• 동의생리병리학회지
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• 제26권5호
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• pp.760-764
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• 2012

The purpose of this study was to report the effect of GwiBiTang and gagambang, acupuncture and moxibustion on essential tremor. This study was made on 6 cases that were treated in the OO University Oriental Medicine hospital and evaluated tremor using Visual Analogue Scale(VAS). GwiBiTang was one of the most generally used herbal medication, diagnosed as dual deficiency of the heart-spleen. In five patients out of six, VAS scores decreased. Two patients's scores decreased to 0 point. Three patients's score decreased to 2, 5 and 6 point, respectively. One patient was maintained on these Korean medical treatment for 26 days with no decrease of VAS score in tremor. The overall therapeutic effect was "markedly improved" in 2 (33.3%), "moderately improved" in 3 (50%), "poor" in 1 (16.7%). The results obtained this study suggest that GwiBiTang and gagambang, acupuncture and moxibustion might be effective in the treatment of tremors. Future studies will be required to ascertain the effect of GwiBiTang.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 제4회 추계심포지움
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• pp.75-84
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• 1996

Platelets from a patient with a mild inherited bleeding disorder and abnormal platelet aggregation and secretion show reduced generation of inositol 1,4,5-trisphosphate (IP$_3$), mobilization of intracellular Ca$\^$2+/, and phosphorylation of pleckstrin in response to several G protein mediated agonists, suggesting a possible defect at the level of phospholipase C (PLC) activation. A procedure was developed that allows quantitation of platelet PLC isozymes. After fractionation of platelet extracts by high-performance liquid chromatography, seven, out often known PLC isoforms were detected by immunoblot analysis. The amount of these isoforms in normal platelets decreased in the order PLC-${\gamma}$2 > PLC-${\beta}$2 > PLC-${\beta}$3 > PLC-${\beta}$l > PLC-${\gamma}$ > PLC-$\delta$1 > PLC-${\beta}$4. Compared with normal platelets, platelets from the patient contained approximately one-third the amount of PLC-${\beta}$2, whereas PLC-${\beta}$4 was increased threefold. These results suggest that the impaired platelet function in the patient in response to multiple G protein mediated agonists is attributable to a deficiency of PLC-${\beta}$2. They document for the first time a specific PLC isozyme deficiency in human platelets and provide an unique opportunity to understand the role of different PLC isozymes in normal platelet function.

• Journal of Acupuncture Research
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• 제22권5호
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• pp.111-120
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• 2005

Objectives : The aim of this study is to investigate the effect of acupuncture stimulation on the relationship of change in magnetocardiography (MCG). Methods : For this purpose, 30 heart deficiency volunteers were acupunctured at Shinmun (HA7) and Naegwan (PC6) acupoint. Then, we measured and observed the change of frequency parameters in MCG. Results : In the mean frequency, during and after acupuncture treated groups of PC6 were decreased the activity of $f\;_{mean-max}$ compared to the control group. In the median frequency, during the acupuncture treated group of PC6 was decreased the activity of $f\;_{median-max}$ compared to the control group. Conclusion : These results suggested that acupuncture stimulation plays an important role to the activities of MCG.

• 대한한의학원전학회지
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• 제32권4호
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• pp.35-46
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• 2019

Objectives : While Comparative Pulse Diagnosis of Renying pulse(人迎脈) and Cunkou pulse(寸口脈) is one of the three major pulse diagnostic methods in "Huangdineijing" along with Three Positions and Nine Indicators Pulse Diagnosis(三部九候脈診法) and Cunkou Pulse Diagnosis(寸口脈診法), it has died out in later periods. This study aims to examine this lost method. Methods : Annotations of "Huangdineijing" were examined along with descriptions of the author's own experience. Results & Conclusions : Renying is the Renying(人迎) point from the Stomach Channel(ST), while Cunkou is the Taiyuan(太淵) point from the Lung Channel(LU). These two points are compared in order to determine the deficiency and excess of the Zangfu(臟腑). Normal pulses(平脈) are Soft(軟脈) or Moderate(緩脈), while Stirred pulses(躁脈) are Stringy(弦脈), Tight(緊脈), Slippery(滑脈) or Long(長脈). If the Renying is once active where Shaoyang pulse is active, purge the Gallbladder and supplement the Liver. If there is Stirred pulse, purge the Triple Burner and supplement the Pericardium. If the Renying is twice active where Taiyang pulse is active, purge the Bladder and supplement the Kidney. If there is Stirred pulse, purge the Small Intestine and supplement the Heart. If the Renying is three times active, where Yangming pulse is active, purge the Stomach and supplement the Spleen. If there is Stirred pulse, purge the Large Intestine and supplement the Lung. If the Cunkou is once active where the Jueyin pulse is active, purge the Liver and supplement the Gallbladder. If there is Stirred pulse, purge the Pericardium and supplement the Triple Energizer. If the Cunkou is twice active where the Shaoyin pulse is active, purge the Kidney and supplement the Bladder. If there is stirred pulse, purge the Heart and supplement the Small Intestine. If the Cunkou is three times active where the Taiyin pulse is active, purge the Stomach and supplement the Spleen. If there is Stirred pulse, purge the Lung and supplement the Large Intestine.

