• 폴리머
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• 제39권3호
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• pp.370-381
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• 2015

고분자와 용매의 굴절률이 서로 일치되어 자체 산란광의 세기가 극소화된 시스템인 폴리(비닐 아세테이트) (PVAc)/디메틸설폭사이드(DMSO) 계에 폴리스티렌 라텍스 탐침입자(표시 직경 200 nm)를 소량 첨가한 뒤 동적 광산란법으로 용액의 PVAc 농도에 대한 입자의 확산 거동을 정밀하게 조사하였다. 구형 입자의 환산확산계수의 농도의존성은 환산농도 $C[{\eta}]$의 신장지수함수로 분석할 수 있었고, 묽은 농도에서는 배제층의 두께가 일정하게 유지되었으나 초기 준희박 농도인 $1{\leq}C[{\eta}]{\leq}2.5$ 범위에서는 배제층의 사슬농도 의존지수가 -0.8로써 이론적 계산치 -0.85와 일치하였다. 그러나 보다 높은 농도에서는 배제층의 두께가 이론적 예측보다 급속히 감소하는 현상 또한 관찰되었으며, 그 원인은 인접한 탐침 입자들 사이에 존재하는 Oosawa 인력 때문인 것으로 설명할 수 있었다.

• Journal of the Korean Wood Science and Technology
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• 제40권2호
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• pp.110-122
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• 2012

This study investigated the effects of layered clay on the thermal curing behavior and tensile properties of resole phenol-formaldehyde (PF) resin/clay/cellulose nanocomposites. The thermal curing behavior of the nanocomposite was characterized using conventional differential scanning calorimetry (DSC) and temperature modulated (TMDSC). The addition of clay was found to accelerate resin curing, as measured by peak temperature ($T_p$) and heat of reaction (${\Delta}H$) of the nanocomposite’ curing reaction increasing clay addition decreased $T_p$ with a minimum at 3~5% clay. However, the reversing heat flow and heat capacity showed that the clay addition up to 3% delayed the vitrification process of the resole PF resin in the nanocomposite, indicating an inhibition effect of the clay on curing in the later stages of the reaction. Three different methods were employed to determineactivation energies for the curing reaction of the nanocomposite. Both the Ozawa and Kissinger methods showed the lowest activation energy (E) at 3% clay content. Using the isoconversional method, the activation energy ($E_{\alpha}$) as a function of the degree of conversion was measured and showed that as the degree of cure increased, the $E_{\alpha}$ showed a gradual decrease, and gave the lowest value at 3% nanoclay. The addition of clay improved the tensile strengths of the nanocomposites, although a slight decrease in the elongation at break was observed as the clay content increased. These results demonstrated that the addition of clay to resole PF resins accelerate the curing behavior of the nanocomposites with an optimum level of 3% clay based on the balance between the cure kinetics and tensile properties.

• International Journal of Oral Biology
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• 제37권3호
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• pp.121-129
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• 2012

Previous clinical studies have demonstrated that gabapentin, a drug that binds to the voltage-gated calcium channel ${\alpha}2{\delta}1$ subunit proteins, is effective in the management of neuropathic pain, but there is limited evidence that addresses the participation of glial cells in the antiallodynic effects of this drug. The present study investigated the participation of glial cells in the anti-nociceptive effects of gabapentin in rats with trigeminal neuropathic pain produced by mal-positioned dental implants. Under anesthesia, the left mandibular second molar was extracted and replaced by a miniature dental implant to induce injury to the inferior alveolar nerve. Mal-positioned dental implants significantly decreased the air-puff thresholds both ipsilateral and contralateral to the injury site. Gabapentin was administered intracisternally beginning on postoperative day (POD) 1 or on POD 7 for three days. Early or late treatment with 0.3, 3, or 30 ${\mu}g$ of gabapentin produced significant anti-allodynic effect in the rats with mal-positioned dental implants. On POD 9, in the mal-positioned dental implants group, OX-42, a microglia marker, and GFAP, an astrocyte marker, were found to be up-regulated in the medullary dorsal horn, compared with the naive group. However, the intracisternal administration of gabapentin (30 ${\mu}g$) failed to reduce the number of activated microglia or astrocytes in the medullary dorsal horn. These findings suggest that gabapentin produces significant antinociceptive effects, which are not mediated by the inhibition of glial cell function in the medullary dorsal horn, in a rat model of trigeminal neuropathic pain.

