• Biomolecules & Therapeutics
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• 제25권2호
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• pp.165-170
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• 2017

Cordyceps bassiana is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. This mushroom has recently demonstrated to have an ability to reduce 2,4-dinitrofluorobenzene-induced atopic dermatitis symptoms in NC/Nga mice. In this study, we further examined phytochemical properties of this mushroom by column chromatography and HPLC analysis. By chromatographic separation and spectroscopic analysis, 8 compounds, such as 1,9-dimethylguanine (1), adenosine (2), uridine (3), nicotinamide (4), 3-methyluracil (5), 1,7-dimethylxanthine (6), nudifloric acid (7), and mannitol (8) were identified from 6 different fractions and 4 more subfractions. Through evaluation of their anti-inflammatory activities using reporter gene assay and mRNA analysis, compound 1 was found to block luciferase activity induced by $NF-{\kappa}B$ and AP-1, suppress the mRNA levels of cyclooxygenase (COX)-2 and tumor necrosis factor $(TNF)-{\alpha}$. Therefore, our data strongly suggests that compound 1 acts as one of major principles in Cordyceps bassiana with anti-inflammatory and anti-atopic dermatitis activities.

• 기본간호학회지
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• 제12권1호
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• pp.15-20
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• 2005

Purpose: This study was done to compare of adult body composition and body image before and after regular exercise program at a sports center. Method: The participants were 32 adults who were beginning regular exercise at a sports center in D city. The body composition was measured by body weight, soft lean mass, fat mass, percent body fat, fat distribution, degree of obesity and BMI, using the Inbody 3.0. Body image. Data were collected using structured questionnaires and analyzed using paired t-test. Results: 1. Significant improvement was shown in body composition. 2. The score for body image increased after the program, but the change was not statistically significant. Conclusion: The short-term exercise program was very effective in improving body composition, but changes in the evaluation of body image need long-term exercise. Also, we were concluded that it is very important to consider preference level when evaluating body composition and body image.

• 국제물리치료학회지
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• 제9권4호
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• pp.1576-1585
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• 2018

Regularly participating in physical activity is known to improve quality of life and body composition in elderly with stroke. However, comparatively less physical activity is performed by the stroke survivors. The factors related to inactivity in elderly female stroke survivors have not been elucidated. Therefore, this study aims to compare the quality of life factors and limb compositions between the active and inactive elderly female stroke survivors. Forty nine subjects between the ages of 65 to 75 years were selected from the KNHANES data between the years 2009 to 2011. In addition, 186 agematched healthy peers were also selected for limb composition comparisons. The subjects were groups based on walking days per week: walkers; 3 days or more, non-walkers; less than 3 days per week. BMI and waist circumference were within the obesity ranges for both the non-walkers and walkers. As results, the trend for greater fat (${\pm}10%$) and lean mass (${\pm}30%$) differences were observed for non-walker and walkers, respectively. Significantly greater reasons for function limitation by stroke and hypertension were reported with significantly greater self-care difficulty was shown by the walkers. In conclusion, elderly female stroke survivals may require customized motivation and continuous support to participate in physical activity regularly.

• 융합정보논문지
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• 제8권3호
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• pp.17-24
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• 2018

본 연구는 도시지역 근로자 5,638명을 대상으로 건강행태와 만성질환 유병률과의 관련성을 파악하고자 하였다. 자료분석은 빈도, 백분율, 교차분석을 실시하고 만성질환에 미치는 영향을 분석하기 위하여 다중로지스틱 회귀분석을 사용하였다. 연구 결과 대상자의 건강행태는 남자가 흡연과 음주가 높게 나타났고, 운동은 남녀 모두 추천건강운동량 기준으로 낮게 나타났으며 만성질환 유병률은 비만과 고지혈증이 높게 나타났다. 만성질환에 영향을 미치는 중요 인자는 연령, 운동, 음주로 확인되었다. 본 연구의 결과는 국가, 지역사회 및 산업현장에서 바람직한 건강행태 형성을 위한 체계적인 건강관리프로그램을 운영할 필요가 있음을 시사한다.

• 한국학교보건학회지
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• 제30권3호
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• pp.181-193
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• 2017

Purpose: This is a qualitative descriptive study with the purpose of identifyng the health problems and related factors of socially vulnerable school-age children in Seoul, South Korea. Methods: Two focus group interviews and two individual interviews were conducted with eleven participants. They were two class teachers, three school nurses and two daycare teachers working at elementary schools and three social workers and a welfare worker working at community childcare centers. Data were analyzed using qualitative content analysis. Results: The identified psychosocial problems were 'distracting and excessive behavior', 'depression and helplessness,' 'aggression and violent behaviors', and 'internet overdependence'. The revealed physical health problems were 'poor hygiene', 'obesity', and 'gastrointestinal problems'. In addition, the fact that physical and psychosocial problems are closely inter-linked was reaffirmed through practical examples. Meanwhile, socioeconomic, family environmental, social experiential and individual factors were found to affect children's health. Relationships within a family or a peer group and healthy lifestyle were considered critical issues to deal with in order to improve the childrens' health status. Conclusion: It was proved that socially vulnerable school-age children have various physical and mental health problems due to multiple factors. Therefore, it is required to design nursing approaches that help them achieve optimal health status.

