variables: main steam flow, feedwater flow, fuel flow, air flow, spray flow, and gas recirculation flow. There are five controlled variables: generator output, main steam pressure, main steam temperature, exhaust gas density, and reheater steam temperature. Therefore, the thermal power plant control system is a multinput and output system. In the control system, the main steam temperature is typically regulated by the fuel flow rate and the spray flow rate, and the reheater steam temperature is regulated by the gas recirculation flow rate. However, strict control of the steam temperature must be maintained to avoid thermal stress. Maintaining the steam temperature can be difficult due to heating value variation to the fuel source, time delay changes in the main steam temperature versus changes in fuel flow rate, difficulty of control of the main steam temperature control and the reheater steam temperature control system owing to the dynamic response characteristics of changes in steam temperature and the reheater steam temperature, and the fluctuation of inner fluid water and steam flow rates during the load-following operation. Up to the present time, the Proportional-Integral-Derivative Controller has been used to operate this system. However, it is very difficult to achieve an optimal PID gain with no experience, since the gain of the PID controller has to be manually tuned by trial and error. This paper focuses on the characteristic comparison of the PID controller and the modified 2-DOF PID Controller (Two-Degrees-Freedom Proportional-Integral-Derivative) on the DCS (Distributed Control System). The method is to design an optimal controller that can be operated on the thermal generating plant in Seoul, Korea. The modified 2-DOF PID controller is designed to enable parameters to fit into the thermal plant during disturbances. To attain an optimal control method, transfer function and operating data from start-up, running, and stop procedures of the thermal plant have been acquired. Through this research, the stable range of a 2-DOF parameter for only this system could be found for the start-up procedure and this parameter could be used for the tuning problem. Also, this paper addressed whether an intelligent tuning method based on immune network algorithms can be used effectively in tuning these controllers.

• Korean journal of applied entomology
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• v.54 no.4
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• pp.431-435
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• 2015

Riptortus pedestris (Fabricius) is one of the important insect pests of leguminous crops, which occurs in most areas of South Korea. It is hard to distinguish each generation in crop fields since not only the longevity of adult R. pedestris is long but also the developmental period is short. Especially, the 2nd generation adults cause enormous damage to soybean while the occurrence time is synchronized with the podding stage of soybean. Controlling the 1st generation of R. pedestris helps to decrease the damage by decreasing the 2nd generation density. This study was conducted to distinguish between the 1st generation and the overwintering generation by using differences in body coloration which is dependent on the day-length during the nymph stage. In addition, the difference was verified by the population dynamics model of R. pedestris. The occurrence time of 1st generation adults could be considered when the summer form is 20% or more. These results will be used for beneficial management decisions to reduce the 2nd generation population.

• Geophysics and Geophysical Exploration
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• v.19 no.2
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• pp.67-75
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• 2016

To investigate spatial and temporal variations of low-frequency (${\leq}5Hz$) ambient seismic noise, we analyzed the noise data recorded for one whole year of 2014 at surface accelerometer stations in South Korea. After decomposed into low-frequency (LF; < 1 Hz) and high-frequency (HF; ${\geq}1Hz$) components, the root-mean-squared (RMS) amplitudes and power spectral densities (PSD) of the noise data were computed. The RMS amplitudes were larger on islands and near-shore stations, but also large RMS amplitudes were observed at inland stations in large cities only for HF components. The RMS amplitudes of HF components were larger in the daytime than at nighttime and during weekdays than on Sunday and holidays. This indicates the HF components are closely related to human activities. On the contrary, daily and weekly variations were not clear in the LF components while they showed seasonal variations with its maximum during the winter and a good correlation with significant wave height. Therefore, we interpret the mechanism of LF components is closely related to natural phenomena such as sea. The amplitude of LF components decreased as an exponential function of the distance to the center of typhoons. The exponential index of -0.76 suggested that ambient seismic noise included both surface and body waves. Peak frequencies of the PSD curves were near 0.34 Hz indicating the double frequency. No temporal variation in the peak frequency was clearly noticed.

• Journal of the Korean Association of Geographic Information Studies
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• v.14 no.2
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• pp.53-68
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• 2011

A selection of viewpoint is a first priority for landscape evaluation. However, it has been artificially carried out by a subjective method without of criterion. Therefore, this study proposed the objective and quantitative viewpoint selection methods using space syntax and GIS. For this, the study area on samduk3 residential improvement district located at Daegu city was divided into 24 sectors of visibility zone by distance and direction. After that, the preliminary viewpoints equally distributed in space were selected by axial map analysis of space syntax and viewshed-frequency analysis of GIS. According to the result of selection of the final viewpoints using the VEI(Viewpoint Evaluation Index), all the final viewpoints were placed in the National Debt Repayment Movement; VEI value of VP-2 was 112.63 in the foreground, VP-10 was 18.31 in the middleground and VP-18 was 5.55 in the background. Selected viewpoints were verified as a big changing of landscape variation and high chance of view such as the public area, the park and the high-density residential area. Thus, VEI will be used as a quantitative method of selecting viewpoints and it is expected to be able to use as the objective indicator.

• Journal of Radiation Protection and Research
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• v.29 no.3
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• pp.165-172
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• 2004

Rice plants were exposed to $I_2$ vapor for 80 min at different growth stages in an exposure box to investigate the parameters concerning direct plant contamination. Deposition velocity $(m\;s^{-1})$ of the $I_2$ vapor for the straws was in the range of $1.4{\times}10^{-5}-1.3{\times}10^{-4}$ depending on the exposure time, being comparatively low during the earlier part of the plant growth. Ear deposition velocity was in the range of $2.5{\times}10^{-5}-6.7{\times}10^{-5}$. Whole-plant deposition velocity was in the range of $1.4{\times}10^{-5}-1.8{\times}10^{-4}$ with the highest from the exposure performed on Aug. 18 (7 d after the start of heading). The time-dependent variation generally decreased when the deposition velocity was normalized to the biomass density No noteworthy tendency in the deposition velocity was observed with regard to the temperature, sunlight and humidity. Translocation factor for the hulled seeds was $3.3{\times}10^{-5}-4.7{\times}10^{-4}$ with the highest from the Aug. 23 exposure. It was found that a leaf deposition even before the ear emergence resulted in a considerable seed translocation.