[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5483/BMBRep.2013.46.8.237

Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia

Kim, MinJeong (Department of Chemistry, Pukyong National University)
Li, Yong-Xin (Marine Bioprocess Research Center, Pukyong National University)
Dewapriya, Pradeep (Department of Chemistry, Pukyong National University)
Ryu, BoMi (School of Pharmacy, The University of Queensland)
Kim, Se-Kwon (Department of Chemistry, Pukyong National University)

Publication Information

BMB Reports / v.46, no.8, 2013 , pp. 398-403 More about this Journal

Abstract

Inflammatory conditions mediated by activated microglia lead to chronic neuro-degenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases. This study was conducted to determine the effect of floridoside isolated from marine red algae Laurencia undulata on LPS (100 ng/ml) activated inflammatory responses in BV-2 microglia cells. The results show that floridoside has the ability to suppress pro-inflammatory responses in microglia by markedly inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS). Moreover, floridoside down-regulated the protein and gene expression levels of iNOS and COX-2 by significantly blocking the phosphorylation of p38 and ERK in BV-2 cells. Collectively, these results indicate that floridoside has the potential to be developed as an active agent for the treatment of neuro-inflammation.

Keywords

Alzheimer's disease; Floridoside; Laurencia undulata; Neuro-inflammation; Oxidative stress;

Citations & Related Records

Times Cited By KSCI : 2 (Citation Analysis)

Reference
Cited By KSCI

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1	Expression of a set of glial cell-specific markers in the Drosophila embryonic central nervous system / [Ahn, Hui Jeong;Jeon, Sang-Hak;Kim, Sang Hee;] / BMB Reports
2	Immunostimulating activity of maysin isolated from corn silk in murine RAW 264.7 macrophages / [Lee, Jisun;Kim, Sun-Lim;Lee, Seul;Chung, Mi Ja;Park, Yong Il;] / BMB Reports
3	Cytochalasin B Modulates Macrophage-Mediated Inflammatory Responses / [Kim, Mi-Yeon;Kim, Jong-Hoon;Cho, Jae Youl;] / Biomolecules & Therapeutics