• 혜화의학회지
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• 제14권2호
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• pp.143-151
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• 2005

Gobjectives and Methods to investigate into the course of incurable and relapse renal stones' differentiation of symptoms and signs and to effectively improve treatment of incurable and relapse renal stones through Oriental Medicine. To search for the papers about treatment of incurable and relapse renal stones from 1994 till 2004, and re-search papers about treatment for indicated differentiation of disease. Result and conclusions : 1. It is the kidney vacuity additionally the deficiency of qi(氣) in middle-burner that the incurable and relapse renal stones' differentiation of disease. 2. The cause is taking an overdose of attacking renal stones to eliminate dampness and heat medicine, aging, chrome disease. a sex act excess, insufficiency of congenital qi(氣), insufficient exercise, wrong treatment and stress. 3. Herb medicines are constituted supplementing kidney drugs for inhibition of renal stone's creation, drugs to diuresis and dissolve calculi, and drugs 10 exclude stasis blood(瘀血) on account of renal stones. 4. Anti-renal stone measures me sufficiently drinking water, not eating greasy food. taking medicine for supplementing kidney, diuresis and dissolve calculi by periods, and drinking substitute water to boll down medical herb as Lysimachiae Herba (金錢草) Polygoni Avicularis Herba(篇蓄).

• Journal of Ginseng Research
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• 제43권4호
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• pp.676-683
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• 2019

Background: Korean Red Ginseng (KRG) is widely used for strengthening the immune system and fighting fatigue, especially in people with deficiency syndrome. However, there is concern that the long-term application or a high dose of KRG can cause "fireness" (上火 in Chinese) because of its "dryness" (燥性 in Chinese). The aim of this study was to assess the safety and efficacy of a 4-week treatment with KRG in participants with deficiency syndrome. Methods: This was a 4-week, randomized, double-blind, placebo-controlled clinical trial. A total of 180 Chinese participants were randomly allocated to three groups: placebo control group, participants were given a placebo, 3.6 g/d; KRG 1.8 g and 3.6 g groups. The primary outcomes were the changes in fireness and safety evaluation (adverse events, laboratory tests, and electrocardiogram). The secondary outcomes were the efficacy of KRG on fatigue, which include the following: traditional Chinese medicine (TCM) symptom scale and fatigue self-assessment scale. Results: Of the 180 patients, 174 completed the full study. After 4 weeks of KRG treatment, the Fire-heat symptoms score including Excess fire-heat score and Deficient fire-heat score showed no significant change as compared with placebo treatment, and no clinically significant changes in any safety parameter were observed. Based on the TCM syndrome score and fatigue self-assessment score, TCM symptoms and fatigue were greatly improved after treatment with KRG, which showed a dose- and time-dependent effect. The total effective rate was also significantly increased in the KRG groups. Conclusion: Our study revealed that KRG has a potent antifatigue effect without significant adverse effects in people with deficiency syndrome. Although a larger sample size and longer treatment may be required for a more definite conclusion, this clinical trial is the first to disprove the common conception of "fireness" related to KRG.

• 동의생리병리학회지
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• 제26권6호
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• pp.934-939
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• 2012

To investigate and characterize basic patterns of prehypertension. Participants were divided into three groups; ideal blood pressure(n=40), prehypertension(n=62), and stage 1 hypertension groups(n=68) according to the JNC 7 standards. They answered questionnaire asking various symptoms and received clinical examination. Data were collected and analyzed in the focus of three Zheng patterns, cold-heat, deficiency-excess and four major hypertension types. Analysis of variance was used to find differences among groups. In addition, relationship between the cold-heat trends and risk factors of hypertension were analyzed using Pearson's correlation analysis. Three risk factors; age, body mass index (BMI), and fasting blood sugar (FBS) showed intergroup differences. Statistical significances were revealed in the cold-heat pattern and two hypertension subtypes. The cold scores decreased from $4.8{\pm}1.84$ to $3.9{\pm}1.88$ and $3.7{\pm}1.27$ (p=0.022), while the heat increased from $1.9{\pm}1.32$ to $2.8{\pm}1.72$ and $2.8{\pm}1.48$ (p=0.009). Additionally two hypertension subtypes, the excessive liver fire, and the yin-yang deficiency showed significant differences. Cold had negative correlations with blood pressure (both systolic and diastolic), BMI, triglyceride, and FBS. Heat had positive correlations with systolic blood pressure, BMI, triglyceride, and FBS. Prehypertension could be characterized by using the cold-heat patterns. The cold-heat are correlated with Blood pressure, BMI, blood lipids and sugar.

