• IMMUNE NETWORK
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• v.15 no.4
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• pp.206-211
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• 2015

Pulmonary edema is a major cause of mortality due to acute lung injury (ALI). The involvement of protein kinase C-${\delta}$ (PKC-${\delta}$) in ALI has been a controversial topic. Here we investigated PKC-${\delta}$ function in ALI using PKC-${\delta}$ knockout (KO) mice and PKC inhibitors. Our results indicated that although the ability to produce proinflammatory mediators in response to LPS injury in PKC-${\delta}$ KO mice was similar to that of control mice, they showed enhanced recruitment of neutrophils to the lung and more severe pulmonary edema. PKC-${\delta}$ inhibition promoted barrier dysfunction in an endothelial cell layer in vitro, and administration of a PKC-${\delta}$-specific inhibitor significantly increased steady state vascular permeability. A neutrophil transmigration assay indicated that the PKC-${\delta}$ inhibition increased neutrophil transmigration through an endothelial monolayer. This suggests that PKC-${\delta}$ inhibition induces structural changes in endothelial cells, allowing extravasation of proteins and neutrophils.

• Molecules and Cells
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• v.27 no.1
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• pp.89-97
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• 2009

We investigate the molecular and cellular etiologies that underlie the deletion of the six amino acid residues (${\Delta}F323-Y328$; ${\Delta}FY$) in human torsin A (HtorA). The most common and severe mutation involved with early-onset torsion dystonia is a glutamic acid deletion (${\Delta}E$ 302/303; ${\Delta}E$) in HtorA which induces protein aggregates in neurons and cells. Even though ${\Delta}FY$ HtorA forms no protein clusters, flies expressing ${\Delta}FY$ HtorA in neurons or muscles manifested a similar but delayed onset of adult locomotor disability compared with flies expressing ${\Delta}E$ in HtorA. In addition, flies expressing ${\Delta}FY$ HtorA had fewer aberrant ultrastructures at synapses compared with flies expressing ${\Delta}E$ HtorA. Taken together, the ${\Delta}FY$ mutation in HtorA may be responsible for behavioral and anatomical aberrations in Drosophila.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.5 no.4
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• pp.357-362
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• 2000

Stable isotope ratios of oxygen and hydrogen were investigated in southern Yellow Sea in August 1997. Salinity showed good positive correlation with ${\delta}^{18}$O and ${\delta}$. The correlation between ${\delta}^{18}$O and ${\delta}$D is good. From the relationship between these parameters, we obtained two lines of conclusion: 1) seawater of study area I in summer is a mixture of Changjiang Water and modified Kuroshio Water; 2) stable isotopes are very useful tracers in studying property and behavior of water masses in the study area. In case when water masses can not be easily distinguished by T-S analysis, the stable isotopes seem to be powerful tools for this purpose.

• Bulletin of the Korean Mathematical Society
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• v.51 no.3
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• pp.659-666
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• 2014

Let $\mathcal{A}$ be the class of analytic functions f in the open unit disk $\mathbb{U}$={z : ${\mid}z{\mid}$ < 1} with the normalization conditions $f(0)=f^{\prime}(0)-1=0$. If $f(z)=z+\sum_{n=2}^{\infty}a_nz^n$ and ${\delta}$ > 0 are given, then the $T_{\delta}$-neighborhood of the function f is defined as $$TN_{\delta}(f)\{g(z)=z+\sum_{n=2}^{\infty}b_nz^n{\in}\mathcal{A}:\sum_{n=2}^{\infty}T_n{\mid}a_n-b_n{\mid}{\leq}{\delta}\}$$, where $T=\{T_n\}_{n=2}^{\infty}$ is a sequence of positive numbers. In the present paper we investigate some problems concerning $T_{\delta}$-neighborhoods of function in various classes of analytic functions with $T=\{2^{-n}/n^2\}_{n=2}^{\infty}$. We also find bounds for $^{\delta}^*_T(A,B)$ defined by $$^{\delta}^*_T(A,B)=jnf\{{\delta}&gt;0:B{\subset}TN_{\delta}(f)\;for\;all\;f{\in}A\}$$ where A, B are given subsets of $\mathcal{A}$.

• Journal of the Korean Ceramic Society
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• v.31 no.12
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• pp.1491-1500
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• 1994

Nonstoichiometry($\delta$) and the phase stability region of a ferrite spinel (Mg0.29Fe0.71)3-$\delta$O4 have been investigated by a coulometric titration method as a function of temperature(T) and oxygen partial pressure(Po2). It has been found that the spinel is thermodynamically stable in the ranges -8.0$\leq$log(PO2/atm)$\leq$-2.4, -7.0$\leq$log(PO2/atm)$\leq$-1.7 respectvely at 100$0^{\circ}C$. The nonstoichiometry extends over the ranges of -0.004$\leq$$\delta$$\leq$0.007, -0.008$\leq$$\delta$$\leq$0.006, -0.033$\leq$$\delta$$\leq$0.004 at 100$0^{\circ}C$, 120$0^{\circ}C$, respectvely. The observed PO2-dependence of $\delta$ suggests that the majority ionic defects are cation interstitials in the low PO2 region and cation vacancies in the high PO2 region.

