• Archives of Pharmacal Research
• /
• 제20권1호
• /
• pp.34-38
• /
• 1997

Recombinant human epidermal growth factor (rhEGF), a polypeptide of 53 amino acid residues, is subject to degradation by numerous enzymes, especially proteases, when it is applied on the skin for the treatment of open wound. Amastatin, aprotinin, bestatin, EDTA, EGTA, gabexate, gentamicin, leupeptin, and TPCK were investigated for the possible protease inhibitors, which may use to protect rhEGF from degradation by the enzymes in the skin. Skin homogenates containing protease inhibitors and rhEGF were incubated at $37^{\circ}C$ for 30 minutes. After the reaction was stopped with trifluoroacetic acid, the amount of rhEGF remaining in the sample was determined with an HPLC method. The percentages of rhEGF degraded, at the skin/PBS ratio of 0.25, in the mouse, rat, and human skin homogenate were 85%, 70%, and 46%, respectively. The degree of degradation of rhEGF in the cytosolic fraction was higher than that in the membrane fraction and these enzyme reactions were completed in 30 minutes. Bestatin, EGTA, and TPCK showed significant inhibitory effects on the degradation of rhEGF in the two fractions (p<0.05), while the other protease inhibitors had no significant inhibitory effects or, even resulted in deleterious effects. Therefore, the formulation containing one or several inhibitors among these effective inhibitors would be a promising topical preparation of rhEGF for the treatment of open wound.

• 한국전기전자재료학회논문지
• /
• 제11권10호
• /
• pp.940-945
• /
• 1998

In this paper, we obtained the data, which is required in training the neural network and diagnosing the degradation degree, by introducing the AE detection that is effective method in ordinary degradation diagnosis on activation. Aa the results of generalization tests by appling neural network to the unknown AE patterns obtained from two kinds of specimen, firstly as to evaluate an objective performance of neural network, the recognition ration for no-void specimen and 1[mm] -void specimen are appeared to be 98.9% and 92.5%, respectively. Also, in the evaluation of the adaptability of neural network with a new type of 0.2[mm] -void specimen, it is confirmed that the result appears to be 64% of recognition ratio at 94% of confidence interval coefficient in expectation output 0.2. On the other hand, the recognition capability of the neural network was confirmed by data from no-void and 1[mm] void specimen. The results prove the promising possibility of the application of ANN to discriminate specific void affecting as main degradation source at partial discharge condition in insulator containing multi-void by accummulated data base.

• 대한화학회지
• /
• 제57권3호
• /
• pp.382-388
• /
• 2013

The present paper focuses on the synthesis, characterization and application of nanophotocatalyst for degradation of quinalphos and monocrotophos. Novel heterostructured ZnO/$TiO_2$ photocatalyst ($Z_9T$) was prepared and characterized with X-ray diffraction (XRD), SEM and UV-vis diffuses reflectance spectroscopy. The average crystalline size of synthesized $Z_9T$ was found to be 21.48 nm. The pesticides were degraded in the presence of nanophotocatalysts i.e., $TiO_2$, ZnO, $TiO_2$/ZnO mixed in various proportions and heterostructured nanophotocatalyst synthesized by Sol-Gel method. The batch experiments were performed by adding photocatalyst to 100 ml of pesticide solution and suspension was subjected to irradiation under UV light. In case of mixed catalyst, the maximum degradation of monocrotophos and quinalphos has been observed when ZnO and $TiO_2$ were in the ratio of 7:3 and 8:2 respectively. The degradation efficiency with synthesized heterostructured nanophotocatalyst ($Z_9T$) was found to be comparable with $TiO_2$.

• 한국건축시공학회:학술대회논문집
• /
• 한국건축시공학회 2009년도 춘계 학술논문 발표대회 학계
• /
• pp.45-48
• /
• 2009

The performance of concrete mainly depend upon its water-cement ratio. If water percentage is excess in concrete, it may cause the degradation of performance. Because of these reasons, the change of water content is managed by using various evaluation method of unit water content. And criterion for the change of water content is regulated and used. However the criterion is set only considering production error and measurement error but criterion does not consider performance degradation of concrete. Therefore this study tries to investigate degradation of performance while adding extra water by artificial manipulation or management error in concrete, The contents of extra water for tests are set as 0, 20, 40, 60kg/m3, to examine the performance degradation of concrete, strength, shrinkage, cracks, carbonation are tested This study conclude that, when extra water content is excess than 20kg/m3 in concrete, then performance level of concrete declined rapidly. 80 it is very important to maintain quality of concrete for its better performance.