• 한국한의학연구원논문집
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• 제2권1호
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• pp.146-176
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• 1996

Through the study of successive literatures from the Han-dynasty(漢代) when ${\\ll}$Keumkweyeuliak(金궤要略)${\gg}$ was written to modern age, we inspected many types of Onkyuatgtang(溫經湯) and prescriptions including the term of 'Okywg(溫湯)' or 'Chokyung(調經), and look into their composition and symptoms respond to administration of this medicine, The results of this study were as follows; 1. The medicine which makes up Onkyuatgtang was 38kinds from the Han-dynasty to the Ching-dynasty(淸代), and up to the present it summed into 43kinds. 2. Onkywgtang which was composed of different kinds of medicine was 10types from the Hun-dynasty to the Chung-dynasty and added 11types in modern days. Therefore it sumed up into 21types. 3. No Onkyuatgtang is seen more common than that of the same composition as in ${\\ll}$Keumkweyeuliak${\gg}$ in successive literature. The next is the same constituents as in ${\\ll}$Buinyangbangdaejeun(婦人良方大全)${\gg}$ Others were rare. 4. Onkywgtang in ${\\ll}$Keumkweyeuliak${\gg}$ was used to treat cold syndrome of the penetration and conception vessles or uterus of deficiency type(衛任 胞宮의 虛寒) and that in Buinyangbangdaejeun was for cold syndrome of the penetration and conception vessels or uterus of excess type(衛任 胞宮의 虛寒). 5. Other names of Ohylmgtang in ${\\ll}$Keumkweyeuliak${\gg}$ were Daeonrkyungtang(大溫經湯), Chokyungsan(調經散), Chokyungtang(調經湯), Chunkeumchokyungtang(千金調經湯), Chunkeumchokyungsan(千金調經散) and Soonkyungtang(小溫經湯), And the prescription in the same constitution was also called Chokyungonkyungtang(仲景溫經湯), Keumkweonkyungtang(千궤溫經湯) and Sibbionkyunghwan(十二溫經丸). 6. Onkywgtang in ${\\ll}$Buinyangbongdaejeun${\gg}$ of Yangbangonkyungtang(良方溫經湯), Jimionkyungtang(指迷溫經湯), Kyunkwionkyungtang(穹歸溫經湯) and Jinssionkyungtang(陣氏溫經湯).

• 대한한의학회지
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• 제16권2호
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• pp.115-133
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• 1995

In the Oriental Western Consideration of Habitual Abortion, the result of this study is summarized as follows: 1. Habitual abortion means repetition of Tatae(abortion within 3 months), Sosan(abortion after 3 months), and Bansan(abortion after 5 months), as it agrees with Hoaltae, Sutatae and Nuing-Nuta in oriental medical science. 2. Frequency in Occurrence of habitual abortion is about 0.2-0.4%> in the whole pregnancy and the Ratio of Risk increases according to frequency and age increase. 3. Generally, the cause of habitual abortion is due to the cause of the mother. Therefore, diagnosis and treatment of before-childbirth are needed, and 'measures taken to prevent abortion' is in use to improve the condition of health of before-childbirth in oriental medical science. 4. The 50-60% of early abortion is due to the heterochromosome and the ratio of risk of habirual abortion is hightest in heterochromosome. 5. The causes of habitual abortion are summarized as vital energe and blood weakness. impairment of Chong and Ren, aflection by exopathogen, fever caused by blood deficiency. weakness of the spleen and the stomach, excess of seven emotion. excess of a sexual desire and injury of a contusion and also the treatments are summarized as invigorating qi (vital energy) and enriching the blood, reducing fever and enriching the blood, reinforcing the spleen, tonifying the Chong and Ren, the practice of a sceticism, psychological peace in oriental medical science. 6. The approch of modem oriental medical science is based on diagnosis and treatment based on 'over all analysis of symptoms and signs' of traditional oriental medical science. it goes abreast with diagnosis of western medical science, and it can be expected mare inclusive effect of treatment because 'Acupuncture for prevent abortion', 'Acupuncture with the needle warmed by burning moxa', and so on being developed except medicinal therapy.

• Journal of Plant Biotechnology
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• 제38권2호
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• pp.130-136
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• 2011

Ions deficiency or excess remains one of the critical ground level environmental problems, affecting crop productivity. In this overview, we will discuss an increased application of proteomics technology in addressing this issue using rice (Oryza sativa L.) as a model crop plant. Proteomics analyses have revealed that rice proteome undergoes changes in the proteins composition and expression in response to several ionic stresses, including mineral nutrients (aluminum, nitrogen, and phosphorous) and heavy metals (arsenic, cadmium, and copper). Developed inventory of responsive proteins and their correlation with changes in physiological symptoms and parameters are a major step forward in: (i) better understanding the underlying mechanisms of ionic stresses-triggered responses in rice; (ii) comparative proteomics studies; and (iii) designing a novel strategy to improve crop plants.

• 혜화의학회지
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• 제8권1호
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• pp.97-114
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• 1999

By studying disease classifications of oriental medicine from Nei-Ching, Chao's-Bing-Yuan, Dong-Yi-Bao-Jian and Korea-standard classification of causes of disease & death. The results were obtained as follows : 1. In Nei-Ching 181 kinds, Chao's-Bing-Yuan 1729 kinds, Dong-Yi-Bao-Jian 966 kinds, and Korea-standard classification of causes of disease & death 2519 kinds of diseases, which suggested more diseases as time flew. 2. In classical books such as Nei-Ching, Chao's-Bing-Yuan, and Dong-Yi-Bao-Jian most of diseases and their names were originated from six kinds of pathogenic factors, Zang-Fu, Jung-Qi-Blood-Fluid, soul, and outer-body-signs, while Korea-standard classification of causes of disease & death classified diseases according to oriental medical departments. 3. Symptoms of Cold-Heat-Excess-Deficiency and pathogenic factors, body parts, Zang-Fu were applied to names of diseases in oriental medicine. 4. In oriental medicine, some symtoms, many intermal diseases were used as disease name, but it is necessary for us to select exact name of diseases in modem clinical treatment. 5. We should consider disease names in Korea-standard classification of causes of disease & death in relations with western medical terms of diseases.

