• 제목/요약/키워드: degenerative diseases

검색결과 327건 처리시간 0.027초

Mitochondria Control Protein as a Novel Therapeutic Target for Metabolic Syndrome

  • KimPak, Young-Mi
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 2008년도 Proceedings of the Convention
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    • pp.23-30
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    • 2008
  • Mitochondria biogenesis requires a coordination of two genomes, nuclear DNA (nDNA) and mitochondrial DNA (mtDNA). Disruption of mitochondria function leads to a loss of mitochondrial membrane potential and ATP generating capacity and consequently results in chronic degenerative diseases including insulin resistance, metabolic syndrome and neurodegenerative diseases. Although PPAR-${\gamma}$ coactivator-$1{\alpha}$ (PGC-$1{\alpha}$) was discovered as a central regulator of mitochondria biogenesis and a transcriptional co-activator of nuclear respiratory factor (NRF) and mitochondrial transcription factor A (Tfam), the expressions of PGC-$1{\alpha}$, NRF and Tfam were not significantly altered in tissues showing abnormal mitochondria functions. This observation suggests that there should be another regulator(s) for mitochondria function. Here, we demonstrate microRNAs (miRNAs) can modulate mitochondria function. Overexpression of microRNA dissipated mitochondrial membrane potential and increased ROS production in vitro and in vivo. It will be discussed the target of microRNA and its role in metabolic syndrome.

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퇴행성 척추 질환에서 Metalloproteinase-1, 2의 역할 (The Roles of Matrix Metalloproteinase-1, -2 in the Degenerative Spinal Diseases)

  • 김기용;조기홍;김진영;박승우;안영환;안영민;윤수한;조경기;심철
    • Journal of Korean Neurosurgical Society
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    • 제29권2호
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    • pp.180-187
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    • 2000
  • Objective : A number of evidence have suggested a pivotal role of matrix metalloproteinases(MMP) on the degeneration of intervertebral disc. Proteins of intervertebral disc mainly consist of collagen and proteoglycan. These proteins can be destructed by MMP, resulting in changes of main collagen type and degeneration of matrix proteins. The present study was to determine the different effects of MMP-1 and MMP-2 on the degenerative spinal diseases, resulting from aging process. Clinical Materials & Methods : Thirty-one patients were randomly selected among 350 patients whose discs were resected during operation from March 1997 to February 1999. Patients were divided into two groups: group I with spinal stenosis and group II with herniated intervertebral disc. Group II was subdivided into the ruptured(Group Iia) and unruptured(Group Iib). Increases in MMP-1 immunopositive cells were observed in both groups, as evidenced by immunocytochemical staining. However, in marked contrast, the number of MMP-2 immunopositive cells were only seen in group II. There was no significant difference between Group IIa and Group IIb. The MMP-2 immunopositive cells were increased in the anulus fibrosus of ruptured(Group Iia) more than unruptured(Group Iib), but statistically it was not significant. In addition, the immunopositivity of MMP-1 and MMP-2 was proportional to patients's age. Conclusion : These results strongly suggests the possible involvement of MMP-2, but not MMP-1 in progressive herniated intervertevral disc.

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Stem cell-derived extracellular vesicle therapy for acute brain insults and neurodegenerative diseases

  • Bang, Oh Young;Kim, Ji-Eun
    • BMB Reports
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    • 제55권1호
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    • pp.20-29
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    • 2022
  • Stem cell-based therapy is a promising approach for treating a variety of disorders, including acute brain insults and neurodegenerative diseases. Stem cells such as mesenchymal stem cells (MSCs) secrete extracellular vesicles (EVs), circular membrane fragments (30 nm-1 ㎛) that are shed from the cell surface, carrying several therapeutic molecules such as proteins and microRNAs. Because EV-based therapy is superior to cell therapy in terms of scalable production, biodistribution, and safety profiles, it can be used to treat brain diseases as an alternative to stem cell therapy. This review presents evidences evaluating the role of stem cell-derived EVs in stroke, traumatic brain injury, and degenerative brain diseases, such as Alzheimer's disease and Parkinson' disease. In addition, stem cell-derived EVs have better profiles in biocompatibility, immunogenicity, and safety than those of small chemical and macromolecules. The advantages and disadvantages of EVs compared with other strategies are discussed. Even though EVs obtained from native stem cells have potential in the treatment of brain diseases, the successful clinical application is limited by the short half-life, limited targeting, rapid clearance after application, and insufficient payload. We discuss the strategies to enhance the efficacy of EV therapeutics. Finally, EV therapies have yet to be approved by the regulatory authorities. Major issues are discussed together with relevant advances in the clinical application of EV therapeutics.

우리나라 중년 남.여의 식이섭취패턴 분류와 각 식이섭취패턴별 일반환경, 영양섭취, 만성질병 발생 특성에 관한 연구 (Study on classification of dietary patterns of Korean adults and their relationships with socio-demographic factors, nutrition intakes, and risk of the chronic degenerative diseases)

  • 이지은;정인경;안윤진;박찬;이일하
    • 대한지역사회영양학회:학술대회논문집
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    • 대한지역사회영양학회 2006년도 춘계학술대회
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    • pp.80-80
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    • 2006
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최소 침습적 외측 요추간 유합술: 적응증, 결과, 합병증 (Minimally Invasive Lateral Lumbar Interbody Fusion: Indications, Outcomes and Complications)

