• Title/Summary/Keyword: de-aggregation

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Spectroscopic Evidence for Aggregation of Stilbene Derivatives in Solution

  • Aguiar, M.;Akcelrud, L.;Pinto, M.R.;Atvars, T.D.Z.;Karasz, F.E.;Saltiel, Jack
    • Journal of Photoscience
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    • v.10 no.1
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    • pp.149-155
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    • 2003
  • The absorption, fluorescence and fluorescence-excitation spectra of concentrated toluene solutions of selected para substituted trans-stilbene derivatives provide strong evidence for aggregation. A red-shifted fluorescence spectrum peaking at 420 nm gains in intensity as the stilbene concentration is increased. The excitation spectrum of this new emission is well to the red of the normal stilbene absorption spectrum, consistent with the appearance of a red shifted shoulder in the UV spectrum. Formation of a fluorescent ground state dimer (or higher aggregate) is proposed to account for these observations. The presence of polar substituents is crucial to the formation of this ground state complex.

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Amyloid pore-channel hypothesis: effect of ethanol on aggregation state using frog oocytes for an Alzheimer's disease study

  • Parodi, Jorge;Ormeno, David;Paz, Lenin D. Ochoa-de la
    • BMB Reports
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    • v.48 no.1
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    • pp.13-18
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    • 2015
  • Alzheimer's disease severely compromises cognitive function. One of the mechanisms to explain the pathology of Alzheimer's disease has been the hypotheses of amyloid-pore/channel formation by complex $A{\beta}$-aggregates. Clinical studies suggested the moderate alcohol consumption can reduces probability developing neurodegenerative pathologies. A recent report explored the ability of ethanol to disrupt the generation of complex $A{\beta}$ in vitro and reduce the toxicity in two cell lines. Molecular dynamics simulations were applied to understand how ethanol blocks the aggregation of amyloid. On the other hand, the in silico modeling showed ethanol effect over the dynamics assembling for complex $A{\beta}$-aggregates mediated by break the hydrosaline bridges between Asp 23 and Lys 28, was are key element for amyloid dimerization. The amyloid pore/ channel hypothesis has been explored only in neuronal models, however recently experiments suggested the frog oocytes such an excellent model to explore the mechanism of the amyloid pore/channel hypothesis. So, the used of frog oocytes to explored the mechanism of amyloid aggregates is new, mainly for amyloid/pore hypothesis. Therefore, this experimental model is a powerful tool to explore the mechanism implicates in the Alzheimer's disease pathology and also suggests a model to prevent the Alzheimer's disease pathology.

Solution properties of sodium n-dodecyl sulfate in the presence of meso-tetrakis (N-methylpyridinium-4-yl) porphyrin (Meso-tetrakis (N-methylpyridinium-4-yl) porphyrin 존재 하에서 sodium n-dodecyl sulfate 용액 성질)

  • Hassanpour, Azin;Azani, Mohammad-Reza;Bordbar, Abdol-Khalegh
    • Journal of the Korean Chemical Society
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    • v.55 no.3
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    • pp.335-340
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    • 2011
  • The solution properties of sodium n-dodecyl sulfate, as an anionic surfactant in the presence of a cationic watersoluble 5, 10, 15, 20-tetrakis (N-methylpyridinium-4-yl) porphyrin (TMPyP) has been comprehensively studied by means of conductometry, UV-vis and resonance light scattering (RLS) spectroscopies. The results represent the decreasing of critical micelle concentration of SDS solution due to increasing of TMPyP concentration. The stabilization of SDS micelle is due to neutralization of negative charge at the micelle surface. The presence of three different species of TMPyP in SDS solution has been unequivocally demonstrated: free porphyrin monomers, porphyrin monomers or aggregates bound to the micelles, and nonmicellar porphyrin/surfactant aggregates. Our results show SDS induced an aggregation in TMPyP. In fact two kinds of J-aggregations were observed: one of them for porphyrin monomers or aggregates bound to the micelles and the other for nonmicellar porphyrin/surfactant aggregates. However, the results represent the electrostatic interaction of TMPyP with SDS anion below the cmc.