• 대한한의학원전학회지
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• 제22권2호
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• pp.231-261
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• 2009

"Byunjeung-okham(辨證玉函)" is composed of four volumes, Eumjeung-yangjeungbyun(陰症陽症辨, Vol.1), Heojeungsiljeungbyeon(虛症實症辨, Vol.2), Sangjeunghajeungbyun(上症下症辨, Vol.3) and Jinjeunggajeungbyun(眞症假症辨, Vol.4) (卷之一 "陰症陽症辨", 卷之二 "虛症實症辨", 卷之三 "上症下症辨", 卷之四 "眞症假症辨"). It is based on the 74 types of disease symptoms, and compared to "Byunjeungrok(辨證錄)", it is rather brief and concise. Thus, its name, "Byunjeung-okham". This study researched vol.2, "Heojeungsiljeungbyun(虛症實症辨)", which is organized according to the deficiency and excess pattern of 20 disease patterns, such as cough. The disease pattern system mentioned in this book is unique compared with other disease pattern systems. The role of the kidney is especially emphasized, and the application of the Five-phase[五行] theory is very original. Consequently, it contributed greatly in the process of broadening the disease pattern system of Traditional Korean Medicine.

• 대한한방내과학회지
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• 제28권3호
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• pp.453-463
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• 2007

Backgrounds : Glutathione-s-transferase (GST) is a kind of phase II metabolism enzyme and plays an important role in the detoxification of various toxic chemicals. It was reported that the genetic polymorphism of GSTM1 and GSTT1 genes may be responsible for asthma development and susceptibility to allergy. Traditional oriental medicine uses a unique diagnostic technique. differentiation-syndrome. to analyze signs and symptoms of patients synthetically. Through differentiation-syndrome. asthma patients can be divided into two groups: the deficiency syndrome group (DSG) and the excess syndrome group (ESG). Objectives : The purpose of this study was to investigate the possible association of GST gene polymorphism with clinical phenotype by differentiation-syndrome of bronchial asthma patients. Materials and Methods : One hundred and ten participants were evaluated by pulmonary function test. Patients with 53 DSG and 31 ESG by differentiation-syndrome were assessed for genetic analysis. GSTM1 and GSTT1 deletion polymorphism was performed by polymerase chain reaction (PCR). Results : GSTM1 gene deletion was detected in 43.4% of individuals in the DSG and in 38.71 % in the ESG. The distribution of GSTM1 polymorphism between DSG and ESG was not significantly different [$x^2$=0.1767, p=0.6742; OR(95% CI)=1.2139(0.4915-2.9979)]. The proportion of GSTT1 null genotypes was 41.51% in the DGS and 45.16% in the ESG. The distribution of GSTT1 polymorphism between DSG and ESG was also not significantly different [$x^2$=0.1065, p=0.7442; OR(95% CI)=0.8618(0.3525-2.1065)]. In the combined analysis of GSTM1 and GSTT1 genes, the frequency of both null type of GSTM1/GSTT1 genes was not significantly different from both positive type of GSTM1/GSTT1 genes[$x^2$=0.0768, p=0.7817; OR(95% CI)=1.2000(0.3303-4.3602)] Conclusions : These results indicate that polymorphism of the GST gene might not be associated with the symptomatic classification of DSG and ESG by differentiation-syndrome in Korean asthmatics.

• 대한한의진단학회지
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• 제9권1호
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• pp.23-46
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• 2005

Background and purpose: Maek Kyoung(脈經) is a book written, compiled, and edited by Wang Hui circa 3 A.D. This book is the first technical book devoted to the diagnostics. These are very important data but never make a special study and translate. so I hope this treatise can be great help to understand diagnosis study. Methods: Maek Kyoung(脈經) consists of ten volumes, and the third volume consists of the five chapters, including inter-generation and inter-restriction of the five viscera and the six entrails and prognosis of diseases. This treatise is made up of principal, notes, study and conclusion, we tried to make a translation faithful to the original. Results and Conclusion: Chapter 3 refers to five things. The first is relation between spleen and stomach, the second is how to diagnose diseases by using intergneration and inter-restriction of five elements, the third is roles of spleen that has an influence on four viscera through four seasons, the forth is the fact that quantity of gastroqi decides prognosis of diseases, and the fifth is that climate change has influence on the seriousness of diseases. Chapter 4 refers to four things. The first is relation between lung and large intestines, the second is ordinary and extraordinary pulse condition of lung, the third is that pulse condition including its speed, and the forth is how to diagnose diseases by using intergneration and inter-restriction of five elements and climate change.