• The Korean Journal of Physiology and Pharmacology
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• v.9 no.5
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• pp.263-268
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• 2005

Striatum has important roles in motor control, habitual learning and memory. It receives glutamatergic inputs from neocortex and thalamus, and dopaminergic inputs from substantia nigra. We examined effects of dopamine (DA) on the corticostriatal synaptic transmission using in vitro extracellular recording technique in rat brain corticostriatal slices. Synaptic responses were elicited by stimulation of cortical glutamatergic inputs on the corpus callosum and recorded in the dorsal striatum. Corticostriatal population spike (PS) amplitudes were decreased ($39.4{\pm}7.9$%) by the application of $100{\mu}M$ DA. We applied receptor subtype specific agonists and antagonists and characterized the modulation of corticostriatal synaptic transmission by different DA receptor subtypes. $D_2$ receptor agonist (quinpirole), antagonist (sulpiride), and $D_1$ receptor antagonist (SKF 83566), but not $D_1$ receptor agonist (SKF 38393), induced significantly the reduction of striatal PS. Pretreatment neither with SKF 83566 nor sulpiride significantly affected corticostriatal synaptic inhibition by DA. However, the inhibition of DA was completely blocked by pretreatment with mixed solution of both SKF 83566 and sulpiride. These results suggest that DA inhibits corticostriatal synaptic transmission through both $D_1$ and $D_2$ receptors in concert with each other.

• Journal of Preventive Medicine and Public Health
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• v.29 no.2 s.53
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• pp.227-238
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• 1996

This study was conducted to evaluate the accuracy of the official death registry in rural area. The base data used for the study was 379 deaths registered during the period of 1993 and 1994 in 4 rural townships of Chonnam province. The interview survey for cause-of-death was performed on the next of kin and/or neighbor. Additional medical informations were collected from hospitals and medical insurance associations for the purpose of verification. The underlying cause-of-death of 278 cases presumed by the survey was compared to the cause on official death registry. There was a prominent disagreement of cause-of-death between the survey data and the registry data(agreement rate: $38.9\sim44.6%$, according to disease classification method). These results may be caused by extremely low rates of physicians' certification, which were mostly confined to the poisoning and injury. Symptoms, signs, and ill defined conditions on death registry could be classified into circulatory disease(32.3%), neoplasm(21.2%), digestive disease(7.1%), injury and poisoning(7.1%) and so on. These results suggest that careful attention and verification be required on utilization of death registry data in rural area.

• The Journal of Korean Medical History
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• v.26 no.2
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• pp.149-160
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• 2013

King Sunjong was the 27th King and the last King in the Joseon Dynasty. He lived an unhappy life as the prince and the King of perishing country. At the age of 22, He witness the death of his mother Queen Myeongseong by Japanese assassin. He has a weak constitution and have many diseases. He get varicella(水痘) in infancy, and suffered from smallpox(紅疫) at 6, and catched the measles(天然痘) at 12. At the age of 25, Having drunk the coffee that contained opium(阿片), he had bloody excrement(血便) and lose the 18 teeth. The Symptoms that appeared frequently at adult age are indigestion(滯症), diarrhea(泄瀉), trophedema(足部浮腫), odontopathy(齒科疾患) etc. This indigestion(滯症) and diarrhea(泄瀉) are occurred by gastroenteropathy(胃腸病). This odontopathy(齒科疾患) is the aftereffect from having 18 false teeth. We assume that this trophedema(足部浮腫) is occurred by cardiac disease(心臟病) and renal disease(腎臟病). The chronic diseases of King Sunjong are gastroenteropathy(胃腸病), renal disease(腎臟病), cardiac disease(心臟病), rheumatism. We assume that the immediate cause of his death is the aggravation of the renal disease(腎臟病) and cardiac disease(心臟病). The medical treatments for him are hardly included in "Formal Records of the Joseon Dynasty(朝鮮王朝實錄)" which is the prime governmental document. Many royal doctors in court used the traditional Korean medicine, but western doctors from Japan often treated him by medical techniques such as injection(注射), consperg(散藥), liquid medicine(水藥).

• Journal of Microbiology
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• v.44 no.4
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• pp.457-460
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• 2006

A suspicious meningococcal meningitis death case was reported to the Beijing CDC. The blood specimen was analyzed via multi-PCR and MLST. 6 isolates from close contacts were analyzed via PFGE and MLST. According to the results of the above analyses, the cause of this case was identified as a serogroup A Neisseria meningitidis, which, in terms of sequence typing, belonged the ST7 group.

• Korean Journal of Biological Psychiatry
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• v.16 no.3
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• pp.198-204
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• 2009

Objectives : Schizophrenia and other psychiatric disorder are associated with an increased risk of premature death. For decades, there have been reports of shorter life expectancy among those with severe mental illness. The purpose of this study was to compare the risk of mortality among institutionalized population, treated for severe mental illness to control group who did not have severe mental illness. Methods : The medical records and the death certificates of 2,029 institutionalized population who had died from 1985 to 2003 in Kkottongnae were investigated. Results : The mean age of the death of severe mental illness(SMI) group(51.4${\pm}$15.3 years old) was lower than that of non-severe mental illness(non-SMI) group(65.0${\pm}$19.3 years old) and it was statistically significant(p<0.0001). The most causes of death among the SMI group were respiratory diseases(23.3%), infectious disease (13.0%) and digestive disease(12.3%). Also, we found that the death due to injuries of the SMI group(8.9%) were three times higher than that of non-SMI group(2.5%). The most causes of death among the non-SMI group were respiratory disease(26.3%), circulatory disease(26.2%) and neoplasm(10.8%). Conclusion : The SMI group demonstrated higher mortality rates compared with the rate in the non-SMI group. The finding suggests that careful intervention is needed not only for menal health but also physical health in long-term facilities.

