• Korean Journal of Veterinary Research
• /
• v.62 no.3
• /
• pp.25.1-25.9
• /
• 2022

Canine cognitive dysfunction syndrome (CDS) is a neurodegenerative disease that causes cognitive and behavioral disorders and reduces the quality of life in dogs and their guardians. This study reviewed the complementary and alternative medicine (CAM) for CDS and compared the diagnosis and therapy of CAM between CDS in canines and dementia in humans. The evaluation tools for the diagnosis of CDS and dementia were similar in the neurological and neuropsychiatric examinations, daily life activity, cognitive tests, and neuroimaging, but the evaluation for dementia was further subdivided. In CAM, pattern identification is a diagnostic method for accurate, personalized treatment, such as herbal medicine. For herbal medicine treatment of cognitive impairment in canines and humans, a similar pattern identification classified as deficiency (Qi, blood, and Yin) and Excess (phlegm, Qi stagnation, and blood stasis) is being used. However, the veterinary clinical basis for verifying the efficacy and safety of CAM therapies for CDS is limited. Therefore, based on CAM evidence in dementia, it is necessary to establish CDS-targeted CAM diagnostic methods and therapeutic techniques considering the anatomical, physiological, and pathological characteristics of dogs.

• Clinical and Experimental Pediatrics
• /
• v.46 no.5
• /
• pp.440-446
• /
• 2003

Purpose : The genetic disturbance of galactosemia is expressed as a cellular deficiency of either galactose-1-phosphate uridyltransferase(GALT) or galactokinase(GALK) or UDP galactose 4-epimerase(GALE). To find-out the pattern of galactosemia in Korea, we retrospectively analyzed cases of galactosemia detected by neonatal screening program. Methods : We analyzed medical records of patients who visited Soonchunhyang University Hospital at age of 1 month after showing abnormalities in neonatal screening of galactosemia. For accurate diagnosis, galactose was measured by enzyme immunoassay(EIA) and fluorophotometer, also galactose-1-phosphate by fluorophotometer. Enzyme activities of GALK, GALT and GALE in RBC and galactose-1-phosphate were measured by radioisotope assay(RIA). Beutler test were done. Patients went on a lactose-free diet and follow-up tests for galactose, galactose-1-phosphate level and enzyme activity were performed. Results : 10 patients(male : 6, female : 4) were diagnosed as galactosemia. Two patients had GALK deficiency and two had GALT deficiency. Six were GALE deficient showing the largest number. In two patients with GALK deficiency, GALT and GALE activities were normal but GALK activities showed respectively reduced activity. For GALT deficiency, two patients had low GALT activity in RBC and showed genotype of Duarte 2/G(galactosemia) in DNA analysis. In one patient, GALT activity was normal. Three patients seemed to be heterozygote state of GALE deficiency according to GALE activity levels. Four patients showed GALK hyperactivity. Conclusion : GALE deficiency provided the highest number. After lactose-free diet, galactose and galactose-1-phosphate were normaly maintained. Neonatal screening on galactosemia is essential for preventing life-threatening symptoms and an accurate diagnosis is needed for finding out the type of galactosemia which is important for prognosis.

• Journal of Life Science
• /
• v.10 no.1
• /
• pp.14-19
• /
• 2000

Variation at 25 allozyme loci in Korean wateralder (Alnus hirsuta Rupr.) from nine distinct populations was measured to estimate the amount and pattern of genetic diversity and population structure. The mean genetic diversity within population was 0.166. Korean alder populations have slightly high levels of genetic diversity compared to those present in associated temperature-zone species and two Canadian alder species. Among population s genetic differentiation accounted for an significant 9% of the total variation. High gene flow(Nm=2.63) was observed. Analysis of fixation indices, calculated for all polymorphic loci in each population, showed a substantial deficiency of heterozygotes relative to Hardy-Weinberg expectations. The mean GST value A. hirsuta in Korea (GST = 0.087) is similar to those of A. rogosa in Canada (GST = 0.052). These low values of GST in two countries. reflecting little spatial genetic differentiation, may indicate extensive gene flow (via pollen and/or seeds) and/or recent colonization. These factors reduce the effect of geographic isolation of breeding and the chance for genetic divergence. A pattern of increasing is observed with increasing rainfall per year. Regression analysis indicates that 54% (F = 4.67) of the variability observed can be explained by this relationship.