  • 소재완;이재철
    • 대한정형외과학회지
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    • 제54권3호
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    • pp.203-210
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    • 2019
  • 최소 침습적 외측 요추체간 유합술의 최신 지견에 대하여 알아보고자 하였다. 아직 도입된 지 얼마 되지 않았으나 근래에 각광받고 있는 최소 침습적 외측 요추체간 유합술에 대한 적응증 및 임상 결과와 유합률, 그리고 합병증에 대하여 문헌 고찰을 하였다. 외측 요추간 유합술의 적응증은 퇴행성 요추부 질환에서 고식적인 전방, 후방 추체간 유합술의 적응증과 거의 유사하다. 특히 척추관 협착증 및 퇴행성 척추 전방 전위증, 퇴행성 척추 변형, 퇴행성 추간판 질환, 인접 분절 퇴행성 질환에서 최소 침습적 수술로서 효과적이다. 또한 고식적 요추부 유합술과 비교하여 임상적 결과 및 유합률이 대등한 것으로 보고되고 있다. 하지만 수술 접근 및 과정에서 발생하는 수술 후 고관절 굴곡근 약화 및 신경 손상, 혈관 손상, 장기 손상, 케이지 침강, 위탈장 등의 비특이적 합병증들이 보고되고 있다. 외측 추체간 유합술은 고식적인 전방 또는 후방 추체간 유합술의 장점을 취합하고 단점을 보완한 수술이며 그 임상 결과나 유합률에도 큰 차이가 없어 퇴행성 요추부 질환의 치료에 최소 침습 수술로서 유용한 치료법이다. 하지만 수술 과정에서 발생하는 비특이적 합병증들을 개선해야 하는 것이 향후 과제이다.

보건문제의 변화와 보건교육의 역할 (Recent Changes of Public Health Problems and the Role of Health Education)

  • 이시백
    • 보건교육건강증진학회지
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    • 제10권1호
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    • pp.1-8
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    • 1993
  • Along with recent changes in the nature of disease, social and environmental conditions and medical care practices, we are faced with a new set of problems for the field of public health. It represents a corresponding increase in importance of the chronic and degenerative diseases. Therefore, it is realized that socio-cultural factors are much more important for these diseases in treatment and prevention. These trends require a real challenge to traditional forms of public health activities in Korea. This paper emphasizes the role of health education in dealing with all aspects of newly appeared health problems on the present stage. It also discusses a brief summary of some of the major trends in the field of health and medical care that have particular behavioral and sociological relevance.

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흉관 삽입 후 발생한 피하 기종을 동반한 척추 경막외 기종: 증례 보고 (Epidural Emphysema Associated with Subcutaneous Emphysema after Chest Tube Placement: A Case Report)

  • 노지영;유승민;조영아;이상민
    • Tuberculosis and Respiratory Diseases
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    • 제69권5호
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    • pp.389-391
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    • 2010
  • Spinal epidural emphysema is rare and has been described secondary to following medical intervention, such as lumbar puncture and epidural analgesia, pneumothorax or pneumomediastinum, degenerative disk disease, epidural abscess, and trauma. Rarely, it occurs after chest tube placement. We report a case of spinal epidural emphysema incidentally noted on HRCT after chest tube placement.

저강도 초음파의 관절염 치료 적용성 평가 (An Evaluation of Low Intensity Ultrasonic Characteristics for Arthritis Healing)

  • 홍성민;한승무
    • 대한기계학회논문집A
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    • 제29권6호
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    • pp.787-794
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    • 2005
  • Nowadays chronic degenerative diseases such as arthritis are increasing rapidly, even though acute infectious diseases are decreasing due to the advance of modern medicine. Although many of remedies are developed for arthritis healing, there is no precise medical prescription, and pathogenesis is not examined exactly. In this study, we confirmed gene expression of BMP 1A, BMP 2B, osteonectin and MGP which are genes related with bone formation in osteoblast by using ultrasonic stimulation. Through this study, we also evaluated the fact that ultrasound could be applied to arthritis healing by making activated osteoblast induce remodeling of cartilage. As a result of this research, BMP 2B and MGP have higher rates of expression in specific ultrasound mode. In conclusion, it is expected that ultrasound could be used efficiently for healing arthritis if we use ultrasounds according to symptoms of arthritis on reasonable terms.

Lymphomatosis Cerebri

  • Choi, Chan-Young;Lee, Chae-Heuck;Joo, Mee
    • Journal of Korean Neurosurgical Society
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    • 제54권5호
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    • pp.420-422
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    • 2013
  • Lymphomatosis cerebri is considered a diffuse form of primary central nervous system lymphoma and very rare. It is not well recognized and may be misdiagnosed with infiltrating tumors, degenerative disorders, ischemic diseases, and infectious diseases developed in the brain. Awareness of the possibility of this rare disease and early biopsy are required for differential diagnosis and preventing poor clinical outcomes. We report a case with lymphomatosis cerebri who presented with rapid neurological deteriorations and review the relevant literatures.

Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia

  • Kim, MinJeong;Li, Yong-Xin;Dewapriya, Pradeep;Ryu, BoMi;Kim, Se-Kwon
    • BMB Reports
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    • 제46권8호
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    • pp.398-403
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    • 2013
  • Inflammatory conditions mediated by activated microglia lead to chronic neuro-degenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases. This study was conducted to determine the effect of floridoside isolated from marine red algae Laurencia undulata on LPS (100 ng/ml) activated inflammatory responses in BV-2 microglia cells. The results show that floridoside has the ability to suppress pro-inflammatory responses in microglia by markedly inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS). Moreover, floridoside down-regulated the protein and gene expression levels of iNOS and COX-2 by significantly blocking the phosphorylation of p38 and ERK in BV-2 cells. Collectively, these results indicate that floridoside has the potential to be developed as an active agent for the treatment of neuro-inflammation.