• Bulletin of the Korean Chemical Society
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• 제32권11호
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• pp.4049-4054
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• 2011

A new compound, kalopanaxin F (3), and 11 known compounds (1, 2, 4-12), were isolated from the stem bark of Kalopanax pictus. Their structures were elucidated on the basis of chemical and spectroscopic methods. Five of the compounds (2, 3, 5, 6, and 12) significantly inhibited $TNF{\alpha}$-induced NF-${\kappa}B$ transcriptional activity in HepG2 cells in a dose-dependent manner, with $IC_{50}$ values ranging from 6.2 to 9.1 ${\mu}M$. Furthermore, the transcriptional inhibitory function of these compounds was confirmed based on decreases in COX-2 and iNOS gene expression in HepG2 cells. Compounds 3-7, 9, and 12 significantly activated the transcriptional activity of PPARs dose-dependently, with $EC_{50}$ values ranging from 4.1-$12.7{\mu}M$. Compounds 4 and 5 exhibited $PPAR{\alpha}$, $PPAR{\gamma}$, and $PPAR{\beta}({\delta})$ transactivational activities in a dose-dependent manner, with $EC_{50}$ values of 16.0 and 17.0, 8.7 and 16.5, 26.2 and 26.3 ${\mu}M$, respectively.

• 한국전기전자재료학회논문지
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• 제14권6호
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• pp.455-459
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• 2001

In this paper, the dielectric and pizoelectric properties of 0.05Pb(M $n_{04}$ $W_{0.2}$N $b_{0.4}$) $O_3$-0.95(PbZ $r_{x}$ $Ti_{1-x}$ ) $O_3$+yN $b_2$ $O_{5}$ , are investigated as a function of the mole ratio of Zr and the amount of N $b_2$ $O_{5}$ . Also, the phase is analyzed by XRD. When the mole ratio of Zr is 0.51, the electromechanical coupling coefficient( $k_{p}$ ), relative dielectric constant ($\varepsilon$$^{T}$ $_{33}$ /$\varepsilon$$_{0}$ ), piezoelectric stain constrain ( $d_{33}$ and dielectric loss tangent show maximum, while the mechanical quality factor shows minimum value ; $k_{p}$ =56.5%, $d_{33}$ =258pC/N, $\varepsilon$$^{T}$ $_{33}$ /$\varepsilon$$_{0}$ =1170, $Q_{m}$ =1150, tan$\delta$=0.51%. At that composition, MPB which rhombohedral and tetragonal phase coexist in this ternary system is shown by the results of XRD analysis. Also, when the amount of N $b_2$ $O_{5}$ is 0.3wt%, the mechanical quality factor is increased to about 2000. The phase transition temperature of the ternary piezoelectric ceramic system showed about 35$0^{\circ}C$.TEX>.>.>.

• 한국광학회지
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• 제7권3호
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• pp.196-199
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• 1996

Gauss 동함수 변조가 이루어진 윤대구경에서 얻어지는 LSF가 전 구경으로 구해지는 LSF( $C_{o}$ $e^{-{\sigma}}$$^{2}$$x^{2}$/)와 같다는 사실을 증명하였다. $C_{o}$ , $C_{1}$은 윤대의 기하학적 구조에 따라서 정해지는 정수이고 진폭 감소율을 .alpha.로 잡을 때 .omega./.root.2<.sigma..leq.(1-.alpha./2.alpha.)$^{1}$2/ .omega.$_{o}$ 의 조건을 얻었다. .alpha.= $e^{-1}$, .lambda.=0.013.mu.m (연 X-선)일 때, .alpha.$_{o}$ '.leq.0.34.alpha.$_{o}$ =1.7cm의 조건을 만족하는 초분해능 윤대구경계로서, l=20cm, .alpha.$_{o}$ =5cm(NA=0.25)일 때, 내경의 최대치 1.7cm보다 약간 작은 .alpha.$_{o}$ '=1.5cm의 반사경계를 제안하였다.