• Transactions of the Korean Society of Mechanical Engineers
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• v.9 no.1
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• pp.1-9
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• 1985

In-plane tension fatigue tests (R = 0.05) were carried out to investigate the initiation and propagation behaviors of micro-surface-fatigue cracks on smooth surfaces of a mild steel. Also, the investigations of saturated cyclic strain which can be obtained by the fatigue tests have been made via the cyclic strain intensity factor, .DELTA. $K_{\epsilon}$/, for the purpose of unifying two approaches of the study of fatigue; the one approach is based on the fracture mechanics concept and the other on lowcycle fatigue concept. Some of the results are as follows; The growth rate, d(2a)/dN, of small cracks cannot be represented by one straight line as a function of .DELTA.K for various of the nominal stress range, .DELTA..sigma., and is higher than that of a larger through crack. The rearrangement of the d(2a)/dN by .DELTA..epsilon..root..pi.s( = .DELTA. $K_{\epsilon}$/) with the stress range .DELTA..epsilon. in .DELTA.K replaced by .DELTA..epsilon., strain range, gives one straight line of the .DELTA. $K_{\epsilon}$-d(2a)/dN relation for various values of stress range .DELTA.$_{\epsilon}$../.X>../.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.39 no.4
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• pp.19-27
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• 2002

We proposed an auto-tuning method of learning rate for performance improvement of backpropagation algorithm. Proposed method is used a fuzzy logic system for automatic tuning of learning rate. Instead of choosing a fixed learning rate, the fuzzy logic system is used to dynamically adjust learning rate. The inputs of fuzzy logic system are ${\Delta}$ and $\bar{{\Delta}}$, and the output is the learning rate. In order to verify the effectiveness of the proposed method, we performed simulations on a N-parity problem, function approximation, and Arabic numerals classification. The results show that the proposed method has considerably improved the performance compared to the backpropagation, the backpropagation with momentum, and the Jacobs' delta-bar-delta.

• Bulletin of the Korean Mathematical Society
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• v.31 no.2
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• pp.193-200
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• 1994

Let x : $M^{n}$ .rarw. $E^{m}$ be an isometric immersion of a manifold $M^{n}$ into the Euclidean space $E^{m}$ and .DELTA. the Laplacian of $M^{n}$ defined by -div.omicron.grad. The family of such immersions satisfying the condition .DELTA.x = .lambda.x, .lambda..mem.R, is characterized by a well known result ot Takahashi (8]): they are either minimal in $E^{m}$ or minimal in some Euclidean hypersphere. As a generalization of Takahashi's result, many authors ([3,6,7]) studied the hypersurfaces $M^{n}$ in $E^{n+1}$ satisfying .DELTA.x = Ax + b, where A is a square matrix and b is a vector in $E^{n+1}$, and they proved independently that such hypersurfaces are either minimal in $E^{n+1}$ or hyperspheres or spherical cylinders. Since .DELTA.x = -nH, the submanifolds mentioned above satisfy .DELTA.H = .lambda.H or .DELTA.H = AH, where H is the mean curvature vector field of M. And the family of hypersurfaces satisfying .DELTA.H = .lambda.H was explored for some cases in [4]. In this paper, we classify space curves x : R .rarw. $E^{3}$ satisfying .DELTA.x = Ax + b or .DELTA.H = AH, and find conditions for such curves to be equivalent.alent.alent.

• Journal of the Korean Ceramic Society
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• v.36 no.7
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• pp.679-684
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• 1999

Specimens of SrZr0.95Ga0.05O3-$\delta$, SrZr0.95Y0.05O3-$\delta$, BaZr0.95Ga0.05O3-$\delta$ and BaZr0.95Y0.05O3-$\delta$ were fabricated by a solid-state reaction method and subsequent sintering at 150$0^{\circ}C$ to 1$600^{\circ}C$ The microstructures and electrical characteristics of the specimens were studied. Only BaZr0.95Ga0.05O3-$\delta$ showed dense microstructure and had typical impedance spectra at various temperature. Its electrical conductivity by impedance analysis was 2.7$\times$10-3$\Omega$-1.cm-1 at 90$0^{\circ}C$ in air. The BaZr0.95Ga0.05O3-$\delta$ exhibited lower grain rsistance in wet atmosphere than in dry atmosphere and the reduction of resistance is due to the proton conduction.

• Journal of the Korean Society of Safety
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• v.11 no.2
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• pp.16-24
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• 1996

In this study we simulate the fatigue test of a compact tension specimen and obtain the displacements, stresses and strains by using the finite element method. And we examine the path independency of $\Delta$J integral values and compare it with $\Delta$J integral values calculated from load-load line displacement curve. From the results of this study, we can find that $\Delta$J integral show the path Independency for saturated materials. We can also find that the path independency of $\Delta$J Is not satisfied when different material Is assumed near the crack tip, but the difference in $\Delta$J is small. And $\Delta$J integral values calculated from load-load line displacement is very analogous with those from integration path but always have lower values than those from integration paths. In the case of crack closing, we found that $\Delta$J integral values from load-load line displacement should be calculated with the load Increment values based on the crack opening point. The unsaturated material is also simulated and its $\Delta$J shows different values according to the path, but the difference is small.