• The Korean journal of internal medicine
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• 제33권6호
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• pp.1129-1136
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• 2018

Background/Aims: Vitamin D modulates innate and adaptive immune responses, and vitamin D deficiency is associated with increased mortality in hospitalized patients with pneumonia. We evaluated the prevalence of vitamin D deficiency in Korean patients with acute respiratory distress syndrome (ARDS) and its effect on the clinical outcomes of ARDS. Methods: We retrospectively analyzed the data of 108 patients who had a measured serum level of 25-hydroxy vitamin D3 ($25(OH)D_3$) at the time of diagnosis with ARDS. The clinical outcomes were evaluated based on $25(OH)D_3$ levels of 20 ng/mL and stratified by quartiles of $25(OH)D_3$ levels. Results: The mean age of patients was 59.4 years old; 77 (71.3%) were male. Vitamin D deficiency was found in 103 patients (95.4%). The mean $25(OH)D_3$ level was $8.3{\pm}7.0ng/mL$. Neither in-hospital mortality (40.0% vs. 68.0%) nor 6-month mortality (40.0% vs. 71.8%) significantly differed between groups. There were no significant differences in $25(OH)D_3$ level between survivors ($8.1{\pm}7.6ng/mL$) and non-survivors ($8.5{\pm}6.8ng/mL$, p = 0.765). There were no trends toward a difference in mortality among quartiles of $25(OH)D_3$ levels. However, $25(OH)D_3$ levels were inversely related with length of hospital stay and intensive care unit stay among in-hospital survivors. Conclusions: Vitamin D deficiency was prevalent in Korean patients with ARDS. However, levels of vitamin D were not associated with mortality. A large, prospective study is needed to evaluate the effects of vitamin D deficiency on clinical outcomes of ARDS.

• 대한한의학방제학회지
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• 제18권2호
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• pp.1-14
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• 2010

This report describes 57 prescriptions including Paeoniae Radix and Glycyrrhizae Radix in Dongeuibogam. Paeoniae Radix and Glycyrrhizae Radix have been used separately or concurrently in Oriental Medicine for a long time as a treatment for various disease. The following conclusions are reached through investigations on the applications of prescriptions including Paeoniae Radix and Glycyrrhizae Radix in Dongeuibogam. 1. 7 times(12.3%) prescriptions are recorded in women chapter, 6 times(10.5%) in cold chapter, 5 times(8.8%) in stool chapter and fatigue chapter each, 4 times(7.0%) in psychiatry chapter, which are arranged in order of frequency. 2. Anxiety, Yin-Yang deficiency, stroke, treating blood, cataract, fever floating due to Yin deficiency, weak and fatigue, pregnancy, abortion, women accessary disease, cold-feeling heart pain, stiffness, etc, among 51 symptoms in prescriptions including Paeoniae Radix and Glycyrrhizae Radix. 3. The dosage of Paeoniae Radix and Glycyrrhizae Radix are from 5 pun:2.5 pun to 2 nyang:1 nyang. 1 jeon:5 pun is recored 39 times(68.4%), 2 jeon:1 jeon and 1 nyang:5 jeon is 6 times(3.21%), 2 nyang:1 nyang is 2 times(1.8%) used among 57 prescriptions including Paeoniae Radix and Glycyrrhizae Radix. 4. 57 prescriptions including Paeoniae Radix and Glycyrrhizae Radix are mostly composed of Samooltang and Sagoonjatang, Gyejitang, Gamgiltang, Bowontang, Goongguitang, Jeongwoneum, Bojoongikgitang, Jigoongsan, Ijintang, Pyeongwuisan, Oryungsan, etc, according to the usage.

• 한방안이비인후피부과학회지
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• 제18권2호
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• pp.99-103
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• 2005

The tinnitus is a very common otorhinolaryngologic disease. But, we do not know the exact cause and the healing method of that. We have a case report of the patient who has both tinnitus during two years. He has also chest distress, chest pain, shoulder.neck pain, obesity. In Oriental Medicine, the cuases of tinnitus have diagnosed as the hepatic fire, phlegm-fire, heart fire, deficiency of the kidney, deficiency of vital energy and blood, and so on. In this study the patient classified by Sasang constitutional medicine, and the cuase of tinnitus diagnosed as cold turbid phlegm in Middle Cho, had a medical effects. And in the result, the other symptoms are reduced. So we report the healing process and result of this patient in this study.

