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http://dx.doi.org/10.14405/kjvr.20220017

Potential application of herbal medicine treatment based on pattern identification for canine cognitive dysfunctional syndrome: a comparative analysis of Korea medicine therapy for patients with dementia  

Jung, Kyungsook (Functional Biomaterials Research Center, Korea Research Institute of Bioscience and Biotechnology)
Zhao, HuiYan (KM Science Research Division, Korea Institute of Oriental Medicine)
Choi, Yujin (KM Science Research Division, Korea Institute of Oriental Medicine)
Jang, Jung-Hee (KM Science Research Division, Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Veterinary Research / v.62, no.3, 2022 , pp. 25.1-25.9 More about this Journal
Abstract
Canine cognitive dysfunction syndrome (CDS) is a neurodegenerative disease that causes cognitive and behavioral disorders and reduces the quality of life in dogs and their guardians. This study reviewed the complementary and alternative medicine (CAM) for CDS and compared the diagnosis and therapy of CAM between CDS in canines and dementia in humans. The evaluation tools for the diagnosis of CDS and dementia were similar in the neurological and neuropsychiatric examinations, daily life activity, cognitive tests, and neuroimaging, but the evaluation for dementia was further subdivided. In CAM, pattern identification is a diagnostic method for accurate, personalized treatment, such as herbal medicine. For herbal medicine treatment of cognitive impairment in canines and humans, a similar pattern identification classified as deficiency (Qi, blood, and Yin) and Excess (phlegm, Qi stagnation, and blood stasis) is being used. However, the veterinary clinical basis for verifying the efficacy and safety of CAM therapies for CDS is limited. Therefore, based on CAM evidence in dementia, it is necessary to establish CDS-targeted CAM diagnostic methods and therapeutic techniques considering the anatomical, physiological, and pathological characteristics of dogs.
Keywords
canine cognitive dysfunction syndrome; herbal medicine; personalized approach; pattern identification;
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1 Zhu W. Traditional Chinese Medicine Diagnostics. China Traditional Chinese Medicine Publishing House, Beijing, 2002.
2 Lee M, Lee J, Choi T, Choi J, Jun J. Preferred Reporting Items for Development of Clinical Practice Guideline in Korean Medicine. pp. 7-13, Korea Institute of Oriental Medicine, Daejeon, 2015.
3 Hasegawa D, Yayoshi N, Fujita Y, Fujita M, Orima H. Measurement of interthalamic adhesion thickness as a criteria for brain atrophy in dogs with and without cognitive dysfunction (dementia). Vet Radiol Ultrasound 2005;46:452-457.   DOI
4 Koh R. Treating cognitive dysfunction syndrome with acupuncture and herbal medicine. Paper presented at: World Small Animal Veterinary Association Congress Proceedings (WSAVA); 2018 Sep 25-28; Singapore. Singapore: WSAVA, 2018.
5 Kline KL. Complementary and alternative medicine for neurologic disorders. Clin Tech Small Anim Pract 2002;17:25-33.   DOI
6 Jeong HG, Han C. Diagnosis and treatment of dementia in primary care. J Korean Med Assoc 2013;56:1104-1112.   DOI
7 Tarter RE, Edwards KL. Neuropsychological Batteries. In: Incagnoli T, Goldstein G, Golden CJ, eds. Clinical Application of Neuropsychological Test Batteries. pp. 135-153, Springer, Boston, 1986.
8 Salvin HE, McGreevy PD, Sachdev PS, Valenzuela MJ. The canine cognitive dysfunction rating scale (CCDR): a data-driven and ecologically relevant assessment tool. Vet J 2011;188:331-336.   DOI
9 Madari A, Farbakova J, Katina S, Smolek T, Novak P, Weissova T, Novak M, Zilka N. Assessment of severity and progression of canine cognitive dysfunction syndrome using the CAnine DEmentia Scale (CADES). Appl Anim Behav Sci 2015;171: 138-145.   DOI
10 Galasko D, Schmitt F, Thomas R, Jin S, Bennett D; Alzheimer's Disease Cooperative Study. Detailed assessment of activities of daily living in moderate to severe Alzheimer's disease. J Int Neuropsychol Soc 2005;11:446-453.   DOI
11 Wade DT, Collin C. The Barthel ADL Index: a standard measure of physical disability? Int Disabil Stud 1988;10:64-67.   DOI
12 Colle M-A, Hauw JJ, Crespeau F, Uchihara T, Akiyama H, Checler F, Pageat P, Duykaerts C. Vascular and parenchymal Abeta deposition in the aging dog: correlation with behavior. Neurobiol Aging 2000;21:695-704.   DOI
13 Dong L, May BH, Feng M, Hyde AJ, Tan HY, Guo X, Zhang AL, Lu C, Xue CC. Chinese herbal medicine for mild cognitive impairment: a systematic review and meta-analysis of cognitive outcomes. Phytother Res 2016;30:1592-1604.   DOI
14 Jung IC. Korean Medicine Clinical Practice Guideline for Dementia, 2021. The Society of Korean Medicine Neuropsychiatry, Yangsan, 2021.