Resource scheduling scheme for 5G mmWave CP-OFDM based wireless networks with delay and power allocation optimizations

  • Marcus Vinicius G. Ferreira;Flavio H. T. Vieira;Alisson A. Cardoso
    • ETRI Journal
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    • v.45 no.1
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    • pp.45-59
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    • 2023
  • In this paper, to optimize the average delay and power allocation (PA) for system users, we propose a resource scheduling scheme for wireless networks based on Cyclic Prefix Orthogonal Frequency Division Multiplexing (CP-OFDM) according to the first fifth-generation standards. For delay minimization, we solve a throughput maximization problem that considers CPOFDM systems with carrier aggregation (CA). Regarding PA, we consider an approach that involves maximizing goodput using an effective signal-to-noise ratio. An algorithm for jointly solving delay minimization through computation of required user rates and optimizing the power allocated to users is proposed to compose the resource allocation approach. In wireless network simulations, we consider a scenario with the following capabilities: CA, 256-Quadrature Amplitude Modulation, millimeter waves above 6 GHz, and a radio frame structure with 120 KHz spacing between the subcarriers. The performance of the proposed resource allocation algorithm is evaluated and compared with those of other algorithms from the literature using computational simulations in terms of various Quality of Service parameters, such as the throughput, delay, fairness index, and loss rate.

Deaggregation and Ultradispersion of Detonation Nanodiamonds in Polar Solvent Using Physicochemical Treatments (물리화학적 처리를 통한 극성 용매 내 나노다이아몬드의 탈응집 및 분산성 향상 연구)

  • Kim, Changkyu;Lee, Gyoung-Ja;Rhee, Changkyu
    • Journal of Powder Materials
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    • v.20 no.6
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    • pp.479-486
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    • 2013
  • In the present work, physicochemical treatments were introduced for de-aggregation and stable dispersion of detonation nanodiamonds (DND) in polar solvents. The DNDs in water exhibited a particle size of 138 nm and high dispersion stability without particular treatment. However, the DNDs in ethanol were severely aggregated to several micrometers in size and showed poor dispersion stability with time. To break down aggregates of DNDs and enhance the dispersion stability of them in ethanol, mechanical force and chemical surfactant were introduced as functions of zirconia ball size, kind of surfactant and amount of surfactant added. From the analyses of average particle size and Turbiscan results, it was suggested that the size of DNDs in ethanol can be reduced by only mechanical force; however, the DNDs were re-aggregated due to high surface activity. The long-term dispersion stability can be achieved by applying mechanical force to break down the aggregates of DNDs and by preventing re-aggregation of them using proper surfactant.

Efficient Topology Aggregation in ATM Networks (ATM망에서의 효율적인 토폴로지 집단화 방법)

  • 유영환;안상현;김종상
    • Proceedings of the Korean Information Science Society Conference
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    • 2000.10c
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    • pp.171-173
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    • 2000
  • 본 논문에서는 ATM PNNI(Private Network-Network Interface) 망에서 경로 배정을 위해 필요로 하는 링크 상태 정보(link state information)를 효율적으로 집단화(aggregation)하는 두 가지 방법을 제시한다. 이 방법들은 집단화할 동료 집단(peer group)의 경계노드(border node)들을 셔플넷(shufflenet)이나 de Bruijn 그래프의 노드들로 사상시킴으로써 표현해야 할 링크의 수를 완전 그물망 방법(full-mesh approach)의 N2에서 aN(a는 정수, N은 경계노드 수)으로 줄인다. 이는 공간 복잡도가 0(N)인 신장 트리(apanning tree) 방법에서 필요로 하는 링크의 수와 비슷하지만, 신장 트리 방법과는 달리 비대칭망(asymmetric network)에서 사용할 수 있다는 것이 큰 장점이다. 모의 실험 결과 셔플넷 방법은 aN개의 링크만을 표현하면서도 상태 정보의 정확성은 완전 그물망 방법에 근접함을 알 수 있었고, de Bruijn 방법은 정보의 정확성에서는 셔플넷 방법에 못 미치지만 가장 널리 사용되고 있는 별모양 방법(star approach) 방법보다는 훨씬 정확하며, 계산 복잡도 면에서 셔플넷 방법보다 효율적이었다.