• 대한한의학원전학회지
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• 제33권2호
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• pp.77-90
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• 2020

Objectives : To determine the meaning of 'yi(噫)' from verses containing the character in 『Huangdineijing』. Methods : First, examples of the usage of 'yi(噫)' in Huangdineijing were collected and analyzed, followed by examples from the other books of the time when 『Huangdineijing』 was written. Finally the term 'ai' which surfaced in a later period than Huangdineijing to refer to eructation was examined. Results & Conclusions : Based on analysis of the usage of 'yi(噫)' in the 『Huangdineijing』, out of a total of 20 cases, 14 cases could be categorized as referring to eructation, 4 cases were difficult to categorize as eructation, and 2 cases were indeterminable. At the time of publication of 『Huangdineijing』, the character 'yi(噫)' was generally used to refer to eructation when used in a medical context, while in non-medical contexts it referred to sigh, or groan. The appearance of 'ai(噯)' is predicted to be during the Song period, but its appearance did not take away the meaning of eructation from 'yi(噫)' and both were used. Based on the change of meaning of 'yi(噫)', we can determine the approximate time when certain contents of the 『Huangdineijing』 were constructed. In the case of '心爲噫[Heart makes 'yi(噫)']', we can understand it as the pectoral qi leaking through the throat manifesting as a sigh in order to relieve stagnation of the excessiveness of the Heart. In cases of deficiency, when the Stomach function is weak, the body is likely to let out a sigh. The term meaning sighing which is 'taixi(大息)' was understood as symptomatic of problems of the Gallbladder as well as the Heart.

• 대한한의학원전학회지
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• 제35권2호
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• pp.99-120
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• 2022

Objectives : To analyze symptoms of olfactory dysfunction caused by COVID-19 from a Korean Medical Perspective. Methods : Previous studies dealing with olfactory dysfunction accompanying COVID-19 were studied and analyzed for general characterization. Physiology and pathology of olfactory functions within the classical texts of Korean Medicine were collected and analyzed, through which symptoms of olfactory dysfunction in COVID-19 were examined. Results : Olfactory dysfunction manifested in high ratios in the early stages of confirmed COVID-19 cases, at times independent of other nasal symptoms such as blockage or discharge. There was a high chance of loss of taste being accompanied, while mental problems such as a tendency to have difficulty concentrating were present as well. In most cases, recovery took one to two weeks. From a Korean Medical perspective, physiology of olfactory function is closely linked to the Lungs, Ancetral Qi[宗氣], and the Heart, while its dysfunction could be explained by pathological factors such as Wind-Cold, Fire stagnation, Qi deficiency, Wind stroke, etc. Conclusions : In the context of external contraction disease[外感病], olfactory dysfunction could be caused by problems in the Lungs and Stomach that are responsible for breathing, or the Heart which is involved in recognizing and differentiating scent. General characteristics of COVID-19 imply it to be closely related to the Heart. In clinical application, overall symptoms need to be considered in diagnosis and treatment planning, after which further approaches could made to determine the problem to be of the Lung and Stomach, or of the Heart.

• 한방안이비인후피부과학회지
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• 제14권2호
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• pp.286-294
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• 2001

I researched clinically one patient with Hypothyroidism who was hospitalized in DongShin Univ Shunchun Oriental Hosp. from the 4th, November, 2000 to the 13th, December, 2000. The results were obtained as follows. 1. Hypothyroidism corresponds to edema of instep (浮腫), consumption (虛勞), infantile retardation of walking (行遲), retardation in speech (語遲), inactivity of Yang-Qi(결양증). It is caused to deficiency of both Qi and blood (氣血兩虛), insufficiency of Yang of the spleen and kidneys (脾腎陽虛), decline of the fire from the vital gate (命門火衰), deficiency of yang of the heart and kidneys (心腎陽虛) 2. In internal medication, it was thought that Yi qi bu xue tang(益氣補血湯). Shao yin ren Bu zhong yi qi tang(少陰人補中益氣湯), Jia wei ta bu tang (加味大補湯) were effective. 3. In acupunture therapy, zu san li(足三里), san yin jiao(三陰交), Ren ying (人迎), Fu tu (扶突), Tian tu(天突) were used frequently and in moxibustion therapy. qi hai(氣海), zhong wan(中脘). Guan yun(關元) were used for Hypothyroidism.