15 Kim HJ, Im H. Assessment of dementia. Brain Neurorehabil 2015;8:11-18.   DOI
16 Gonzalez-Martinez A, Rosado B, Pesini P, Garcia-Belenguer S, Palacio J, Villegas A, Suarez ML, Santamarina G, Sarasa M. Effect of age and severity of cognitive dysfunction on two simple tasks in pet dogs. Vet J 2013;198:176-181.   DOI
17 Zhou S, Dong L, He Y, Xiao H. Acupuncture plus herbal medicine for Alzheimer's disease: a systematic review and meta-analysis. Am J Chin Med 2017;45:1327-1344.   DOI
18 Xin XD. The sequence of Traditional Medicine syndrome differentiation and treatment. J Korean Med 1990;11:202-204.
19 Han JM, Yang WM. A review on Korean medicine and personalized medicine: syndrome-based personalized medicine on the basis of syndrome differentiation and treatment. J Korean Med 2014;35:40-48.   DOI
20 Heo EJ, Kang HW, Jeon WK. Preliminary research for development of instrument for cold-heat & deficiency-excess pat- tern identification of dementia. Korean J Orient J Physiol Pathol 2013;27:553-562.
21 Tian JZ, Shi J, Ni JN, Wei MQ, Zhang XK, Chen KJ, Wang YY. Sequential therapy based on evolvement of patterns: a new model for treatment of Alzheimer's disease. Chin J Integr Med 2019;25:565-573.   DOI
22 Fast R, Rodell A, Gjedde A, Mouridsen K, Alstrup AK, Bjarkam CR, West MJ, Berendt M, Moller A. PiB fails to map amyloid deposits in cerebral cortex of aged dogs with canine cognitive dysfunction. Front Aging Neurosci 2013;5:99.
23 Zakosek Pipan M, Prpar Mihevc S, Strbenc M, Kosak U, German Ilic I, Trontelj J, Zakelj S, Gobec S, Pavlin D, Majdic G. Treatment of canine cognitive dysfunction with novel butyrylcholinesterase inhibitor. Sci Rep 2021;11:18098.   DOI
24 Prpar Mihevc S, Majdic G. Canine cognitive dysfunction and Alzheimer's disease: two facets of the same disease? Front Neurosci 2019;13:604.   DOI
25 Rose WJ, Sargeant JM, Hanna WJ, Kelton D, Wolfe DM, Wisener LV. A scoping review of the evidence for efficacy of acupuncture in companion animals. Anim Health Res Rev 2017;18:177-185.   DOI
26 Kim YN, Bae JS, Eom YJ, Lee KS, Yoon HM, Cho SH. Results of Korean medicine treatment in community dwelling elderly with mild cognitive impairment: focusing on the change in cognitive ability. J Orient Neuropsychiatry 2019;30:185-198.
27 Lee HL, Lim SA, Lee HW, Yoo HR, Kim HG. Yuk-Mi-Ji- hwang-Tang, a traditional Korean multiple herbal formulae, improves hippocampal memory on scopolamine injection-induced amnesia model of C57BL/6 mice. Evid Based Complement Alternat Med 2018;2018:2821040.
28 Lin SK, Tzeng JN, Lai JN. The core pattern of Chinese herbal formulae and drug-herb concurrent usage in patients with dementia. Medicine (Baltimore) 2019;98:e13931.   DOI
29 Okahara K, Ishida Y, Hayashi Y, Inoue T, Tsuruta K, Takeuchi K, Yoshimuta H, Kiue K, Ninomiya Y, Kawano J, Yoshida K, Noda S, Tomita S, Fujimoto M, Hosomi J, Mitsuyama Y. Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 2010;34:532-536.   DOI
30 Ryu CH, Jung IC, Cho SH, Hwang WW, Kang WC, Lee SR. Preliminary study to develop the instrument of oriental medical evaluation for dementia. J Orient Neuropsychiatry 2010; 21:123-135.
31 Gu C, Shen T, An H, Yuan C, Zhou J, Ye Q, Liu T, Wang X, Zhang T. Combined therapy of Di-Huang-Yi-Zhi with Donepezil in patients with Parkinson's disease dementia. Neurosci Lett 2015;606:13-17.   DOI
32 Kim YS, Choi KH. Clinical observations on small animal patients treated by Oriental medicine. J Acupunct Res 2003;20: 120-127.
33 Kim DH, Seo BI, Kim BK, Kim GC, Shin SS. Standard principles for the designing of prescriptions: the theory for monarch, minister, adjuvant and dispatcher. Korean J Orient Med Prescr 2003;11:1-18.
34 Iwasaki K, Kobayashi S, Chimura Y, Taguchi M, Inoue K, Cho S, Akiba T, Arai H, Cyong JC, Sasaki H. A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine "ba wei di huang wan" in the treatment of dementia. J Am Geriatr Soc 2004;52:1518-1521.   DOI
35 Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiol Aging 2008;29:39-50.   DOI
36 Jiang WY. Therapeutic wisdom in traditional Chinese medicine: a perspective from modern science. Trends Pharmacol Sci 2005;26:558-563.   DOI
37 Lee GE, Moon KS, Kim NK, Chung SY, Jung IC, Kang HW. Preliminary study to develop the Korean medical pathologic aging scale and Korean medical pattern identification for dementia. J Korean Med 2017;38:111-123.   DOI
38 Moon HS, Hong WS. A study on the uplift of recipe. J Korean Med Classics 2001;14:11-51.
39 Heo EJ, Lee SW, Jeon WK, Lyu YS, Kang HW. The evaluation of instrument for cold-heat & deficiency-excess pattern identification of dementia. J Orient Neuropsychiatry 2015;26:283-292.   DOI