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Topology Aggregation Schemes for Asymmetric Link State Information

  • Yoo, Young-Hwan;Ahn, Sang-Hyun;Kim, Chong-Sang
    • Journal of Communications and Networks
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    • v.6 no.1
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    • pp.46-59
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    • 2004
  • In this paper, we present two algorithms for efficiently aggregating link state information needed for quality-of-service (QoS) routing. In these algorithms, each edge node in a group is mapped onto a node of a shufflenet or a node of a de Bruijn graph. By this mapping, the number of links for which state information is maintained becomes aN (a is an integer, N is the number of edge nodes) which is significantly smaller than N2 in the full-mesh approach. Our algorithms also can support asymmetric link state parameters which are common in practice, while many previous algorithms such as the spanning tree approach can be applied only to networks with symmetric link state parameters. Experimental results show that the performance of our shufflenet algorithm is close to that of the full-mesh approach in terms of the accuracy of bandwidth and delay information, with only a much smaller amount of information. On the other hand, although it is not as good as the shufflenet approach, the de Bruijn algorithm also performs far better than the star approach which is one of the most widely accepted schemes. The de Bruijn algorithm needs smaller computational complexity than most previous algorithms for asymmetric networks, including the shufflenet algorithm.

A Study on De-Identification of Metering Data for Smart Grid Personal Security in Cloud Environment

  • Lee, Donghyeok;Park, Namje
    • Journal of Multimedia Information System
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    • v.4 no.4
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    • pp.263-270
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    • 2017
  • Various security threats exist in the smart grid environment due to the fact that information and communication technology are grafted onto an existing power grid. In particular, smart metering data exposes a variety of information such as users' life patterns and devices in use, and thereby serious infringement on personal information may occur. Therefore, we are in a situation where a de-identification algorithm suitable for metering data is required. Hence, this paper proposes a new de-identification method for metering data. The proposed method processes time information and numerical information as de-identification data, respectively, so that pattern information cannot be analyzed by the data. In addition, such a method has an advantage that a query such as a direct range search and aggregation processing in a database can be performed even in a de-identified state for statistical processing and availability.

A Study on the de-identification of Personal Information of Hotel Users (호텔 이용 고객의 개인정보 비식별화 방안에 관한 연구)

  • Kim, Taekyung
    • Journal of Korea Society of Digital Industry and Information Management
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    • v.12 no.4
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    • pp.51-58
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    • 2016
  • In the area of hotel and tourism sector, various research are analyzed using big data. Big data is being generated by any digital devices around us all the times. All the digital process and social media exchange produces the big data. In this paper, we analyzed the de-identification method of big data to use the personal information of hotel guests. Through the analysis of these big data, hotel can provide differentiated and diverse services to hotel guests and can improve the service and support the marketing of hotels. If the hotel wants to use the information of the guest, the private data should be de-identified. There are several de-identification methods of personal information such as pseudonymisation, aggregation, data reduction, data suppression and data masking. Using the comparison of these methods, the pseudonymisation is discriminated to the suitable methods for the analysis of information for the hotel guest. Also, among the pseudonymisation methods, the t-closeness was analyzed to the secure and efficient method for the de-identification of personal information in hotel.

The Antithrombotic Effects of Green Tea Catechins (녹차 카테킨류의 항혈전 효과)

  • 윤여표;강원식;이미애
    • Journal of Food Hygiene and Safety
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    • v.11 no.2
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    • pp.77-82
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    • 1996
  • Green tea catechins(GTC) were studied for its inhibitory effect on human platelet aggregation in vitro, for its antithrombotic effect in mice in viro, and bleeding and clotting time in rats. The catechins were isolated and purified from green tea, which were composed of (-)-epigallocatechin gallate, (-)-epigallocatechin, (-)epicatechin gallate and (-)-epicatechin, GTC produced a potent inhibition of human platelet aggregation in a dose-dependent manner against the stimulants such as ADP, collagen, epinephrine and ristocetin n vitro. GTC also prevented death due to the formation of pulmonary thrombosis by platelet aggregates in mice in a dose-de-pendent manner in viro. GTC increased the bleeding time, whole blood clotting time and plasma clotting time in rats, too. These results suggest that GTC is a promising antithrombotic agent.

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