• Journal of the Korean Society of Food Culture
• /
• v.15 no.5
• /
• pp.413-422
• /
• 2000

This study was undertaken to investigate meal pattern, nutrition knowledge and food preference of 438 rural middle school students living in ChunNam area. As far as nutrition knowledge is concerned, most subjects did not answer correctly on the items of basic five food groups, animal fat and vegetable oil, empty source of soft drink, nutrient requirement and water's role in energy metabolism. However they responded well on the item of iron deficiency and dietary source of Ca. Male students were significantly better in the answering the items of dietary source of energy and nutrient requirement than females, while female students were significantly better on the items of water's role in energy metabolism related to obesity. Generally the respondents did neither consume oil often nor consider consumption of salty food. Furthermore, only 38.6% of subjects drink milk daily in spite of understanding dietary source of Ca, which suggested that they should incorporate nutrition knowledge into dietary behavior. The preferred foods for most subjects were fruit, kimbab and ice cream. Contrastingly the food that they did not prefer was fermented vegetable probably due to strong flavor.

• The Journal of Internal Korean Medicine
• /
• v.37 no.1
• /
• pp.77-89
• /
• 2016

Objectives: The aim of this study was to develop a standard instrument of pattern identification and evaluation for chemotherapy-induced peripheral neuropathy (CIPN).Methods: The advisory committee for this study was organized by 12 professors of traditional Korean medicine from the Korean Association of Traditional Oncology. The items and structure of the instrument were designed based on a review of previous publications. We revised the instrument in consultation with the advisory committee and received additional advice via email.Results: We divided the symptoms and signs of CIPN into four pattern identifications: wind arthralgia (風痺), cold arthralgia (寒痺), dampness arthralgia (濕痺), and arthralgia of the deficiency type (虛痺). We obtained the mean weights to reflect the standard deviations from each symptom of the four pattern identifications, which were scored on a 5-point scale by the advisor committee. After we obtained the answers to discrimination between variable symptoms (變症) and ordinary symptoms (素症) from the 12 experts, we gained the final weight from the combination of the ratio of pattern identification to the number of total answers of the advisory committee and the mean weight.Conclusions: The Instrument on Pattern Identification and Evaluation for CIPN was developed through a discussion between 12 experts. There was a limitation that the validity and reliability of this instrument have not been proven. However, the significance of this study was that it is the first Instrument on Pattern Identification and Evaluation aimed at assessing CIPN in traditional Korean medicine.

• The korean journal of orthodontics
• /
• v.11 no.2
• /
• pp.77-83
• /
• 1981

The author analyzed the morphological pattern of mandibles and lower third molars in order to study and predict the impaction of the developmental third molars. The subjects consisted of 37 males and 87 females with malocclusion. The following results were obtained: 1. The mandible was shown to be shorter in the impacted third molar group than in the erupted group, both in over-all length and in body length. 2. The developmental mesial angulation of the third molar to the mandibular plane was higher in the impacted third molar group. 3. There was a tendency for impacted third molars to be slightly larger than those which erupted except Class II malocclusion in female. 4. In the available space for the eruption of the third molar, significant space deficiency was found in association with the impacted third molar group compared with the erupted group.

• The Journal of Korean Medicine
• /
• v.43 no.2
• /
• pp.110-116
• /
• 2022

Objectve: To inform a clinical usefulness of Nangan-geon (暖肝煎) decoction to treat a refractory abdominal pain especially in eldery. Methods: This case report presents an 85-year old male patient who had been suffered with a refractory abdominal pain without any abnormality in laboratory test and radiological examination for 5-years. The clinical outcome was observed by numerical rating scale (NRS) of self-reporting method. Results: Based on his previous multiple normal examination results from Western hospitals and clinical features including thin body (19.6 BMI), nocturnal pain around lower abdomen and cold-sensitivity, author diagnosed him as "deficiency and cold of liver-Qi (肝氣虛寒)" similar to intestinal spasm. After prescription with Nangan-geon (暖肝煎) for one month, all symptoms became improved notably (NRS 5), and almost completely recovered as a level of normal condition in 3 months (NRS 1). Conclusion: This study would show the potential of traditional Korean medicine (TKM) therapies for a refractory functional abdominal pain, and especially efficacy of Nangan-geon against cold-pattern of nonspecific abdominal pain in elderly patients.