• 한국산학기술학회논문지
• /
• 제6권4호
• /
• pp.337-341
• /
• 2005

본 연구에서는 광촉매 $TiO_2/P-25$를 POF에 코팅하여 IPA 분해 활성을 고찰한 결과, 코팅 시 용매의 조건은 에탄올에서 IPA의 분해효율이 가장 우수하였고 무기바인더(KR-400), 유기바인더(A-9540) 및 무$\cdot$유기 복합바인더(GPTMS, TMOS)중에서 유기 바인더인 A-9540을 사용했을 때 효율이 가장 우수한 것으로 나왔다. 유기 바인더는 광 분해반응에 의하여 바인더 자체가 분해되고 무기 바인더는 부착성이 떨어졌다. 유$\cdot$무기 복합 바인더 중에서 광분해 효율이 뛰어난 TMOS를 바인더로 선정하여 TMOS/P-25의 비율을 0.05부터 1로 바꾸어 광분해 실험을 수행한 결과, 바인더로써 TMOS의 첨가는 IPA분해 효율을 낮게 하였다.

• 한국환경과학회지
• /
• 제31권3호
• /
• pp.227-235
• /
• 2022

In this study, a biodegradation model of based on molecular cellulose was established. It is a mathematical, kinetic model, assuming that two major enzymes randomly break glycosidic bonds of cellulose molecules, and calculates the number of molecules by applying the corresponding probability and degradation reaction coefficients. Model calculations considered enzyme dose, cellulose chain length, and reaction rate constant ratio. Degradation increased almost by two folds with increase of temperature (5℃→25℃). The change of degradation was not significant over the higher temperatures. As temperature increased, the degradation rate of the molecules increased along with higher production of shorter chain molecules. As the reaction rates of the two enzymes were comparative the degree of degradation for any combinations of enzyme application was not affected much. Enzyme dose was also tested through experiment. While enzyme dose ranged from 1 mg/L to 10 mg/L, the gap between real data and model calculations was trivial. However, at higher dose of those enzymes (>15 mg/L), the experimental result showed the lower concentrations of reductive sugar than the corresponding model calculation did. We determined that the optimal enzyme dose for maximum generation of reductive sugar was 10 mg/L.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2008년도 제39회 하계학술대회
• /
• pp.1110-1111
• /
• 2008

The life time of PV module is semi-permanent. But, because of installation and module fabrication process, its important part can not be finished. In this paper, we analyze 15 years old modules made from different company. Among the PV modules, the maximum power drop ratio was 12.23% minimum and 80.63% maximum. Also the effect of solar cell's short circuit current difference was analyzed. The PV module exposed about 65days, its the maximum power drop ratio was 1.29% minimum and 23.43% maximum. It is for reduction of current value. And the reason for current reduction was due to reduction of parallel resistance of solar cell. To prevent early degradation, it is need to have attention to fabrication, installation and maintenance.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
• /
• 제5B권4호
• /
• pp.358-365
• /
• 2005

In induction machine drive without a speed sensor, the estimation of the motor flux and speed often becomes deteriorated at low speeds with low back EMF. Our analysis shows that, in addition to the state resistance variation, the estimated value of field orientation angle is often corrupted by accumulative errors from the integration of voltage variables at motor terminals that have low signal/noise ratio at low frequencies. A repetitive loop path of integration in the feedback can amplify this type of error, thus speeding up the degradation process. The control system runs into information starvation due to the loss of correct field orientation. The machine's spiral vectors are controlled only in a reduced dimension in this situation. A novel control scheme is developed to improve the control performance of motor's current, torque and speed at low frequencies. The scheme gains a full-dimensional vector control and is less sensitive to the combined effect of the error sources at the low frequencies. Experimental tests demonstrate promising performances are achievable even below 0.5 Hz.

• 한국전자파학회논문지
• /
• 제12권3호
• /
• pp.470-477
• /
• 2001

Multucarrier code-division multiple access(MC-CDMA) is one of the promising technique for high capacity wireless communication. Hower the carrier phase error and frequency offest cause the performance degradation of MC-CDMA due to the inter-carrier interference. In this work, downlink performance of the partially coherent MC-CDMA is analytically derived in Rayleigh fading channels. The bit error rate sensitivity by combining method, Maxiaml ratio combining (MRC)and Equal gain combining(EGC), is compared as functions of phase errors. multi-user interference, and received signal-to-noise ratio. The results show that the susceptibility for the performance degradation of EGc and MRC is negligible for loop SNR's of above 15 dB and above 10 dB, respectivtely.

• 비파괴검사학회지
• /
• 제36권3호
• /
• pp.175-180
• /
• 2016

Nondestructive evaluation for material health monitoring is important in aerospace industries. Composite laminates are exposed to heat cyclic loading and humid environment depending on flight conditions. Cyclic heat loading and moisture absorption may lead to material degradation such as matrix breaking, debonding, and delamination. In this paper, the moisture absorption ratio was investigated by measuring the Lamb wave velocity. The composite laminates were manufactured and subjected to different thermal aging cycles and moisture absorption. For various conditions of these cycles, not only changes in weight and also ultrasonic wave velocity were measured, and the Lamb wave velocity at various levels of moisture on a carbon-epoxy plate was investigated. Results from the experiment show a linear correlation between moisture absorption ratio and Lamb wave velocity at different thermal fatigue stages. The presented method can be applied as an alternative solution in the online monitoring of composite laminate moisture levels in commercial flights.