• Toxicological Research
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• 제17권4호
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• pp.309-316
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• 2001

Male Sprague Dawley rats were exposed to 0, 0.04, 0.2, and 0.8% Pb acetate in drinking water for 13 weeks and fed a commercial diet. Dose-related adverse effects observed at the end of the Pb acetate exposure in the drinking water were as follows: decrease in body weight gain, decrease in hemoglobin, hematocrit(HCT), mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH), increase in serum glucose, decrease in serum testosterone, increase in lead accumulation and $\delta$-ALA release in urine, and decrease in $\delta$-ALAD activities DNA content and histopathlogy (intranuclear inclusion body in kidney proximal tubule cell). Taken together, repeated exposure of lead acetate induced toxicities in hematopoietic system, especially testis and kidney.

• KSBB Journal
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• 제5권4호
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• pp.403-410
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• 1990

Application of the Rheocatch Hotwire Monitoring System for food biotechnology process was evaluated. The growth of microogranism, E coli (JM 83 and Sigma) and Corynesccfertun glutamicum, were monitored. in the fermentor. The cell growth could not be detected the temperature differences between the hotwire and samples($\Delta$T) as indicated by the monitoring system during the fermentation processes. The cell concentration of less than 2g/dl was not sufficient to generate the measurable temperature difference in the fermentor. In order to calibrate the Rheocatch Monitoring System, the temperature difference as a function of solute concentration (microbial cells, sodium cholide, sucrose and dextran) was studied. The relationship between $\Delta$T and the concentration of microbial cells, sucrose and dextran can be expressed in a power series. Further studied with dextran indicated that viscosity and/or kinematic viscosity increase exponentially with an increase in $\Delta$T This is regardless of the concentration and molecular weight of dextran. $\Delta$T linearly increases with the logarithm of molecular weight, while the logarithm of viscosity and the logarithm of kinematic viscosity increase with the logarithm of molecular weight.

• Journal of applied mathematics & informatics
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• 제23권1_2호
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• pp.153-165
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• 2007

This paper deals with the empirical Bayes two-action problem of testing $H_0\;:\;{\theta}{\leq}{\theta}_0$: versus $H_1\;:\;{\theta}>{\theta}_0$ using a linear error loss for some discrete nonexponential families having probability function either $$f_1(x{\mid}{\theta})=(x{\alpha}+1-{\theta}){\theta}^x\prod\limits_{j=0}^x\;(j{\alpha}+1)$$ or $$f_2(x{\mid}{\theta})=[{\theta}\prod\limits_{j=0}^{x-1}(j{\alpha}+1-{\theta})]/[\prod\limits_{j=0}^x\;(j{\alpha}+1)]$$. Two empirical Bayes tests ${\delta}_n^*\;and\;{\delta}_n^{**}$ are constructed. We have shown that both ${\delta}_n^*\;and\;{\delta}_n^{**}$ are asymptotically optimal, and their regrets converge to zero at an exponential decay rate O(exp(-cn)) for some c>0, where n is the number of historical data available when the present decision problem is considered.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 학술회의 논문집 정보 및 제어부문 B
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• pp.361-364
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• 2003

In this paper, a high-resolution multibit sigma-delta modulator implemented in a.0.35-um CMOS technology is introduced. This modulator consists of two switched capacitor integrators, 3-bits A/D converter, and 3-bits D/A converter For the verification of the internal function blocks, HSPICE simulator is used. This circuit is normally operated at 130 MHz clock and the total power dissapation is 70 mW.

• 한국광학회지
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• 제7권4호
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• pp.434-439
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• 1996

본 연구에서는 가우스 진폭을 갖는 입사광의 단락된 정도와 광학 디스크 상의 bump의 형태가 재생신호에 미치는 영향과 디스크 bump에 맺히는 회절광 PSF(point spread function)와의 관계를 알아보기 위해 스칼라 회절 이론을 사용하였다. 단락된 가우스 진폭으로 .sigma.=0, 0.5, 1.5, 2.5인 경우를 고려하였으며 bump의 높이는 n.DELTA.$_{o}$ =.lambda./4로서 이는 위상 높이 .PHI.$_{o}$ =.pi.가 된다. 또한 본 연구에서 고려한 bump 형태 즉 직사각형(.DELTA.p$_{o}$ =0)과 준 원추형(.DELTA.p$_{o}$ /2) 그리고 원추형(.DELTA.p$_{o}$ =p$_{o}$ )의 세 가지 경우이다. 본 연구에서 고려한 입사광의 단락된 정도가 작을 수록 bump에 맺는 중심 회절상의 반경이 작게 나타났으며 이때 재생 신호의 극대치는 입사광의 단락된 정도가 작을수록 bump에 맺는 중심 회절상의 반경이 작계 나타났으며 이때 재생 신호의 극대치는 입사광의 단락된 정도가 큰 경우보다 크게 나타났고 bump의 크기도 작게 나타났다. 이러한 결과들로부터 입사광의 단락된 정도가 작을수록 광학 디스크로부터 큰 재생 신호를 얻을 수 있으며 cross-talk가 줄어듬을 알 수 있었다. 그러므로 실제 광학 디스크에 가능한 단락된 정도가 작은 가우스 진폭을 갖는 레이저 광을 입사광으로 사용하면 유용하리라 생각된다.