• 천문학회보
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• 제38권2호
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• pp.80-80
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• 2013

대규모 광도곡선 자료에서 다양한 주기변광성들의 정확한 주기를 효율적으로 검출하는 실험을 시도하였다. 실험을 위해 OGLE-III 맥동 변광성(RR Lyrae, Delta Scuti, Cepheid) 목록 중, I 필터로 관측된 총 31,324개의 광도 곡선을 사용하였다. 이 실험에 사용한 주기분석 알고리즘 MS_Period(Multi-Step period searching method)는 주기를 놓치지 않기 위해 두 가지 다른 방법(Multi Polynomial function, Phase Dispersion)으로 후보 주기를 구하고 정밀주기를 도출하기 위해 후보 주기 주변부를 Spline fitting을 통해 재탐색하는 방법이다. 기존의 MS_Period 방식은 주기 탐색 간격(dP/P)이 일정하였으나, 우리는 탐색 주기 구간을 나누고 짧은 주기에서는 작은 간격으로, 긴 주기에서는 보다 넓은 간격으로 주기를 탐색하는 과정을 추가하였다. 그 결과 98% 이상의 별에서 OGLE-III와 거의 일치하는 주기를 얻었으며, 긴 주기에서의 불필요한 정밀 탐색을 회피함으로써 분석시간도 단축되었다. 주기 결정이 어려운 경우들은 주로 1) periodogram에서 실제 주기가 아닌 1일 근처에서 noise보다 큰 peak가 보이는 경우, 2) 하나의 별에 대해 여러 주기가 비슷한 Phase diagram을 보이고, periodogram에서도 비슷한 peak를 갖는 경우, 3) OGLE-III의 주기와 전혀 다른 주기만 찾은 경우, 4) OGLE-III에서 제시하지 않은 혼합된 주기의 존재가 의심되는 경우인 것을 확인하였고, 각 사례들의 특징을 살펴보았다.

• 대한기계학회논문집
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• 제11권6호
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• pp.953-962
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• 1987

본 연구에서는 국산 구조용강의 SM 45C 와 SUS 304 재를 최고 강도치가 나타 나는 압접조건하에서 압접하여 우재료의 용착금속부, 열영향부, 각 모재부 소정의 장 소에 미소원공을 가공한 시험편을 토대로 피로크랙의 발생 및 전파거동을 응력 레벨의 고저를 고려하여 고찰하였다.

• 한국재료학회지
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• 제4권1호
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• pp.90-96
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• 1994

플라즈마 CVD(PECVFD)장치로 금속유기물인 Diethylzinc와 $N_{2}O$를 합성하여 $300^{\circ}C$이하의 낮은 기판 온도에서 ZnO 박막을 증착하여, 증착변수가 박막의 증착속도 및 결정구조에 미치는 영향을 알아 보았다. 기판 온도 $150^{\circ}C$에서부터 이미 결정화된 ZnO 박막의 증착이 가능했으며, $200^{\circ}C$이상에서 X-ray rocking curve분석결과, 표준편차값($\delta$)이 6˚ 미만의 c축 배향성이 뛰어난 ZnO박막이 유리 기판위에 증착되었다. 기판온도오 인가된 rf전력에 의한 증착속도의 변화 양상은 매우 다양하였으며, 특히 결정화에 따른 증착속도 변화의 전이점이 관찰되었다. 200 W와 250W의 rf 전력에서 증착된 박막의 경우 활성화 에너지는 각각 3.1 KJ/mol과 1.9 KJ/mol이었다.

• Journal of Ginseng Research
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• 제14권2호
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• pp.178-186
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• 1990

The analgesic effect of morphine was antagonized and the development of tolerance was suppressed by the modification of the neurologic function in the animals treated with ginseng saponins The activation of the spinal descending inhibitory systems as well as the supraspinal structures by the administration of morphine was inhibited in the animals treated with ginseng saponine intracerebrally or intrathecally. The development of morphine tolerance and dependence, and the abrupt expression of naloxone inducted abstinence syndrom were also inhibited by ginsenoside Rb1, Rb2, Rg1 and Re. These results suggest that ginsenoside Rbl, Hbs, Rgl and Re are the bioactive components of panax ginseng on the inhibition of the development of morphine tolerance and dependence, and the inhibition of abrupt abstinence sindrome. In addition, further research on the minor components of Pnnnxkinsenl should be investigated. A single or daily treatment with ginseng saponins did not induce any appreciable changes in the brain in level of monoamines at the variolls time intervals and at the various day intervals, respectively. The inhibitory or facilitated effects of ginseng saponins on electrically evoked contractions in guinea pig ileum ($\mu$-receptor) and mouse vats deferens ($\delta$-receptor) were not mediated through opioid receptors. The antagonism of a $\chi$ receptor agonist, U-50, 488H was also not mediated through opioid receptors in the animals treated with ginseng saponins, but mediated through serotonergic mechanisms. Ginseng saponins inhibited morphine 6-dehydrogenase which catalyzed the production of morphinone from morphine, and increased hepatic glutathione contents for the detoxication of morphinone. This result suggests that the dual action of the above plays an important role in the inhibition of the development of morphine tolerance and dependence.