• 동서간호학연구지
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• 제27권2호
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• pp.166-176
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• 2021

Purpose: This study was conducted to assess the effect of household types on the occurrence of chronic diseases depending on gender and to identify the factors associated with chronic disease occurrence in one-person households. Methods: Multivariate logistic regression analysis was conducted using the data of 15,949 adults with the age of 19 years or older from the sixth Korea National Health and Nutrition Examination Survey (2013~2015). Results: For male, the risk of chronic disease occurrence was higher in one-person households than in multi-person households, and the same held true after adjusting for the confounding factors. For female, no significant relationship was found between household types and chronic disease occurrence. Factors associated with chronic disease occurrence were age, employment state, marital state, smoking, perceived stress, and depression in male, and age, employment state, physical activity, and obesity in female. Conclusion: It is necessary to monitor the disparity in health depending on household types in male. Additionally, providing a gender specific chronic disease prevention and health enhancement program is required.

• 한국컴퓨터정보학회논문지
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• 제24권4호
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• pp.129-136
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• 2019

The purpose of this study was to provide basic data necessary for the development of clothing that can improve the satisfaction of body shape of elderly men by examining subjective characteristics and characteristics of perception type of older men's body shape. Using the Q methodology, I investigated and analyzed the process of formation and main characteristics of subjectivity of various types of recognition that elderly men express about their body shape. There were four types of perception of body shape in elderly men: flat hip and bird legs skinny body, back bent and abdominal obese body, thick neck and upper body development body, forward cervical neck and protruding abdomen obese body. The actual body shape of elderly men was classified according to the bust, waist circumference, hip circumference, and body part angle. But recognition body shape of elderly men was classified by visual factors like the abdomen, the angle of the neck, the inclination of the back, the slope of the waist, and the degree of obesity. It is necessary to consider the trend of silver fashion which is increasing in demand. In addition, it is necessary to develop clothing patterns of comfortable fit through ergonomic study on the physical characteristics of older men. Consideration should be given to the design and pattern that can reduce the difference between the ideal body shape and the body shape recognized by older men.

• 한국자원식물학회지
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• 제34권3호
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• pp.216-222
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• 2021

Ulcerative colitis (UC) is an inflammatory bowel disease and a chronic gastrointestinal disorder. Rubi Fructus (RF), the fruit of Rubus coreanus Miquel, is known to exert several pharmacological effects including anti-oxidative, anti-obesity and anti-inflammatory properties. However, the improving effect and mechanism of RF on intestinal inflammation is not been fully understood. The purpose of this study was to investigate the regulatory effect of RF on dextran sulfate sodium (DSS)-induced colitis in mice. We evaluated the effects of RF on DSS-induced clinical signs by analyzing weight loss and colon length. The inhibitory effects of RF on inflammatory mediators such as prostaglandin E₂ (PGE₂), cyclooxygenase (COX)-2, as well as the activation of nuclear factor-κB (NF-κB), were determined in colitis tissue. Our data indicated that mice treated with DSS showed clinical symptoms of colitis, including weight loss, colon length decrease and diarrhea. However, we observed that RF treatment significantly improved these clinical symptoms of weight loss, colon length decrease and diarrhea induced by DSS. RF inhibited the enhanced levels of COX-2 and PGE₂ caused by DSS. We also showed that the anti-inflammatory mechanism of RF by suppressing the activation of NF-kB in DSS-treated colon tissues. Collectively, the findings of this study indicate the prospect of developing new drugs from RF for UC treatment.

• Journal of Korean Biological Nursing Science
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• 제23권3호
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• pp.247-255
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• 2021

Purpose: The goal of this study was to see how different aerobic exercise intensities affected AMP-activated protein kinase (AMPK), reactive oxygen, and antioxidant enzymes in young mice during an 8-week period. Methods: Forty male C57BL/6 mice, aged seven weeks, were randomly assigned to one of four groups: control (n=10), low-intensity exercise (n=10), moderate-intensity exercise (n=10), and high-intensity exercise (n=10). For eight weeks, aerobic activity was performed once a day for 35-40 minutes, five days a week. The data were analyzed using descriptive statistics, analysis of variance (ANOVA), chi-squared tests, and the Tukey test in the SPSS/WIN 25.0 program. Results: Weight (p=.001) was substantially different between the moderate-intensity exercise group and the control group in AMPK (p<.001). In addition, there were no significant differences between the moderate-intensity exercise group and the control group in reactive oxygen malondialdehyde (MDA) levels (p=.136) and antioxidant enzyme superoxide dismutase (SOD) levels (p=.521). Conclusion: These findings suggest that moderate-intensity aerobic exercise increased AMPK activation and helped young mice shed weight.

• 여성건강간호학회지
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• 제27권2호
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• pp.93-103
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• 2021

Purpose: The purpose of this study was to explore unmet healthcare needs among low-income overweight and obese women and to identify the factors affecting unmet healthcare needs. Methods: The study was a secondary analysis of data from the 2017 Korea National Health and Nutrition Examination Survey. A final sample of 388 out of 8,127 participants was analyzed using complex descriptive statistics, the chi-square test, the independent t-test, and logistic regression. Results: The mean age of the participants was 66.51±1.05 years. Unmet healthcare needs were experienced by 19.4% of low-income overweight and obese women. Women with depression, stress, and poor self-reported health status were significantly more likely than their counterparts to experience unmet healthcare needs. Poor self-reported health status was confirmed to be related to unmet health needs in low-income overweight and obese women (odds ratio, 2.65; p=.011). Conclusion: The study provides the novel insight that the unmet healthcare needs of low-income overweight and obese women were influenced by self-reported health status. Healthcare providers should make efforts to develop strategies to reduce unmet healthcare needs among low-income overweight and obese women, who constitute a vulnerable population.