• Journal of Ceramic Processing Research
• /
• v.13 no.spc2
• /
• pp.403-406
• /
• 2012

Effect of thickness on ZnO properties including the compositional ratio and crystallinity has been systematically investigated using a variety of characterization tools of x-ray diffraction, field emission scanning electron microscopy, x-ray fluorescence and x-ray photoelectron spectroscopy. Interestingly, it was observed that ZnO films below 80 nm in thickness were in oxygen deficiency, while the oxygen ratio was increased in the films above the thickness, although the compositional ratio of ZnO film was not linearly varied with increasing film thickness. Also, ZnO crystallinity, which is characterized by (002) diffraction pattern, was clearly improved with increasing film thickness. The properties of ZnO film with different sputtering time and the nature of direct current reactive sputtering process were discussed in terms of compositional ratio, especially oxygen ratio in ZnO film.

• Journal of Korean Medical classics
• /
• v.36 no.4
• /
• pp.41-54
• /
• 2023

Objectives : To examine Korean Medical treatment of abnormal uterine bleeding in classical texts, along with their clinical applicability. Methods : The Benglou chapters in the Donguibogam, Fuqingzhunuke, Xuezhenglun were examined in terms of diagnostic pattern and treatment. Benglou chapters of other medical texts were referenced as well. Basic Korean Medical knowledge of abnormal uterine bleeding and its clinical application were studied. Results : As abnormal uterine bleeding is generally caused by internal damage or deficiency from excessive labor, sexual activity, food, emotional stress, specific causes for each individual should be considered when approaching each case. Conclusions : Korean Medical treatment allows for a tailored approach to each pathology according to age and duration of illness, and has strength in dealing with various situations such as emergency situations, excessive bleeding, blood stagnation. As such, application of Korean Medicine in abnormal uterine bleeding is highly appropriate.

• Journal of Ecology and Environment
• /
• v.30 no.2
• /
• pp.187-193
• /
• 2007

Higher plants can be categorized as C3, C4 or CAM according to their photosynthetic pathways, and some succulent plants are known to shift their patterns of photosynthesis from C3 to CAM in response to environmental stresses such as salt treatment or water deficiency. To investigate fundamental photosynthetic patterns and the induction of pattern shifts (C3, CAM, C3-CAM etc.) as a result of environmental stresses, we measured the water content, diurnal changes in pH, net $CO_2$ exchange, transpiration rate, total ionic contents, and osmolality of Kalancoe daigremontiana, Sedum kamschaticum and Sedum sarmentosum which belong to Crassulaceae known as representative CAM plant, after 10 days of drought treatment. S. kamschaticum and S. sarmentosum did not show a significant difference in diurnal pH variation in the treatment and control conditions. However, the pH of drought-treated Kalancoe was low at night and high in the daytime, with a pH value between 4 and 5. Typical CAM plants display a net $CO_2$ exchange that increases at night and decreases in the daytime. Kalancoe displayed the predicted pattern. However, S. kamschaticum and S. sarmentosum showed a photosynthetic pattern more typical of C3 plants, and did not show changes in photosynthetic pattern under drought stress. Kalancoe also showed a transpiration rate typical for CAM pho-tosynthesis, whereas the transpiration rates of S. kamschaticum and S. sarmentosum were in the typical range for C3 photosynthesis. Kalancoe had high total ionic contents during the night, which decreased somewhat during the daytime, whereas S. kamschaticum and S. sarmentosum displayed the opposite pattern. This result is similar to the diurnal patterns of changes in pH in the three plant species, which suggests a relationship between pH and ionic contents. S. sarmentosum showed lower osmolality under drought stress than in the control condition, whereas the osmolality of Kalancoe and S. kamschaticum did not differ between conditions. S. sarmentosum may have maintained internal water content by lowering its osmolality and raising its total ionic contents. In conclusion, Kalancoe displayed the characteristic responses of a typical CAM plant, whereas S. kamschaticum and S. sarmentosum displayed aspects of the C3 photosynthetic pattern under drought conditions. These results suggest that S. kamschaticum and S. sarmentosum (Crassulacea) in Korea overcome drought stress by increasing solute and ionic contents internally rather than changing their photosynthetic pattern from C3 to CAM under drought stress.