• The Journal of Korean Medical History
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• v.24 no.2
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• pp.125-134
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• 2011

King Gojong was the twenty-sixth King in the Choseon Dynasty. He took the throne when he was only 12 years old and had to set up regency for 10 years. During his period, situations were worsened in both domestic and foreign affairs. In the end, after 3 years from abdication of the throne, the Choseon Dynasty was overthrown in compliance with a coercion by Japanese empire. He died in 68 years old. We can assume that his inveterate disease are weakness of the spleen and the stomach. In addition, he suffered from a boil, a cold, dermatosis, eye disease, an external wound, dentistry disease, arthritis, etc. The official cause of his death was cerebral hemorrhage. But we assume that the possibility of poison murdering is high.

• Journal of Chest Surgery
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• v.18 no.4
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• pp.711-717
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• 1985

Over a period from July 1984 to June 1985, 39 cases of open heart surgery were done under cardiopulmonary bypass. There were 23 male and 16 female patients, ranging in age from 18 months to 58 years. Thirty cases were valvular disease. The most common of congenital heart disease is VSD. Among the 9 cases of acquired valvular diseae,1 MAP, 5 MVR, 2 MVR+TAP, and 1 MVR+AVR were done. There were 1 operative death[11%] which was done MVR+TAP. Operative mortality in 30 congenital heart disease was 7%; 1 death [5%] in 22 acyanotic and 1[13%] in 8 cyanotic cases. Finally, overall mortality for 39 cases was 8%; 7% for congenital heart disease and 11% for acquired heart disease.

• The Journal of Korean Medicine
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• v.30 no.4
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• pp.142-161
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• 2009

Objectives: There are many unknowns surrounding Jeong-Jo's death. To better understand Jeong-Jo's death, we closely inspected his medical records from the 20 days before his death in The Annals of the Chosun Dynasty (朝鮮王朝實錄) and Seungjeongwon Ilgi (承政院日記), Understanding medical treatment before death, we can correctly trace the cause of Jeong-Jo's death. Methods: According to The Annals of the Chosun Dynasty (朝鮮王朝實錄) and Seungjeongwon Ilgi (承政院日記), we examined his medical records between June 14 and June 28 of 1800, as to the change in chief complaint, cold and heat, thirst, syndrome differentiation, the opinions of Jeong-Jo, and the opinions of doctors, The original work, The Annals of the Chosun Dynasty and Seungjeongwon Ilgi were provided by NIKH (The National Institute of Korean History). The Korean translation of The Annals of the Chosun Dynasty was also provided by NIKH. Seungjeongwon Ilgi (original work written in Chinese characters) was directly translated into Korean by the study author. Results: 1. Jeong-Jo's is likely to have died of septicemia caused by an abscess on his back. 2. The cause of Jeong-Jo's death could be stroke due to hypertension, mental stress, and 'Wha (火) disease' Conclusions: The dominant view that Jeong-Jo was murdered by poison is not likely.

• The Plant Pathology Journal
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• v.21 no.4
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• pp.395-401
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• 2005

The dlm (disease lesion mimic) mutant of soybean (Glycine max L. Merr) shows the similar lesion of a soybean disease caused by a fungus, Corynespora cassilcola. The lesion was examined at cellular and molecular level. Trypan blue staining result indicated that cell death was detectable in the entire region of leaves excluding veins when the lesions had already been developed. We found that the mesophyll cells of palisade layer in the dim mutant appeared to be wider apart from each other. The chloroplasts of the dim mutant cells contained bigger starch granules than those in normal plants. We also found that the lesion development of dlm plant was light-dependent and the starch degradation during the dark period of diurnal cycle was impaired in the mutant. Three soybean pathogenesis-related genes, PR-1a, PR-4, and PR-10, were examined for their expression patterns during the development of disease lesion mimic. The expression of all three genes was up-regulated to some extent upon the appearance of the disease lesion mimic. Although the exact function of DLM protein remains elusive, our data would provide some insight into mechanism underling the cell death associated with the dim mutation.

• Journal of Veterinary Clinics
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• v.17 no.2
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• pp.515-518
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• 2000

The mortalities of the gorals (Nemorhaedus goral raddeanus) that have been raised in Everland Zoological Gardens were retrospectively analyzed based on the clinical charts and autopsy reports from 1976 to 1999. During that Period a total of 17 gorals were died. Infectious factos (35.2%), digestive (23.5%) and respiratory disorders (17.6%) account feta the majority of cause of death. The The mortality of newborn gorals (50%) were significantly higher than that of adult (20%) and juvenile gorals (0%) due to infectious disease. 83.5% of the infectious disease were found in the garals younger than 5 months old. The cause of death of 5 newborn gorals died by infectious disease were as follows: 1aryngeal diphtheria, 2 (40%); actinobacillosis,2 (40%): coccidiosis. 1 (20%). It was considered that proper hygenic epic precautions in goral Pens ir feeding Places together with avoidance of rough feed are needed for the prevention of death of infectious cause at the goral raising in zoo-logical gardens.