• Reproductive and Developmental Biology
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• 제33권2호
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• pp.77-83
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• 2009

Erythropoietin (EPO), a glycoprotein hormone produced from primarily cells of the peritubular capillary endothelium of the kidney, is responsible for the regulation of red blood cell production. We have been investigating the roles of glycosylation site added in the biosynthesis and function of recombinant protein. We constructed three EPO mutants ($\Delta$69, $\Delta$105 and $\Delta$69,105), containing an additional oligosaccharide chains. EPOWT and EPO$\Delta$69 were effectively expressed in transient and stably transfected CHO-K1 cell lines. But, it wasn't detected any protein in the culture medium of EPO$\Delta$105 and EPO$\Delta$69,105 mutants. The growth and differentiation of EPO-dependent human leukemic cell line (F36E) were used to measure the cytokine dependency and in vitro bioactivity of rec-hEPO. MTT assay values were increased by survival of F36E cells at 24h. To analysis biological activity in vivo, two groups of ICR-mice (7 weeks old) were injected subcutaneously with 10 IU per mice of rec-hEPO molecules on days 0 and 2. Red blood cell and hematocrit values were measured on 6 days after the first injection. The hematocrit values were remarkably increased in all treatment groups. The pharmacokinetic analysis was also affected in the mice injected with rec-hEPO molecules 2.5 IU by tail intravenous. Protein samples were detected by Western blotting. An EPO$\Delta$69 protein migrated as a broad band with an average apparent molecular and detected slightly high band. Enzymatic N-deglycosylation resulted in narrow band and was the same molecular size. The biological activity of EPO$\Delta$69 was enhanced to compare with wt-hEPO. The half-life was longer than wt-hEPO. The results suggest that hyperglycosyalted recombinant human erythropoietin (EPO$\Delta$69) may have important biological and therapeutic good points.

• 천문학회지
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• 제33권2호
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• pp.89-95
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• 2000

As an efficient method to detect blending of general gravitational microlensing events, it is proposed to measure the shift of source star image centroid caused by microlensing. The conventional method to detect blending by this method is measuring the difference between the positions of the source star image point spread function measured on the images taken before and during the event (the PSF centroid shift, ${\delta}{\theta}$c,PSF). In this paper, we investigate the difference between the centroid positions measured on the reference and the subtracted images obtained by using the difference image analysis method (DIA centroid shift, ${\delta}{\theta}$c.DIA), and evaluate its relative usefulness in detecting blending over the conventional method based on ${\delta}{\theta}$c,PSF measurements. From this investigation, we find that the DIA centroid shift of an event is always larger than the PSF centroid shift. We also find that while ${\delta}{\theta}$c,PSF becomes smaller as the event amplification decreases, ${\delta}{\theta}$c.DIA remains constant regardless of the amplification. In addition, while ${\delta}{\theta}$c,DIA linearly increases with the increasing value of the blended light fraction, ${\delta}{\theta}$c,PSF peaks at a certain value of the blended light fraction and then eventually decreases as the fraction further increases. Therefore, measurements of ${\delta}{\theta}$c,DIA instead of ${\delta}{\theta}$c,PSF will be an even more efficient method to detect the blending effect of especially of highly blended events, for which the uncertainties in the determined time scales are high, as well as of low amplification events, for which the current method is highly inefficient.

• Communications for Statistical Applications and Methods
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• 제2권2호
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• pp.43-51
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• 1995

For the stress-strengh function, hierarchical Bayes estimations considered under squared error loss and entropy loss. In particular, the desired marginal postrior densities ate obtained via Gibbs sampler, an iterative Monte Carlo method, and Normal approximation (by Delta method). A simulation is presented.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2005년도 춘계학술대회 학술발표 논문집 제15권 제1호
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• pp.147-148
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• 2005

In this paper we study Laplace transform of the fuzzy Dirac delta function and the examples of fuzzy impulsive differential equations.

• 한국치위생학회지
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• 제19권3호
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• pp.351-362
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• 2019

Objectives: The study aimed to analyze the factors affecting the maturity of dental biofilm, which was assessed with quantitative light-induced fluorescence-digital(QLF-D), in a sample of Korean older adults. Methods: This cross-sectional study included 67 participants, aged 65 years and older. All participants completed a questionnaire and tests to measure their manual dexterity and handgrip strength, which are parameters that indicate hand function abilities. To evaluate dental biofilm maturity, 804 surfaces of six index teeth were imaged using QLF-D and then quantified as ${\Delta}R$ values. All data were collected from May 25, 2017 to April 30, 2018. The independent t-test, one-way analysis of variance, and step-wise multiple linear regression were performed to analyze the factors associated with the maturity of dental biofilm (${\Delta}R$). Results: The multivariate linear regression analysis revealed that the factor most strongly related to dental biofilm maturity(${\Delta}R$) was manual dexterity (${\beta}=-0.326$), followed by handgrip strength (${\beta}=-0.303$) and use of interdental cleaning devices (${\beta}=-0.283$) (p<0.05). Conclusions: Manual dexterity, handgrip strength, and use of interdental cleaning devices are factors that can predict dental biofilm maturity in adults aged 65 years or older. Therefore, the hand function of a patient should be evaluated first, before assessing the oral hygiene status of the patient or providing him/her with oral health education, and the dental hygienist should provide differentiated oral hygiene care depending on the patient's hand function ability. Finally, dental hygienists should help older adults to recognize the importance of auxiliary oral hygiene devices such as interdental brushes and keep motivating them to use the devices more frequently.